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The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
CDK9 (Cyclin Dependent Kinase 9) is a Protein Coding gene. Diseases associated with CDK9 include Immune Deficiency Disease and Retinoblastoma. Among its related pathways are Signaling by GPCR and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IEA | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0001223 | transcription coactivator binding | IPI | 12037672 |
GO:0003677 | DNA binding | IDA | 16109376 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0008023 | transcription elongation factor complex | TAS,IDA | 22195968 |
GO:0008024 | cyclin/CDK positive transcription elongation factor complex | IDA | 9499409 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
2 | HIV Life Cycle |
.91
.64
|
.45
|
3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
4 | Gene Expression |
.48
|
|
5 | MicroRNAs in cardiomyocyte hypertrophy |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006282 | regulation of DNA repair | IDA | 20493174 |
GO:0006366 | transcription by RNA polymerase II | TAS | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | 10866664 |
GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Alvocidib | Experimental, Investigational | Pharma | Target, inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 65 | |
Olomoucine | Experimental | Pharma | Cyclin-dependent kinase inhibitor | 0 | ||
seliciclib | Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
ATP | Investigational | Nutra | 0 | |||
Dinaciclib | Investigational | Pharma | inhibitor, Biomarker | CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
|||
(R)-CR8 |
|
294646-77-8 |
|
|
||
Arcyriaflavin A |
|
118458-54-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
(R)-CR8 | Dual cdk1/cdk5 inhibitor; also inhibits CK1 | 294646-77-8 |
Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) | 118458-54-1 |
AZD 5438 | Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor | 602306-29-6 |
Olomoucine | Cyclin-dependent kinase inhibitor | 101622-51-9 |
SU 9516 | Potent cdk2 inhibitor | 377090-84-1 |
Compound | Action | Cas Number |
---|---|---|
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
AT7519 Hydrochloride | Multi-CDK inhibitor | 902135-91-5 |
AT7519 trifluoroacetate | CDK/cyclin inhibitor | 1431697-85-6 |
AZD-5438 | Potent CDK1/2/9 inhibitor | 602306-29-6 |
CDK9 inhibitor | CDK9 inhibitor | 1415559-43-1 |
CDK9 inhibitor 2 | 1263369-28-3 | |
Dinaciclib (SCH727965) | Potent CDK inhibitor | 779353-01-4 |
LDC000067 | 1073485-20-7 | |
LY2857785 | CDK9 inhibitor | 1619903-54-6 |
P276-00 | CDK-1/CDK4/CDK9 inhibitor | 920113-03-7 |
PHA-767491 | Cdc7/cdk9 inhibitor, potent, ATP-competitive | 845714-00-3 |
SNS-032 (BMS-387032) | CDK inhibitor | 345627-80-7 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK9 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDK9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdk9 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK9 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDK9 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDK9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk9 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | cdk9-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdk9 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008541 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cdk9 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | cdk-9 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTK1 31 |
|
OneToMany | |
SGV1 33 |
|
|
|||
Rice (Oryza sativa) |
Liliopsida | Os.14473 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2443 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cdk9 30 |
|
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3217739 | Benign: not provided | 127,787,511(+) |
C/T NM_001261.4(CDK9):c.175-7C>T |
INTRON | |
rs55640715 | - |
p.Phe59Leu |
|||
rs767418586 | - |
p.Arg225Cys |
|||
VAR_013456 | - |
p.Gly231Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12879n54 | CNV | loss | 21841781 |
dgv12880n54 | CNV | loss | 21841781 |
esv3891727 | CNV | gain | 25118596 |
nsv466573 | CNV | loss | 19166990 |
nsv466575 | CNV | loss | 19166990 |
nsv466576 | CNV | loss | 19166990 |
nsv471323 | CNV | loss | 18288195 |
nsv615371 | CNV | loss | 21841781 |
nsv615373 | CNV | loss | 21841781 |
nsv615374 | CNV | loss | 21841781 |
nsv825094 | CNV | gain | 20364138 |
nsv825095 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immune deficiency disease |
|
|
retinoblastoma |
|
|
human immunodeficiency virus type 1 |
|
|
nut midline carcinoma |
|
|
leukemia, chronic lymphocytic |
|
|