The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008] See more...

Aliases for CDK5R2 Gene

Aliases for CDK5R2 Gene

  • Cyclin Dependent Kinase 5 Regulatory Subunit 2 2 3 5
  • NCK5AI 2 3 4
  • P39 2 3 4
  • Cyclin-Dependent Kinase 5 Activator 2 3 4
  • CDK5 Activator 2 3 4
  • P39nck5ai 2 3
  • P39I 3 4
  • Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39) 2
  • Cyclin-Dependent Kinase 5 Regulatory Subunit 2 4
  • Neuronal CDK5 Activator Isoform 2
  • CDK5R2 5

External Ids for CDK5R2 Gene

Previous GeneCards Identifiers for CDK5R2 Gene

  • GC02P217840
  • GC02P218545
  • GC02P219788
  • GC02P220026
  • GC02P219649
  • GC02P219532
  • GC02P211678
  • GC02P219824

Summaries for CDK5R2 Gene

Entrez Gene Summary for CDK5R2 Gene

  • The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK5R2 Gene

CDK5R2 (Cyclin Dependent Kinase 5 Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with CDK5R2 include Bardet-Biedl Syndrome 9. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

UniProtKB/Swiss-Prot Summary for CDK5R2 Gene

Gene Wiki entry for CDK5R2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK5R2 Gene

Genomics for CDK5R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK5R2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK5R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK5R2

Top Transcription factor binding sites by QIAGEN in the CDK5R2 gene promoter:
  • E47
  • Hand1
  • Oct-B1
  • oct-B2
  • oct-B3
  • Pax-5
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for CDK5R2 Gene

Latest Assembly
chr2:218,959,666-218,962,155
(GRCh38/hg38)
Size:
2,490 bases
Orientation:
Plus strand

Previous Assembly
chr2:219,824,388-219,826,877
(GRCh37/hg19 by Entrez Gene)
Size:
2,490 bases
Orientation:
Plus strand

chr2:219,824,377-219,826,876
(GRCh37/hg19 by Ensembl)
Size:
2,500 bases
Orientation:
Plus strand

Genomic View for CDK5R2 Gene

Genes around CDK5R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5R2 Gene

Proteins for CDK5R2 Gene

  • Protein details for CDK5R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13319-CD5R2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 5 activator 2
    Protein Accession:
    Q13319
    Secondary Accessions:
    • Q4ZFW6

    Protein attributes for CDK5R2 Gene

    Size:
    367 amino acids
    Molecular mass:
    38705 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit and a regulatory subunit.

neXtProt entry for CDK5R2 Gene

Post-translational modifications for CDK5R2 Gene

  • Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK5R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CDK5R2

No data available for DME Specific Peptides for CDK5R2 Gene

Domains & Families for CDK5R2 Gene

Gene Families for CDK5R2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDK5R2 Gene

InterPro:
Blocks:
  • Cyclin-dependent kinase 5 activator

Suggested Antigen Peptide Sequences for CDK5R2 Gene

GenScript: Design optimal peptide antigens:
  • p39I (CD5R2_HUMAN)
  • Cyclin-dependent kinase 5, regulatory subunit 2 (P39) (Q5XKD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13319

UniProtKB/Swiss-Prot:

CD5R2_HUMAN :
  • Belongs to the cyclin-dependent kinase 5 activator family.
Family:
  • Belongs to the cyclin-dependent kinase 5 activator family.
genes like me logo Genes that share domains with CDK5R2: view

Function for CDK5R2 Gene

Molecular function for CDK5R2 Gene

UniProtKB/Swiss-Prot Function:
Activator of CDK5/TPKII.

Phenotypes From GWAS Catalog for CDK5R2 Gene

Gene Ontology (GO) - Molecular Function for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,ISS --
GO:0008289 lipid binding IEA --
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity TAS 17491008
genes like me logo Genes that share ontologies with CDK5R2: view
genes like me logo Genes that share phenotypes with CDK5R2: view

Animal Models for CDK5R2 Gene

MGI Knock Outs for CDK5R2:

miRNA for CDK5R2 Gene

miRTarBase miRNAs that target CDK5R2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK5R2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5R2 Gene

Localization for CDK5R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5R2 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK5R2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane ISS --
GO:0016533 protein kinase 5 complex IEA --
GO:0030426 growth cone IEA,ISS --
genes like me logo Genes that share ontologies with CDK5R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDK5R2 Gene

Pathways & Interactions for CDK5R2 Gene

genes like me logo Genes that share pathways with CDK5R2: view

Pathways by source for CDK5R2 Gene

1 Qiagen pathway for CDK5R2 Gene
  • Reelin Pathway (Cajal-Retzius cells)
1 Cell Signaling Technology pathway for CDK5R2 Gene
1 GeneTex pathway for CDK5R2 Gene

Gene Ontology (GO) - Biological Process for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7592934
GO:0001764 neuron migration IEA --
GO:0021549 cerebellum development IEA --
GO:0021722 superior olivary nucleus maturation IEA --
GO:0021766 hippocampus development IEA --
genes like me logo Genes that share ontologies with CDK5R2: view

No data available for SIGNOR curated interactions for CDK5R2 Gene

Drugs & Compounds for CDK5R2 Gene

(10) Drugs for CDK5R2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT7519 Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0
PHA-848125 Pharma CDK inhibitor,potent and ATP-competitive 0

(8) ApexBio Compounds for CDK5R2 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK5R2: view

Drug products for research

Transcripts for CDK5R2 Gene

mRNA/cDNA for CDK5R2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK5R2

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5R2 Gene

No ASD Table

Relevant External Links for CDK5R2 Gene

GeneLoc Exon Structure for
CDK5R2

Expression for CDK5R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK5R2 Gene

mRNA differential expression in normal tissues according to GTEx for CDK5R2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.1), Brain - Putamen (basal ganglia) (x5.5), Brain - Cortex (x5.5), Brain - Hippocampus (x4.3), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CDK5R2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK5R2 Gene



Protein tissue co-expression partners for CDK5R2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK5R2

SOURCE GeneReport for Unigene cluster for CDK5R2 Gene:

Hs.158460

mRNA Expression by UniProt/SwissProt for CDK5R2 Gene:

Q13319-CD5R2_HUMAN
Tissue specificity: Brain and neuron specific.

Evidence on tissue expression from TISSUES for CDK5R2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CDK5R2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5R2 Gene

Orthologs for CDK5R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK5R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK5R2 29 30
  • 99.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDK5R2 29 30
  • 94.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDK5R2 29 30
  • 93.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk5r2 29
  • 91.28 (n)
Mouse
(Mus musculus)
Mammalia Cdk5r2 29 16 30
  • 91.19 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CDK5R2 29 30
  • 76.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK5R2 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdk5r2 29
  • 65.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii cdk5r2a 30
  • 63 (a)
OneToMany
cdk5r2b 30
  • 55 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Cdk5alpha 30 31
  • 27 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T23F11.3 31
  • 51 (a)
cdka-1 30
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToMany
Species where no ortholog for CDK5R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDK5R2 Gene

ENSEMBL:
Gene Tree for CDK5R2 (if available)
TreeFam:
Gene Tree for CDK5R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK5R2: view image
Alliance of Genome Resources:
Additional Orthologs for CDK5R2

Paralogs for CDK5R2 Gene

Paralogs for CDK5R2 Gene

(1) SIMAP similar genes for CDK5R2 Gene using alignment to 2 proteins:

  • CD5R2_HUMAN
  • Q5XKD4_HUMAN
genes like me logo Genes that share paralogs with CDK5R2: view

Variants for CDK5R2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDK5R2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDK5R2 Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv3169 CNV deletion 18451855
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897

Variation tolerance for CDK5R2 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK5R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK5R2
Leiden Open Variation Database (LOVD)
CDK5R2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK5R2 Gene

Disorders for CDK5R2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK5R2 Gene - From: COP

Disorder Aliases PubMed IDs
bardet-biedl syndrome 9
  • bbs9
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDK5R2

genes like me logo Genes that share disorders with CDK5R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK5R2 Gene

Publications for CDK5R2 Gene

  1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PMID: 7592934) Tang D … Wang JH (The Journal of biological chemistry 1995) 2 3 4 22
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PMID: 15917097) Rademakers R … Cruts M (Neurobiology of aging 2005) 3 22
  4. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PMID: 10965112) Muravenko OV … Zelenin AV (Cytogenetics and cell genetics 2000) 3 22
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for CDK5R2 Gene

Sources for CDK5R2 Gene