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Aliases for CDKN2B-AS1 Gene

Subcategory (RNA class) for CDKN2B-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for CDKN2B-AS1 Gene

  • CDKN2B Antisense RNA 1 2 3 5
  • CDKN2B Antisense RNA (Non-Protein Coding) 2 2
  • Prostate Cancer Associated Transcript 12 2 3
  • P15 Antisense RNA 2 3
  • CDKN2B Antisense RNA 1 (Non-Protein Coding) 3
  • Antisense Noncoding RNA In The INK4 Locus 3
  • Antisense RNA In The INK4 Locus 2
  • Non-Protein Coding RNA 89 2
  • NCRNA00089 3
  • CDKN2B-AS 3
  • CDKN2BAS 3
  • PCAT12 3
  • ANRIL 3
  • P15AS 3

External Ids for CDKN2B-AS1 Gene

Previous HGNC Symbols for CDKN2B-AS1 Gene


Summaries for CDKN2B-AS1 Gene

Entrez Gene Summary for CDKN2B-AS1 Gene

  • This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

GeneCards Summary for CDKN2B-AS1 Gene

CDKN2B-AS1 (CDKN2B Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CDKN2B-AS1 include Intracranial Aneurysm and Periodontitis.

Gene Wiki entry for CDKN2B-AS1 Gene

Additional gene information for CDKN2B-AS1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKN2B-AS1 Gene

Genomics for CDKN2B-AS1 Gene

GeneHancer (GH) Regulatory Elements for CDKN2B-AS1 Gene

Promoters and enhancers for CDKN2B-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021992 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.1 -110 3.7 HDGF PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 RUNX3 SP3 TSHZ1 ZNF518A CDKN2A CDKN2B-AS1 ENSG00000266446 CDKN2B PIR47863 GC09M021977 ENSG00000264545
GH09J021996 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 650.7 +1.9 1889 0.2 ZSCAN4 FEZF1 ZIC2 ZNF335 ZFHX2 GLIS2 PATZ1 PRDM10 EZH2 EGR2 CDKN2A CDKN2B-AS1 ENSG00000266446 CDKN2B MTAP ENSG00000264545
GH09J021809 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -182.7 -182683 4.8 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF143 FOS RUNX3 PIR60166 TUBB8P1 MTAP CDKN2A CDKN2B-AS1 CDKN2A-DT CDKN2B UBA52P6 ENSG00000264545
GH09J021852 Promoter/Enhancer 1.4 EPDnew ENCODE 11.6 -139.8 -139800 5.1 PKNOX1 FOXA2 BATF IRF4 RAD21 YY1 EGR1 ATF7 ETV6 IKZF2 MTAP CDKN2B-AS1 CDKN2A ENSG00000265194 TUBB8P1 ENSG00000264545
GH09J022116 Enhancer 1.4 VISTA Ensembl ENCODE dbSUPER 10.8 +123.3 123280 3.1 CTCF KLF1 PKNOX1 USF1 MAX FEZF1 ZIC2 RAD21 RARA GATA3 ENSG00000277653 MTAP ENSG00000265194 KLHL9 CDKN2A CDKN2B-AS1 GC09M022195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDKN2B-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDKN2B-AS1 Gene

Genomic Locations for CDKN2B-AS1 Gene
126,320 bases
Plus strand
126,320 bases
Plus strand

Genomic View for CDKN2B-AS1 Gene

Genes around CDKN2B-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2B-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2B-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B-AS1 Gene

Proteins for CDKN2B-AS1 Gene

Post-translational modifications for CDKN2B-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CDKN2B-AS1 Gene

Domains & Families for CDKN2B-AS1 Gene

Gene Families for CDKN2B-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDKN2B-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CDKN2B-AS1 Gene

Function for CDKN2B-AS1 Gene

Phenotypes From GWAS Catalog for CDKN2B-AS1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKN2B-AS1 Gene

Localization for CDKN2B-AS1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2B-AS1 gene
Compartment Confidence
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CDKN2B-AS1 Gene

Pathways & Interactions for CDKN2B-AS1 Gene

SuperPathways for CDKN2B-AS1 Gene

No Data Available

Interacting Proteins for CDKN2B-AS1 Gene

Gene Ontology (GO) - Biological Process for CDKN2B-AS1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CDKN2B-AS1 Gene

Drugs & Compounds for CDKN2B-AS1 Gene

(1) Drugs for CDKN2B-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antiinflammatory agents, non-steroids Pharma 0
genes like me logo Genes that share compounds with CDKN2B-AS1: view

Transcripts for CDKN2B-AS1 Gene

mRNA/cDNA for CDKN2B-AS1 Gene

(18) Additional mRNA sequences :
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(28) RNA Central transcripts :

Unigene Clusters for CDKN2B-AS1 Gene

CDKN2B antisense RNA 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B-AS1 Gene

No ASD Table

Relevant External Links for CDKN2B-AS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKN2B-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDKN2B-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B-AS1 Gene

This gene is overexpressed in Colon - Transverse (x23.6), Small Intestine - Terminal Ileum (x9.8), and Pituitary (x4.0).

SOURCE GeneReport for Unigene cluster for CDKN2B-AS1 Gene:

genes like me logo Genes that share expression patterns with CDKN2B-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKN2B-AS1 Gene

Orthologs for CDKN2B-AS1 Gene

Evolution for CDKN2B-AS1 Gene

Gene Tree for CDKN2B-AS1 (if available)
Gene Tree for CDKN2B-AS1 (if available)

No data available for Orthologs for CDKN2B-AS1 Gene

Paralogs for CDKN2B-AS1 Gene

No data available for Paralogs for CDKN2B-AS1 Gene

Variants for CDKN2B-AS1 Gene

Sequence variations from dbSNP and Humsavar for CDKN2B-AS1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1014358179 likely-benign, uncertain-significance, Hereditary cutaneous melanoma, Hereditary cancer-predisposing syndrome 21,994,180(+) C/G upstream_transcript_variant
rs1057517575 uncertain-significance, Melanoma-pancreatic cancer syndrome 21,994,253(+) T/G upstream_transcript_variant
rs1057517601 uncertain-significance, Melanoma-pancreatic cancer syndrome, Hereditary cutaneous melanoma 21,994,270(+) C/T upstream_transcript_variant
rs1057517639 uncertain-significance, Melanoma-pancreatic cancer syndrome 21,994,364(+) C/T upstream_transcript_variant
rs1060501262 pathogenic, Hereditary cutaneous melanoma, not provided 21,994,138(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv1254e201 CNV deletion 23290073
dgv3966n106 CNV deletion 24896259
esv1002544 CNV insertion 20482838
esv1998859 CNV deletion 18987734
esv2589724 CNV deletion 19546169
esv2738282 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3619975 CNV loss 21293372
nsv1018514 CNV gain 25217958
nsv1029889 CNV loss 25217958
nsv1135729 CNV deletion 24896259
nsv1143377 CNV deletion 24896259
nsv1146629 CNV deletion 26484159
nsv1150074 CNV deletion 26484159
nsv416308 CNV deletion 16902084
nsv613760 CNV loss 21841781
nsv824877 CNV loss 20364138
nsv8426 CNV loss 18304495
nsv956142 CNV deletion 24416366

Additional Variant Information for CDKN2B-AS1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CDKN2B-AS1 Gene

Disorders for CDKN2B-AS1 Gene

MalaCards: The human disease database

(55) MalaCards diseases for CDKN2B-AS1 Gene - From: LncRNADisease, HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intracranial aneurysm
  • brain aneurysm
  • chronic pericementitis
aortic aneurysm
  • abdominal aortic aneurysm, ruptured
atherosclerosis susceptibility
  • aths
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDKN2B-AS1

genes like me logo Genes that share disorders with CDKN2B-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2B-AS1 Gene

Publications for CDKN2B-AS1 Gene

  1. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. (PMID: 23416462) Wan G … Lu X (Cellular signalling 2013) 2 3 58
  2. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PMID: 21532571) Burdon KP … Craig JE (Nature genetics 2011) 2 3 58
  3. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PMID: 18048406) Broadbent HM … PROCARDIS consortium (Human molecular genetics 2008) 2 3 58
  4. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PMID: 17440112) Pasmant E … Bièche I (Cancer research 2007) 2 3 58
  5. Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma. (PMID: 29127494) Ma J … Yuan H (Journal of cancer research and clinical oncology 2018) 3 58

Products for CDKN2B-AS1 Gene

Sources for CDKN2B-AS1 Gene

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