Aliases for CDO1 Gene

Aliases for CDO1 Gene

  • Cysteine Dioxygenase Type 1 2 3 4 5
  • Cysteine Dioxygenase, Type I 2 3
  • EC 1.13.11.20 4 50
  • CDO-I 3 4
  • Cysteine Dioxygenase Type I 4
  • CDO1 5
  • CDO 4

External Ids for CDO1 Gene

Previous GeneCards Identifiers for CDO1 Gene

  • GC05M114908
  • GC05M115547
  • GC05M115171
  • GC05M115216
  • GC05M115168
  • GC05M110321
  • GC05M115140

Summaries for CDO1 Gene

GeneCards Summary for CDO1 Gene

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include Hepatoblastoma and Gallbladder Disease. Among its related pathways are superpathway of methionine degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and cysteamine dioxygenase activity.

UniProtKB/Swiss-Prot Summary for CDO1 Gene

  • Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDO1 Gene

Genomics for CDO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDO1

Top Transcription factor binding sites by QIAGEN in the CDO1 gene promoter:
  • c-Myb
  • Evi-1
  • FOXD1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for CDO1 Gene

Latest Assembly
chr5:115,804,733-115,816,659
(GRCh38/hg38)
Size:
11,927 bases
Orientation:
Minus strand

Previous Assembly
chr5:115,140,430-115,152,356
(GRCh37/hg19 by Entrez Gene)
Size:
11,927 bases
Orientation:
Minus strand

chr5:115,140,430-115,152,651
(GRCh37/hg19 by Ensembl)
Size:
12,222 bases
Orientation:
Minus strand

Genomic View for CDO1 Gene

Genes around CDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDO1 Gene

Proteins for CDO1 Gene

  • Protein details for CDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16878-CDO1_HUMAN
    Recommended name:
    Cysteine dioxygenase type 1
    Protein Accession:
    Q16878
    Secondary Accessions:
    • B2RAK4
    • P78513
    • Q6FHZ8
    • Q8TB64

    Protein attributes for CDO1 Gene

    Size:
    200 amino acids
    Molecular mass:
    22972 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CDO1 Gene

neXtProt entry for CDO1 Gene

Selected DME Specific Peptides for CDO1 Gene

Q16878:
  • LQGNLKETLF
  • FDQRTGH
  • NLMILCWG
  • TFHSKFG
  • ENQCAYINDS
  • YTRNLVD

Post-translational modifications for CDO1 Gene

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDO1 Gene

Domains & Families for CDO1 Gene

Gene Families for CDO1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDO1 Gene

InterPro:
Blocks:
  • Cysteine dioxygenase type I

Suggested Antigen Peptide Sequences for CDO1 Gene

GenScript: Design optimal peptide antigens:
  • Cysteine dioxygenase type I (CDO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16878

UniProtKB/Swiss-Prot:

CDO1_HUMAN :
  • Belongs to the cysteine dioxygenase family.
Family:
  • Belongs to the cysteine dioxygenase family.
genes like me logo Genes that share domains with CDO1: view

Function for CDO1 Gene

Molecular function for CDO1 Gene

UniProtKB/Swiss-Prot Function:
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+); Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;.
UniProtKB/Swiss-Prot Induction:
In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).
GENATLAS Biochemistry:
cysteine dioxygenase-1,cytosolic,expressed in liver

Enzyme Numbers (IUBMB) for CDO1 Gene

Phenotypes From GWAS Catalog for CDO1 Gene

Gene Ontology (GO) - Molecular Function for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008198 ferrous iron binding IEA,IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA 21873635
GO:0017172 cysteine dioxygenase activity IBA,ISS --
genes like me logo Genes that share ontologies with CDO1: view
genes like me logo Genes that share phenotypes with CDO1: view

Animal Models for CDO1 Gene

MGI Knock Outs for CDO1:
  • Cdo1 Cdo1<tm1.1Mhst>

miRNA for CDO1 Gene

miRTarBase miRNAs that target CDO1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDO1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDO1 Gene

Localization for CDO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDO1 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS 12110289
genes like me logo Genes that share ontologies with CDO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDO1 Gene

Pathways & Interactions for CDO1 Gene

genes like me logo Genes that share pathways with CDO1: view

Pathways by source for CDO1 Gene

UniProtKB/Swiss-Prot Q16878-CDO1_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

SIGNOR curated interactions for CDO1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000097 sulfur amino acid biosynthetic process TAS 12110289
GO:0006534 cysteine metabolic process TAS 12110289
GO:0006954 inflammatory response TAS 12110289
GO:0007595 lactation IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with CDO1: view

Drugs & Compounds for CDO1 Gene

(9) Drugs for CDO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteine Approved Nutra Target 278
carbocisteine Approved, Investigational Pharma Enzyme, substrate 0
NADH Approved Nutra Target 0
Oxygen Approved, Vet_approved Pharma 0
3-Sulfinoalanine Experimental Pharma 0

(2) Additional Compounds for CDO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDO1: view

Transcripts for CDO1 Gene

mRNA/cDNA for CDO1 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDO1

Alternative Splicing Database (ASD) splice patterns (SP) for CDO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CDO1 Gene

GeneLoc Exon Structure for
CDO1

Expression for CDO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDO1 Gene

mRNA differential expression in normal tissues according to GTEx for CDO1 Gene

This gene is overexpressed in Liver (x10.6) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for CDO1 Gene

This gene is overexpressed in Breast (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDO1 Gene



Protein tissue co-expression partners for CDO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDO1

SOURCE GeneReport for Unigene cluster for CDO1 Gene:

Hs.442378

mRNA Expression by UniProt/SwissProt for CDO1 Gene:

Q16878-CDO1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.

Evidence on tissue expression from TISSUES for CDO1 Gene

  • Nervous system(4.8)
  • Liver(4.7)
genes like me logo Genes that share expression patterns with CDO1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDO1 Gene

Orthologs for CDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDO1 29 30
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDO1 29 30
  • 92.83 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDO1 30
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDO1 29 30
  • 91.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDO1 30
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdo1 29
  • 88 (n)
Mouse
(Mus musculus)
Mammalia Cdo1 29 16 30
  • 87.33 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CDO1 29 30
  • 75.25 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDO1 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdo1 29
  • 75.33 (n)
MGC75851 29
African clawed frog
(Xenopus laevis)
Amphibia MGC68656 29
Zebrafish
(Danio rerio)
Actinopterygii zgc73181 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG5493 29 30 31
  • 59.18 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005153 29
  • 58.43 (n)
Worm
(Caenorhabditis elegans)
Secernentea cdo-1 29 30
  • 56.44 (n)
OneToOne
F56F10.3 31
  • 50 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06625 29
  • 52.61 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10917 30
  • 45 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5694 29
Species where no ortholog for CDO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDO1 Gene

ENSEMBL:
Gene Tree for CDO1 (if available)
TreeFam:
Gene Tree for CDO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDO1: view image
Alliance of Genome Resources:
Additional Orthologs for CDO1

Paralogs for CDO1 Gene

(1) SIMAP similar genes for CDO1 Gene using alignment to 1 proteins:

  • CDO1_HUMAN
genes like me logo Genes that share paralogs with CDO1: view

No data available for Paralogs for CDO1 Gene

Variants for CDO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDO1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_036170 A colorectal cancer sample p.Glu143Gln
rs1042867 -- p.Thr45Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDO1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CDO1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDO1 Gene

Human Gene Mutation Database (HGMD)
CDO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDO1
Leiden Open Variation Database (LOVD)
CDO1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDO1 Gene

Disorders for CDO1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDO1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatoblastoma
gallbladder disease
  • gall bladder
barrett esophagus
  • barrett metaplasia
xanthogranulomatous cholecystitis
  • cx
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CDO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDO1

genes like me logo Genes that share disorders with CDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDO1 Gene

Publications for CDO1 Gene

  1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PMID: 7524679) McCann KP … Ramsden DB (Biochimica et biophysica acta 1994) 2 3 4 22
  2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PMID: 9497919) Ramsden DB … Williams AC (Molecular pathology : MP 1997) 3 4 22
  3. Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PMID: 19199799) de Visser SP … Straganz GD (The journal of physical chemistry. A 2009) 3 22
  4. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PMID: 17135237) Ye S … Rao Z (The Journal of biological chemistry 2007) 4 25
  5. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PMID: 17327371) Dominy JE … Stipanuk MH (American journal of physiology. Endocrinology and metabolism 2007) 3 22

Products for CDO1 Gene

Sources for CDO1 Gene