Aliases for CDY1 Gene
External Ids for CDY1 Gene
Previous GeneCards Identifiers for CDY1 Gene
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDY1 Gene
CDY1 (Chromodomain Y-Linked 1) is a Protein Coding gene. Diseases associated with CDY1 include Spermatogenic Failure, Y-Linked, 2 and Male Reproductive System Disease. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and methylated histone binding. An important paralog of this gene is CDY1B.
UniProtKB/Swiss-Prot for CDY1 Gene
Has histone acetyltransferase activity, with a preference for histone H4.