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Aliases for CDON Gene

Aliases for CDON Gene

  • Cell Adhesion Associated, Oncogene Regulated 2 3 5
  • Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes 2 3
  • CDO 3 4
  • Surface Glycoprotein, Ig Superfamily Member 3
  • Cdon Homolog (Mouse) 2
  • Cdon Homolog 3
  • CDON1 3
  • HPE11 3
  • ORCAM 3

External Ids for CDON Gene

Previous GeneCards Identifiers for CDON Gene

  • GC11M127831
  • GC11M127343
  • GC11M125866
  • GC11M125368
  • GC11M125335
  • GC11M121768

Summaries for CDON Gene

Entrez Gene Summary for CDON Gene

  • This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

GeneCards Summary for CDON Gene

CDON (Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Diseases associated with CDON include Holoprosencephaly 11 and Microform Holoprosencephaly. Among its related pathways are Signaling by Hedgehog and Ectoderm Differentiation. An important paralog of this gene is BOC.

UniProtKB/Swiss-Prot for CDON Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Gene Wiki entry for CDON Gene

Additional gene information for CDON Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDON Gene

Genomics for CDON Gene

GeneHancer (GH) Regulatory Elements for CDON Gene

Promoters and enhancers for CDON Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J126060 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 656.1 +1.0 965 3.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 CDON TIRAP STT3A TMEM218 FEZ1 SRPRA PIR48177
GH11J126153 Enhancer 1.1 ENCODE dbSUPER 22.5 -90.8 -90802 2.5 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF213 KLF7 FOS ZNF662 TSHZ1 CDON ENSG00000254694 FOXRED1 ENSG00000254833 GC11M126140
GH11J125591 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +470.6 470601 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B STT3A FEZ1 STT3A-AS1 HP11014 TMEM218 CHEK1 TIRAP MSANTD2 ENSG00000254509 ENSG00000254694
GH11J126210 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -148.7 -148693 3 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FAM118B RPUSD4 FOXRED1 ENSG00000254694 STT3A HP11014 SRPRA CDON RNU4-86P
GH11J125273 Enhancer 1 ENCODE dbSUPER 10 +789.4 789435 0.2 TCF12 ZNF766 ZBTB11 REST ZNF592 MEF2D ZNF184 KLF16 IKZF1 MGA MSANTD2 TMEM218 ENSG00000254509 ENSG00000254694 STT3A CDON GC11M125262 RNU6-321P PKNOX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDON on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDON gene promoter:
  • MyoD
  • E2F-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-5
  • COMP1
  • POU2F1
  • POU2F1a

Genomic Locations for CDON Gene

Genomic Locations for CDON Gene
107,540 bases
Minus strand
107,540 bases
Minus strand

Genomic View for CDON Gene

Genes around CDON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDON Gene

Proteins for CDON Gene

  • Protein details for CDON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Protein Accession:
    Secondary Accessions:
    • O14631

    Protein attributes for CDON Gene

    1287 amino acids
    Molecular mass:
    139147 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.

    Three dimensional structures from OCA and Proteopedia for CDON Gene

    Alternative splice isoforms for CDON Gene


neXtProt entry for CDON Gene

Post-translational modifications for CDON Gene

  • N-glycosylated.
  • Glycosylation at posLast=932932, Asn873, Asn570, posLast=427427, posLast=342342, posLast=294294, posLast=287287, Asn180, posLast=100100, and posLast=8888
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDON Gene

Domains & Families for CDON Gene

Gene Families for CDON Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CDON Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDON: view

No data available for UniProtKB/Swiss-Prot for CDON Gene

Function for CDON Gene

Molecular function for CDON Gene

UniProtKB/Swiss-Prot Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Phenotypes From GWAS Catalog for CDON Gene

Gene Ontology (GO) - Molecular Function for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 11782431
genes like me logo Genes that share ontologies with CDON: view
genes like me logo Genes that share phenotypes with CDON: view

Human Phenotype Ontology for CDON Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDON Gene

MGI Knock Outs for CDON:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDON

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDON

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDON Gene

Localization for CDON Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDON Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDON gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 colocalizes_with extracellular matrix TAS 22261194
genes like me logo Genes that share ontologies with CDON: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDON Gene

Pathways & Interactions for CDON Gene

genes like me logo Genes that share pathways with CDON: view

SIGNOR curated interactions for CDON Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007155 cell adhesion TAS 9214393
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with CDON: view

Drugs & Compounds for CDON Gene

No Compound Related Data Available

Transcripts for CDON Gene

mRNA/cDNA for CDON Gene

Unigene Clusters for CDON Gene

Cell adhesion associated, oncogene regulated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDON

Alternative Splicing Database (ASD) splice patterns (SP) for CDON Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for CDON Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDON Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDON Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDON Gene

This gene is overexpressed in Testis (33.0), Plasma (21.7), and Vitreous humor (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDON Gene

Protein tissue co-expression partners for CDON Gene

NURSA nuclear receptor signaling pathways regulating expression of CDON Gene:


SOURCE GeneReport for Unigene cluster for CDON Gene:


Evidence on tissue expression from TISSUES for CDON Gene

  • Nervous system(4.5)
  • Lung(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDON Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • brain
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
  • hair
  • skin
genes like me logo Genes that share expression patterns with CDON: view

No data available for mRNA Expression by UniProt/SwissProt for CDON Gene

Orthologs for CDON Gene

This gene was present in the common ancestor of animals.

Orthologs for CDON Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDON 34 33
  • 98.81 (n)
(Canis familiaris)
Mammalia CDON 34 33
  • 86.95 (n)
(Bos Taurus)
Mammalia CDON 34 33
  • 84.84 (n)
(Mus musculus)
Mammalia Cdon 16 34 33
  • 82.43 (n)
(Rattus norvegicus)
Mammalia Cdon 33
  • 81.49 (n)
(Monodelphis domestica)
Mammalia CDON 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CDON 34
  • 70 (a)
(Gallus gallus)
Aves CDON 34
  • 62 (a)
(Anolis carolinensis)
Reptilia CDON 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdon 33
  • 62.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdon-A 33
(Danio rerio)
Actinopterygii cdon 34
  • 49 (a)
wufa10c02 33
fruit fly
(Drosophila melanogaster)
Insecta ihog 34
  • 20 (a)
boi 34
  • 20 (a)
CG6490 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
-- 34
  • 30 (a)
Species where no ortholog for CDON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDON Gene

Gene Tree for CDON (if available)
Gene Tree for CDON (if available)
Evolutionary constrained regions (ECRs) for CDON: view image

Paralogs for CDON Gene

Paralogs for CDON Gene

(7) SIMAP similar genes for CDON Gene using alignment to 7 proteins:

  • E9PN78_HUMAN
genes like me logo Genes that share paralogs with CDON: view

Variants for CDON Gene

Sequence variations from dbSNP and Humsavar for CDON Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000834545 uncertain-significance, Holoprosencephaly 125,957,332(-) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1005690333 uncertain-significance, Holoprosencephaly 125,959,615(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1029187380 uncertain-significance, Holoprosencephaly 125,959,434(-) T/A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1047070 benign, Holoprosencephaly 125,957,177(-) G/A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1054157340 uncertain-significance, Holoprosencephaly 125,959,197(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDON Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
esv3627998 CNV loss 21293372
nsv1040649 CNV loss 25217958
nsv535 CNV deletion 18451855
nsv556525 CNV gain 21841781
nsv819513 CNV loss 19587683

Variation tolerance for CDON Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDON Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDON Gene

Disorders for CDON Gene

MalaCards: The human disease database

(12) MalaCards diseases for CDON Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDON in MalaCards View complete list of genes associated with diseases


  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269 PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDON

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDON: view

No data available for Genatlas for CDON Gene

Publications for CDON Gene

  1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PMID: 9214393) Kang JS … Krauss RS (The Journal of cell biology 1997) 2 3 4 22 58
  2. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PMID: 21802063) Bae GU … Krauss RS (American journal of human genetics 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PMID: 20519495) Kavran JM … Leahy DJ (The Journal of biological chemistry 2010) 3 4 58
  5. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. (PMID: 19470755) Bae GU … Kang JS (Molecular and cellular biology 2009) 3 22 58

Products for CDON Gene

Sources for CDON Gene

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