CDNF Gene (Protein Coding)

Cerebral Dopamine Neurotrophic Factor

GC10M014771
GIFtS:
37

Aliases for CDNF Gene

Aliases for CDNF Gene

  • Cerebral Dopamine Neurotrophic Factor 2 3 4 5
  • Conserved Dopamine Neurotrophic Factor 2 3 4
  • Arginine-Rich, Mutated In Early Stage Tumors-Like 1 2 3
  • ARMET-Like Protein 1 3 4
  • ARMETL1 3 4

External Ids for CDNF Gene

Previous HGNC Symbols for CDNF Gene

  • ARMETL1

Previous GeneCards Identifiers for CDNF Gene

  • GC10M014902
  • GC10M014861

Summaries for CDNF Gene

GeneCards Summary for CDNF Gene

CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.

UniProtKB/Swiss-Prot Summary for CDNF Gene

  • Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

Additional gene information for CDNF Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDNF Gene

Genomics for CDNF Gene

GeneHancer (GH) Regulatory Elements for CDNF Gene

Promoters and enhancers for CDNF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDNF on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDNF Gene

Genomic Locations for CDNF Gene
chr10:14,819,245-14,838,575
(GRCh38/hg38)
Size:
19,331 bases
Orientation:
Minus strand
chr10:14,861,249-14,880,574
(GRCh37/hg19)
Size:
19,326 bases
Orientation:
Minus strand

Genomic View for CDNF Gene

Genes around CDNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDNF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDNF Gene

Proteins for CDNF Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AH0-CDNF_HUMAN
    Recommended name:
    Cerebral dopamine neurotrophic factor
    Protein Accession:
    Q49AH0
    Secondary Accessions:
    • A2RUU0
    • B4DVW3

    Protein attributes for CDNF Gene

    Size:
    187 amino acids
    Molecular mass:
    20964 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDNF Gene

    Alternative splice isoforms for CDNF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDNF Gene

Protein Expression for CDNF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CDNF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDNF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDNF Gene

Domains & Families for CDNF Gene

Gene Families for CDNF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CDNF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDNF Gene

GenScript: Design optimal peptide antigens:
  • Conserved dopamine neurotrophic factor (CDNF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q49AH0

UniProtKB/Swiss-Prot:

CDNF_HUMAN :
  • Belongs to the ARMET family.
Family:
  • Belongs to the ARMET family.
genes like me logo Genes that share domains with CDNF: view

Function for CDNF Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CDNF Gene

UniProtKB/Swiss-Prot Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
UniProtKB/Swiss-Prot Induction:
Not induced by endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for CDNF Gene

Gene Ontology (GO) - Molecular Function for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CDNF: view
genes like me logo Genes that share phenotypes with CDNF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDNF

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDNF Gene

Localization for CDNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDNF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDNF gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum IBA 21873635
genes like me logo Genes that share ontologies with CDNF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDNF Gene

Pathways & Interactions for CDNF Gene

PathCards logo

SuperPathways for CDNF Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0031175 neuron projection development IBA 21873635
GO:0071542 dopaminergic neuron differentiation IBA 21873635
genes like me logo Genes that share ontologies with CDNF: view

No data available for Pathways by source and SIGNOR curated interactions for CDNF Gene

Drugs & Compounds for CDNF Gene

Products:

  1. Drug

(8) Drugs for CDNF Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 4684
Autonomic Agents Pharma 12019
Cardiotonic Agents Pharma 1064
Dopamine Agents Pharma 4519
Neurotransmitter Agents Pharma 22296
genes like me logo Genes that share compounds with CDNF: view

Transcripts for CDNF Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDNF Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDNF Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for CDNF Gene

GeneLoc Exon Structure for
CDNF
ECgene alternative splicing isoforms for
CDNF

Expression for CDNF Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDNF Gene

mRNA expression in normal human tissues for CDNF Gene
mRNA expression by GTEx for CDNF GenemRNA expression by BioGPS for CDNF Gene

mRNA differential expression in normal tissues according to GTEx for CDNF Gene

This gene is overexpressed in Muscle - Skeletal (x8.2) and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CDNF Gene

This gene is overexpressed in Tonsil (38.9), Liver (22.1), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDNF Gene



Protein tissue co-expression partners for CDNF Gene

NURSA nuclear receptor signaling pathways regulating expression of CDNF Gene:

CDNF

SOURCE GeneReport for Unigene cluster for CDNF Gene:

Hs.559067

mRNA Expression by UniProt/SwissProt for CDNF Gene:

Q49AH0-CDNF_HUMAN
Tissue specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.

Evidence on tissue expression from TISSUES for CDNF Gene

  • Spleen(4)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CDNF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDNF Gene

Orthologs for CDNF Gene

This gene was present in the common ancestor of animals.

Orthologs for CDNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDNF 33 32
  • 99.29 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CDNF 33 32
  • 87.52 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CDNF 33 32
  • 87.34 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdnf 17 33 32
  • 82.89 (n)
rat
(Rattus norvegicus)
 Mammalia Cdnf 32
  • 82.71 (n)
oppossum
(Monodelphis domestica)
 Mammalia CDNF 33
  • 67 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CDNF 33
  • 58 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CDNF 33
  • 58 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdnf 32
  • 67.13 (n)
zebrafish
(Danio rerio)
 Actinopterygii cdnf 33 32
  • 59.28 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Manf 33
  • 46 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea Y54G2A.23 33
  • 44 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.9334 33
  • 47 (a)
 OneToMany
Species where no ortholog for CDNF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDNF Gene

ENSEMBL:
Gene Tree for CDNF (if available)
TreeFam:
Gene Tree for CDNF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDNF: view image

Paralogs for CDNF Gene

Paralogs for CDNF Gene

(1) SIMAP similar genes for CDNF Gene using alignment to 1 proteins:

  • CDNF_HUMAN
genes like me logo Genes that share paralogs with CDNF: view

Variants for CDNF Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CDNF Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000074989 -- 14,819,146(-) C/T downstream_transcript_variant
rs1000309553 -- 14,837,637(-) G/A intron_variant
rs1000360658 -- 14,829,067(-) G/A intron_variant
rs1000393177 -- 14,829,376(-) C/T intron_variant
rs1000416448 -- 14,831,529(-) ACACA/ACA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDNF Gene

Variant ID Type Subtype PubMed ID
nsv1043133 CNV loss 25217958
nsv471664 CNV gain+loss 15918152
nsv5899 CNV insertion 18451855

Variation tolerance for CDNF Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDNF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDNF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDNF Gene

Disorders for CDNF Gene

Additional Disease Information for CDNF

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDNF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDNF Gene

Publications for CDNF Gene

  1. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. (PMID: 17611540) Lindholm P … Saarma M (Nature 2007) 2 3 4 56
  2. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PMID: 19258449) Parkash V … Goldman A (Protein engineering, design & selection : PEDS 2009) 3 4 56
  3. Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population. (PMID: 29298719) Yang Y … Lv L (Behavioral and brain functions : BBF 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression. (PMID: 28622392) Wang L … Yu X (PloS one 2017) 3 56

ExternalLinks

View latest publications for CDNF gene in Mastermind

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Sources for CDNF Gene