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Aliases for CDR1 Gene

Aliases for CDR1 Gene

  • Cerebellar Degeneration Related Protein 1 2 3 5
  • Cerebellar Degeneration-Related Protein 1, 34kDa 2 3
  • CDR34 3 4
  • Cerebellar Degeneration-Related Protein-1 (34kD) 2
  • Cerebellar Degeneration-Related Protein (34kD) 2
  • Cerebellar Degeneration-Related Antigen 1 3
  • CDR62A 3
  • CDR 3

External Ids for CDR1 Gene

Previous HGNC Symbols for CDR1 Gene

  • CDR

Previous GeneCards Identifiers for CDR1 Gene

  • GC0XM134395
  • GC0XM136723
  • GC0XM137810
  • GC0XM138571
  • GC0XM139590
  • GC0XM139692
  • GC0XM139865
  • GC0XM129119

Summaries for CDR1 Gene

Entrez Gene Summary for CDR1 Gene

  • Autoantibodies directed against the protein encoded by this intronless gene have been found in some patients with paraneoplastic cerebellar degeneration. The encoded protein contains several hexapeptide repeats. [provided by RefSeq, Jan 2010]

GeneCards Summary for CDR1 Gene

CDR1 (Cerebellar Degeneration Related Protein 1) is a Protein Coding gene. Diseases associated with CDR1 include Cerebellar Degeneration and Paraneoplastic Cerebellar Degeneration.

Gene Wiki entry for CDR1 Gene

Additional gene information for CDR1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDR1 Gene

Genomics for CDR1 Gene

GeneHancer (GH) Regulatory Elements for CDR1 Gene

Promoters and enhancers for CDR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI140820 Enhancer 0.2 ENCODE 12.4 -36.6 -36594 1.1 CDR1 MIR320D2
GH0XI140710 Enhancer 0.6 FANTOM5 2.6 +73.9 73879 0.2 MXI1 PKNOX1 USF1 POLR2A L3MBTL2 ZNF547 PRDM10 LINC00632 CDR1 GC0XP140723
GH0XI140918 Enhancer 0.7 ENCODE 0.1 -133.7 -133740 0.2 CTCF ESRRA MAX ZNF384 BMI1 RAD21 YY1 ZNF143 SMC3 ZNF444 MIR320D2 CDR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDR1 gene promoter:

Genomic Locations for CDR1 Gene

Genomic Locations for CDR1 Gene
2,467 bases
Minus strand

Genomic View for CDR1 Gene

Genes around CDR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDR1 Gene

Proteins for CDR1 Gene

  • Protein details for CDR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cerebellar degeneration-related antigen 1
    Protein Accession:
    Secondary Accessions:
    • Q5JXH6

    Protein attributes for CDR1 Gene

    262 amino acids
    Molecular mass:
    31279 Da
    Quaternary structure:
    No Data Available
    • Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.
    • Sequence=AAA51962.1; Type=Miscellaneous discrepancy; Note=Frameshifts in positions 134, 176.; Evidence={ECO:0000305}; Sequence=AAA52472.1; Type=Frameshift; Positions=134, 176; Evidence={ECO:0000305};

neXtProt entry for CDR1 Gene

Post-translational modifications for CDR1 Gene

No Post-translational modifications

Other Protein References for CDR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDR1 Gene

Domains & Families for CDR1 Gene

Gene Families for CDR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDR1 Gene


Suggested Antigen Peptide Sequences for CDR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDR1: view

No data available for UniProtKB/Swiss-Prot for CDR1 Gene

Function for CDR1 Gene

Molecular function for CDR1 Gene

GENATLAS Biochemistry:
cerebellar degeneration-related minor antigen,34kDa,putative neuronal signal transduction protein,identified using antisera Yo from patients with breast and ovarian cancers and a paraneoplastic neurologic disorder

Gene Ontology (GO) - Molecular Function for CDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDR1: view
genes like me logo Genes that share phenotypes with CDR1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDR1 Gene

Localization for CDR1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDR1 gene
Compartment Confidence
plasma membrane 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDR1 Gene

Pathways & Interactions for CDR1 Gene

No Data Available

Interacting Proteins for CDR1 Gene

Gene Ontology (GO) - Biological Process for CDR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CDR1 Gene

Drugs & Compounds for CDR1 Gene

(2) Drugs for CDR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CDR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDR1: view

Transcripts for CDR1 Gene

mRNA/cDNA for CDR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(110) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDR1 Gene

Cerebellar degeneration-related protein 1, 34kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDR1 Gene

No ASD Table

Relevant External Links for CDR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.5), Brain - Cerebellum (x9.5), Brain - Putamen (basal ganglia) (x7.8), and Brain - Caudate (basal ganglia) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of CDR1 Gene:


SOURCE GeneReport for Unigene cluster for CDR1 Gene:


mRNA Expression by UniProt/SwissProt for CDR1 Gene:

Tissue specificity: Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.

Evidence on tissue expression from TISSUES for CDR1 Gene

  • Nervous system(4.2)
  • Spleen(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDR1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • immune
  • nervous
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CDR1: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CDR1 Gene

Orthologs for CDR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CDR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CDR1 33
  • 80.59 (n)
(Mus musculus)
Mammalia Cdr1 34
  • 17 (a)
Species where no ortholog for CDR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDR1 Gene

Gene Tree for CDR1 (if available)
Gene Tree for CDR1 (if available)

Paralogs for CDR1 Gene

No data available for Paralogs for CDR1 Gene

Variants for CDR1 Gene

Sequence variations from dbSNP and Humsavar for CDR1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000303469 -- 140,785,901(-) T/A upstream_transcript_variant
rs1000590275 -- 140,786,408(-) C/T upstream_transcript_variant
rs1001813973 -- 140,785,208(-) AACAACAACAACA/AACAACAACAACAACA upstream_transcript_variant
rs1002097830 -- 140,785,764(-) C/T upstream_transcript_variant
rs1002460840 -- 140,786,257(-) A/G upstream_transcript_variant

Variation tolerance for CDR1 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDR1 Gene

Disorders for CDR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebellar degeneration
paraneoplastic cerebellar degeneration
  • disseminated candidiasis
opportunistic mycosis
  • opportunistic mycoses
- elite association - COSMIC cancer census association via MalaCards
Search CDR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDR1

genes like me logo Genes that share disorders with CDR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDR1 Gene

Publications for CDR1 Gene

  1. Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. (PMID: 2326268) Chen YT … Old LJ (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4 58
  2. Physical and genetic mapping of the CDR gene with particular reference to its position with respect to the FRAXA site. (PMID: 1708201) Siniscalco M … Old LJ (American journal of medical genetics 1991) 3 22 58
  3. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. (PMID: 3474619) Dropcho EJ … Old LJ (Proceedings of the National Academy of Sciences of the United States of America 1987) 3 4 58
  4. Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme. (PMID: 26683098) Barbagallo D … Purrello M (Oncotarget 2016) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CDR1 Gene

Sources for CDR1 Gene

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