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Aliases for CDY2B Gene

Aliases for CDY2B Gene

  • Chromodomain Y-Linked 2B 2 3 5
  • Chromodomain Protein, Y-Linked, 2B 2 3
  • Testis-Specific Chromodomain Protein Y Protein 2 Related 3
  • Chromodomain Protein, Y Chromosome, 2 Related 3
  • Testis-Specific Chromodomain Protein Y 2 3
  • Y Chromosome Chromodomain Protein 2B 3
  • EC 4
  • CDY2 4
  • CDY 3

External Ids for CDY2B Gene

Previous GeneCards Identifiers for CDY2B Gene

  • GC0YM018428
  • GC0YM018499
  • GC0YM019990

Summaries for CDY2B Gene

Entrez Gene Summary for CDY2B Gene

  • This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDY2B Gene

CDY2B (Chromodomain Y-Linked 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is CDY2A.

UniProtKB/Swiss-Prot for CDY2B Gene

  • May have histone acetyltransferase activity.

Additional gene information for CDY2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDY2B Gene

Genomics for CDY2B Gene

GeneHancer (GH) Regulatory Elements for CDY2B Gene

Top Transcription factor binding sites by QIAGEN in the CDY2B gene promoter:
  • RORalpha2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • c-Myc
  • Max
  • PPAR-gamma2
  • PPAR-gamma1
  • Bach1
  • N-Myc

Genomic Locations for CDY2B Gene

Genomic Locations for CDY2B Gene
2,811 bases
Minus strand
2,811 bases
Minus strand

Genomic View for CDY2B Gene

Genes around CDY2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDY2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDY2B Gene

Proteins for CDY2B Gene

  • Protein details for CDY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific chromodomain protein Y 2
    Protein Accession:
    Secondary Accessions:
    • A8K868
    • A8K868

    Protein attributes for CDY2B Gene

    541 amino acids
    Molecular mass:
    60524 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDY2B Gene

neXtProt entry for CDY2B Gene

Post-translational modifications for CDY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDY2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDY2B Gene

Domains & Families for CDY2B Gene

Gene Families for CDY2B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDY2B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDY2B: view

No data available for UniProtKB/Swiss-Prot for CDY2B Gene

Function for CDY2B Gene

Molecular function for CDY2B Gene

UniProtKB/Swiss-Prot Function:
May have histone acetyltransferase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.

Enzyme Numbers (IUBMB) for CDY2B Gene

Gene Ontology (GO) - Molecular Function for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with CDY2B: view
genes like me logo Genes that share phenotypes with CDY2B: view

Animal Model Products

CRISPR Products

miRNA for CDY2B Gene

miRTarBase miRNAs that target CDY2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDY2B

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDY2B Gene

Localization for CDY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDY2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDY2B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CDY2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDY2B Gene

Pathways & Interactions for CDY2B Gene

SuperPathways for CDY2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 9381176
GO:0008152 metabolic process IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with CDY2B: view

No data available for Pathways by source and SIGNOR curated interactions for CDY2B Gene

Drugs & Compounds for CDY2B Gene

No Compound Related Data Available

Transcripts for CDY2B Gene

mRNA/cDNA for CDY2B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDY2B Gene

Chromodomain protein, Y-linked, 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDY2B

Alternative Splicing Database (ASD) splice patterns (SP) for CDY2B Gene

No ASD Table

Relevant External Links for CDY2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDY2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDY2B Gene

Protein differential expression in normal tissues from HIPED for CDY2B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDY2B Gene

Protein tissue co-expression partners for CDY2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDY2B Gene:


SOURCE GeneReport for Unigene cluster for CDY2B Gene:


mRNA Expression by UniProt/SwissProt for CDY2B Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with CDY2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDY2B Gene

Orthologs for CDY2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDY2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDY1 34 34 33
  • 98.15 (n)
-- 34
  • 92 (a)
-- 34
  • 92 (a)
-- 34
  • 92 (a)
(Canis familiaris)
Mammalia -- 34
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Bos Taurus)
Mammalia CDYL 34
  • 59 (a)
(Gallus gallus)
Aves -- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
(Danio rerio)
Actinopterygii cdyl 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3680 34
  • 9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 34
  • 22 (a)
ECI1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 34
  • 26 (a)
Species where no ortholog for CDY2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDY2B Gene

Gene Tree for CDY2B (if available)
Gene Tree for CDY2B (if available)

Paralogs for CDY2B Gene

Paralogs for CDY2B Gene

(9) SIMAP similar genes for CDY2B Gene using alignment to 2 proteins:

  • A1L473_HUMAN
genes like me logo Genes that share paralogs with CDY2B: view

Variants for CDY2B Gene

Sequence variations from dbSNP and Humsavar for CDY2B Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs374343845 -- 17,880,120(-) G/A 5_prime_UTR_variant
rs3992878 -- 17,880,570(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDY2B Gene

Variant ID Type Subtype PubMed ID
esv1670141 OTHER inversion 17803354
esv3575095 CNV loss 25503493
esv3577586 CNV gain 25503493
esv3577589 CNV gain 25503493
nsv469874 CNV gain+loss 16826518

Additional Variant Information for CDY2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CDY2B Gene

Disorders for CDY2B Gene

Additional Disease Information for CDY2B

No disorders were found for CDY2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDY2B Gene

Publications for CDY2B Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn BT … Page DC (Nature genetics 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn BT … Page DC (Science (New York, N.Y.) 1997) 2 3 58
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  5. Crystal structures of human CDY proteins reveal a crotonase-like fold. (PMID: 19507244) Wu H … Plotnikov AN (Proteins 2009) 4 58

Products for CDY2B Gene

Sources for CDY2B Gene

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