This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a num... See more...

Aliases for CDKN2B-AS1 Gene

Subcategory (RNA class) for CDKN2B-AS1 Gene

lncRNA

Number of RNA Genes sources:

4 / 17

Aliases for CDKN2B-AS1 Gene

  • CDKN2B Antisense RNA 1 2 3 5
  • CDKN2B-AS1 2 5 165
  • Prostate Cancer Associated Transcript 12 2 3
  • P15 Antisense RNA 2 3
  • NCRNA00089 2 3
  • CDKN2B-AS 2 3
  • PCAT12 2 3
  • ANRIL 2 3
  • P15AS 2 3
  • CDKN2B Antisense RNA 1 (Non-Protein Coding) 3
  • CDKN2B Antisense RNA (Non-Protein Coding) 2
  • Antisense Noncoding RNA In The INK4 Locus 3
  • Antisense RNA In The INK4 Locus 2
  • Non-Protein Coding RNA 89 2
  • NONHSAG051899.2 91
  • HSALNG0070397 164
  • RP11-145E5.4 2
  • CDKN2BAS 3

External Ids for CDKN2B-AS1 Gene

Previous HGNC Symbols for CDKN2B-AS1 Gene

  • CDKN2BAS

Summaries for CDKN2B-AS1 Gene

Entrez Gene Summary for CDKN2B-AS1 Gene

  • This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

GeneCards Summary for CDKN2B-AS1 Gene

CDKN2B-AS1 (CDKN2B Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with CDKN2B-AS1 include Intracranial Aneurysm and Periodontitis.

Gene Wiki entry for CDKN2B-AS1 Gene

Rfam classification for CDKN2B-AS1 Gene

  • CDKN2B antisense RNA 1 convserved region 3
  • CDKN2B antisense RNA 1 convserved region 2
  • CDKN2B antisense RNA 1 intronic convserved region

Additional gene information for CDKN2B-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for CDKN2B-AS1 Gene

Genomics for CDKN2B-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDKN2B-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDKN2B-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for CDKN2B-AS1 Gene

Genomic Locations for CDKN2B-AS1 Gene
chr9:21,994,139-22,239,122
(GRCh38/hg38)
Size:
244,984 bases
Orientation:
Plus strand
chr9:21,994,777-22,121,096
(GRCh37/hg19)
Size:
126,320 bases
Orientation:
Plus strand

Genomic View for CDKN2B-AS1 Gene

Genes around CDKN2B-AS1 on UCSC Golden Path with GeneCards custom track
CDKN2B-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
CDKN2B-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2B-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2B-AS1 Gene

Proteins for CDKN2B-AS1 Gene

Post-translational modifications for CDKN2B-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CDKN2B-AS1 Gene

Domains & Families for CDKN2B-AS1 Gene

Gene Families for CDKN2B-AS1 Gene

genes like me logo Genes that share domains with CDKN2B-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CDKN2B-AS1 Gene

Function for CDKN2B-AS1 Gene

Phenotypes From GWAS Catalog for CDKN2B-AS1 Gene

Gene Ontology (GO) - Molecular Function for CDKN2B-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CDKN2B-AS1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKN2B-AS1 Gene

Localization for CDKN2B-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2B-AS1 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CDKN2B-AS1 Gene

Pathways & Interactions for CDKN2B-AS1 Gene

PathCards logo

SuperPathways for CDKN2B-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKN2B-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IEA --
GO:0010628 positive regulation of gene expression IMP 28344092
GO:0010629 negative regulation of gene expression IMP 28344092
GO:0030335 positive regulation of cell migration IMP 28344092
genes like me logo Genes that share ontologies with CDKN2B-AS1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CDKN2B-AS1 Gene

Drugs & Compounds for CDKN2B-AS1 Gene

(1) Drugs for CDKN2B-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antiinflammatory agents, non-steroids Pharma 0
genes like me logo Genes that share compounds with CDKN2B-AS1: view

Transcripts for CDKN2B-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for CDKN2B-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000048C294_9606 lncRNA 2660 5

RefSeq: NR_047539,

Ensembl: ENST00000584351 (view in UCSC) ,

LncBook: HSALNT0147430,

LNCipedia: CDKN2B-AS1:2,

NONCODE: NONHSAT130418.2,

URS000004D655_9606 lncRNA 1260 5

RefSeq: NR_047540,

Ensembl: ENST00000580467 (view in UCSC) ,

LncBook: HSALNT0147428,

LNCipedia: CDKN2B-AS1:6,

NONCODE: NONHSAT130417.2,

URS00000E38C6_9606 lncRNA 856 5

RefSeq: NR_047533,

Ensembl: ENST00000583719 (view in UCSC) ,

LncBook: HSALNT0147429,

LNCipedia: CDKN2B-AS1:7,

NONCODE: NONHSAT130414.2,

URS00008C073E_9606 lncRNA 3837 4

Ensembl: ENST00000428597 (view in UCSC) ,

LncBook: HSALNT0147433,

LNCipedia: CDKN2B-AS1:12,

NONCODE: NONHSAT130421.2,

URS000075B87C_9606 lncRNA 1067 4

RefSeq: NR_047541,

LncBook: HSALNT0147441,

LNCipedia: CDKN2B-AS1:9,

NONCODE: NONHSAT130416.2,

CDKN2B-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for CDKN2B-AS1 Gene

19 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2B-AS1 Gene

No ASD Table

Relevant External Links for CDKN2B-AS1 Gene

GeneLoc Exon Structure for
CDKN2B-AS1

Expression for CDKN2B-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDKN2B-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for CDKN2B-AS1 Gene

This gene is overexpressed in Colon - Transverse (x23.6), Small Intestine - Terminal Ileum (x9.8), and Pituitary (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDKN2B-AS1

SOURCE GeneReport for Unigene cluster for CDKN2B-AS1 Gene:

Hs.493614

Evidence on tissue expression from TISSUES for CDKN2B-AS1 Gene

  • Blood(2.3)
  • Heart(2.2)
  • Muscle(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with CDKN2B-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKN2B-AS1 Gene

Orthologs for CDKN2B-AS1 Gene

Evolution for CDKN2B-AS1 Gene

ENSEMBL:
Gene Tree for CDKN2B-AS1 (if available)
TreeFam:
Gene Tree for CDKN2B-AS1 (if available)

No data available for Orthologs for CDKN2B-AS1 Gene

Paralogs for CDKN2B-AS1 Gene

No data available for Paralogs for CDKN2B-AS1 Gene

Variants for CDKN2B-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDKN2B-AS1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
753382 Likely Benign: not provided 22,008,788(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
790615 Benign: not provided 22,006,044(+) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
812639 Protective: Three Vessel Coronary Disease 22,003,368(+) G/A THREE_PRIME_UTR_VARIANT
812640 Risk Factor: Three Vessel Coronary Disease 22,096,056(+) A/G
812641 Protective: Three Vessel Coronary Disease 22,103,814(+) A/G

Additional dbSNP identifiers (rs#s) for CDKN2B-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDKN2B-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv1254e201 CNV deletion 23290073
dgv3966n106 CNV deletion 24896259
esv1002544 CNV insertion 20482838
esv1998859 CNV deletion 18987734
esv2589724 CNV deletion 19546169
esv2738282 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3619975 CNV loss 21293372
nsv1018514 CNV gain 25217958
nsv1029889 CNV loss 25217958
nsv1135729 CNV deletion 24896259
nsv1143377 CNV deletion 24896259
nsv1146629 CNV deletion 26484159
nsv1150074 CNV deletion 26484159
nsv416308 CNV deletion 16902084
nsv613760 CNV loss 21841781
nsv824877 CNV loss 20364138
nsv8426 CNV loss 18304495
nsv956142 CNV deletion 24416366

Additional Variant Information for CDKN2B-AS1 Gene

Human Gene Mutation Database (HGMD)
CDKN2B-AS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDKN2B-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CDKN2B-AS1 Gene

Disorders for CDKN2B-AS1 Gene

MalaCards: The human disease database

(59) MalaCards diseases for CDKN2B-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CDKN2B-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2B-AS1 Gene

Publications for CDKN2B-AS1 Gene

  1. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. (PMID: 23416462) Wan G … Lu X (Cellular signalling 2013) 2 3
  2. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. (PMID: 21532571) Burdon KP … Craig JE (Nature genetics 2011) 2 3
  3. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (PMID: 18048406) Broadbent HM … PROCARDIS consortium (Human molecular genetics 2008) 2 3
  4. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. (PMID: 17440112) Pasmant E … Bièche I (Cancer research 2007) 2 3
  5. Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis. (PMID: 32011499) Xu LB … Xu GD (Medicine 2020) 3

Products for CDKN2B-AS1 Gene

Sources for CDKN2B-AS1 Gene