This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided b... See more...

Aliases for CDON Gene

Aliases for CDON Gene

  • Cell Adhesion Associated, Oncogene Regulated 2 3 5
  • Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes 2 3 4
  • CDO 3 4
  • Surface Glycoprotein, Ig Superfamily Member 3
  • Cdon Homolog (Mouse) 2
  • Cdon Homolog 3
  • CDON1 3
  • HPE11 3
  • ORCAM 3

External Ids for CDON Gene

Previous GeneCards Identifiers for CDON Gene

  • GC11M127831
  • GC11M127343
  • GC11M125866
  • GC11M125368
  • GC11M125335
  • GC11M121768

Summaries for CDON Gene

Entrez Gene Summary for CDON Gene

  • This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

GeneCards Summary for CDON Gene

CDON (Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Diseases associated with CDON include Holoprosencephaly 11 and Septopreoptic Holoprosencephaly. Among its related pathways are Signaling events mediated by the Hedgehog family and Ectoderm Differentiation. An important paralog of this gene is HMCN2.

UniProtKB/Swiss-Prot Summary for CDON Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Gene Wiki entry for CDON Gene

Additional gene information for CDON Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDON Gene

Genomics for CDON Gene

GeneHancer (GH) Regulatory Elements for CDON Gene

Promoters and enhancers for CDON Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDON on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDON

Top Transcription factor binding sites by QIAGEN in the CDON gene promoter:
  • COMP1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • MyoD
  • POU2F1
  • POU2F1a

Genomic Locations for CDON Gene

Genomic Locations for CDON Gene
chr11:125,955,796-126,063,335
(GRCh38/hg38)
Size:
107,540 bases
Orientation:
Minus strand
chr11:125,825,691-125,933,230
(GRCh37/hg19)
Size:
107,540 bases
Orientation:
Minus strand

Genomic View for CDON Gene

Genes around CDON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDON Gene

Proteins for CDON Gene

  • Protein details for CDON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMG0-CDON_HUMAN
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Protein Accession:
    Q4KMG0
    Secondary Accessions:
    • O14631

    Protein attributes for CDON Gene

    Size:
    1287 amino acids
    Molecular mass:
    139147 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.

    Three dimensional structures from OCA and Proteopedia for CDON Gene

    Alternative splice isoforms for CDON Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDON Gene

Post-translational modifications for CDON Gene

  • N-glycosylated.
  • Glycosylation at Asn88, Asn100, Asn180, Asn287, Asn294, Asn342, Asn427, Asn570, Asn873, and Ser932
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDON Gene

Domains & Families for CDON Gene

Gene Families for CDON Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDON Gene

Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin I-set
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDON Gene

GenScript: Design optimal peptide antigens:
  • Cell adhesion molecule-related/down-regulated by oncogenes (CDON_HUMAN)
genes like me logo Genes that share domains with CDON: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CDON Gene

Function for CDON Gene

Molecular function for CDON Gene

UniProtKB/Swiss-Prot Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Phenotypes From GWAS Catalog for CDON Gene

Gene Ontology (GO) - Molecular Function for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 11782431
genes like me logo Genes that share ontologies with CDON: view
genes like me logo Genes that share phenotypes with CDON: view

Human Phenotype Ontology for CDON Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDON Gene

MGI Knock Outs for CDON:
  • Cdon Cdon<tm2Rsk>
  • Cdon Cdon<tm1Rsk>
  • Cdon Cdon<tm1Aok>
  • Cdon Cdon<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDON

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDON

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDON Gene

Localization for CDON Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDON Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDON gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0062023 colocalizes_with collagen-containing extracellular matrix TAS 22261194
genes like me logo Genes that share ontologies with CDON: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDON Gene

Pathways & Interactions for CDON Gene

genes like me logo Genes that share pathways with CDON: view

SIGNOR curated interactions for CDON Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007155 cell adhesion TAS 9214393
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with CDON: view

Drugs & Compounds for CDON Gene

No Compound Related Data Available

Transcripts for CDON Gene

mRNA/cDNA for CDON Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDON

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDON Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CDON Gene

GeneLoc Exon Structure for
CDON

Expression for CDON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDON Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDON Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDON Gene

This gene is overexpressed in Testis (33.0), Plasma (21.7), and Vitreous humor (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDON Gene



Protein tissue co-expression partners for CDON Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDON

SOURCE GeneReport for Unigene cluster for CDON Gene:

Hs.38034

Evidence on tissue expression from TISSUES for CDON Gene

  • Nervous system(4.5)
  • Lung(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDON Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with CDON: view

No data available for mRNA Expression by UniProt/SwissProt for CDON Gene

Orthologs for CDON Gene

This gene was present in the common ancestor of animals.

Orthologs for CDON Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDON 31 30
  • 98.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDON 31 30
  • 86.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDON 31 30
  • 84.84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdon 17 31 30
  • 82.43 (n)
rat
(Rattus norvegicus)
Mammalia Cdon 30
  • 81.49 (n)
oppossum
(Monodelphis domestica)
Mammalia CDON 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDON 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDON 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDON 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdon 30
  • 62.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdon-A 30
zebrafish
(Danio rerio)
Actinopterygii cdon 31
  • 49 (a)
OneToOne
wufa10c02 30
fruit fly
(Drosophila melanogaster)
Insecta ihog 31
  • 20 (a)
ManyToMany
boi 31
  • 20 (a)
ManyToMany
CG6490 31
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for CDON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDON Gene

ENSEMBL:
Gene Tree for CDON (if available)
TreeFam:
Gene Tree for CDON (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDON: view image

Paralogs for CDON Gene

(7) SIMAP similar genes for CDON Gene using alignment to 7 proteins:

  • CDON_HUMAN
  • E9PN78_HUMAN
  • E9PNF2_HUMAN
  • E9PPQ7_HUMAN
  • E9PRD8_HUMAN
  • H0YCZ4_HUMAN
  • H0YEX4_HUMAN
genes like me logo Genes that share paralogs with CDON: view

Variants for CDON Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDON Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
598564 Uncertain Significance: not provided 125,981,327(-) AT/A FRAMESHIFT_VARIANT
637955 Likely Pathogenic: Congenital ocular coloboma 126,018,348(-) G/A NONSENSE
663287 Uncertain Significance: Holoprosencephaly 11 126,018,336(-) C/A MISSENSE_VARIANT
rs1047070 Benign: Holoprosencephaly sequence 125,957,177(-) G/A THREE_PRIME_UTR_VARIANT
rs1065398 Benign: Holoprosencephaly sequence 125,958,112(-) T/C THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for CDON Gene

Structural Variations from Database of Genomic Variants (DGV) for CDON Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
esv3627998 CNV loss 21293372
nsv1040649 CNV loss 25217958
nsv535 CNV deletion 18451855
nsv556525 CNV gain 21841781
nsv819513 CNV loss 19587683

Variation tolerance for CDON Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDON Gene

Human Gene Mutation Database (HGMD)
CDON
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDON

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDON Gene

Disorders for CDON Gene

MalaCards: The human disease database

(23) MalaCards diseases for CDON Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDON in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDON_HUMAN
  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269 PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDON

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDON: view

No data available for Genatlas for CDON Gene

Publications for CDON Gene

  1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PMID: 9214393) Kang JS … Krauss RS (The Journal of cell biology 1997) 2 3 4 23 54
  2. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PMID: 21802063) Bae GU … Krauss RS (American journal of human genetics 2011) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PMID: 20519495) Kavran JM … Leahy DJ (The Journal of biological chemistry 2010) 3 4 54
  5. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. (PMID: 19470755) Bae GU … Kang JS (Molecular and cellular biology 2009) 3 23 54

Products for CDON Gene

Sources for CDON Gene