Aliases for CDKN2B Gene
External Ids for CDKN2B Gene
Previous GeneCards Identifiers for CDKN2B Gene
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDKN2B Gene
CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) is a Protein Coding gene. Diseases associated with CDKN2B include Lipoprotein Quantitative Trait Locus and Ovarian Cancer. Among its related pathways are Cellular Senescence (REACTOME) and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN2A.
UniProtKB/Swiss-Prot Summary for CDKN2B Gene
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.