Aliases for CDSN Gene
External Ids for CDSN Gene
Previous GeneCards Identifiers for CDSN Gene
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
GeneCards Summary for CDSN Gene
CDSN (Corneodesmosin) is a Protein Coding gene. Diseases associated with CDSN include Peeling Skin Syndrome 1 and Hypotrichosis 2. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.
UniProtKB/Swiss-Prot Summary for CDSN Gene
Important for the epidermal barrier integrity.