Aliases for CDX1 Gene
External Ids for CDX1 Gene
Previous GeneCards Identifiers for CDX1 Gene
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDX1 Gene
CDX1 (Caudal Type Homeobox 1) is a Protein Coding gene. Diseases associated with CDX1 include Mesenchymal Chondrosarcoma and Esophagus Melanoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is CDX2.
UniProtKB/Swiss-Prot Summary for CDX1 Gene
Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).