Aliases for CEACAM19 Gene

Aliases for CEACAM19 Gene

  • CEA Cell Adhesion Molecule 19 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 19 2 3 4
  • CEAL1 2 3 4
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 19 2 3
  • Carcinoembryonic Antigen-Like 1 3 4
  • CEACAM19 5
  • CEACM19 3

External Ids for CEACAM19 Gene

Previous GeneCards Identifiers for CEACAM19 Gene

  • GC19P049870
  • GC19P045174
  • GC19P041606

Summaries for CEACAM19 Gene

GeneCards Summary for CEACAM19 Gene

CEACAM19 (CEA Cell Adhesion Molecule 19) is a Protein Coding gene. Diseases associated with CEACAM19 include Alveoli Adenoma and Bronchial Benign Neoplasm. An important paralog of this gene is HEPACAM2.

Additional gene information for CEACAM19 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM19 Gene

Genomics for CEACAM19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEACAM19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM19

Top Transcription factor binding sites by QIAGEN in the CEACAM19 gene promoter:
  • AREB6
  • CUTL1
  • E4BP4
  • FOXJ2
  • FOXJ2 (long isoform)
  • SRF
  • SRF (504 AA)
  • STAT3
  • STAT5A
  • ZID

Genomic Locations for CEACAM19 Gene

Genomic Locations for CEACAM19 Gene
chr19:44,662,278-44,684,359
(GRCh38/hg38)
Size:
22,082 bases
Orientation:
Plus strand
chr19:45,165,545-45,187,631
(GRCh37/hg19)
Size:
22,087 bases
Orientation:
Plus strand

Genomic View for CEACAM19 Gene

Genes around CEACAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM19 Gene

Proteins for CEACAM19 Gene

  • Protein details for CEACAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z692-CEA19_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 19
    Protein Accession:
    Q7Z692
    Secondary Accessions:
    • Q5XJ15
    • Q7Z693

    Protein attributes for CEACAM19 Gene

    Size:
    300 amino acids
    Molecular mass:
    32638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP70002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP70003.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM19 Gene

Post-translational modifications for CEACAM19 Gene

  • Glycosylation at Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM19 Gene

Antibody Products

  • Boster Bio Antibodies for CEACAM19

No data available for DME Specific Peptides for CEACAM19 Gene

Domains & Families for CEACAM19 Gene

Gene Families for CEACAM19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CEACAM19 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for CEACAM19 Gene

GenScript: Design optimal peptide antigens:
  • Carcinoembryonic antigen-like 1 (CEA19_HUMAN)
  • cDNA FLJ77499, highly similar to Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 19, mRNA (Q5XJ15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z692

UniProtKB/Swiss-Prot:

CEA19_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM19: view

Function for CEACAM19 Gene

Molecular function for CEACAM19 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by dexamethasone (in vitro).

Phenotypes From GWAS Catalog for CEACAM19 Gene

Gene Ontology (GO) - Molecular Function for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20374249
genes like me logo Genes that share ontologies with CEACAM19: view
genes like me logo Genes that share phenotypes with CEACAM19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CEACAM19

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM19 Gene

Localization for CEACAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM19 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM19 gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
endoplasmic reticulum 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM19: view

Pathways & Interactions for CEACAM19 Gene

PathCards logo

SuperPathways for CEACAM19 Gene

No Data Available

Interacting Proteins for CEACAM19 Gene

Selected Interacting proteins: Q7Z692-CEA19_HUMAN for CEACAM19 Gene via IID

Symbol External ID(s) Details
BCL3
TRIM25

Gene Ontology (GO) - Biological Process for CEACAM19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM19 Gene

Drugs & Compounds for CEACAM19 Gene

No Compound Related Data Available

Transcripts for CEACAM19 Gene

mRNA/cDNA for CEACAM19 Gene

2 REFSEQ mRNAs :
78 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM19

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM19 Gene

No ASD Table

Relevant External Links for CEACAM19 Gene

GeneLoc Exon Structure for
CEACAM19

Expression for CEACAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM19

SOURCE GeneReport for Unigene cluster for CEACAM19 Gene:

Hs.416925

mRNA Expression by UniProt/SwissProt for CEACAM19 Gene:

Q7Z692-CEA19_HUMAN
Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bone marrow and ovary.
genes like me logo Genes that share expression patterns with CEACAM19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM19 Gene

Orthologs for CEACAM19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CEACAM19 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CEACAM19 30
  • 81.15 (n)
Cow
(Bos Taurus)
Mammalia CEACAM19 30 31
  • 79.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ceacam19 30
  • 77.21 (n)
Mouse
(Mus musculus)
Mammalia Ceacam19 30 17 31
  • 75.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CEACAM19 31
  • 43 (a)
OneToOne
Species where no ortholog for CEACAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CEACAM19 Gene

ENSEMBL:
Gene Tree for CEACAM19 (if available)
TreeFam:
Gene Tree for CEACAM19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM19: view image

Paralogs for CEACAM19 Gene

Variants for CEACAM19 Gene

Additional dbSNP identifiers (rs#s) for CEACAM19 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEACAM19 Gene

Variant ID Type Subtype PubMed ID
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789
nsv9737 CNV gain 18304495

Variation tolerance for CEACAM19 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM19 Gene

Disorders for CEACAM19 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CEACAM19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alveoli adenoma
  • adenoma of alveoli
bronchial benign neoplasm
  • bronchus neoplasm
penile cancer
  • ca penis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CEACAM19

genes like me logo Genes that share disorders with CEACAM19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM19 Gene

Publications for CEACAM19 Gene

  1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PMID: 12801635) Scorilas A … Diamandis EP (Gene 2003) 3 4 23
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB. (PMID: 30217308) Zhao H … Che Y (Surgical oncology 2018) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for CEACAM19 Gene

Sources for CEACAM19 Gene