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Aliases for CDS1 Gene

Aliases for CDS1 Gene

  • CDP-Diacylglycerol Synthase 1 2 3 4 5
  • CTP:Phosphatidate Cytidylyltransferase 1 3 4
  • CDP-Diglyceride Pyrophosphorylase 1 3 4
  • CDP-Diglyceride Synthase 1 3 4
  • CDP-DAG Synthase 1 3 4
  • CDP-DG Synthase 1 3 4
  • CDS 1 3 4
  • CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 1 3
  • Phosphatidate Cytidylyltransferase 1 3
  • Phosphatidate Cytidylyltransferase 2
  • CDP-Diglyceride Synthetase 1 3
  • CDP-DG Synthetase 1 3
  • EC 2.7.7.41 4
  • CDS 4

External Ids for CDS1 Gene

Previous GeneCards Identifiers for CDS1 Gene

  • GC04P085428
  • GC04P085797
  • GC04P085962
  • GC04P085861
  • GC04P081245

Summaries for CDS1 Gene

Entrez Gene Summary for CDS1 Gene

  • Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDS1 Gene

CDS1 (CDP-Diacylglycerol Synthase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS2.

UniProtKB/Swiss-Prot for CDS1 Gene

  • Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Gene Wiki entry for CDS1 Gene

Additional gene information for CDS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDS1 Gene

Genomics for CDS1 Gene

GeneHancer (GH) Regulatory Elements for CDS1 Gene

Promoters and enhancers for CDS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J084581 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 650.7 +1.2 1205 5.6 PKNOX1 CLOCK ATF1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A FEZF1 YY1 CDS1 LOC102723338 NKX6-1 WDFY3-AS2 PIR31866
GH04J084531 Enhancer 0.7 ENCODE 16.6 -51.3 -51274 1.1 NCOA3 PKNOX1 CLOCK ESRRA GFI1B DPF2 FEZF1 ZBTB40 OSR2 CTBP1 CDS1 NKX6-1 WDFY3-AS2 RPL3P13 LOC102723338
GH04J084680 Enhancer 0.9 Ensembl ENCODE 10.4 +99.8 99757 3.7 ELF3 SOX13 FOXA2 TEAD4 RARA CTBP1 ETV6 SOX5 STAT1 HLF WDFY3-AS1 CDS1 WDFY3-AS2 RN7SL552P PIR31866 WDFY3
GH04J084690 Enhancer 0.8 Ensembl ENCODE 10.9 +108.5 108489 2.1 JUN SIN3A MAFG CEBPB EP300 SP1 FOSL1 JUND POLR2A SMARCA4 PIR54500 CDS1 WDFY3-AS1 WDFY3-AS2 WDFY3
GH04J084647 Enhancer 0.5 ENCODE 10.9 +64.6 64559 0.2 JUND POLR2A RXRA MAX CDS1 PIR31866 LOC102723338
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDS1 gene promoter:
  • AREB6
  • IRF-7A
  • PPAR-gamma2
  • PPAR-gamma1
  • ATF6
  • Arnt
  • MIF-1
  • FOXD3
  • C/EBPbeta

Genomic Locations for CDS1 Gene

Genomic Locations for CDS1 Gene
chr4:84,582,904-84,651,340
(GRCh38/hg38)
Size:
68,437 bases
Orientation:
Plus strand
chr4:85,504,057-85,572,493
(GRCh37/hg19)
Size:
68,437 bases
Orientation:
Plus strand

Genomic View for CDS1 Gene

Genes around CDS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDS1 Gene

Proteins for CDS1 Gene

  • Protein details for CDS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92903-CDS1_HUMAN
    Recommended name:
    Phosphatidate cytidylyltransferase 1
    Protein Accession:
    Q92903
    Secondary Accessions:
    • B2RAL5
    • O00163

    Protein attributes for CDS1 Gene

    Size:
    461 amino acids
    Molecular mass:
    53304 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with FOS; this interaction may enhance catalytic activity.

neXtProt entry for CDS1 Gene

Post-translational modifications for CDS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDS1 Gene

No data available for DME Specific Peptides for CDS1 Gene

Domains & Families for CDS1 Gene

Gene Families for CDS1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CDS1 Gene

Suggested Antigen Peptide Sequences for CDS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92903

UniProtKB/Swiss-Prot:

CDS1_HUMAN :
  • Belongs to the CDS family.
Family:
  • Belongs to the CDS family.
genes like me logo Genes that share domains with CDS1: view

Function for CDS1 Gene

Molecular function for CDS1 Gene

UniProtKB/Swiss-Prot Function:
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.
UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
GENATLAS Biochemistry:
CDP-diacylglycerol synthase (CDS) 1,photoreceptor specific,highly expressed in photoreceptor layer of adult retina,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway

Enzyme Numbers (IUBMB) for CDS1 Gene

Phenotypes From GWAS Catalog for CDS1 Gene

Gene Ontology (GO) - Molecular Function for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004142 diacylglycerol cholinephosphotransferase activity NAS 9115637
GO:0004605 phosphatidate cytidylyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDS1: view
genes like me logo Genes that share phenotypes with CDS1: view

Animal Model Products

miRNA for CDS1 Gene

miRTarBase miRNAs that target CDS1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDS1 Gene

Localization for CDS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDS1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDS1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IBA,TAS --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDS1: view

Pathways & Interactions for CDS1 Gene

genes like me logo Genes that share pathways with CDS1: view

UniProtKB/Swiss-Prot Q92903-CDS1_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

SIGNOR curated interactions for CDS1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006655 phosphatidylglycerol biosynthetic process IBA --
GO:0006657 CDP-choline pathway IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS,IDA --
GO:0007165 signal transduction NAS 9115637
genes like me logo Genes that share ontologies with CDS1: view

Drugs & Compounds for CDS1 Gene

(4) Drugs for CDS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Magnesium Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0

(60) Additional Compounds for CDS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-DG(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
  • CDP-Diacylglycerol(32:0)
CDP-DG(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
  • CDP-Diacylglycerol(34:0)
CDP-DG(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1N7)
  • CDP-DG(16:0/18:1W7)
CDP-DG(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1N9)
  • CDP-DG(16:0/18:1W9)
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2N6)
  • CDP-DG(16:0/18:2W6)
genes like me logo Genes that share compounds with CDS1: view

Transcripts for CDS1 Gene

mRNA/cDNA for CDS1 Gene

Unigene Clusters for CDS1 Gene

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for CDS1 Gene

GeneLoc Exon Structure for
CDS1
ECgene alternative splicing isoforms for
CDS1

Expression for CDS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDS1 Gene

This gene is overexpressed in Nasal epithelium (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDS1 Gene



Protein tissue co-expression partners for CDS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDS1 Gene:

CDS1

SOURCE GeneReport for Unigene cluster for CDS1 Gene:

Hs.654899

mRNA Expression by UniProt/SwissProt for CDS1 Gene:

Q92903-CDS1_HUMAN
Tissue specificity: Expressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.

Evidence on tissue expression from TISSUES for CDS1 Gene

  • Lung(4.3)
  • Nervous system(4.3)
  • Eye(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CDS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDS1 Gene

Orthologs for CDS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDS1 34 33
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDS1 34 33
  • 94.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDS1 34 33
  • 92.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDS1 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDS1 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cds1 16 34 33
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Cds1 33
  • 86.04 (n)
chicken
(Gallus gallus)
Aves CDS1 34 33
  • 77.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDS1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cds1 33
  • 74.66 (n)
zebrafish
(Danio rerio)
Actinopterygii cds1 34 33
  • 72.56 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007175 33
  • 54.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CdsA 34 35 33
  • 54.75 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33H5.18 33
  • 55.84 (n)
C33H5.18b 35
  • 53 (a)
C33H5.18a 35
  • 53 (a)
cdgs-1 34
  • 48 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL084W 33
  • 49.14 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24640g 33
  • 48.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDS1 36 34 33
  • 48.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26770 33
  • 49.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11292 33
rice
(Oryza sativa)
Liliopsida Os01g0758400 33
  • 51.12 (n)
Os.15356 33
wheat
(Triticum aestivum)
Liliopsida Ta.6386 33
barley
(Hordeum vulgare)
Liliopsida Hv.4226 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.03 33
  • 50 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09643 33
  • 49.09 (n)
Species where no ortholog for CDS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDS1 Gene

ENSEMBL:
Gene Tree for CDS1 (if available)
TreeFam:
Gene Tree for CDS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDS1: view image

Paralogs for CDS1 Gene

Paralogs for CDS1 Gene

(1) SIMAP similar genes for CDS1 Gene using alignment to 2 proteins:

  • CDS1_HUMAN
  • D6RGC8_HUMAN
genes like me logo Genes that share paralogs with CDS1: view

Variants for CDS1 Gene

Sequence variations from dbSNP and Humsavar for CDS1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_036129 A breast cancer sample p.Lys204Thr
rs10000060 -- 84,620,245(+) T/C intron_variant
rs1000006843 -- 84,593,285(+) A/G intron_variant
rs1000015301 -- 84,586,435(+) A/G intron_variant
rs1000021239 -- 84,627,378(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDS1 Gene

Variant ID Type Subtype PubMed ID
esv2727911 CNV deletion 23290073
esv3569548 CNV loss 25503493
esv3601225 CNV loss 21293372
nsv4406 CNV insertion 18451855

Variation tolerance for CDS1 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDS1 Gene

Disorders for CDS1 Gene

Additional Disease Information for CDS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDS1 Gene

Publications for CDS1 Gene

  1. Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. (PMID: 9806839) Halford S … Hunt DM (Genomics 1998) 2 3 4 22 58
  2. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. (PMID: 9115637) Weeks R … Leung DW (DNA and cell biology 1997) 2 3 4 22 58
  3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A … Jackowski S (The Journal of biological chemistry 1997) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CDS1 Gene

Sources for CDS1 Gene

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