Aliases for CEACAM18 Gene

Aliases for CEACAM18 Gene

  • CEA Cell Adhesion Molecule 18 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 18 2 3 4
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 18 2 3
  • CEACAM18 5

External Ids for CEACAM18 Gene

Previous GeneCards Identifiers for CEACAM18 Gene

  • GC19U900557
  • GC19P056674
  • GC19P051979
  • GC19P048311

Summaries for CEACAM18 Gene

GeneCards Summary for CEACAM18 Gene

CEACAM18 (CEA Cell Adhesion Molecule 18) is a Protein Coding gene. An important paralog of this gene is CEACAM1.

Additional gene information for CEACAM18 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM18 Gene

Genomics for CEACAM18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEACAM18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051477 Promoter/Enhancer 1.3 Ensembl ENCODE 606.8 +0.4 379 3.7 CREB1 ATF7 REST TFE3 RFX1 IKZF1 JUND FOXA1 MTA2 PHF21A CEACAM18 ZNF577 ZNF766 ZNF616 ZNF432 ZNF649 SIGLEC12 ZNF841
GH19J051570 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +93.7 93684 3.6 PRDM10 ZNF629 REST SIX5 IKZF1 ZNF692 JUND STAT3 GABPA ZNF143 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
GH19J051338 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 -138.7 -138742 3.2 SP1 CTCF HNRNPL PRDM10 ZNF512 LEF1 IKZF1 ZNF692 BACH1 JUND VSIG10L ENSG00000267905 ZNF841 ZNF577 POLD1 ZNF616 ZNF175 ZNF480 ZNF766 ZNF350
GH19J051701 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 11 +225.1 225104 4.3 SP1 CREB1 CTCF TFE3 IKZF1 ZNF692 POLR2A BACH1 JUND LARP7 lnc-HAS1-2 SIGLEC14 HAS1 FPR1 FPR3 CEACAM18 RPL7P51 SIGLEC5 SPACA6 NONHSAG026381.2
GH19J051531 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.6 +53.2 53188 1.4 JUND ZNF24 IKZF2 POLR2A HDAC1 EP300 MGA CBX3 UBTF ZNF766 SIGLEC6 SIGLEC12 CEACAM18 SIGLEC8 SIGLEC5 RPL7P51 SIGLEC14 lnc-SIGLEC12-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM18

Top Transcription factor binding sites by QIAGEN in the CEACAM18 gene promoter:
  • ARP-1
  • c-Myb
  • E47
  • HOXA9B
  • Meis-1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • RORalpha1
  • Tal-1beta

Genomic Locations for CEACAM18 Gene

Genomic Locations for CEACAM18 Gene
chr19:51,478,543-51,491,261
(GRCh38/hg38)
Size:
12,719 bases
Orientation:
Plus strand
chr19:51,979,838-51,994,206
(GRCh37/hg19)
Size:
14,369 bases
Orientation:
Plus strand

Genomic View for CEACAM18 Gene

Genes around CEACAM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM18 Gene

Proteins for CEACAM18 Gene

  • Protein details for CEACAM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTB9-CEA18_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 18
    Protein Accession:
    A8MTB9
    Secondary Accessions:
    • C9JN24

    Protein attributes for CEACAM18 Gene

    Size:
    384 amino acids
    Molecular mass:
    43320 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CEACAM18 Gene

Post-translational modifications for CEACAM18 Gene

  • Glycosylation at Asn108, Asn112, Asn121, Asn162, and Asn270

Other Protein References for CEACAM18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM18 Gene

Domains & Families for CEACAM18 Gene

Gene Families for CEACAM18 Gene

Protein Domains for CEACAM18 Gene

Suggested Antigen Peptide Sequences for CEACAM18 Gene

GenScript: Design optimal peptide antigens:
  • Carcinoembryonic antigen-related cell adhesion molecule 18 (CEA18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MTB9

UniProtKB/Swiss-Prot:

CEA18_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM18: view

Function for CEACAM18 Gene

Phenotypes From GWAS Catalog for CEACAM18 Gene

Phenotypes for CEACAM18 Gene

genes like me logo Genes that share phenotypes with CEACAM18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CEACAM18

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM18 Gene

Localization for CEACAM18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM18 gene
Compartment Confidence
plasma membrane 2
extracellular 1
nucleus 1
cytosol 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CEACAM18 Gene

Pathways & Interactions for CEACAM18 Gene

PathCards logo

SuperPathways for CEACAM18 Gene

No Data Available

Interacting Proteins for CEACAM18 Gene

Gene Ontology (GO) - Biological Process for CEACAM18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM18 Gene

Drugs & Compounds for CEACAM18 Gene

No Compound Related Data Available

Transcripts for CEACAM18 Gene

mRNA/cDNA for CEACAM18 Gene

2 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM18

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM18 Gene

No ASD Table

Relevant External Links for CEACAM18 Gene

GeneLoc Exon Structure for
CEACAM18

Expression for CEACAM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM18 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM18

SOURCE GeneReport for Unigene cluster for CEACAM18 Gene:

Hs.653111
genes like me logo Genes that share expression patterns with CEACAM18: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM18 Gene

Orthologs for CEACAM18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM18 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CEACAM18 30 31
  • 98.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC484346 30
  • 73.28 (n)
CEACAM18 31
  • 52 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC615876 30
  • 73.28 (n)
CEACAM18 31
  • 55 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ceacam18 30 17 31
  • 71.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ceacam18 30
  • 69.95 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 29 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 24 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 9 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-11o1.2 31
  • 19 (a)
ManyToMany
si:dkey-250k15.9 31
  • 18 (a)
ManyToMany
si:dkey-250k15.10 31
  • 16 (a)
ManyToMany
cxcr3.1 31
  • 15 (a)
ManyToMany
si:dkey-11o1.3 31
  • 14 (a)
ManyToMany
si:dkey-250k15.7 31
  • 13 (a)
ManyToMany
si:ch211-264f5.6 31
  • 12 (a)
ManyToMany
ceacam1 31
  • 5 (a)
ManyToMany
Species where no ortholog for CEACAM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CEACAM18 Gene

ENSEMBL:
Gene Tree for CEACAM18 (if available)
TreeFam:
Gene Tree for CEACAM18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM18: view image

Paralogs for CEACAM18 Gene

(4) SIMAP similar genes for CEACAM18 Gene using alignment to 1 proteins:

  • CEA18_HUMAN

Pseudogenes.org Pseudogenes for CEACAM18 Gene

genes like me logo Genes that share paralogs with CEACAM18: view

Variants for CEACAM18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM18 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12610545 - p.Thr161Ala
rs8106673 - p.Leu160His

Additional dbSNP identifiers (rs#s) for CEACAM18 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEACAM18 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3357728 CNV insertion 20981092
esv3644671 CNV loss 21293372
nsv1140251 OTHER inversion 24896259

Variation tolerance for CEACAM18 Gene

Gene Damage Index Score: 6.84; 79.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM18 Gene

Disorders for CEACAM18 Gene

Additional Disease Information for CEACAM18

No disorders were found for CEACAM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM18 Gene

Publications for CEACAM18 Gene

  1. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PMID: 16139472) Zebhauser R … Zimmermann W (Genomics 2005) 3
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for CEACAM18 Gene

Sources for CEACAM18 Gene