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Aliases for CEACAM16 Gene

Aliases for CEACAM16 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 16 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16 2 3
  • CEAL2 3 4
  • Carcinoembryonic Antigen Like-2 Protein 3
  • Carcinoembryonic Antigen-Like 2 4
  • DFNA4B 3

External Ids for CEACAM16 Gene

Previous GeneCards Identifiers for CEACAM16 Gene

  • GC19P049893
  • GC19P045202
  • GC19P041634

Summaries for CEACAM16 Gene

Entrez Gene Summary for CEACAM16 Gene

  • The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

GeneCards Summary for CEACAM16 Gene

CEACAM16 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 16) is a Protein Coding gene. Diseases associated with CEACAM16 include Deafness, Autosomal Dominant 4B and Nonsyndromic Deafness. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CEACAM5.

UniProtKB/Swiss-Prot for CEACAM16 Gene

  • Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

Additional gene information for CEACAM16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM16 Gene

Genomics for CEACAM16 Gene

GeneHancer (GH) Regulatory Elements for CEACAM16 Gene

Promoters and enhancers for CEACAM16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044697 Enhancer 0.2 ENCODE 650.7 -0.1 -58 0 CEACAM16 GC19P044691 ENSG00000266903
GH19J044736 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +40.4 40441 3.4 FOXA2 SIN3A YY1 ATF7 FOS RUNX3 RXRA SP5 REST SREBF1 RELB CEACAM16 ENSG00000266903 BCL3 CLASRP BLOC1S3 GC19M044726 ENSG00000252200 GC19M044733
GH19J044734 Enhancer 0.8 ENCODE dbSUPER 12.5 +37.5 37498 0.6 SMARCE1 SMAD5 JUN MAX GTF2B EP300 PCBP2 ZNF121 FOSL1 JUND FBXO46 ZNF180 CEACAM16 BLOC1S3 CLASRP ZNF155 ZNF230 GC19M044726 ENSG00000252200 BCL3
GH19J044732 Enhancer 0.5 dbSUPER 12.5 +35.0 35043 1.1 SMARCA5 BCOR ZNF664 ZFP36 ZMYM3 KDM1A CEACAM16 GC19M044726 ENSG00000252200 BCL3
GH19J044722 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 3.6 +23.8 23824 0.7 IKZF1 CEBPB ATF7 ZBTB33 IKZF2 RUNX3 APOE CEACAM19 CEACAM16 CLASRP ENSG00000266903 GC19M044726 ENSG00000252200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEACAM16 gene promoter:
  • Pax-4a
  • Tal-1beta
  • ITF-2
  • HEN1
  • E47
  • AhR
  • PPAR-alpha
  • Pax-5
  • MyoD
  • AML1a

Genomic Locations for CEACAM16 Gene

Genomic Locations for CEACAM16 Gene
chr19:44,697,504-44,710,714
(GRCh38/hg38)
Size:
13,211 bases
Orientation:
Plus strand
chr19:45,202,421-45,213,986
(GRCh37/hg19)
Size:
11,566 bases
Orientation:
Plus strand

Genomic View for CEACAM16 Gene

Genes around CEACAM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM16 Gene

Proteins for CEACAM16 Gene

  • Protein details for CEACAM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2WEN9-CEA16_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 16
    Protein Accession:
    Q2WEN9
    Secondary Accessions:
    • A7LI12

    Protein attributes for CEACAM16 Gene

    Size:
    425 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    • Homooligomer; can for homodimers and homotetramers (PubMed:21368133, PubMed:25589040). Interacts with TECTA (PubMed:21368133).
    SequenceCaution:
    • Sequence=AAQ05841.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CEACAM16 Gene

Post-translational modifications for CEACAM16 Gene

  • Glycosylation at Asn394, Asn216, and posLast=3636
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM16 Gene

Domains & Families for CEACAM16 Gene

Protein Domains for CEACAM16 Gene

Suggested Antigen Peptide Sequences for CEACAM16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2WEN9

UniProtKB/Swiss-Prot:

CEA16_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM16: view

Function for CEACAM16 Gene

Molecular function for CEACAM16 Gene

UniProtKB/Swiss-Prot Function:
Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

Phenotypes From GWAS Catalog for CEACAM16 Gene

Gene Ontology (GO) - Molecular Function for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 25589040
genes like me logo Genes that share ontologies with CEACAM16: view
genes like me logo Genes that share phenotypes with CEACAM16: view

Human Phenotype Ontology for CEACAM16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CEACAM16 Gene

MGI Knock Outs for CEACAM16:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM16 Gene

Localization for CEACAM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM16 Gene

Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane. {ECO:0000250 UniProtKB:E9QA28}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25589040
GO:0032426 stereocilium tip ISS --
genes like me logo Genes that share ontologies with CEACAM16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM16 Gene

Pathways & Interactions for CEACAM16 Gene

SuperPathways for CEACAM16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IMP 21368133
genes like me logo Genes that share ontologies with CEACAM16: view

No data available for Pathways by source and SIGNOR curated interactions for CEACAM16 Gene

Drugs & Compounds for CEACAM16 Gene

No Compound Related Data Available

Transcripts for CEACAM16 Gene

mRNA/cDNA for CEACAM16 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEACAM16 Gene

Carcinoembryonic antigen-related cell adhesion molecule 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM16 Gene

No ASD Table

Relevant External Links for CEACAM16 Gene

GeneLoc Exon Structure for
CEACAM16
ECgene alternative splicing isoforms for
CEACAM16

Expression for CEACAM16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM16 Gene

This gene is overexpressed in Pancreas (x13.1), Adrenal Gland (x5.9), and Liver (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM16 Gene:

CEACAM16

SOURCE GeneReport for Unigene cluster for CEACAM16 Gene:

Hs.456381

Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM16 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with CEACAM16: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for CEACAM16 Gene

Orthologs for CEACAM16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM16 34 33
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CEACAM16 34 33
  • 89.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEACAM16 34 33
  • 87.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ceacam16 33
  • 84.16 (n)
mouse
(Mus musculus)
Mammalia Ceacam16 16 34 33
  • 83.22 (n)
oppossum
(Monodelphis domestica)
Mammalia CEACAM16 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEACAM16 34
  • 22 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:198329 34
  • 15 (a)
ManyToMany
Species where no ortholog for CEACAM16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM16 Gene

ENSEMBL:
Gene Tree for CEACAM16 (if available)
TreeFam:
Gene Tree for CEACAM16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM16: view image

Paralogs for CEACAM16 Gene

(10) SIMAP similar genes for CEACAM16 Gene using alignment to 1 proteins:

  • CEA16_HUMAN
genes like me logo Genes that share paralogs with CEACAM16: view

Variants for CEACAM16 Gene

Sequence variations from dbSNP and Humsavar for CEACAM16 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs387907149 pathogenic, Deafness, autosomal dominant 4b, Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614] 44,704,053(+) A/C coding_sequence_variant, missense_variant
rs746164064 pathogenic, Nonsyndromic hearing loss and deafness 44,705,631(+) C/T coding_sequence_variant, missense_variant
rs876661405 pathogenic, Deafness, autosomal dominant 4b, Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614] 44,704,140(+) G/A coding_sequence_variant, missense_variant
rs114645388 likely-benign, not specified 44,704,154(+) C/T coding_sequence_variant, synonymous_variant
rs199597608 likely-benign, not specified 44,708,169(+) G/A/C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM16 Gene

Variant ID Type Subtype PubMed ID
esv2718627 CNV deletion 23290073
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789
nsv833841 CNV loss 17160897
nsv9737 CNV gain 18304495

Variation tolerance for CEACAM16 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM16 Gene

Human Gene Mutation Database (HGMD)
CEACAM16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM16 Gene

Disorders for CEACAM16 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CEACAM16 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 4b
  • dfna4b
nonsyndromic deafness
  • nonsyndromic hearing loss
non-syndromic genetic deafness
  • isolated genetic deafness
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
autosomal dominant nonsyndromic deafness
  • autosomal dominant deafness
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CEA16_HUMAN
  • Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:21368133, ECO:0000269 PubMed:25589040}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CEACAM16

genes like me logo Genes that share disorders with CEACAM16: view

No data available for Genatlas for CEACAM16 Gene

Publications for CEACAM16 Gene

  1. Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). (PMID: 21368133) Zheng J … Dallos P (Proceedings of the National Academy of Sciences of the United States of America 2011) 2 3 4 58
  2. Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family. (PMID: 25589040) Wang H … Feng Y (Journal of human genetics 2015) 3 4 58
  3. Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma. (PMID: 26497080) Yan L … Peng J (Oncology reports 2016) 3 58
  4. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. (PMID: 23565137) Miyashita A … Kuwano R (PloS one 2013) 3 58
  5. Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. (PMID: 22544735) Kammerer R … Zimmermann W (The Journal of biological chemistry 2012) 3 58

Products for CEACAM16 Gene

Sources for CEACAM16 Gene

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