Aliases for CDKAL1 Gene
External Ids for CDKAL1 Gene
Previous GeneCards Identifiers for CDKAL1 Gene
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
GeneCards Summary for CDKAL1 Gene
CDKAL1 (CDK5 Regulatory Subunit Associated Protein 1 Like 1) is a Protein Coding gene. Diseases associated with CDKAL1 include Type 2 Diabetes Mellitus and Obesity Due To Melanocortin 4 Receptor Deficiency. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity and iron-sulfur cluster binding. An important paralog of this gene is CDK5RAP1.
UniProtKB/Swiss-Prot Summary for CDKAL1 Gene
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.