The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deleti... See more...

Aliases for CDKL3 Gene

Aliases for CDKL3 Gene

  • Cyclin Dependent Kinase Like 3 2 3 5
  • Cyclin-Dependent Kinase-Like 3 2 3 4
  • NKIAMRE 2 3 4
  • Serine-Threonine Protein Kinase NKIAMRE 2 3
  • EC 2.7.11.22 4 51
  • Serine/Threonine-Protein Kinase NKIAMRE 4
  • EC 2.7.11 51
  • CDKL3 5

External Ids for CDKL3 Gene

Previous GeneCards Identifiers for CDKL3 Gene

  • GC05M133292
  • GC05M134158
  • GC05M133664
  • GC05M133710
  • GC05M133662
  • GC05M128818
  • GC05M133541

Summaries for CDKL3 Gene

Entrez Gene Summary for CDKL3 Gene

  • The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKL3 Gene

CDKL3 (Cyclin Dependent Kinase Like 3) is a Protein Coding gene. Diseases associated with CDKL3 include Orofaciodigital Syndrome Vi. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.

Additional gene information for CDKL3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDKL3 Gene

Genomics for CDKL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDKL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDKL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDKL3

Top Transcription factor binding sites by QIAGEN in the CDKL3 gene promoter:
  • ARP-1
  • COUP
  • COUP-TF
  • COUP-TF1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1

Genomic Locations for CDKL3 Gene

Genomic Locations for CDKL3 Gene
chr5:134,236,120-134,372,380
(GRCh38/hg38)
Size:
136,261 bases
Orientation:
Minus strand
chr5:133,541,305-133,706,738
(GRCh37/hg19)
Size:
165,434 bases
Orientation:
Minus strand

Genomic View for CDKL3 Gene

Genes around CDKL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL3 Gene

Proteins for CDKL3 Gene

  • Protein details for CDKL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW4-CDKL3_HUMAN
    Recommended name:
    Cyclin-dependent kinase-like 3
    Protein Accession:
    Q8IVW4
    Secondary Accessions:
    • D3DQA0
    • D3DQA1
    • Q9P114

    Protein attributes for CDKL3 Gene

    Size:
    592 amino acids
    Molecular mass:
    67514 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDKL3 Gene

    Alternative splice isoforms for CDKL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDKL3 Gene

Selected DME Specific Peptides for CDKL3 Gene

Q8IVW4:
  • YVATRWYR
  • HENLVNL
  • YGKPVDIWA
  • FQILRAI
  • NLVNLIEVFR
  • TGQIVAIK
  • HRDIKPEN
  • TRWYRAPE
  • KLCDFGFARTLAAPG

Post-translational modifications for CDKL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDKL3 Gene

Gene Families for CDKL3 Gene

Protein Domains for CDKL3 Gene

Suggested Antigen Peptide Sequences for CDKL3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50407, highly similar to Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (B4DGS2_HUMAN)
  • cDNA FLJ50629, highly similar to Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (B4DRK6_HUMAN)
  • cDNA FLJ50724, highly similar to Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (B4DX41_HUMAN)
  • Serine/threonine-protein kinase NKIAMRE (CDKL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVW4

UniProtKB/Swiss-Prot:

CDKL3_HUMAN :
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL3: view

Function for CDKL3 Gene

Molecular function for CDKL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.

Enzyme Numbers (IUBMB) for CDKL3 Gene

Phenotypes From GWAS Catalog for CDKL3 Gene

Gene Ontology (GO) - Molecular Function for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 10463609
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDKL3: view
genes like me logo Genes that share phenotypes with CDKL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDKL3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDKL3

Clone Products

  • Addgene plasmids for CDKL3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKL3 Gene

Localization for CDKL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKL3 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
cytoskeleton 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDKL3: view

Pathways & Interactions for CDKL3 Gene

PathCards logo

SuperPathways for CDKL3 Gene

No Data Available

Pathways by source for CDKL3 Gene

1 GeneTex pathway for CDKL3 Gene

Gene Ontology (GO) - Biological Process for CDKL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10463609
GO:0006468 protein phosphorylation IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0030517 negative regulation of axon extension IBA 21873635
GO:0050775 positive regulation of dendrite morphogenesis IBA 21873635
genes like me logo Genes that share ontologies with CDKL3: view

No data available for SIGNOR curated interactions for CDKL3 Gene

Drugs & Compounds for CDKL3 Gene

(1) Drugs for CDKL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDKL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with CDKL3: view

Transcripts for CDKL3 Gene

mRNA/cDNA for CDKL3 Gene

7 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDKL3

Clone Products

  • Addgene plasmids for CDKL3

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - - -
SP3:
SP4: - -

Relevant External Links for CDKL3 Gene

GeneLoc Exon Structure for
CDKL3

Expression for CDKL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDKL3 Gene

mRNA differential expression in normal tissues according to GTEx for CDKL3 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CDKL3 Gene

This gene is overexpressed in Plasma (31.3), Bone marrow mesenchymal stem cell (19.7), Liver, secretome (10.7), and Pancreatic juice (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDKL3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDKL3

SOURCE GeneReport for Unigene cluster for CDKL3 Gene:

Hs.719926

Evidence on tissue expression from TISSUES for CDKL3 Gene

  • Heart(4.2)
genes like me logo Genes that share expression patterns with CDKL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKL3 Gene

Orthologs for CDKL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDKL3 30 31
  • 99.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDKL3 30
  • 91.54 (n)
PPP2CA 31
  • 87 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDKL3 30 31
  • 90.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdkl3 30 17 31
  • 83.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdkl3 30
  • 82.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia CDKL3 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDKL3 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDKL3 31
  • 67 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7236 31
  • 29 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y42A5A.4 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToMany
Species where no ortholog for CDKL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CDKL3 Gene

ENSEMBL:
Gene Tree for CDKL3 (if available)
TreeFam:
Gene Tree for CDKL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDKL3: view image

Paralogs for CDKL3 Gene

(69) SIMAP similar genes for CDKL3 Gene using alignment to 12 proteins:

  • CDKL3_HUMAN
  • B4DGS2_HUMAN
  • B4DMR2_HUMAN
  • B4DRK6_HUMAN
  • B4DX41_HUMAN
  • B7Z2C5_HUMAN
  • E5RFT9_HUMAN
  • E5RGK4_HUMAN
  • E5RI54_HUMAN
  • E7ET86_HUMAN
  • H0YAP8_HUMAN
  • H0YB17_HUMAN
genes like me logo Genes that share paralogs with CDKL3: view

Variants for CDKL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDKL3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
787043 Benign: not provided 134,306,639(-) A/G SYNONYMOUS_VARIANT
790795 Benign: not provided 134,308,718(-) T/C SYNONYMOUS_VARIANT
rs367537996 Not Provided: not provided 134,371,618(-) G/C MISSENSE_VARIANT
rs35687772 - p.Met394Thr

Additional dbSNP identifiers (rs#s) for CDKL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDKL3 Gene

Variant ID Type Subtype PubMed ID
esv3606845 CNV loss 21293372
esv3606846 CNV loss 21293372

Variation tolerance for CDKL3 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDKL3 Gene

Human Gene Mutation Database (HGMD)
CDKL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDKL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL3 Gene

Disorders for CDKL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDKL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
orofaciodigital syndrome vi
  • ofd6
- elite association - COSMIC cancer census association via MalaCards
Search CDKL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDKL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDKL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDKL3 Gene

Publications for CDKL3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. (PMID: 17945021) Jaluria P … Shiloach J (BMC biotechnology 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. (PMID: 12927787) Yee KW … Minden MD (Biochemical and biophysical research communications 2003) 3 23
  5. Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. (PMID: 10463609) Midmer M … Zanke BW (Cancer research 1999) 2 3

Products for CDKL3 Gene

Sources for CDKL3 Gene