Aliases for CDKN2AIPNL Gene

Aliases for CDKN2AIPNL Gene

  • CDKN2A Interacting Protein N-Terminal Like 2 3 5
  • CDKN2A-Interacting Protein N-Terminal-Like Protein 3 4
  • CDKN2AIP N-Terminal-Like Protein 3 4
  • C2AIL 3

External Ids for CDKN2AIPNL Gene

Previous GeneCards Identifiers for CDKN2AIPNL Gene

  • GC05M133756
  • GC05M128922

Summaries for CDKN2AIPNL Gene

GeneCards Summary for CDKN2AIPNL Gene

CDKN2AIPNL (CDKN2A Interacting Protein N-Terminal Like) is a Protein Coding gene. Diseases associated with CDKN2AIPNL include Retinitis Pigmentosa 7. An important paralog of this gene is CDKN2AIP.

Additional gene information for CDKN2AIPNL Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDKN2AIPNL Gene

Genomics for CDKN2AIPNL Gene

GeneHancer (GH) Regulatory Elements for CDKN2AIPNL Gene

Promoters and enhancers for CDKN2AIPNL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDKN2AIPNL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDKN2AIPNL

Top Transcription factor binding sites by QIAGEN in the CDKN2AIPNL gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • GCNF
  • GCNF-1
  • GCNF-2
  • Lmo2
  • Olf-1
  • Pax-4a
  • PPAR-gamma2

Genomic Locations for CDKN2AIPNL Gene

Genomic Locations for CDKN2AIPNL Gene
chr5:134,402,065-134,414,603
(GRCh38/hg38)
Size:
12,539 bases
Orientation:
Minus strand
chr5:133,737,756-133,747,598
(GRCh37/hg19)
Size:
9,843 bases
Orientation:
Minus strand

Genomic View for CDKN2AIPNL Gene

Genes around CDKN2AIPNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKN2AIPNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKN2AIPNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKN2AIPNL Gene

Proteins for CDKN2AIPNL Gene

  • Protein details for CDKN2AIPNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HQ2-C2AIL_HUMAN
    Recommended name:
    CDKN2AIP N-terminal-like protein
    Protein Accession:
    Q96HQ2
    Secondary Accessions:
    • Q8WVE3

    Protein attributes for CDKN2AIPNL Gene

    Size:
    116 amino acids
    Molecular mass:
    13196 Da
    Quaternary structure:
    • Interacts with XRN2; the interaction is direct.

    Alternative splice isoforms for CDKN2AIPNL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDKN2AIPNL Gene

Post-translational modifications for CDKN2AIPNL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDKN2AIPNL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDKN2AIPNL Gene

Domains & Families for CDKN2AIPNL Gene

Gene Families for CDKN2AIPNL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDKN2AIPNL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDKN2AIPNL Gene

GenScript: Design optimal peptide antigens:
  • CDKN2A-interacting protein N-terminal-like protein (C2AIL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HQ2

UniProtKB/Swiss-Prot:

C2AIL_HUMAN :
  • Belongs to the CARF family.
Family:
  • Belongs to the CARF family.
genes like me logo Genes that share domains with CDKN2AIPNL: view

Function for CDKN2AIPNL Gene

Phenotypes From GWAS Catalog for CDKN2AIPNL Gene

Gene Ontology (GO) - Molecular Function for CDKN2AIPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26496610
genes like me logo Genes that share ontologies with CDKN2AIPNL: view
genes like me logo Genes that share phenotypes with CDKN2AIPNL: view

Animal Models for CDKN2AIPNL Gene

MGI Knock Outs for CDKN2AIPNL:

Animal Model Products

CRISPR Products

miRNA for CDKN2AIPNL Gene

miRTarBase miRNAs that target CDKN2AIPNL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDKN2AIPNL Gene

Localization for CDKN2AIPNL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKN2AIPNL gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDKN2AIPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA 21873635
GO:0005730 nucleolus IBA 21873635
genes like me logo Genes that share ontologies with CDKN2AIPNL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDKN2AIPNL Gene

Pathways & Interactions for CDKN2AIPNL Gene

PathCards logo

SuperPathways for CDKN2AIPNL Gene

No Data Available

Interacting Proteins for CDKN2AIPNL Gene

;

Gene Ontology (GO) - Biological Process for CDKN2AIPNL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDKN2AIPNL Gene

Drugs & Compounds for CDKN2AIPNL Gene

No Compound Related Data Available

Transcripts for CDKN2AIPNL Gene

mRNA/cDNA for CDKN2AIPNL Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKN2AIPNL Gene

No ASD Table

Relevant External Links for CDKN2AIPNL Gene

GeneLoc Exon Structure for
CDKN2AIPNL

Expression for CDKN2AIPNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDKN2AIPNL Gene

Protein differential expression in normal tissues from HIPED for CDKN2AIPNL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7) and Monocytes (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDKN2AIPNL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDKN2AIPNL

SOURCE GeneReport for Unigene cluster for CDKN2AIPNL Gene:

Hs.156506

Evidence on tissue expression from TISSUES for CDKN2AIPNL Gene

  • Nervous system(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with CDKN2AIPNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKN2AIPNL Gene

Orthologs for CDKN2AIPNL Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKN2AIPNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDKN2AIPNL 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDKN2AIPNL 31 30
  • 92.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDKN2AIPNL 31 30
  • 91.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdkn2aipnl 17 31 30
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Cdkn2aipnl 30
  • 88.51 (n)
oppossum
(Monodelphis domestica)
Mammalia CDKN2AIPNL 31
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 2 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CDKN2AIPNL 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkn2aipnl 30
  • 65.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.27136 30
zebrafish
(Danio rerio)
Actinopterygii cdkn2aipnl 31 30
  • 64.76 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7108 30
fruit fly
(Drosophila melanogaster)
Insecta CG31301 31
  • 5 (a)
OneToMany
Species where no ortholog for CDKN2AIPNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDKN2AIPNL Gene

ENSEMBL:
Gene Tree for CDKN2AIPNL (if available)
TreeFam:
Gene Tree for CDKN2AIPNL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDKN2AIPNL: view image

Paralogs for CDKN2AIPNL Gene

Paralogs for CDKN2AIPNL Gene

(1) SIMAP similar genes for CDKN2AIPNL Gene using alignment to 1 proteins:

  • C2AIL_HUMAN

Pseudogenes.org Pseudogenes for CDKN2AIPNL Gene

genes like me logo Genes that share paralogs with CDKN2AIPNL: view

Variants for CDKN2AIPNL Gene

Additional dbSNP identifiers (rs#s) for CDKN2AIPNL Gene

Variation tolerance for CDKN2AIPNL Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDKN2AIPNL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDKN2AIPNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CDKN2AIPNL Gene

Disorders for CDKN2AIPNL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDKN2AIPNL Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 7
  • rp7
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDKN2AIPNL

genes like me logo Genes that share disorders with CDKN2AIPNL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKN2AIPNL Gene

Publications for CDKN2AIPNL Gene

  1. Structural basis and function of XRN2 binding by XTB domains. (PMID: 26779609) Richter H … Großhans H (Nature structural & molecular biology 2016) 2 3 4 54
  2. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 54
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S … Dorf ME (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 54
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 54

Products for CDKN2AIPNL Gene

Sources for CDKN2AIPNL Gene