Aliases for CDX1 Gene
External Ids for CDX1 Gene
Previous GeneCards Identifiers for CDX1 Gene
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDX1 Gene
CDX1 (Caudal Type Homeobox 1) is a Protein Coding gene. Diseases associated with CDX1 include Adult Acute Lymphocytic Leukemia and Mesenchymal Chondrosarcoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is CDX2.
UniProtKB/Swiss-Prot for CDX1 Gene
Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).