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Aliases for CEACAM21 Gene

Aliases for CEACAM21 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 21 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 2 3
  • R29124_1 3
  • CEACAM3 3

External Ids for CEACAM21 Gene

Previous GeneCards Identifiers for CEACAM21 Gene

  • GC19P046775
  • GC19P042041
  • GC19P038514
  • GC19P042055

Summaries for CEACAM21 Gene

GeneCards Summary for CEACAM21 Gene

CEACAM21 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 21) is a Protein Coding gene. An important paralog of this gene is CEACAM1.

Additional gene information for CEACAM21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM21 Gene

Genomics for CEACAM21 Gene

GeneHancer (GH) Regulatory Elements for CEACAM21 Gene

Promoters and enhancers for CEACAM21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041575 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 656.4 +27.4 27374 2 CTCF CEBPG ZBTB40 ELK1 POLR2A VEZF1 ETV6 SRF ZNF263 ZBTB11 CEACAM21 CEACAMP3 CCDC97 COQ8B ZNF526 SNRPA ENSG00000269843 HNRNPUL1 CIC ZNF574
GH19J041547 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 28.4 +3.5 3477 10.5 HDGF HDAC1 PKNOX1 SMAD1 ZBTB7B ZNF335 SCRT2 ETV6 IKZF2 RUNX3 ENSG00000280014 CEACAMP3 CEACAM21 DMAC2 ERICH4 BCKDHA EXOSC5 LINC01480 ENSG00000268355 TMEM91
GH19J041438 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -109.6 -109575 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B DMAC2 GC19M041438 ZNF526 CCDC97 SNRPA EXOSC5 HNRNPUL1 ENSG00000269843 SERTAD3 ITPKC
GH19J041521 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 12.2 -27.2 -27199 1.7 PKNOX1 SUZ12 BACH1 ZNF335 POLR2A IKZF2 RUNX3 EZH2 ZNF687 ZNF280D PLEKHA3P1 CEACAM21 DMAC2 ERICH4 BCKDHA EXOSC5 LINC01480 PCAT19 ENSG00000268355
GH19J041261 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 -284.4 -284400 7.3 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D HNRNPUL1 ZNF526 ZNF574 CCDC97 SNRPA ENSG00000269843 CYP2F2P NUMBL ITPKC ENSG00000271299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CEACAM21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEACAM21 gene promoter:

Genomic Locations for CEACAM21 Gene

Genomic Locations for CEACAM21 Gene
chr19:41,549,250-41,586,844
(GRCh38/hg38)
Size:
37,595 bases
Orientation:
Plus strand
chr19:42,055,886-42,093,197
(GRCh37/hg19)

Genomic View for CEACAM21 Gene

Genes around CEACAM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM21 Gene

Proteins for CEACAM21 Gene

  • Protein details for CEACAM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KPI0-CEA21_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 21
    Protein Accession:
    Q3KPI0
    Secondary Accessions:
    • B7WNQ6
    • O75296
    • Q6UY47
    • Q96ER7

    Protein attributes for CEACAM21 Gene

    Size:
    293 amino acids
    Molecular mass:
    32373 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM21 Gene

Post-translational modifications for CEACAM21 Gene

  • Glycosylation at Asn111
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEACAM21 Gene

Domains & Families for CEACAM21 Gene

Suggested Antigen Peptide Sequences for CEACAM21 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KPI0

UniProtKB/Swiss-Prot:

CEA21_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM21: view

Function for CEACAM21 Gene

Phenotypes From GWAS Catalog for CEACAM21 Gene

genes like me logo Genes that share phenotypes with CEACAM21: view

Animal Model Products

miRNA for CEACAM21 Gene

miRTarBase miRNAs that target CEACAM21

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM21 Gene

Localization for CEACAM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM21 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM21 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM21 Gene

Pathways & Interactions for CEACAM21 Gene

SuperPathways for CEACAM21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEACAM21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM21 Gene

Drugs & Compounds for CEACAM21 Gene

No Compound Related Data Available

Transcripts for CEACAM21 Gene

Unigene Clusters for CEACAM21 Gene

Carcinoembryonic antigen-related cell adhesion molecule 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for CEACAM21 Gene

GeneLoc Exon Structure for
CEACAM21
ECgene alternative splicing isoforms for
CEACAM21

Expression for CEACAM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM21 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM21 Gene

This gene is overexpressed in Whole Blood (x21.5) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM21 Gene:

CEACAM21

SOURCE GeneReport for Unigene cluster for CEACAM21 Gene:

Hs.655885
genes like me logo Genes that share expression patterns with CEACAM21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM21 Gene

Orthologs for CEACAM21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEACAM1 34
  • 29 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 16 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg18 34
  • 15 (a)
ManyToMany
Species where no ortholog for CEACAM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM21 Gene

ENSEMBL:
Gene Tree for CEACAM21 (if available)
TreeFam:
Gene Tree for CEACAM21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM21: view image

Paralogs for CEACAM21 Gene

(21) SIMAP similar genes for CEACAM21 Gene using alignment to 2 proteins:

  • CEA21_HUMAN
  • B5MCY7_HUMAN

Pseudogenes.org Pseudogenes for CEACAM21 Gene

genes like me logo Genes that share paralogs with CEACAM21: view

Variants for CEACAM21 Gene

Sequence variations from dbSNP and Humsavar for CEACAM21 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057280 -- 41,575,631(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000141865 -- 41,584,189(+) C/T intron_variant
rs1000427941 -- 41,551,959(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000534793 -- 41,575,294(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000546555 -- 41,550,562(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM21 Gene

Variant ID Type Subtype PubMed ID
dgv3549n100 CNV gain 25217958
dgv6455n54 CNV loss 21841781
dgv6456n54 CNV loss 21841781
esv2668558 CNV deletion 23128226
esv2718577 CNV deletion 23290073
esv3556412 CNV deletion 23714750
esv3583419 CNV loss 25503493
esv3644387 CNV loss 21293372
nsv1055515 CNV loss 25217958
nsv442463 CNV loss 18776908
nsv519408 CNV gain 19592680
nsv579603 CNV loss 21841781

Variation tolerance for CEACAM21 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM21 Gene

Disorders for CEACAM21 Gene

Additional Disease Information for CEACAM21

No disorders were found for CEACAM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM21 Gene

Publications for CEACAM21 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (PMID: 23065704) Amin Al Olama A … Eeles RA (Human molecular genetics 2013) 3 58

Products for CEACAM21 Gene

Sources for CEACAM21 Gene

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