Aliases for CDK8 Gene
Aliases for CDK8 Gene
External Ids for CDK8 Gene
- HGNC: 1779
- Entrez Gene: 1024
- Ensembl: ENSG00000132964
- OMIM: 603184
- UniProtKB: P49336
Previous GeneCards Identifiers for CDK8 Gene
- GC13P024808
- GC13P020808
- GC13P025758
- GC13P024626
- GC13P025726
- GC13P026828
- GC13P007646
Summaries for CDK8 Gene
-
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
GeneCards Summary for CDK8 Gene
CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Colorectal Adenocarcinoma and Hemophagocytic Lymphohistiocytosis, Familial, 3. Among its related pathways are Gene Expression and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK19.
UniProtKB/Swiss-Prot for CDK8 Gene
-
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Additional gene information for CDK8 Gene
- Monarch Initiative
- Search for CDK8 at DataMed
- Search for CDK8 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK8 Gene
Genomics for CDK8 Gene
GeneHancer (GH) Regulatory Elements for CDK8 Gene
Promoters and enhancers for CDK8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDK8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CDK8 gene promoter:
-
- TBP
- Nkx3-1 v1
- Nkx3-1
- Nkx3-1 v2
- Nkx3-1 v3
Regulatory Element Products
Genomic Locations for CDK8 Gene
Genomic Locations for CDK8 Gene
- chr13:26,254,104-26,405,238
- (GRCh38/hg38)
- Size:
- 151,135 bases
- Orientation:
- Plus strand
- chr13:26,828,276-26,979,375
- (GRCh37/hg19)
- Size:
- 151,100 bases
- Orientation:
- Plus strand
Genomic View for CDK8 Gene
Genes around CDK8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.13 by Entrez Gene
- 13q12.13 by HGNC
- 13q12.13 by Ensembl
CDK8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK8 Gene
Proteins for CDK8 Gene
-
Protein details for CDK8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49336-CDK8_HUMAN
- Recommended name:
- Cyclin-dependent kinase 8
- Protein Accession:
- P49336
- Q5VUF3
- Q6ISB5
Protein attributes for CDK8 Gene
- Size:
- 464 amino acids
- Molecular mass:
- 53284 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.
Three dimensional structures from OCA and Proteopedia for CDK8 Gene
Protein Expression for CDK8 Gene
Post-translational modifications for CDK8 Gene
Other Protein References for CDK8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CDK8 (CDK8)
-
Custom Antibody ServicesOriGene Antibodies for CDK8
- Novus Biologicals Antibodies for CDK8
-
Abcam antibodies for CDK8
- Invitrogen Antibodies for CDK8
- GeneTex CDK8 Antibody for CDK8
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK8
Protein Products
-
OriGene Purified Proteins for CDK8
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK8
- Origene Custom Protein Services for CDK8
- Search GeneTex for Proteins for CDK8
-
Abcam proteins for CDK8
Assay Products
No data available for DME Specific Peptides for CDK8 Gene
Domains & Families for CDK8 Gene
Gene Families for CDK8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CDK8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P49336UniProtKB/Swiss-Prot:
CDK8_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK8 Gene
Molecular function for CDK8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Enzyme Numbers (IUBMB) for CDK8 Gene
Phenotypes From GWAS Catalog for CDK8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,TAS | 7568034 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 7568034 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CDK8 Gene
- MGI mutant phenotypes for CDK8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CDK8:
-
- Decreased viability
- Decreased substrate adherent cell growth
- Increased G1 DNA content
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Reduced beta-catenin activity and colon cancer cell proliferation
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Paclitaxel antagonistic effect
- Apoptosis resistance
- Mildly decreased CFP-tsO45G cell surface transport
Animal Models for CDK8 Gene
- MGI Knock Outs for CDK8:
-
- Cdk8 Cdk8<tm1b(EUCOMM)Hmgu>
Animal Model Products
-
Taconic Biosciences Mouse Models for CDK8
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK8
-
CRISPR Products
-
OriGene CRISPR knockouts for CDK8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK8
- genomics-online: gRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- Applied Biological Materials CRISPR for CDK8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK8
- GenScript: Design CRISPR guide RNA sequences for CDK8
miRNA for CDK8 Gene
- miRTarBase miRNAs that target CDK8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK8
- Browse OriGene Inhibitory RNA Products For CDK8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK8
- genomics-online: shRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDK8
- VectorBuilder custom plasmid, inducible vectors for CDK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK8
- Applied Biological Materials Clones for CDK8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDK8
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK8 Gene
Localization for CDK8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 16109376 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | 22869755 |
| GO:0016592 | mediator complex | IEA,IDA | 14638676 |
| GO:0032991 | protein-containing complex | IDA | 22869755 |
Pathways & Interactions for CDK8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for CDK8 Gene
1 Sino Biological pathway for CDK8 Gene
1 GeneTex pathway for CDK8 Gene
1 BioSystems pathway for CDK8 Gene
1 GeneGo (Thomson Reuters) pathway for CDK8 Gene
1 R&D Systems pathway for CDK8 Gene
2 Qiagen pathways for CDK8 Gene
1 Cell Signaling Technology pathway for CDK8 Gene
Interacting Proteins for CDK8 Gene
Selected Interacting proteins:
P49336-CDK8_HUMAN
ENSP00000370938
for CDK8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDK8
SIGNOR curated interactions for CDK8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
Drugs & Compounds for CDK8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved | Nutra | 0 | |||
| Alvocidib | Experimental, Investigational | Pharma | inhibitor, Target | Pan-cdk inhibitor, Kinase Inhibitors | 60 | |
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 | ||
| Senexin A | Pharma | CDK8 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
(1) ApexBio Compounds for CDK8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Senexin A | CDK8 inhibitor | 1366002-50-7 |
Transcripts for CDK8 Gene
mRNA/cDNA for CDK8 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (85) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000536792 3032 bps (uc001uqt.2)
- ENST00000381527 3055 bps (uc001uqr.2)
- ENST00000465820 586 bps (uc031zzu.2)
- ENST00000477277 1770 bps (uc058vzn.1)
- ENST00000625988 795 bps (uc058vzo.1)
Unigene Clusters for CDK8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK8
- genomics-online: gRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- Applied Biological Materials CRISPR for CDK8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK8
- GenScript: Design CRISPR guide RNA sequences for CDK8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK8
- Browse OriGene Inhibitory RNA Products For CDK8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK8
- genomics-online: shRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDK8
- VectorBuilder custom plasmid, inducible vectors for CDK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK8
- Applied Biological Materials Clones for CDK8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | - |
Expression for CDK8 Gene
This gene is overexpressed in Adrenal (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK8 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK8 Gene:
CDK8SOURCE GeneReport for Unigene cluster for CDK8 Gene:
Hs.382306Evidence on tissue expression from TISSUES for CDK8 Gene
- Intestine(2.2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CDK8
-
OriGene qPCR primer pairs for CDK8
- genomics-online: primer clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK8 Gene
Orthologs for CDK8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | CDK8 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CDK8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CDK8 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDK8 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CDK8 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cdk8 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdk8 33 |
|
||
| chicken (Gallus gallus) |
Aves | CDK8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CDK8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk8 33 |
|
||
| MGC76204 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cdk8 34 33 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009936 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdk8 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cdk-8 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSN3 36 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.2989 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.10765 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10765 33 |
|
- Species where no ortholog for CDK8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CDK8 Gene
- ENSEMBL:
- Gene Tree for CDK8 (if available)
- TreeFam:
- Gene Tree for CDK8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDK8: view image
Paralogs for CDK8 Gene
(23) SIMAP similar genes for CDK8 Gene using alignment to 4 proteins:
- CDK8_HUMAN
- F5H6D4_HUMAN
- Q64FY6_HUMAN
- U4PPA3_HUMAN
Pseudogenes.org Pseudogenes for CDK8 Gene
Variants for CDK8 Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041980 | A lung neuroendocrine carcinoma sample | p.Asp189Asn | |||
| VAR_041981 | A colorectal adenocarcinoma sample | p.Arg424Cys | |||
| rs1000009077 | -- | 26,269,693(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000029689 | -- | 26,363,576(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000030007 | -- | 26,279,317(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3304269 | CNV | mobile element insertion | 20981092 |
| esv3360510 | CNV | insertion | 20981092 |
| esv3361608 | CNV | insertion | 20981092 |
| esv3631600 | CNV | loss | 21293372 |
| nsv1138203 | CNV | deletion | 24896259 |
| nsv561357 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.25;
5.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDK8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK8 Gene
Disorders for CDK8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal adenocarcinoma |
|
|
| hemophagocytic lymphohistiocytosis, familial, 3 |
|
|
Search CDK8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDK8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CDK8 Gene
Publications for CDK8 Gene
- Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PMID: 7568034) Tassan JP … Nigg EA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
- Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (PMID: 15546612) Fryer CJ … Jones KA (Molecular cell 2004) 3 4 22 58
- The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. (PMID: 21806996) Schneider EV … Maskos K (Journal of molecular biology 2011) 3 4 58
- CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. (PMID: 19790197) Firestein R … Ogino S (International journal of cancer 2010) 3 22 58
- CDK8 is a positive regulator of transcriptional elongation within the serum response network. (PMID: 20098423) Donner AJ … Espinosa JM (Nature structural & molecular biology 2010) 3 22 58
Products for CDK8 Gene
- R&D Systems Antibodies for CDK8 (CDK8)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CDK8
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK8
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK8
- Origene Custom Protein Services for CDK8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK8
- Browse OriGene Inhibitory RNA Products For CDK8
- OriGene qPCR primer pairs and template standards for CDK8
- OriGene qPCR primer pairs for CDK8
- OriGene CRISPR knockouts for CDK8
- OriGene ORF clones in human for CDK8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK8
- GenScript: Next-day shipping of latest version cDNA ORF clones for CDK8 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CDK8
- GenScript Custom Assay Services for CDK8
- GenScript Custom overexpressing Cell Line Services for CDK8
- GenScript: Design CRISPR guide RNA sequences for CDK8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK8
- Sino Biological Human cDNA Clone for CDK8
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Assays
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- Taconic Biosciences Mouse Models for CDK8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK8
- VectorBuilder custom plasmid, inducible vectors for CDK8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK8
- antibodies-online: Search results for 92 available CDK8 Antibodies ranked by validation data
- Compare Top CDK8 Antibodies
- antibodies-online: Search results for 19 available CDK8 Elisa Kits ranked by validation data
- Compare Top CDK8 Elisa Kits
- antibodies-online: Search results for 15 available CDK8 Proteins ranked by validation data
- Compare Top CDK8 Proteins
- GeneTex CDK8 Antibody for CDK8
- Search GeneTex for Proteins for CDK8
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK8
- Search Santa Cruz Biotechnology (SCBT) for CDK8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK8
- Horizon Cell Lines for CDK8
- genomics-online: cdna clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- orf clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- genomics-online: gRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- genomics-online: primer clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- genomics-online: shRNA clones - Search results for 85 available CDK8 gene related products
- Overview of 85 available CDK8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK8
- GeneCopoeia miRNA 3'UTR Target clone products for CDK8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK8
Sources for CDK8 Gene
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