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The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
CDKN2D (Cyclin Dependent Kinase Inhibitor 2D) is a Protein Coding gene. Diseases associated with CDKN2D include Adult Central Nervous System Primitive Neuroectodermal Neoplasm and Parathyroid Adenoma. Among its related pathways are Oncogene Induced Senescence and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | IDA | 8741839 |
GO:0005515 | protein binding | IPI | 9751050 |
GO:0016301 | kinase activity | IEA | -- |
GO:0019901 | protein kinase binding | IPI | 8741839 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 8741839 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 15750620 |
GO:0005829 | cytosol | TAS | -- |
GO:0097129 | cyclin D2-CDK4 complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
G1-S Phase Transition
.67
|
.31
|
2 | Cellular Senescence (REACTOME) | ||
3 | Cell Cycle, Mitotic |
.83
|
|
4 | Mitotic G1-G1/S phases | ||
5 | Cell cycle |
.58
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | 8741839 |
GO:0000082 | G1/S transition of mitotic cell cycle | IDA | 10208428 |
GO:0000731 | DNA synthesis involved in DNA repair | IMP | 15750620 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007050 | cell cycle arrest | IDA | 10208428 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDKN2D 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDKN2D 30 |
|
||
Cow (Bos Taurus) |
Mammalia | CDKN2D 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cdkn2d 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDKN2D 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDKN2D 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDKN2D 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdkn2d 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100333252 30 |
|
||
cdkn2d 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult central nervous system primitive neuroectodermal neoplasm |
|
|
parathyroid adenoma |
|
|
non-invasive bladder urothelial carcinoma |
|
|
pharynx squamous cell carcinoma |
|
|
t-cell lymphoblastic leukemia/lymphoma |
|