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Aliases for CDNF Gene

Aliases for CDNF Gene

  • Cerebral Dopamine Neurotrophic Factor 2 3 5
  • Conserved Dopamine Neurotrophic Factor 2 3 4
  • Arginine-Rich, Mutated In Early Stage Tumors-Like 1 2 3
  • ARMET-Like Protein 1 3 4
  • ARMETL1 3 4

External Ids for CDNF Gene

Previous HGNC Symbols for CDNF Gene

  • ARMETL1

Previous GeneCards Identifiers for CDNF Gene

  • GC10M014902
  • GC10M014861

Summaries for CDNF Gene

GeneCards Summary for CDNF Gene

CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is MANF.

UniProtKB/Swiss-Prot for CDNF Gene

  • Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

Additional gene information for CDNF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDNF Gene

Genomics for CDNF Gene

GeneHancer (GH) Regulatory Elements for CDNF Gene

Promoters and enhancers for CDNF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I014836 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 355 3.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B E2F8 CDNF ENSG00000284024 HSPA14 DCLRE1C RPP38
GH10I014601 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +235.0 234974 4.9 HDGF PKNOX1 SMAD1 SIN3A FEZF1 YBX1 ZNF2 IRF4 ZNF213 ZNF302 FAM107B LOC105376429 CDNF HSPA14 C10orf111 GC10M014524
GH10I014558 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +272.0 272039 16.3 CLOCK FOXA2 ZNF133 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ETS1 YY1 FAM107B HSPA14 CDNF LOC105376429 DCLRE1C GC10M014524
GH10I014875 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -39.6 -39569 5 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 SUV39H2 ENSG00000272853 DCLRE1C RPP38 HSPA14 CDNF LOC100421372
GH10I014958 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -121.5 -121480 2.5 PKNOX1 ARNT ZFP64 SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 E2F8 GC10M014933 MEIG1 DCLRE1C HSPA14 RPP38 SUV39H2 CDNF OR7E110P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDNF on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDNF Gene

Genomic Locations for CDNF Gene
chr10:14,819,245-14,838,575
(GRCh38/hg38)
Size:
19,331 bases
Orientation:
Minus strand
chr10:14,861,249-14,880,574
(GRCh37/hg19)

Genomic View for CDNF Gene

Genes around CDNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDNF Gene

Proteins for CDNF Gene

  • Protein details for CDNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AH0-CDNF_HUMAN
    Recommended name:
    Cerebral dopamine neurotrophic factor
    Protein Accession:
    Q49AH0
    Secondary Accessions:
    • A2RUU0
    • B4DVW3

    Protein attributes for CDNF Gene

    Size:
    187 amino acids
    Molecular mass:
    20964 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDNF Gene

    Alternative splice isoforms for CDNF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDNF Gene

Post-translational modifications for CDNF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDNF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDNF Gene

Domains & Families for CDNF Gene

Gene Families for CDNF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CDNF Gene

Suggested Antigen Peptide Sequences for CDNF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AH0

UniProtKB/Swiss-Prot:

CDNF_HUMAN :
  • Belongs to the ARMET family.
Family:
  • Belongs to the ARMET family.
genes like me logo Genes that share domains with CDNF: view

Function for CDNF Gene

Molecular function for CDNF Gene

UniProtKB/Swiss-Prot Function:
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
UniProtKB/Swiss-Prot Induction:
Not induced by endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for CDNF Gene

Gene Ontology (GO) - Molecular Function for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CDNF: view
genes like me logo Genes that share phenotypes with CDNF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDNF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDNF Gene

Localization for CDNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDNF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDNF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with CDNF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDNF Gene

Pathways & Interactions for CDNF Gene

No Data Available

Interacting Proteins for CDNF Gene

Gene Ontology (GO) - Biological Process for CDNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of receptor activity IEA --
GO:0031175 neuron projection development IBA --
GO:0071542 dopaminergic neuron differentiation IBA --
genes like me logo Genes that share ontologies with CDNF: view

No data available for Pathways by source and SIGNOR curated interactions for CDNF Gene

Drugs & Compounds for CDNF Gene

No Compound Related Data Available

Transcripts for CDNF Gene

Unigene Clusters for CDNF Gene

Cerebral dopamine neurotrophic factor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDNF Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for CDNF Gene

GeneLoc Exon Structure for
CDNF
ECgene alternative splicing isoforms for
CDNF

Expression for CDNF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDNF Gene

mRNA differential expression in normal tissues according to GTEx for CDNF Gene

This gene is overexpressed in Muscle - Skeletal (x8.2) and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CDNF Gene

This gene is overexpressed in Tonsil (38.9), Liver (22.1), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDNF Gene



Protein tissue co-expression partners for CDNF Gene

NURSA nuclear receptor signaling pathways regulating expression of CDNF Gene:

CDNF

SOURCE GeneReport for Unigene cluster for CDNF Gene:

Hs.559067

mRNA Expression by UniProt/SwissProt for CDNF Gene:

Q49AH0-CDNF_HUMAN
Tissue specificity: Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.

Evidence on tissue expression from TISSUES for CDNF Gene

  • Spleen(4)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CDNF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDNF Gene

Orthologs for CDNF Gene

This gene was present in the common ancestor of animals.

Orthologs for CDNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDNF 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CDNF 33 34
  • 87.52 (n)
dog
(Canis familiaris)
Mammalia CDNF 33 34
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Cdnf 33 16 34
  • 82.89 (n)
rat
(Rattus norvegicus)
Mammalia Cdnf 33
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia CDNF 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDNF 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDNF 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdnf 33
  • 67.13 (n)
zebrafish
(Danio rerio)
Actinopterygii cdnf 33 34
  • 59.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Manf 34
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.23 34
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9334 34
  • 47 (a)
OneToMany
Species where no ortholog for CDNF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDNF Gene

ENSEMBL:
Gene Tree for CDNF (if available)
TreeFam:
Gene Tree for CDNF (if available)

Paralogs for CDNF Gene

Paralogs for CDNF Gene

(1) SIMAP similar genes for CDNF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDNF: view

Variants for CDNF Gene

Sequence variations from dbSNP and Humsavar for CDNF Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000074989 -- 14,819,146(-) C/T downstream_transcript_variant
rs1000309553 -- 14,837,637(-) G/A intron_variant
rs1000360658 -- 14,829,067(-) G/A intron_variant
rs1000393177 -- 14,829,376(-) C/T intron_variant
rs1000416448 -- 14,831,529(-) ACACA/ACA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDNF Gene

Variant ID Type Subtype PubMed ID
nsv1043133 CNV loss 25217958
nsv471664 CNV gain+loss 15918152
nsv5899 CNV insertion 18451855

Variation tolerance for CDNF Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDNF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDNF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDNF Gene

Disorders for CDNF Gene

Additional Disease Information for CDNF

No disorders were found for CDNF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDNF Gene

Publications for CDNF Gene

  1. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. (PMID: 17611540) Lindholm P … Saarma M (Nature 2007) 2 3 4 58
  2. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PMID: 19258449) Parkash V … Goldman A (Protein engineering, design & selection : PEDS 2009) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression. (PMID: 28622392) Wang L … Yu X (PloS one 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CDNF Gene

Sources for CDNF Gene

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