Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic ac... See more...

Aliases for CDS1 Gene

Aliases for CDS1 Gene

  • CDP-Diacylglycerol Synthase 1 2 3 4 5
  • CTP:Phosphatidate Cytidylyltransferase 1 3 4
  • Phosphatidate Cytidylyltransferase 1 3 4
  • CDP-Diglyceride Pyrophosphorylase 1 3 4
  • CDP-Diglyceride Synthase 1 3 4
  • CDP-DAG Synthase 1 3 4
  • CDP-DG Synthase 1 3 4
  • EC 2.7.7.41 4 51
  • CDS 1 3 4
  • CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 1 3
  • Phosphatidate Cytidylyltransferase 2
  • CDP-Diglyceride Synthetase 1 3
  • CDP-DG Synthetase 1 3
  • CDS1 5
  • CDS 4

External Ids for CDS1 Gene

Previous GeneCards Identifiers for CDS1 Gene

  • GC04P085428
  • GC04P085797
  • GC04P085962
  • GC04P085861
  • GC04P081245

Summaries for CDS1 Gene

Entrez Gene Summary for CDS1 Gene

  • Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDS1 Gene

CDS1 (CDP-Diacylglycerol Synthase 1) is a Protein Coding gene. Diseases associated with CDS1 include Muscular Dystrophy, Congenital, With Cataracts And Intellectual Disability. Among its related pathways are Inositol phosphate metabolism (KEGG) and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS2.

UniProtKB/Swiss-Prot Summary for CDS1 Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity).

Gene Wiki entry for CDS1 Gene

Additional gene information for CDS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDS1 Gene

Genomics for CDS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J084581 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.2 1178 5.6 CREB1 TEAD4 PRDM10 ZNF629 ZNF512 KDM1A ZNF692 ZHX2 JUND FOXA1 CDS1 lnc-NKX6-1-5 NKX6-1 WDFY3-AS2 FJ601684-348 WDFY3
GH04J084530 Enhancer 0.8 Ensembl ENCODE 16.6 -51.6 -51615 1.8 CTBP1 OSR2 ESRRA PKNOX1 JUND GATA3 DPF2 ZBTB40 FEZF1 PRDM6 CDS1 NKX6-1 WDFY3-AS2 piR-30188-131 lnc-NKX6-1-3 LOC102723338 lnc-NKX6-1-5
GH04J084647 Enhancer 0.8 Ensembl ENCODE 15.1 +65.5 65470 2.8 POLR2A CEBPA FOXA2 YY1 JUND NR2F2 SPI1 HNF4A RXRA MAX CDS1 WDFY3-AS2 piR-30867 piR-43164-050 WDFY3
GH04J084680 Promoter/Enhancer 1 Ensembl ENCODE 10.4 +99.7 99730 3.7 ETV6 GABPA SOX13 TCF7 CTCF CTBP1 FOXA2 MEF2D RUNX1 FOXP1 WDFY3-AS1 CDS1 WDFY3-AS2 RN7SL552P piR-36573-052 WDFY3
GH04J084690 Enhancer 0.8 Ensembl ENCODE 10.9 +108.7 108670 3.6 SCRT2 SP1 JUND NFE2 CEBPB FOS JUN FOSL1 MAFG EP300 piR-33501 CDS1 WDFY3-AS1 WDFY3-AS2 lnc-NKX6-1-8 WDFY3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDS1

Top Transcription factor binding sites by QIAGEN in the CDS1 gene promoter:
  • AREB6
  • Arnt
  • ATF6
  • C/EBPbeta
  • FOXD3
  • IRF-7A
  • MIF-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CDS1 Gene

Genomic Locations for CDS1 Gene
chr4:84,582,931-84,651,334
(GRCh38/hg38)
Size:
68,404 bases
Orientation:
Plus strand
chr4:85,504,057-85,572,493
(GRCh37/hg19)
Size:
68,437 bases
Orientation:
Plus strand

Genomic View for CDS1 Gene

Genes around CDS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDS1 Gene

Proteins for CDS1 Gene

  • Protein details for CDS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92903-CDS1_HUMAN
    Recommended name:
    Phosphatidate cytidylyltransferase 1
    Protein Accession:
    Q92903
    Secondary Accessions:
    • B2RAL5
    • O00163

    Protein attributes for CDS1 Gene

    Size:
    461 amino acids
    Molecular mass:
    53304 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with FOS; this interaction may enhance catalytic activity (By similarity).

neXtProt entry for CDS1 Gene

Selected DME Specific Peptides for CDS1 Gene

Q92903:
  • KCFHEIITIGY
  • KRAFKIKDF
  • KTWEGFIG
  • NYFFYGE
  • VTQSHLVI
  • MDRFDCQ
  • PFGGFFASG
  • YHRFISF
  • SFIRGPNPSK
  • FVLSLVKK
  • LSSRWKNWW

Post-translational modifications for CDS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDS1 Gene

Domains & Families for CDS1 Gene

Gene Families for CDS1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CDS1 Gene

InterPro:
Blocks:
  • Phosphatidate cytidylyltransferase
ProtoNet:

Suggested Antigen Peptide Sequences for CDS1 Gene

GenScript: Design optimal peptide antigens:
  • CTP:phosphatidate cytidylyltransferase 1 (CDS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92903

UniProtKB/Swiss-Prot:

CDS1_HUMAN :
  • Belongs to the CDS family.
Family:
  • Belongs to the CDS family.
genes like me logo Genes that share domains with CDS1: view

Function for CDS1 Gene

Molecular function for CDS1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; Evidence={ECO:0000269|PubMed:9407135};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45648, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77091, ChEBI:CHEBI:85349; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45660, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77098, ChEBI:CHEBI:85352; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45652, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:72864, ChEBI:CHEBI:85350; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45656, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77126, ChEBI:CHEBI:85351; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45664, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74560, ChEBI:CHEBI:85353; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45668, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77130, ChEBI:CHEBI:85354; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45672, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:77128, ChEBI:CHEBI:85355; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate; Xref=Rhea:RHEA:45676, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:74546, ChEBI:CHEBI:85356; Evidence={ECO:0000269|PubMed:25375833};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid {ECO:0000269|PubMed:25375833}; KM=0.6 uM for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid {ECO:0000269|PubMed:25375833}; Vmax=3.3 umol/min/mg enzyme for 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid {ECO:0000269|PubMed:25375833}; Vmax=3.6 umol/min/mg enzyme for 1-stearoyl-2-linoleoyl-sn-phosphatidic acid {ECO:0000269|PubMed:25375833};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by its anionic phospholipid end products, with phosphatidylinositol-(4,5)- bisphosphate showing the strongest inhibition.
GENATLAS Biochemistry:
CDP-diacylglycerol synthase (CDS) 1,photoreceptor specific,highly expressed in photoreceptor layer of adult retina,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway

Enzyme Numbers (IUBMB) for CDS1 Gene

Phenotypes From GWAS Catalog for CDS1 Gene

Gene Ontology (GO) - Molecular Function for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004142 diacylglycerol cholinephosphotransferase activity NAS 9115637
GO:0004605 phosphatidate cytidylyltransferase activity IDA 8863531
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDS1: view
genes like me logo Genes that share phenotypes with CDS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDS1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDS1 Gene

Localization for CDS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDS1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDS1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane ISS --
genes like me logo Genes that share ontologies with CDS1: view

Pathways & Interactions for CDS1 Gene

genes like me logo Genes that share pathways with CDS1: view

UniProtKB/Swiss-Prot Q92903-CDS1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

SIGNOR curated interactions for CDS1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006657 CDP-choline pathway IEA --
GO:0006661 phosphatidylinositol biosynthetic process IDA,TAS --
GO:0007165 signal transduction NAS 9115637
GO:0007602 phototransduction NAS 9806839
genes like me logo Genes that share ontologies with CDS1: view

Drugs & Compounds for CDS1 Gene

(3) Drugs for CDS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0

(61) Additional Compounds for CDS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-DG(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
  • CDP-Diacylglycerol(32:0)
CDP-DG(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
  • CDP-Diacylglycerol(34:0)
CDP-DG(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1N7)
  • CDP-DG(16:0/18:1W7)
CDP-DG(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1N9)
  • CDP-DG(16:0/18:1W9)
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2N6)
  • CDP-DG(16:0/18:2W6)
genes like me logo Genes that share compounds with CDS1: view

Transcripts for CDS1 Gene

mRNA/cDNA for CDS1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDS1

Alternative Splicing Database (ASD) splice patterns (SP) for CDS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for CDS1 Gene

GeneLoc Exon Structure for
CDS1

Expression for CDS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDS1 Gene

This gene is overexpressed in Nasal epithelium (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDS1 Gene



Protein tissue co-expression partners for CDS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDS1

SOURCE GeneReport for Unigene cluster for CDS1 Gene:

Hs.654899

mRNA Expression by UniProt/SwissProt for CDS1 Gene:

Q92903-CDS1_HUMAN
Tissue specificity: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.

Evidence on tissue expression from TISSUES for CDS1 Gene

  • Nervous system(4.4)
  • Lung(4.4)
  • Blood(4.2)
  • Eye(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with CDS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDS1 Gene

Orthologs for CDS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDS1 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDS1 30 31
  • 94.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDS1 30 31
  • 92.39 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDS1 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDS1 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cds1 30 17 31
  • 86.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cds1 30
  • 86.04 (n)
Chicken
(Gallus gallus)
Aves CDS1 30 31
  • 77.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDS1 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cds1 30
  • 74.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii cds1 30 31
  • 72.56 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007175 30
  • 54.94 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CdsA 30 31 32
  • 54.75 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C33H5.18 30
  • 55.84 (n)
C33H5.18a 32
  • 53 (a)
C33H5.18b 32
  • 53 (a)
cdgs-1 31
  • 48 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL084W 30
  • 49.14 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24640g 30
  • 48.94 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDS1 30 31 33
  • 48.24 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G26770 30
  • 49.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11292 30
Rice
(Oryza sativa)
Liliopsida Os01g0758400 30
  • 51.12 (n)
Os.15356 30
Barley
(Hordeum vulgare)
Liliopsida Hv.4226 30
Wheat
(Triticum aestivum)
Liliopsida Ta.6386 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.03 30
  • 50 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09643 30
  • 49.09 (n)
Species where no ortholog for CDS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDS1 Gene

ENSEMBL:
Gene Tree for CDS1 (if available)
TreeFam:
Gene Tree for CDS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDS1: view image

Paralogs for CDS1 Gene

Paralogs for CDS1 Gene

(1) SIMAP similar genes for CDS1 Gene using alignment to 2 proteins:

  • CDS1_HUMAN
  • D6RGC8_HUMAN
genes like me logo Genes that share paralogs with CDS1: view

Variants for CDS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDS1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
775994 Likely Benign: not provided 84,635,256(+) A/T INTRON_VARIANT
VAR_036129 A breast cancer sample p.Lys204Thr
rs36068434 - p.Leu99Phe

Additional dbSNP identifiers (rs#s) for CDS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDS1 Gene

Variant ID Type Subtype PubMed ID
esv2727911 CNV deletion 23290073
esv3569548 CNV loss 25503493
esv3601225 CNV loss 21293372
nsv4406 CNV insertion 18451855

Variation tolerance for CDS1 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDS1 Gene

Disorders for CDS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDS1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CDS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDS1 Gene

Publications for CDS1 Gene

  1. Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. (PMID: 9806839) Halford S … Hunt DM (Genomics 1998) 2 3 4 23
  2. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. (PMID: 9115637) Weeks R … Leung DW (DNA and cell biology 1997) 2 3 4 23
  3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A … Jackowski S (The Journal of biological chemistry 1997) 3 4 23
  4. CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. (PMID: 31548309) Xu Y … Yang H (The Journal of biological chemistry 2019) 3 4
  5. CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. (PMID: 26946540) Qi Y … Yang H (Journal of lipid research 2016) 3 4

Products for CDS1 Gene

Sources for CDS1 Gene