Aliases for CDR2L Gene

Aliases for CDR2L Gene

  • Cerebellar Degeneration Related Protein 2 Like 2 3 5
  • Cerebellar Degeneration-Related Protein 2-Like 2 3 4
  • HUMPPA 2 3 4
  • Paraneoplastic 62 KDa Antigen 3 4
  • Paraneoplastic Antigen 2 3
  • CDR2L 5

External Ids for CDR2L Gene

Previous GeneCards Identifiers for CDR2L Gene

  • GC17P070496
  • GC17P072983
  • GC17P068394

Summaries for CDR2L Gene

GeneCards Summary for CDR2L Gene

CDR2L (Cerebellar Degeneration Related Protein 2 Like) is a Protein Coding gene. Diseases associated with CDR2L include Cerebellar Degeneration and Spinocerebellar Ataxia, Autosomal Recessive 13. An important paralog of this gene is CDR2.

Additional gene information for CDR2L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDR2L Gene

Genomics for CDR2L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDR2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDR2L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDR2L

Top Transcription factor binding sites by QIAGEN in the CDR2L gene promoter:
  • aMEF-2
  • AREB6
  • c-Rel
  • CP2
  • Ik-1
  • LCR-F1
  • MEF-2A
  • Pbx1a
  • Sox9
  • Tal-1beta

Genomic Locations for CDR2L Gene

Genomic Locations for CDR2L Gene
chr17:74,987,632-75,005,800
(GRCh38/hg38)
Size:
18,169 bases
Orientation:
Plus strand
chr17:72,983,727-73,001,895
(GRCh37/hg19)
Size:
18,169 bases
Orientation:
Plus strand

Genomic View for CDR2L Gene

Genes around CDR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR2L Gene

Proteins for CDR2L Gene

  • Protein details for CDR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X02-CDR2L_HUMAN
    Recommended name:
    Cerebellar degeneration-related protein 2-like
    Protein Accession:
    Q86X02
    Secondary Accessions:
    • B4DFA7
    • Q15175

    Protein attributes for CDR2L Gene

    Size:
    465 amino acids
    Molecular mass:
    53010 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA91850.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH47534.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDR2L Gene

Post-translational modifications for CDR2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR2L Gene

Domains & Families for CDR2L Gene

Gene Families for CDR2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDR2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDR2L Gene

GenScript: Design optimal peptide antigens:
  • Paraneoplastic 62 kDa antigen (CDR2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86X02

UniProtKB/Swiss-Prot:

CDR2L_HUMAN :
  • Belongs to the CDR2 family.
Family:
  • Belongs to the CDR2 family.
genes like me logo Genes that share domains with CDR2L: view

Function for CDR2L Gene

Phenotypes From GWAS Catalog for CDR2L Gene

Gene Ontology (GO) - Molecular Function for CDR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with CDR2L: view
genes like me logo Genes that share phenotypes with CDR2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDR2L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR2L Gene

Localization for CDR2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDR2L gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR2L Gene

Pathways & Interactions for CDR2L Gene

PathCards logo

SuperPathways for CDR2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDR2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDR2L Gene

Drugs & Compounds for CDR2L Gene

No Compound Related Data Available

Transcripts for CDR2L Gene

mRNA/cDNA for CDR2L Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDR2L

Alternative Splicing Database (ASD) splice patterns (SP) for CDR2L Gene

No ASD Table

Relevant External Links for CDR2L Gene

GeneLoc Exon Structure for
CDR2L

Expression for CDR2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDR2L Gene

mRNA differential expression in normal tissues according to GTEx for CDR2L Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for CDR2L Gene

This gene is overexpressed in Plasma (39.2) and Heart (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDR2L Gene



Protein tissue co-expression partners for CDR2L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDR2L

SOURCE GeneReport for Unigene cluster for CDR2L Gene:

Hs.78358

Evidence on tissue expression from TISSUES for CDR2L Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with CDR2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDR2L Gene

Orthologs for CDR2L Gene

This gene was present in the common ancestor of animals.

Orthologs for CDR2L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDR2L 30 31
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDR2L 30 31
  • 91.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDR2L 30 31
  • 91.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdr2l 30
  • 88.6 (n)
Mouse
(Mus musculus)
Mammalia Cdr2l 30 17 31
  • 88.24 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDR2L 31
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDR2L 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDR2L 30 31
  • 76.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDR2L 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdr2l 30
  • 70.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii cdr2l 30 31
  • 67.57 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Cen 31
  • 13 (a)
OneToMany
Species where no ortholog for CDR2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDR2L Gene

ENSEMBL:
Gene Tree for CDR2L (if available)
TreeFam:
Gene Tree for CDR2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDR2L: view image

Paralogs for CDR2L Gene

Paralogs for CDR2L Gene

(1) SIMAP similar genes for CDR2L Gene using alignment to 1 proteins:

  • CDR2L_HUMAN
genes like me logo Genes that share paralogs with CDR2L: view

Variants for CDR2L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDR2L Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs36057512 - p.Asp300Glu

Additional dbSNP identifiers (rs#s) for CDR2L Gene

Structural Variations from Database of Genomic Variants (DGV) for CDR2L Gene

Variant ID Type Subtype PubMed ID
nsv1056788 CNV gain 25217958
nsv833540 CNV loss 17160897

Variation tolerance for CDR2L Gene

Gene Damage Index Score: 1.98; 36.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDR2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDR2L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDR2L Gene

Disorders for CDR2L Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDR2L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebellar degeneration
spinocerebellar ataxia, autosomal recessive 13
  • scar13
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
fallopian tube adenocarcinoma
  • adenocarcinoma of the fallopian tube
small intestine benign neoplasm
  • neoplasm of small intestine
- elite association - COSMIC cancer census association via MalaCards
Search CDR2L in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR2L Gene

Publications for CDR2L Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration. (PMID: 29299667) Small M … Desestret V (Acta neuropathologica 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Cerebellar degeneration-related proteins 2 and 2-like are present in ovarian cancer in patients with and without Yo antibodies. (PMID: 28710511) Raspotnig M … Vedeler CA (Cancer immunology, immunotherapy : CII 2017) 3
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3

Products for CDR2L Gene

Sources for CDR2L Gene