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Aliases for CDPF1 Gene

Aliases for CDPF1 Gene

  • Cysteine Rich DPF Motif Domain Containing 1 2 3 5
  • C22orf40 3 4
  • Cysteine-Rich DPF Motif Domain-Containing Protein 1 3
  • Cysteine-Rich, DPF Motif Domain Containing 1 2
  • Cysteine Rich, DPF Motif Domain Containing 1 2
  • Chromosome 22 Open Reading Frame 40 2
  • UPF0595 Protein C22orf40 3

External Ids for CDPF1 Gene

Previous HGNC Symbols for CDPF1 Gene

  • C22orf40

Previous GeneCards Identifiers for CDPF1 Gene

  • GC22M046641

Summaries for CDPF1 Gene

GeneCards Summary for CDPF1 Gene

CDPF1 (Cysteine Rich DPF Motif Domain Containing 1) is a Protein Coding gene.

Additional gene information for CDPF1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDPF1 Gene

Genomics for CDPF1 Gene

GeneHancer (GH) Regulatory Elements for CDPF1 Gene

Promoters and enhancers for CDPF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J046249 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 225 2.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CDPF1 GC22P046250 TTC38 PKDREJ RPS10P31 SMC1B PRR34
GH22J046049 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 63.3 +177.9 177939 45.7 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 SIN3A FEZF1 ZNF2 IRF4 YY1 LOC642648 PRR34 CDPF1 TRMU LINC00899 ENSG00000273243 ATXN10 ENSG00000273287 FAM118A TTC38
GH22J046760 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 37.5 -512.4 -512364 4.7 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 ENSG00000260708 TBC1D22A GC22M046764 CDPF1 LINC00899 LOC642648 GC22P046796 GC22P046797 GC22P046799 GC22P046798
GH22J045978 Promoter/Enhancer 1.5 Ensembl ENCODE 52.1 +271.6 271644 0.9 HDGF ZNF133 ARID4B SIN3A GLI4 ZNF2 ZNF48 YY1 GLIS2 ZNF143 WNT7B TRMU CDPF1 FBLN1 ENSG00000273243 LINC00899 LOC642648 KIAA0930 NUP50 ATXN10
GH22J045289 Enhancer 1.3 Ensembl ENCODE dbSUPER 57 +959.8 959829 2 HDGF PKNOX1 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 ATF7 ZNF548 SP3 CDPF1 ENSG00000273243 LINC00899 FAM118A LOC642648 PHF21B RPS10P31 ENSG00000236079 FBLN1 SMC1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDPF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDPF1 Gene

Genomic Locations for CDPF1 Gene
chr22:46,244,011-46,250,679
(GRCh38/hg38)
Size:
6,669 bases
Orientation:
Minus strand
chr22:46,639,908-46,646,576
(GRCh37/hg19)
Size:
6,669 bases
Orientation:
Minus strand

Genomic View for CDPF1 Gene

Genes around CDPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDPF1 Gene

Proteins for CDPF1 Gene

  • Protein details for CDPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVV7-CDPF1_HUMAN
    Recommended name:
    Cysteine-rich DPF motif domain-containing protein 1
    Protein Accession:
    Q6NVV7
    Secondary Accessions:
    • A6NCA1
    • A9IU12
    • A9IU16
    • Q3ZCR8

    Protein attributes for CDPF1 Gene

    Size:
    123 amino acids
    Molecular mass:
    13877 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDPF1 Gene

Post-translational modifications for CDPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDPF1 Gene

No data available for DME Specific Peptides for CDPF1 Gene

Domains & Families for CDPF1 Gene

Gene Families for CDPF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDPF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDPF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NVV7

UniProtKB/Swiss-Prot:

CDPF1_HUMAN :
  • Belongs to the CDPF1 family.
Family:
  • Belongs to the CDPF1 family.
genes like me logo Genes that share domains with CDPF1: view

Function for CDPF1 Gene

Phenotypes From GWAS Catalog for CDPF1 Gene

Gene Ontology (GO) - Molecular Function for CDPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDPF1: view
genes like me logo Genes that share phenotypes with CDPF1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDPF1 Gene

Localization for CDPF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDPF1 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDPF1 Gene

Pathways & Interactions for CDPF1 Gene

SuperPathways for CDPF1 Gene

No Data Available

Interacting Proteins for CDPF1 Gene

Gene Ontology (GO) - Biological Process for CDPF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDPF1 Gene

Drugs & Compounds for CDPF1 Gene

No Compound Related Data Available

Transcripts for CDPF1 Gene

Unigene Clusters for CDPF1 Gene

Cysteine-rich, DPF motif domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDPF1 Gene

No ASD Table

Relevant External Links for CDPF1 Gene

GeneLoc Exon Structure for
CDPF1
ECgene alternative splicing isoforms for
CDPF1

Expression for CDPF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDPF1 Gene

Protein differential expression in normal tissues from HIPED for CDPF1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDPF1 Gene



Protein tissue co-expression partners for CDPF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDPF1 Gene:

CDPF1

SOURCE GeneReport for Unigene cluster for CDPF1 Gene:

Hs.592209
genes like me logo Genes that share expression patterns with CDPF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDPF1 Gene

Orthologs for CDPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDPF1 34 33
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDPF1 34 33
  • 84.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDPF1 34 33
  • 80.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdpf1 16 34 33
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia CDPF1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDPF1 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H22ORF40 34 33
  • 66.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDPF1 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdpf1 33
  • 68.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1582 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-239e6.4 33
  • 63.13 (n)
CDPF1 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11755 34
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToOne
Species where no ortholog for CDPF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDPF1 Gene

ENSEMBL:
Gene Tree for CDPF1 (if available)
TreeFam:
Gene Tree for CDPF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDPF1: view image

Paralogs for CDPF1 Gene

Pseudogenes.org Pseudogenes for CDPF1 Gene

genes like me logo Genes that share paralogs with CDPF1: view

No data available for Paralogs for CDPF1 Gene

Variants for CDPF1 Gene

Sequence variations from dbSNP and Humsavar for CDPF1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000444257 -- 46,245,824(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000732227 -- 46,245,595(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000757257 -- 46,251,183(-) G/A upstream_transcript_variant
rs1000889451 -- 46,250,058(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000941102 -- 46,249,757(-) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDPF1 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv3647950 CNV loss 21293372
nsv1152661 OTHER inversion 26484159
nsv829281 CNV gain 20364138
nsv829293 CNV gain 20364138
nsv834224 CNV loss 17160897

Variation tolerance for CDPF1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDPF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDPF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDPF1 Gene

Disorders for CDPF1 Gene

Additional Disease Information for CDPF1

No disorders were found for CDPF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDPF1 Gene

Publications for CDPF1 Gene

  1. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CDPF1 Gene

Sources for CDPF1 Gene

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