Aliases for CDO1 Gene

Aliases for CDO1 Gene

  • Cysteine Dioxygenase Type 1 2 3 4 5
  • Cysteine Dioxygenase, Type I 2 3
  • EC 1.13.11.20 4 54
  • CDO-I 3 4
  • Cysteine Dioxygenase Type I 4
  • CDO 4

External Ids for CDO1 Gene

Previous GeneCards Identifiers for CDO1 Gene

  • GC05M114908
  • GC05M115547
  • GC05M115171
  • GC05M115216
  • GC05M115168
  • GC05M110321
  • GC05M115140

Summaries for CDO1 Gene

GeneCards Summary for CDO1 Gene

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include Hepatoblastoma and Xanthogranulomatous Cholecystitis. Among its related pathways are superpathway of methionine degradation and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and cysteamine dioxygenase activity.

UniProtKB/Swiss-Prot Summary for CDO1 Gene

  • Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Additional gene information for CDO1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDO1 Gene

Genomics for CDO1 Gene

GeneHancer (GH) Regulatory Elements for CDO1 Gene

Promoters and enhancers for CDO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J115815 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 783 +1.6 1553 4 ZNF785 CTCF ZBTB6 ZNF362 RAD21 SP1 SP7 ZSCAN21 PRDM1 KLF14 CDO1 lnc-ATG12-1 lnc-AP3S1-124 ATG12 AP3S1 PGGT1B RNU2-49P ENSG00000251118
GH05J115838 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 34.5 -25.0 -24981 6.7 SP1 ZBTB40 CTCF LCORL MLX RBPJ POLR2A NR2F6 CREB1 HCFC1 ATG12 AP3S1 lnc-CDO1-3 CDO1 ENSG00000250015 CCT5P1 PGGT1B SEMA6A-AS1 lnc-CDO1-1 FJ601672-002
GH05J115806 Enhancer 0.6 Ensembl ENCODE 30.2 +10.0 9960 1.2 SP1 PRDM1 DPF2 GATA3 BCL6 CDO1 RNU2-49P ENSG00000251118 AP3S1 ATG12 TMED7 TMED7-TICAM2 lnc-ATG12-1 lnc-CDO1-2
GH05J115734 Enhancer 0.9 FANTOM5 Ensembl 17.9 +80.5 80453 3.8 FOXA1 RAD21 POU5F1 SP1 PRDM1 RXRA FOXA2 JUND ATF3 ZBTB33 CDO1 ENSG00000251118 RNU2-49P LVRN ENSG00000248709 piR-61614-095
GH05J115848 Enhancer 0.7 Ensembl 22.8 -33.1 -33147 3.4 SP7 HNF1A PKNOX1 CREB1 ZIC2 PRDM10 ZNF7 ZNF629 ZNF692 ATF7 CDO1 ATG12 AP3S1 FJ601672-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDO1 gene promoter:
  • c-Myb
  • Evi-1
  • FOXD1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for CDO1 Gene

Genomic Locations for CDO1 Gene
chr5:115,804,733-115,816,954
(GRCh38/hg38)
Size:
12,222 bases
Orientation:
Minus strand
chr5:115,140,430-115,152,651
(GRCh37/hg19)
Size:
12,222 bases
Orientation:
Minus strand

Genomic View for CDO1 Gene

Genes around CDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDO1 Gene

Proteins for CDO1 Gene

  • Protein details for CDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16878-CDO1_HUMAN
    Recommended name:
    Cysteine dioxygenase type 1
    Protein Accession:
    Q16878
    Secondary Accessions:
    • B2RAK4
    • P78513
    • Q6FHZ8
    • Q8TB64

    Protein attributes for CDO1 Gene

    Size:
    200 amino acids
    Molecular mass:
    22972 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CDO1 Gene

neXtProt entry for CDO1 Gene

Selected DME Specific Peptides for CDO1 Gene

Q16878:
  • LQGNLKETLF
  • FDQRTGH
  • NLMILCWG
  • TFHSKFG
  • ENQCAYINDS
  • YTRNLVD

Post-translational modifications for CDO1 Gene

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDO1 Gene

Domains & Families for CDO1 Gene

Gene Families for CDO1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDO1 Gene

Suggested Antigen Peptide Sequences for CDO1 Gene

GenScript: Design optimal peptide antigens:
  • Cysteine dioxygenase type I (CDO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16878

UniProtKB/Swiss-Prot:

CDO1_HUMAN :
  • Belongs to the cysteine dioxygenase family.
Family:
  • Belongs to the cysteine dioxygenase family.
genes like me logo Genes that share domains with CDO1: view

Function for CDO1 Gene

Molecular function for CDO1 Gene

UniProtKB/Swiss-Prot Function:
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+); Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;.
UniProtKB/Swiss-Prot Induction:
In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA).
GENATLAS Biochemistry:
cysteine dioxygenase-1,cytosolic,expressed in liver

Enzyme Numbers (IUBMB) for CDO1 Gene

Phenotypes From GWAS Catalog for CDO1 Gene

Gene Ontology (GO) - Molecular Function for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008198 ferrous iron binding IBA,IEA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA 21873635
GO:0017172 cysteine dioxygenase activity IBA,ISS --
genes like me logo Genes that share ontologies with CDO1: view
genes like me logo Genes that share phenotypes with CDO1: view

Animal Models for CDO1 Gene

MGI Knock Outs for CDO1:
  • Cdo1 Cdo1<tm1.1Mhst>

Animal Model Products

CRISPR Products

miRNA for CDO1 Gene

miRTarBase miRNAs that target CDO1

Clone Products

  • Addgene plasmids for CDO1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDO1 Gene

Localization for CDO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDO1 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS 12110289
genes like me logo Genes that share ontologies with CDO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDO1 Gene

Pathways & Interactions for CDO1 Gene

genes like me logo Genes that share pathways with CDO1: view

UniProtKB/Swiss-Prot Q16878-CDO1_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

SIGNOR curated interactions for CDO1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000097 sulfur amino acid biosynthetic process TAS 12110289
GO:0006534 cysteine metabolic process TAS 12110289
GO:0006954 inflammatory response TAS 12110289
GO:0007595 lactation IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with CDO1: view

Drugs & Compounds for CDO1 Gene

(8) Drugs for CDO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra Target 0
NADH Approved Nutra Target 0
Iron Approved, Experimental Pharma 1452
Oxygen Approved, Vet_approved Pharma 0
3-Sulfinoalanine Experimental Pharma 0

(3) Additional Compounds for CDO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CDO1: view

Transcripts for CDO1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CDO1

Alternative Splicing Database (ASD) splice patterns (SP) for CDO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CDO1 Gene

GeneLoc Exon Structure for
CDO1
ECgene alternative splicing isoforms for
CDO1

Expression for CDO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDO1 Gene

mRNA differential expression in normal tissues according to GTEx for CDO1 Gene

This gene is overexpressed in Liver (x10.6) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for CDO1 Gene

This gene is overexpressed in Breast (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDO1 Gene



Protein tissue co-expression partners for CDO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDO1 Gene:

CDO1

SOURCE GeneReport for Unigene cluster for CDO1 Gene:

Hs.442378

mRNA Expression by UniProt/SwissProt for CDO1 Gene:

Q16878-CDO1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.

Evidence on tissue expression from TISSUES for CDO1 Gene

  • Nervous system(4.8)
  • Liver(4.6)
genes like me logo Genes that share expression patterns with CDO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDO1 Gene

Orthologs for CDO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDO1 33 32
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDO1 33 32
  • 92.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDO1 33
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDO1 33 32
  • 91.33 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDO1 33
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdo1 32
  • 88 (n)
mouse
(Mus musculus)
Mammalia Cdo1 17 33 32
  • 87.33 (n)
chicken
(Gallus gallus)
Aves CDO1 33 32
  • 75.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDO1 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdo1 32
  • 75.33 (n)
MGC75851 32
African clawed frog
(Xenopus laevis)
Amphibia MGC68656 32
zebrafish
(Danio rerio)
Actinopterygii zgc73181 32
fruit fly
(Drosophila melanogaster)
Insecta CG5493 33 34 32
  • 59.18 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005153 32
  • 58.43 (n)
worm
(Caenorhabditis elegans)
Secernentea cdo-1 33 32
  • 56.44 (n)
OneToOne
F56F10.3 34
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06625 32
  • 52.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10917 33
  • 45 (a)
OneToOne
Cin.5694 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5694 32
Species where no ortholog for CDO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDO1 Gene

ENSEMBL:
Gene Tree for CDO1 (if available)
TreeFam:
Gene Tree for CDO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDO1: view image

Paralogs for CDO1 Gene

(1) SIMAP similar genes for CDO1 Gene using alignment to 1 proteins:

  • CDO1_HUMAN
genes like me logo Genes that share paralogs with CDO1: view

No data available for Paralogs for CDO1 Gene

Variants for CDO1 Gene

Sequence variations from dbSNP and Humsavar for CDO1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_036170 A colorectal cancer sample p.Glu143Gln
rs1000579373 -- 115,810,227(-) T/C intron_variant
rs1000727074 -- 115,804,259(-) G/A downstream_transcript_variant
rs1000858561 -- 115,815,378(-) G/T intron_variant
rs1001042153 -- 115,809,133(-) T/C intron_variant

Variation tolerance for CDO1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDO1 Gene

Human Gene Mutation Database (HGMD)
CDO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDO1 Gene

Disorders for CDO1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CDO1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatoblastoma
xanthogranulomatous cholecystitis
  • cx
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
gallbladder disease
  • gall bladder
- elite association - COSMIC cancer census association via MalaCards
Search CDO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDO1

genes like me logo Genes that share disorders with CDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDO1 Gene

Publications for CDO1 Gene

  1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PMID: 7524679) McCann KP … Ramsden DB (Biochimica et biophysica acta 1994) 2 3 4 23 56
  2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PMID: 9497919) Ramsden DB … Williams AC (Molecular pathology : MP 1997) 3 4 23 56
  3. Why do cysteine dioxygenase enzymes contain a 3-His ligand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PMID: 19199799) de Visser SP … Straganz GD (The journal of physical chemistry. A 2009) 3 23 56
  4. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PMID: 17327371) Dominy JE … Stipanuk MH (American journal of physiology. Endocrinology and metabolism 2007) 3 23 56
  5. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PMID: 17135237) Ye S … Rao Z (The Journal of biological chemistry 2007) 4 26 56

Products for CDO1 Gene

Sources for CDO1 Gene