The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and memb... See more...

Aliases for CDK6 Gene

Aliases for CDK6 Gene

  • Cyclin Dependent Kinase 6 2 3 5
  • Serine/Threonine-Protein Kinase PLSTIRE 3 4
  • Cell Division Protein Kinase 6 3 4
  • Cyclin-Dependent Kinase 6 3 4
  • EC 2.7.11.22 4 51
  • PLSTIRE 2 3
  • EC 2.7.11 51
  • MCPH12 3
  • CDKN6 4
  • CDK6 5

External Ids for CDK6 Gene

Previous GeneCards Identifiers for CDK6 Gene

  • GC07M090779
  • GC07M091841
  • GC07M091855
  • GC07M091878
  • GC07M092072
  • GC07M092234
  • GC07M086843

Summaries for CDK6 Gene

Entrez Gene Summary for CDK6 Gene

  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

CIViC Summary for CDK6 Gene

  • CDK6, along with its partner CDK4, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors.

GeneCards Summary for CDK6 Gene

CDK6 (Cyclin Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include Microcephaly 12, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are C-MYB transcription factor network and Small cell lung cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot Summary for CDK6 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

Tocris Summary for CDK6 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK6 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK6 Gene

Genomics for CDK6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK6

Top Transcription factor binding sites by QIAGEN in the CDK6 gene promoter:
  • AML1a

Genomic Locations for CDK6 Gene

Genomic Locations for CDK6 Gene
chr7:92,604,921-92,836,573
(GRCh38/hg38)
Size:
231,653 bases
Orientation:
Minus strand
chr7:92,234,235-92,465,941
(GRCh37/hg19)
Size:
231,707 bases
Orientation:
Minus strand

Genomic View for CDK6 Gene

Genes around CDK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK6 Gene

Proteins for CDK6 Gene

  • Protein details for CDK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00534-CDK6_HUMAN
    Recommended name:
    Cyclin-dependent kinase 6
    Protein Accession:
    Q00534
    Secondary Accessions:
    • A4D1G0

    Protein attributes for CDK6 Gene

    Size:
    326 amino acids
    Molecular mass:
    36938 Da
    Quaternary structure:
    • Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177 (By similarity). Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral reactivation by reducing viral LANA levels.
    Miscellaneous:
    • Over-expressed in some leukemias and malignancies (including sarcoma, glioma, breast tumors, lymphoma and melanoma) as a consequence of nearby translocations.
    • Enhances beta-cells engraftment in pancreatic islets of Langerhans of diabetic patients.

    Three dimensional structures from OCA and Proteopedia for CDK6 Gene

neXtProt entry for CDK6 Gene

Selected DME Specific Peptides for CDK6 Gene

Q00534:
  • GCIFAEM
  • WSVGCIFAE
  • TLVFEHVDQDL
  • HPNVVRL
  • VVHRDLK
  • VVTLWYR
  • LADFGLA
  • WSVGCIFAEMFRRKPLF
  • RTDRETK
  • HRDLKPQN
  • VHRDLKP

Post-translational modifications for CDK6 Gene

  • Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
  • Ubiquitination at Lys3, Lys26, Lys29, Lys147, Lys160, Lys230, Lys257, Lys264, Lys274, Lys279, Lys287, and Lys307
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK6 Gene

Antibody Products

  • Abcam antibodies for CDK6

Domains & Families for CDK6 Gene

Gene Families for CDK6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDK6 Gene

Suggested Antigen Peptide Sequences for CDK6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94044, Homo sapiens cyclin-dependent kinase 6 (CDK6), mRNA (A4D1G0_HUMAN)
  • Serine/threonine-protein kinase PLSTIRE (CDK6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00534

UniProtKB/Swiss-Prot:

CDK6_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK6: view

Function for CDK6 Gene

Molecular function for CDK6 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection. Induced by NANOG during S-phase entry.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991, 4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast).
GENATLAS Biochemistry:
cyclin dependent kinase 6,cdc2 related gene family,involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3)

Enzyme Numbers (IUBMB) for CDK6 Gene

Phenotypes From GWAS Catalog for CDK6 Gene

Gene Ontology (GO) - Molecular Function for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 8114739
GO:0005515 protein binding IPI 8001816
genes like me logo Genes that share ontologies with CDK6: view
genes like me logo Genes that share phenotypes with CDK6: view

Human Phenotype Ontology for CDK6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDK6 Gene

MGI Knock Outs for CDK6:
  • Cdk6 Cdk6<tm1b(EUCOMM)Wtsi>
  • Cdk6 Cdk6<tm1Bbd>
  • Cdk6 Cdk6<tm1Phin>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK6

CRISPR Products

miRNA for CDK6 Gene

miRTarBase miRNAs that target CDK6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK6

No data available for Transcription Factor Targets and HOMER Transcription for CDK6 Gene

Localization for CDK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK6 Gene

Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250 UniProtKB:Q64261, ECO:0000269 PubMed:23918663}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 3
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0001726 ruffle IDA 10205165
GO:0005634 nucleus IBA,IDA 14985467
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 14985467
genes like me logo Genes that share ontologies with CDK6: view

Pathways & Interactions for CDK6 Gene

genes like me logo Genes that share pathways with CDK6: view

Pathways by source for CDK6 Gene

4 GeneGo (Thomson Reuters) pathways for CDK6 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Regulation of G1/S transition (part 2)
8 Qiagen pathways for CDK6 Gene
  • Calpain Protease Regulates Cellular Mechanics
  • Cell Cycle Control of Chromosomal Replication
  • Cyclins and Cell Cycle Regulation
  • G1-S Phase Transition
  • GADD45 Pathway
1 Cell Signaling Technology pathway for CDK6 Gene
1 GeneTex pathway for CDK6 Gene

SIGNOR curated interactions for CDK6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 16294322
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 10205165
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0003323 type B pancreatic cell development IDA 20668294
genes like me logo Genes that share ontologies with CDK6: view

Drugs & Compounds for CDK6 Gene

(95) Drugs for CDK6 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palbociclib Approved, Investigational Pharma Target, inhibitor, Inhibition 229
Tamoxifen Approved Pharma Agonist, Antagonist TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 451
abemaciclib Approved, Investigational Pharma Target, inhibitor 0
ribociclib Approved, Investigational Pharma Target, antagonist, inhibitor 0
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy 337

(13) Additional Compounds for CDK6 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
(R)-CR8
294646-77-8
Arcyriaflavin A
118458-54-1

(5) Tocris Compounds for CDK6 Gene

Compound Action Cas Number
(R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1 294646-77-8
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
AZD 5438 Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor 602306-29-6
Olomoucine Cyclin-dependent kinase inhibitor 101622-51-9
SU 9516 Potent cdk2 inhibitor 377090-84-1

(11) ApexBio Compounds for CDK6 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
Flavopiridol hydrochloride 131740-09-5
LDC000067 1073485-20-7
LEE011 CDK4/6 inhibitor 1211441-98-3
LEE011 hydrochloride CDK inhibitor 1211443-80-9
LEE011 succinate CDK inhibitor 1374639-75-4
LY2835219 CDK4/6 inhibitor,potent and selective 1231930-82-7
LY2835219 free base CDK inhibitor 1231929-97-7
Palbociclib (PD0332991) Isethionate CDK4/6 inhibitor,highly selective 827022-33-3
PD 0332991 (Palbociclib) HCl CDK4/6 inhibitor,highly selective 827022-32-2
genes like me logo Genes that share compounds with CDK6: view

Drug Products

Transcripts for CDK6 Gene

mRNA/cDNA for CDK6 Gene

2 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK6

Alternative Splicing Database (ASD) splice patterns (SP) for CDK6 Gene

No ASD Table

Relevant External Links for CDK6 Gene

GeneLoc Exon Structure for
CDK6

Expression for CDK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8) and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK6

SOURCE GeneReport for Unigene cluster for CDK6 Gene:

Hs.119882

mRNA Expression by UniProt/SwissProt for CDK6 Gene:

Q00534-CDK6_HUMAN
Tissue specificity: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.

Evidence on tissue expression from TISSUES for CDK6 Gene

  • Nervous system(4.7)
  • Bone marrow(3.4)
  • Skin(3.2)
  • Lung(3)
  • Intestine(3)
  • Liver(3)
  • Blood(2.9)
  • Stomach(2.8)
  • Pancreas(2.8)
  • Lymph node(2.8)
  • Kidney(2.8)
  • Heart(2.6)
  • Muscle(2.5)
  • Spleen(2.4)
  • Thyroid gland(2.2)
  • Bone(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • chin
  • cranial nerve
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • pelvis
  • ureter
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with CDK6: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDK6 Gene

Orthologs for CDK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK6 30 31
  • 99.8 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK6 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CDK6 30 31
  • 92.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDK6 30 31
  • 92.64 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDK6 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk6 30
  • 90.39 (n)
Mouse
(Mus musculus)
Mammalia Cdk6 30 17
  • 89.98 (n)
E030030I06Rik 31
  • 23 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDK6 30 31
  • 83.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK6 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdk6 30
  • 80.25 (n)
Str.20309 30
Zebrafish
(Danio rerio)
Actinopterygii cdk6 30 31
  • 74.2 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005817 30
  • 53.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Cdk4 30 31 32
  • 53.52 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cdk-4 30 31 32
  • 51.01 (n)
ManyToMany
F52B5.2 31
  • 26 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 31
  • 45 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for CDK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDK6 Gene

ENSEMBL:
Gene Tree for CDK6 (if available)
TreeFam:
Gene Tree for CDK6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK6: view image

Paralogs for CDK6 Gene

Variants for CDK6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CDK6 Gene

CDK6_HUMAN-Q00534
Genetic variations in CDK6 may influence stature as a quantitative trait, contributing to the stature quantitative trait locus 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK6 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
712006 Likely Benign: not provided 92,833,258(-) G/A SYNONYMOUS_VARIANT
712661 Likely Benign: not provided 92,615,176(-) C/T SYNONYMOUS_VARIANT
717291 Likely Benign: not provided 92,671,485(-) G/A SYNONYMOUS_VARIANT
719802 Likely Benign: not provided 92,671,527(-) C/T SYNONYMOUS_VARIANT
723240 Likely Benign: not provided 92,774,771(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CDK6 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK6 Gene

Variant ID Type Subtype PubMed ID
esv2762687 CNV loss 21179565
esv3576407 CNV gain 25503493
esv3614146 CNV loss 21293372
esv3614148 CNV gain 21293372
esv3614149 CNV loss 21293372
nsv1074529 CNV deletion 25765185
nsv1133666 CNV deletion 24896259
nsv473626 CNV novel sequence insertion 20440878
nsv516592 CNV gain+loss 19592680
nsv819408 CNV gain 19587683
nsv831062 CNV gain 17160897

Variation tolerance for CDK6 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK6 Gene

Human Gene Mutation Database (HGMD)
CDK6
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CDK6

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Disorders for CDK6 Gene

MalaCards: The human disease database

(50) MalaCards diseases for CDK6 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDK6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK6_HUMAN
  • Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269 PubMed:23918663}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CDK6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDK6: view

No data available for Genatlas for CDK6 Gene

Publications for CDK6 Gene

  1. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H … Gayther SA (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 41
  2. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato EM … Pharoah PD (Breast cancer research : BCR 2008) 3 23 41
  3. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver KE … Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team (Carcinogenesis 2008) 3 23 41
  4. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. (PMID: 18361427) Ye Y … Gu J (Cancer 2008) 3 23 41
  5. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PMID: 17431401) Fujimoto T … Nerlov C (The EMBO journal 2007) 3 4 23

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