Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene ... See more...

Aliases for CDYL Gene

Aliases for CDYL Gene

  • Chromodomain Y Like 2 3 5
  • CDYL1 2 3 4
  • Testis-Specific Chromodomain Y-Like Protein 2 3
  • Chromodomain Protein, Y-Like 2 3
  • Chromodomain Y-Like Protein 3 4
  • Crotonyl-CoA Hydratase 3 4
  • CDY-Like, Autosomal 2 3
  • Chromodomain Protein, Y Chromosome-Like 2
  • DKFZP586C1622 2
  • EC 2.3.1.48 51
  • EC 4.2.1.- 4
  • CDY-Like 4
  • CDYL 5

External Ids for CDYL Gene

Previous GeneCards Identifiers for CDYL Gene

  • GC06P004691
  • GC06P004651
  • GC06P004582

Summaries for CDYL Gene

Entrez Gene Summary for CDYL Gene

  • Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDYL Gene

CDYL (Chromodomain Y Like) is a Protein Coding gene. Diseases associated with CDYL include Chromosome 6Pter-P24 Deletion Syndrome. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and methylated histone binding. An important paralog of this gene is CDY2A.

UniProtKB/Swiss-Prot Summary for CDYL Gene

  • [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity).
  • [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672).
  • [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDYL Gene

Genomics for CDYL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDYL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDYL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDYL

Top Transcription factor binding sites by QIAGEN in the CDYL gene promoter:
  • AP-4
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max1
  • XBP-1

Genomic Locations for CDYL Gene

Latest Assembly
chr6:4,706,138-4,955,551
(GRCh38/hg38)
Size:
249,414 bases
Orientation:
Plus strand

Previous Assembly
chr6:4,706,372-4,955,778
(GRCh37/hg19 by Entrez Gene)
Size:
249,407 bases
Orientation:
Plus strand

chr6:4,706,393-4,955,785
(GRCh37/hg19 by Ensembl)
Size:
249,393 bases
Orientation:
Plus strand

Genomic View for CDYL Gene

Genes around CDYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDYL Gene

Proteins for CDYL Gene

  • Protein details for CDYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y232-CDYL_HUMAN
    Recommended name:
    Chromodomain Y-like protein
    Protein Accession:
    Q9Y232
    Secondary Accessions:
    • A8K6D6
    • B4DLG4
    • Q0VDG7
    • Q32NC5
    • Q5VX99
    • Q6P7T5
    • Q9BWZ2
    • Q9Y424

    Protein attributes for CDYL Gene

    Size:
    598 amino acids
    Molecular mass:
    66482 Da
    Quaternary structure:
    • Forms multimers and multimerization is required for stable binding to chromatin (PubMed:19808672). Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity). Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2 (PubMed:19061646). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2 (PubMed:22009739). Interacts with CHAF1A and CHAF1B; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (PubMed:28402439). Interacts with MCM3 and MCM5; bridging the CAF-1 complex to the MCM2-7 (MCM) complex (PubMed:28402439). Recruited to Xist RNA-coated X chromosome (By similarity). Interacts with EHMT2 and PRDM9; interaction only takes place when PRDM9 is bound to hotspot DNA (By similarity).
    SequenceCaution:
    • Sequence=CAB43304.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Major isoform.

    Three dimensional structures from OCA and Proteopedia for CDYL Gene

    Alternative splice isoforms for CDYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDYL Gene

Selected DME Specific Peptides for CDYL Gene

Q9Y232:
  • YLVRWKGYD
  • KALVRCN
  • DDTWEPEQHL
  • VNGPAIGLGASILPLCD
  • GSVFCCGLDF
  • NFVNTFIQFKKPI
  • KGLVSQVF
  • VWANEKAWFQTPYTTFGQSPDGCS
  • AAADDSKLVL

Post-translational modifications for CDYL Gene

  • Ubiquitination at Lys172, Lys538, Lys576, and Lys589
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for CDYL
  • Boster Bio Antibodies for CDYL
  • Santa Cruz Biotechnology (SCBT) Antibodies for CDYL

Domains & Families for CDYL Gene

Gene Families for CDYL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDYL Gene

GenScript: Design optimal peptide antigens:
  • Chromodomain Y-like protein (CDYL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y232

UniProtKB/Swiss-Prot:

CDYL_HUMAN :
  • The chromo domain recognizes and binds histone H3K9me3, histone H3K27me2 and histone H3K27me3.
Domain:
  • The chromo domain recognizes and binds histone H3K9me3, histone H3K27me2 and histone H3K27me3.
  • The acetyl-CoA-binding domain mediates crotonyl-coA hydratase activity (PubMed:28803779). The acetyl-CoA-binding domain is required for recruitment to sites of DNA double strand breaks and for binding to poly (ADP ribose) moieties (PubMed:29177481).
genes like me logo Genes that share domains with CDYL: view

Function for CDYL Gene

Molecular function for CDYL Gene

UniProtKB/Swiss-Prot Function:
[Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O; Xref=Rhea:RHEA:45584, ChEBI:CHEBI:15377, ChEBI:CHEBI:57332, ChEBI:CHEBI:78611; Evidence={ECO:0000269|PubMed:28803779};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=73.75 uM for (2E)-butenoyl-CoA {ECO:0000269|PubMed:28803779};
GENATLAS Biochemistry:
derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region

Enzyme Numbers (IUBMB) for CDYL Gene

Phenotypes From GWAS Catalog for CDYL Gene

Gene Ontology (GO) - Molecular Function for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0003714 transcription corepressor activity IMP 19061646
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 16415788
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with CDYL: view
genes like me logo Genes that share phenotypes with CDYL: view

Animal Models for research

  • Taconic Biosciences Mouse Models for CDYL

miRNA for CDYL Gene

miRTarBase miRNAs that target CDYL

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDYL

Clone products for research

  • Addgene plasmids for CDYL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDYL Gene

Localization for CDYL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDYL Gene

[Isoform 2]: Nucleus. Chromosome. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). {ECO:0000269 PubMed:19808672, ECO:0000269 PubMed:29177481}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDYL gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18450745
GO:0005694 chromosome ISS --
GO:0005737 cytoplasm ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDYL: view

Pathways & Interactions for CDYL Gene

PathCards logo

SuperPathways for CDYL Gene

SuperPathway Contained pathways
1 Transcriptional Regulatory Network in Embryonic Stem Cell
-
2 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with CDYL: view

Pathways by source for CDYL Gene

1 BioSystems pathway for CDYL Gene
1 Qiagen pathway for CDYL Gene
  • Transcriptional Regulatory Network in Embryonic Stem Cell

Gene Ontology (GO) - Biological Process for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 10192397
GO:0007286 spermatid development ISS --
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0060816 random inactivation of X chromosome ISS --
genes like me logo Genes that share ontologies with CDYL: view

No data available for SIGNOR curated interactions for CDYL Gene

Drugs & Compounds for CDYL Gene

(1) Drugs for CDYL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for CDYL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with CDYL: view

Transcripts for CDYL Gene

mRNA/cDNA for CDYL Gene

7 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDYL

Clone products for research

  • Addgene plasmids for CDYL

Alternative Splicing Database (ASD) splice patterns (SP) for CDYL Gene

No ASD Table

Relevant External Links for CDYL Gene

GeneLoc Exon Structure for
CDYL

Expression for CDYL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDYL Gene

Protein differential expression in normal tissues from HIPED for CDYL Gene

This gene is overexpressed in Adipocyte (39.4) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDYL Gene



Protein tissue co-expression partners for CDYL Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDYL

SOURCE GeneReport for Unigene cluster for CDYL Gene:

Hs.269092

mRNA Expression by UniProt/SwissProt for CDYL Gene:

Q9Y232-CDYL_HUMAN
Tissue specificity: Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMed:19808672). Isoform 2: Most abundantly expressed isoform (PubMed:19808672).

Evidence on tissue expression from TISSUES for CDYL Gene

  • Liver(4.4)
  • Eye(4.1)
  • Nervous system(2.8)
  • Skin(2.7)
  • Intestine(2.6)
  • Muscle(2.4)
  • Kidney(2.4)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with CDYL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDYL Gene

Orthologs for CDYL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDYL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDYL 30 31
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
CDYL 30
  • 90.42 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 89 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Cdyl 30 17 31
  • 86.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdyl 30
  • 86.39 (n)
Cow
(Bos Taurus)
Mammalia CDYL 30 31
  • 82.54 (n)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 89 (a)
OneToMany
CDYL 30
  • 80.21 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 87 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdyl 30
  • 72.58 (n)
Zebrafish
(Danio rerio)
Actinopterygii cdyl 30 31
  • 66.67 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG3680 31
  • 12 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 31
  • 24 (a)
ManyToMany
ECI1 31 33
  • 21 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2946 31
  • 28 (a)
OneToMany
Species where no ortholog for CDYL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDYL Gene

ENSEMBL:
Gene Tree for CDYL (if available)
TreeFam:
Gene Tree for CDYL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDYL: view image

Paralogs for CDYL Gene

Variants for CDYL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDYL Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs34649909 Benign: not specified 4,943,770(+) T/TA
NM_004824.4(CDYL):c.1332+31dup
INTRON
rs13196069 - p.Val48Ala
rs28360500 - p.Ala60Gly
rs3812178 - p.Ser9Pro
rs3812179 - p.Thr2Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDYL Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDYL Gene

Variant ID Type Subtype PubMed ID
dgv3259n106 CNV deletion 24896259
esv23619 CNV gain 19812545
esv2422499 CNV duplication 17116639
esv2663092 CNV deletion 23128226
esv2731510 CNV deletion 23290073
esv3570736 CNV loss 25503493
esv3570737 CNV loss 25503493
esv3607953 CNV loss 21293372
esv3607955 CNV loss 21293372
esv3607956 CNV loss 21293372
esv3607957 CNV loss 21293372
esv3607959 CNV loss 21293372
esv3607960 CNV loss 21293372
esv3890784 CNV loss 25118596
nsv1015888 CNV loss 25217958
nsv1074369 CNV deletion 25765185
nsv1074370 CNV deletion 25765185
nsv1124023 CNV deletion 24896259
nsv1126745 CNV deletion 24896259
nsv1137056 CNV deletion 24896259
nsv462622 CNV gain 19166990
nsv528627 CNV gain 19592680
nsv600871 CNV gain 21841781
nsv819186 CNV gain 19587683
nsv830577 CNV loss 17160897
nsv950764 CNV deletion 24416366
nsv970071 CNV duplication 23825009

Variation tolerance for CDYL Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDYL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDYL

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDYL Gene

Disorders for CDYL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDYL Gene - From: COP

Disorder Aliases PubMed IDs
chromosome 6pter-p24 deletion syndrome
  • 6p subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CDYL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDYL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDYL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDYL Gene

Publications for CDYL Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn BT … Page DC (Nature genetics 1999) 2 3 4 23
  2. CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair. (PMID: 29177481) Abu-Zhayia ER … Ayoub N (Journal of molecular cell biology 2018) 3 4
  3. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks. (PMID: 28402439) Liu Y … Liang J (Journal of molecular cell biology 2017) 3 4
  4. Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. (PMID: 28803779) Liu S … Shang Y (Molecular cell 2017) 3 4
  5. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. (PMID: 22009739) Zhang Y … Liang J (The Journal of biological chemistry 2011) 3 4

Products for CDYL Gene

Sources for CDYL Gene