Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of ... See more...
Aliases for CDT1 Gene
Aliases for CDT1 Gene
External Ids for CDT1 Gene
- HGNC: 24576
- Entrez Gene: 81620
- Ensembl: ENSG00000167513
- OMIM: 605525
- UniProtKB: Q9H211
Previous GeneCards Identifiers for CDT1 Gene
- GC16M080446
- GC16M090107
- GC16P088573
- GC16P088614
- GC16P087397
- GC16P088870
- GC16P074567
Summaries for CDT1 Gene
-
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
GeneCards Summary for CDT1 Gene
CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Cell cycle Role of SCF complex in cell cycle regulation.
UniProtKB/Swiss-Prot Summary for CDT1 Gene
-
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).
Additional gene information for CDT1 Gene
- HGNC(24576)
- Entrez Gene(81620)
- Ensembl(ENSG00000167513)
- OMIM(605525)
- UniProtKB(Q9H211)
- Open Targets Platform(ENSG00000167513)
- Monarch Initiative
- Search for CDT1 at DataMed
- Search for CDT1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDT1 Gene
Genomics for CDT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDT1
- Top Transcription factor binding sites by QIAGEN in the CDT1 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- NF-kappaB1
- p53
Genomic Locations for CDT1 Gene
Genomic Locations for CDT1 Gene
- chr16:88,803,789-88,809,258
- (GRCh38/hg38)
- Size:
- 5,470 bases
- Orientation:
- Plus strand
- chr16:88,869,621-88,875,666
- (GRCh37/hg19)
- Size:
- 6,046 bases
- Orientation:
- Plus strand
Genomic View for CDT1 Gene
Genes around CDT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by HGNC
- 16q24.3 by Entrez Gene
- 16q24.3 by Ensembl
CDT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDT1 Gene
Proteins for CDT1 Gene
-
Protein details for CDT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H211-CDT1_HUMAN
- Recommended name:
- DNA replication factor Cdt1
- Protein Accession:
- Q9H211
- Q86XX9
- Q96CJ5
- Q96GK5
- Q96H67
- Q96HE6
- Q9BWM0
Protein attributes for CDT1 Gene
- Size:
- 546 amino acids
- Molecular mass:
- 60390 Da
- Quaternary structure:
-
- Interacts with GMNN; inhibits binding of the MCM complex to origins of replication (PubMed:11125146, PubMed:14672932, PubMed:14993212, PubMed:15257290). Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with PCNA (PubMed:16861906). Interacts with LRWD1 during G1 phase and during mitosis (PubMed:22645314). Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (PubMed:22581055). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with KAT7 (PubMed:18832067). Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (PubMed:26842564).
- SequenceCaution:
-
- Sequence=AF070552; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for CDT1 Gene
Post-translational modifications for CDT1 Gene
- Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37 (PubMed:27296872).
- Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation.
-
Ubiquitination at Lys24, Lys166, Lys189, Lys240, and Lys377
- NX_Q9H211 (NX_Q9H211-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CDT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CDT1 Antibody
- GeneTex Anti-CDT1 antibody, C-term and Anti-CDT1 antibody
- Novus Biologicals Antibodies for CDT1
-
Abcam antibodies for CDT1
- Invitrogen Antibodies for CDT1 (AFLGC-CDT1)
-
Biorbyt antibodies for CDT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDT1
Protein Products
-
OriGene Purified Proteins for CDT1
- Search Origene for MassSpec and Protein Over-expression Lysates for CDT1
- Origene Custom Protein Services for CDT1
- Novus Biologicals lysates for CDT1
-
Signalway Proteins for CDT1
Assay Products
- antibodies-online: Show 7 available CDT1 Elisa Kits ranked by validation data
- Compare Top CDT1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for CDT1
No data available for DME Specific Peptides for CDT1 Gene
Domains & Families for CDT1 Gene
Gene Families for CDT1 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CDT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDT1 Gene
- GenScript: Design optimal peptide antigens:
-
- CDT1 protein (A0PJB2_HUMAN)
- Double parked homolog (CDT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H211UniProtKB/Swiss-Prot:
CDT1_HUMAN :- The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
- Belongs to the Cdt1 family.
- Domain:
-
- The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
- Family:
-
- Belongs to the Cdt1 family.
Function for CDT1 Gene
Molecular function for CDT1 Gene
- UniProtKB/Swiss-Prot Function:
- Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Induced by E2F transcription factors (PubMed:14990995).
Phenotypes From GWAS Catalog for CDT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA,ISS | -- |
| GO:0003682 | chromatin binding | IDA | 11125146 |
| GO:0005515 | protein binding | IPI | 11125146 |
| GO:0070182 | DNA polymerase binding | IBA | 21873635 |
Phenotypes for CDT1 Gene
- MGI mutant phenotypes for CDT1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CDT1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Two nuclei (binuclear)
- Decreased viability (cell death)
- Increased cell number in S
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDT1 - Select products 50% OFF >
- * CDT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDT1
miRNA for CDT1 Gene
- miRTarBase miRNAs that target CDT1
-
- hsa-miR-193b-3p (MIRT016534)
- hsa-miR-186-5p (MIRT045201)
- hsa-miR-20a-5p (MIRT050529)
- hsa-miR-520g-3p (MIRT285530)
- hsa-miR-520h (MIRT285531)
- hsa-miR-2110 (MIRT285532)
- hsa-miR-3153 (MIRT285533)
- hsa-miR-3926 (MIRT285536)
- hsa-miR-4476 (MIRT285538)
- hsa-miR-4493 (MIRT285539)
- hsa-miR-4667-5p (MIRT285540)
- hsa-miR-4700-5p (MIRT285541)
- hsa-miR-4753-5p (MIRT285542)
- hsa-miR-6733-5p (MIRT285544)
- hsa-miR-6739-5p (MIRT285545)
- hsa-miR-6876-5p (MIRT285546)
- hsa-miR-8089 (MIRT285547)
- hsa-miR-96-3p (MIRT344141)
- hsa-miR-2681-3p (MIRT344142)
- hsa-miR-6780b-5p (MIRT564059)
- hsa-miR-4725-3p (MIRT564060)
- hsa-miR-4271 (MIRT564061)
- hsa-miR-4731-5p (MIRT564062)
- hsa-miR-4279 (MIRT635623)
- hsa-miR-377-3p (MIRT635624)
- hsa-miR-6778-3p (MIRT635625)
- hsa-miR-1976 (MIRT635626)
- hsa-miR-3653-5p (MIRT635627)
- hsa-miR-325 (MIRT635628)
- hsa-miR-6747-3p (MIRT635629)
- hsa-miR-1228-3p (MIRT635630)
- hsa-miR-6727-3p (MIRT637709)
- hsa-miR-4722-3p (MIRT637710)
- hsa-miR-6836-3p (MIRT718821)
- hsa-miR-550b-2-5p (MIRT718822)
- hsa-miR-6783-3p (MIRT718823)
- hsa-miR-1343-3p (MIRT718824)
- hsa-miR-550a-5p (MIRT718825)
- hsa-miR-550a-3-5p (MIRT718826)
- hsa-miR-1271-3p (MIRT718827)
- hsa-miR-23b-5p (MIRT718828)
- hsa-miR-23a-5p (MIRT718829)
- hsa-miR-6829-3p (MIRT718830)
- hsa-miR-6791-3p (MIRT718831)
- hsa-miR-6742-3p (MIRT718832)
- hsa-miR-6852-5p (MIRT718833)
- hsa-miR-939-3p (MIRT718834)
- hsa-miR-660-3p (MIRT718835)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDT1
- Browse OriGene Inhibitory RNA Products For CDT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDT1
Clone Products
- Applied Biological Materials (abm): Clones for CDT1 - Select products 50% OFF >
- * CDT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDT1
- Addgene plasmids for CDT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDT1
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDT1 Gene
Localization for CDT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDT1 Gene
- Nucleus. Chromosome, centromere, kinetochore. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000269 PubMed:22581055}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IDA | 22581055 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IBA,IDA | 11125146 |
Pathways & Interactions for CDT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.78
|
| 2 | E2F mediated regulation of DNA replication |
.64
Cell cycle Start of DNA replication in early S phase
.53
|
|
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Mitotic G1-G1/S phases |
.83
|
|
| 5 | DNA Damage | ||
Pathways by source for CDT1 Gene
2 BioSystems pathways for CDT1 Gene
19 Reactome pathways for CDT1 Gene
2 GeneGo (Thomson Reuters) pathways for CDT1 Gene
- Cell cycle Role of SCF complex in cell cycle regulation
- Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for CDT1 Gene
- Cell Cycle Control of Chromosomal Replication
1 Cell Signaling Technology pathway for CDT1 Gene
Interacting Proteins for CDT1 Gene
Selected Interacting proteins:
Q9H211-CDT1_HUMAN
ENSP00000301019
for CDT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | IEA,IDA | 14672932 |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000278 | mitotic cell cycle | IMP | 22581055 |
| GO:0006260 | DNA replication | IBA | 21873635 |
Transcripts for CDT1 Gene
mRNA/cDNA for CDT1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000301019 2664 nts (view in UCSC)
- ENST00000562747 735 nts (view in UCSC)
- ENST00000569140 571 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDT1 - Select products 50% OFF >
- * CDT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDT1
- Browse OriGene Inhibitory RNA Products For CDT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDT1
Clone Products
- Applied Biological Materials (abm): Clones for CDT1 - Select products 50% OFF >
- * CDT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDT1
- Addgene plasmids for CDT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - |
Relevant External Links for CDT1 Gene
- GeneLoc Exon Structure for
- CDT1
Expression for CDT1 Gene
This gene is overexpressed in Heart (64.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDT1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDT1
SOURCE GeneReport for Unigene cluster for CDT1 Gene:
Hs.122908Evidence on tissue expression from TISSUES for CDT1 Gene
- Nervous system(4.5)
- Skin(2.7)
- Intestine(2.7)
- Blood(2.6)
- Kidney(2.5)
- Liver(2.4)
- Lung(2.3)
- Bone marrow(2.2)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CDT1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- inner ear
- jaw
- larynx
- lip
- mandible
- maxilla
- middle ear
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
- vocal cord
Thorax:
- breast
- bronchus
- chest wall
- clavicle
- esophagus
- lung
- rib
- rib cage
- scapula
- sternum
- trachea
Abdomen:
- stomach
Pelvis:
- pelvis
- penis
- testicle
- uterus
- vagina
- vulva
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- hair
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for CDT1
-
OriGene qPCR primer pairs and template standards for CDT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDT1 Gene
Orthologs for CDT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDT1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdt1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cdt1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CDT1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CDT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdt1 30 |
|
||
| Str.3346 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cdt1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cdt1 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2597 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | dup 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | cdt-1 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9171 31 |
|
OneToOne |
- Species where no ortholog for CDT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CDT1 Gene
- ENSEMBL:
- Gene Tree for CDT1 (if available)
- TreeFam:
- Gene Tree for CDT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDT1: view image
Paralogs for CDT1 Gene
No data available for Paralogs for CDT1 Gene
Variants for CDT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDT1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711599 | Likely Benign: not provided | 88,805,647(+) | C/T | INTRON_VARIANT | |
| 712850 | Benign: not provided | 88,804,568(+) | G/A | SYNONYMOUS_VARIANT | |
| 718646 | Likely Benign: not provided | 88,805,714(+) | C/G | INTRON_VARIANT | |
| 722740 | Likely Benign: not provided | 88,807,301(+) | G/A | SYNONYMOUS_VARIANT | |
| 723206 | Likely Benign: not provided | 88,808,188(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3064n100 | CNV | gain | 25217958 |
| dgv3065n100 | CNV | gain | 25217958 |
| dgv37n68 | CNV | loss | 17160897 |
| dgv5313n54 | CNV | loss | 21841781 |
| dgv5319n54 | CNV | loss | 21841781 |
| esv3639555 | CNV | gain | 21293372 |
| esv3892938 | CNV | loss | 25118596 |
| nsv1061256 | CNV | gain | 25217958 |
| nsv1063024 | CNV | gain | 25217958 |
| nsv1063441 | CNV | loss | 25217958 |
| nsv1070367 | CNV | deletion | 25765185 |
| nsv457617 | CNV | gain | 19166990 |
| nsv471115 | CNV | loss | 18288195 |
| nsv471117 | CNV | gain | 18288195 |
| nsv482951 | CNV | loss | 15286789 |
| nsv521217 | CNV | loss | 19592680 |
| nsv528898 | CNV | loss | 19592680 |
| nsv573674 | CNV | gain | 21841781 |
| nsv573677 | CNV | loss | 21841781 |
| nsv573712 | CNV | loss | 21841781 |
| nsv573714 | CNV | gain | 21841781 |
| nsv573715 | CNV | loss | 21841781 |
| nsv573718 | CNV | loss | 21841781 |
| nsv819907 | CNV | gain | 19587683 |
| nsv952071 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.40;
54.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDT1 Gene
Disorders for CDT1 Gene
(6) MalaCards diseases for CDT1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| meier-gorlin syndrome 4 |
|
|
| meier-gorlin syndrome 1 |
|
|
| genitourinary tract anomalies |
|
|
| isolated growth hormone deficiency, type ia |
|
|
| microcephaly |
|
|
Search CDT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CDT1_HUMAN- Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CDT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for CDT1 Gene
Publications for CDT1 Gene
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 4 23
- The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. (PMID: 17029205) Gao J … Shen HB (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2006) 3 23 41
- Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PMID: 14993212) Sugimoto N … Fujita M (The Journal of biological chemistry 2004) 3 4 23
- Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PMID: 15257290) Ballabeni A … Helin K (The EMBO journal 2004) 3 4 23
- The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PMID: 11555648) Nishitani H … Nishimoto T (The Journal of biological chemistry 2001) 2 3 23
ExternalLinks
Products for CDT1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDT1
- Search Origene for MassSpec and Protein Over-expression Lysates for CDT1
- Origene Custom Protein Services for CDT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDT1
- Browse OriGene Inhibitory RNA Products For CDT1
- OriGene qPCR primer pairs for CDT1
- OriGene qPCR primer pairs and template standards for CDT1
- OriGene CRISPR knockouts for CDT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDT1
- Sino Biological Human cDNA Clone for CDT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CDT1
- Novus Biologicals lysates for CDT1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CDT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CDT1 (AFLGC-CDT1)
- VectorBuilder Custom and pre-made DNA vectors for CDT1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDT1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDT1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDT1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDT1
- Addgene plasmids for CDT1
- antibodies-online: Show 10 available CDT1 Antibodies ranked by validation data
- Compare Top CDT1 Antibodies
- antibodies-online: Show 7 available CDT1 Elisa Kits ranked by validation data
- Compare Top CDT1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available CDT1 Proteins ranked by validation data
- Compare Top CDT1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDT1
- Search Santa Cruz Biotechnology (SCBT) for CDT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDT1
- Biorbyt antibodies for CDT1
Sources for CDT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB