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The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
CDK7 (Cyclin Dependent Kinase 7) is a Protein Coding gene. Diseases associated with CDK7 include Xeroderma Pigmentosum, Variant Type and Cockayne Syndrome. Among its related pathways are RNA Polymerase I Promoter Escape and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,TAS | 7533895 |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 15530371 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000439 | transcription factor TFIIH core complex | IDA | 8692841 |
GO:0001650 | fibrillar center | IDA | -- |
GO:0005634 | nucleus | IDA | 16109376 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005675 | transcription factor TFIIH holo complex | IEA,IDA | 9852112 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
.93
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2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
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3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
5 | HIV Life Cycle |
.91
.64
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.45
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | 7533895 |
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Alvocidib | Experimental, Investigational | Pharma | Target, inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 65 | |
Phosphonothreonine | Experimental | Pharma | Target | 0 | ||
seliciclib | Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
SNS-032 | Investigational | Pharma | Target, Inhibition, inhibitor | 0 | ||
ATP | Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
BS-181 | CDK7 inhibitor,highly selective | 1092443-52-1 |
BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
Flavopiridol hydrochloride | 131740-09-5 | |
JNJ-7706621 | Potent CDK/Aurora kinase inhibitor | 443797-96-4 |
LDC000067 | 1073485-20-7 | |
PHA-793887 | Pan-Cdk inhibitor | 718630-59-2 |
PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
Roscovitine (Seliciclib,CYC202) | CDK inhibitor,potent and selective | 186692-46-6 |
SNS-032 (BMS-387032) | CDK inhibitor | 345627-80-7 |
THZ1 | Covalent CDK7 inhibitor,potent and selective | |
THZ1 Hydrochloride | CDK7 inhibitor | |
THZ2 | CDK7 inhibitor | 1604810-84-5 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK7 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDK7 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDK7 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK7 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cdk7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk7 30 |
|
||
Chicken (Gallus gallus) |
Aves | CDK7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk7 30 |
|
||
Str.10484 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1768 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdk7 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Cdk7 30 31 32 |
|
OneToOne | |
CG6800 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002646 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cdk-7 30 31 |
|
OneToOne | |
H01G02.2 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIN28 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E14785g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL283W 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CAK4 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.2689 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mcs6 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03659 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.961 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34584424 | - |
p.Thr285Met |
|||
VAR_023118 | - |
p.Gly163Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5694n100 | CNV | gain | 25217958 |
nsv821643 | CNV | loss | 15273396 |
Disorder | Aliases | PubMed IDs |
---|---|---|
xeroderma pigmentosum, variant type |
|
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cockayne syndrome |
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xeroderma pigmentosum, complementation group b |
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breast cancer |
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xeroderma pigmentosum, complementation group d |
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