The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of ... See more...

Aliases for CDT1 Gene

Aliases for CDT1 Gene

  • Chromatin Licensing And DNA Replication Factor 1 2 3 5
  • DUP 2 3 4
  • DNA Replication Factor Cdt1 3 4
  • RIS2 2 3
  • Double Parked, Drosophila, Homolog Of 3
  • Double Parked Homolog 4
  • CDT1 5

External Ids for CDT1 Gene

Previous GeneCards Identifiers for CDT1 Gene

  • GC16M080446
  • GC16M090107
  • GC16P088573
  • GC16P088614
  • GC16P087397
  • GC16P088870
  • GC16P074567

Summaries for CDT1 Gene

Entrez Gene Summary for CDT1 Gene

  • The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

GeneCards Summary for CDT1 Gene

CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are E2F mediated regulation of DNA replication and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot Summary for CDT1 Gene

  • Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).

Gene Wiki entry for CDT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDT1 Gene

Genomics for CDT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDT1

Top Transcription factor binding sites by QIAGEN in the CDT1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB1
  • p53

Genomic Locations for CDT1 Gene

Latest Assembly
chr16:88,803,789-88,809,258
(GRCh38/hg38)
Size:
5,470 bases
Orientation:
Plus strand

Previous Assembly
chr16:88,870,197-88,875,666
(GRCh37/hg19 by Entrez Gene)
Size:
5,470 bases
Orientation:
Plus strand

chr16:88,869,621-88,875,666
(GRCh37/hg19 by Ensembl)
Size:
6,046 bases
Orientation:
Plus strand

Genomic View for CDT1 Gene

Genes around CDT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDT1 Gene

Proteins for CDT1 Gene

  • Protein details for CDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H211-CDT1_HUMAN
    Recommended name:
    DNA replication factor Cdt1
    Protein Accession:
    Q9H211
    Secondary Accessions:
    • Q86XX9
    • Q96CJ5
    • Q96GK5
    • Q96H67
    • Q96HE6
    • Q9BWM0

    Protein attributes for CDT1 Gene

    Size:
    546 amino acids
    Molecular mass:
    60390 Da
    Quaternary structure:
    • Interacts with GMNN; inhibits binding of the MCM complex to origins of replication (PubMed:11125146, PubMed:14672932, PubMed:14993212, PubMed:15257290). Interacts with CDC6; are mutually dependent on one another for loading MCM complexes onto chromatin (PubMed:14672932). Interacts with PCNA (PubMed:16861906). Interacts with LRWD1 during G1 phase and during mitosis (PubMed:22645314). Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (PubMed:22581055). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with KAT7 (PubMed:18832067). Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (PubMed:26842564).
    SequenceCaution:
    • Sequence=AF070552; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDT1 Gene

neXtProt entry for CDT1 Gene

Post-translational modifications for CDT1 Gene

  • Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37 (PubMed:27296872).
  • Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation.
  • Ubiquitination at Lys24, Lys166, Lys189, Lys240, and Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for CDT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDT1 Gene

Domains & Families for CDT1 Gene

Gene Families for CDT1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CDT1 Gene

Suggested Antigen Peptide Sequences for CDT1 Gene

GenScript: Design optimal peptide antigens:
  • CDT1 protein (A0PJB2_HUMAN)
  • Double parked homolog (CDT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H211

UniProtKB/Swiss-Prot:

CDT1_HUMAN :
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
  • Belongs to the Cdt1 family.
Domain:
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
Family:
  • Belongs to the Cdt1 family.
genes like me logo Genes that share domains with CDT1: view

Function for CDT1 Gene

Molecular function for CDT1 Gene

UniProtKB/Swiss-Prot Function:
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced by E2F transcription factors (PubMed:14990995).

Phenotypes From GWAS Catalog for CDT1 Gene

Gene Ontology (GO) - Molecular Function for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,ISS --
GO:0003682 chromatin binding IDA 11125146
GO:0005515 protein binding IPI 11125146
GO:0070182 DNA polymerase binding IBA 21873635
genes like me logo Genes that share ontologies with CDT1: view
genes like me logo Genes that share phenotypes with CDT1: view

Human Phenotype Ontology for CDT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDT1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDT1 Gene

Localization for CDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDT1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000269 PubMed:22581055}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDT1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IDA 22581055
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IBA,IDA 11125146
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CDT1: view

Pathways & Interactions for CDT1 Gene

genes like me logo Genes that share pathways with CDT1: view

Pathways by source for CDT1 Gene

2 BioSystems pathways for CDT1 Gene
2 GeneGo (Thomson Reuters) pathways for CDT1 Gene
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for CDT1 Gene
  • Cell Cycle Control of Chromosomal Replication
1 Cell Signaling Technology pathway for CDT1 Gene

SIGNOR curated interactions for CDT1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint IEA,IDA 14672932
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle IMP 22581055
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with CDT1: view

Drugs & Compounds for CDT1 Gene

(1) Drugs for CDT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDT1: view

Transcripts for CDT1 Gene

mRNA/cDNA for CDT1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDT1

Alternative Splicing Database (ASD) splice patterns (SP) for CDT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: -

Relevant External Links for CDT1 Gene

GeneLoc Exon Structure for
CDT1

Expression for CDT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDT1 Gene

Protein differential expression in normal tissues from HIPED for CDT1 Gene

This gene is overexpressed in Heart (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDT1 Gene



Protein tissue co-expression partners for CDT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDT1

SOURCE GeneReport for Unigene cluster for CDT1 Gene:

Hs.122908

Evidence on tissue expression from TISSUES for CDT1 Gene

  • Nervous system(4.5)
  • Skin(2.6)
  • Intestine(2.5)
  • Blood(2.4)
  • Kidney(2.4)
  • Liver(2.3)
  • Lung(2.2)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDT1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • stomach
Pelvis:
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with CDT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDT1 Gene

Orthologs for CDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDT1 29 30
  • 97.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDT1 29 30
  • 81.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDT1 29 30
  • 79.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdt1 29
  • 76.14 (n)
Mouse
(Mus musculus)
Mammalia Cdt1 29 16 30
  • 75.58 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDT1 30
  • 55 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDT1 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDT1 29 30
  • 62.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDT1 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdt1 29
  • 59.69 (n)
Str.3346 29
African clawed frog
(Xenopus laevis)
Amphibia cdt1 29
Zebrafish
(Danio rerio)
Actinopterygii cdt1 29 30
  • 58.76 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2597 29
Fruit Fly
(Drosophila melanogaster)
Insecta dup 30 31
  • 23 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cdt-1 30
  • 18 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9171 30
  • 40 (a)
OneToOne
Species where no ortholog for CDT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDT1 Gene

ENSEMBL:
Gene Tree for CDT1 (if available)
TreeFam:
Gene Tree for CDT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDT1: view image
Alliance of Genome Resources:
Additional Orthologs for CDT1

Paralogs for CDT1 Gene

No data available for Paralogs for CDT1 Gene

Variants for CDT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDT1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
1001691 Uncertain Significance: not provided 88,806,072(+) GG/TT
NM_030928.4(CDT1):c.884_885delinsTT (p.Arg295Leu)
MISSENSE
1006017 Uncertain Significance: not provided 88,805,634(+) G/A
NM_030928.4(CDT1):c.683G>A (p.Arg228His)
MISSENSE
1012020 Uncertain Significance: not provided 88,803,887(+) G/A
NM_030928.4(CDT1):c.56G>A (p.Arg19His)
MISSENSE
1015874 Uncertain Significance: not provided 88,803,877(+) G/A
NM_030928.4(CDT1):c.46G>A (p.Gly16Arg)
MISSENSE
1016370 Uncertain Significance: not provided 88,807,151(+) C/T
NM_030928.4(CDT1):c.1223C>T (p.Pro408Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDT1 Gene

Variant ID Type Subtype PubMed ID
dgv3064n100 CNV gain 25217958
dgv3065n100 CNV gain 25217958
dgv37n68 CNV loss 17160897
dgv5313n54 CNV loss 21841781
dgv5319n54 CNV loss 21841781
esv3639555 CNV gain 21293372
esv3892938 CNV loss 25118596
nsv1061256 CNV gain 25217958
nsv1063024 CNV gain 25217958
nsv1063441 CNV loss 25217958
nsv1070367 CNV deletion 25765185
nsv457617 CNV gain 19166990
nsv471115 CNV loss 18288195
nsv471117 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv521217 CNV loss 19592680
nsv528898 CNV loss 19592680
nsv573674 CNV gain 21841781
nsv573677 CNV loss 21841781
nsv573712 CNV loss 21841781
nsv573714 CNV gain 21841781
nsv573715 CNV loss 21841781
nsv573718 CNV loss 21841781
nsv819907 CNV gain 19587683
nsv952071 CNV deletion 24416366

Variation tolerance for CDT1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDT1 Gene

Human Gene Mutation Database (HGMD)
CDT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDT1
Leiden Open Variation Database (LOVD)
CDT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDT1 Gene

Disorders for CDT1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CDT1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search CDT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDT1_HUMAN
  • Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for CDT1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CDT1: view

No data available for Genatlas for CDT1 Gene

Publications for CDT1 Gene

  1. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PMID: 21358632) Bicknell LS … Jackson AP (Nature genetics 2011) 3 4 72
  2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 4 22
  3. The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. (PMID: 17029205) Gao J … Shen HB (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2006) 3 22 40
  4. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PMID: 14993212) Sugimoto N … Fujita M (The Journal of biological chemistry 2004) 3 4 22
  5. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PMID: 15257290) Ballabeni A … Helin K (The EMBO journal 2004) 3 4 22

Products for CDT1 Gene

Sources for CDT1 Gene