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Aliases for CDK5R2 Gene

Aliases for CDK5R2 Gene

  • Cyclin Dependent Kinase 5 Regulatory Subunit 2 2 3 5
  • Neuronal CDK5 Activator Isoform 2 3
  • CDK5 Activator 2 3 4
  • NCK5AI 3 4
  • P39I 3 4
  • P39 3 4
  • Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (P39) 2
  • Cyclin-Dependent Kinase 5 Activator Isoform P39i 3
  • Cyclin-Dependent Kinase 5 Regulatory Subunit 2 4
  • Cyclin-Dependent Kinase 5 Activator 2 3
  • P39nck5ai 3

External Ids for CDK5R2 Gene

Previous GeneCards Identifiers for CDK5R2 Gene

  • GC02P217840
  • GC02P218545
  • GC02P219788
  • GC02P220026
  • GC02P219649
  • GC02P219532
  • GC02P211678
  • GC02P219824

Summaries for CDK5R2 Gene

Entrez Gene Summary for CDK5R2 Gene

  • The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK5R2 Gene

CDK5R2 (Cyclin Dependent Kinase 5 Regulatory Subunit 2) is a Protein Coding gene. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and Lissencephaly gene (LIS1) in neuronal migration and development. Gene Ontology (GO) annotations related to this gene include lipid binding and cyclin-dependent protein kinase 5 activator activity. An important paralog of this gene is CDK5R1.

UniProtKB/Swiss-Prot for CDK5R2 Gene

  • Activator of CDK5/TPKII.

Gene Wiki entry for CDK5R2 Gene

Additional gene information for CDK5R2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5R2 Gene

Genomics for CDK5R2 Gene

GeneHancer (GH) Regulatory Elements for CDK5R2 Gene

Promoters and enhancers for CDK5R2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218959 Enhancer 1 Ensembl ENCODE 650.7 +0.4 435 2.1 PKNOX1 ATF1 SIN3A ETS1 ZNF335 GLIS2 FOS CREM SP3 SP5 CDK5R2 ENSG00000235024 USP37 NHEJ1 DNPEP CNOT9
GH02J218908 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -50.0 -50030 2.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 ENSG00000235024 CDK5R2 ENSG00000269068
GH02J219438 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 9.9 +483.7 483695 9.5 PKNOX1 ZFP64 BMI1 ZNF335 GLIS2 EGR1 EGR2 ZBTB11 ZC3H11A ZNF398 CNOT9 STK36 USP37 BCS1L ASIC4 ANKZF1 GMPPA DES ENSG00000272644 ENSG00000227432
GH02J219110 Enhancer 1.1 ENCODE dbSUPER 10.5 +152.7 152654 3 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 NFKBIZ RXRA SP5 ZHX2 IHH MIR375 LOC100129175 CRYBA2 FEV LINC00608 PTPRN NHEJ1 CDK5R2 ENSG00000235024
GH02J219109 Enhancer 0.7 ENCODE dbSUPER 10.3 +150.0 150011 1.1 ZFHX2 POLR2A HLF CEBPB CEBPG EGR2 NHEJ1 SLC23A3 IHH CRYBA2 FEV LINC00608 PTPRN LOC100129175 MIR375 ENSG00000235024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK5R2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDK5R2 gene promoter:
  • E47
  • Pax-5
  • Hand1
  • SRF
  • SRF (504 AA)
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a

Genomic Locations for CDK5R2 Gene

Genomic Locations for CDK5R2 Gene
2,535 bases
Plus strand
2,501 bases
Plus strand

Genomic View for CDK5R2 Gene

Genes around CDK5R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5R2 Gene

Proteins for CDK5R2 Gene

  • Protein details for CDK5R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 5 activator 2
    Protein Accession:
    Secondary Accessions:
    • Q4ZFW6

    Protein attributes for CDK5R2 Gene

    367 amino acids
    Molecular mass:
    38705 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit and a regulatory subunit.

neXtProt entry for CDK5R2 Gene

Post-translational modifications for CDK5R2 Gene

  • Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK5R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDK5R2 Gene

Domains & Families for CDK5R2 Gene

Gene Families for CDK5R2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDK5R2 Gene

Suggested Antigen Peptide Sequences for CDK5R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin-dependent kinase 5 activator family.
  • Belongs to the cyclin-dependent kinase 5 activator family.
genes like me logo Genes that share domains with CDK5R2: view

Function for CDK5R2 Gene

Molecular function for CDK5R2 Gene

UniProtKB/Swiss-Prot Function:
Activator of CDK5/TPKII.

Phenotypes From GWAS Catalog for CDK5R2 Gene

Gene Ontology (GO) - Molecular Function for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0016534 cyclin-dependent protein kinase 5 activator activity TAS 17491008
genes like me logo Genes that share ontologies with CDK5R2: view
genes like me logo Genes that share phenotypes with CDK5R2: view

Animal Models for CDK5R2 Gene

MGI Knock Outs for CDK5R2:

Animal Model Products

CRISPR Products

miRNA for CDK5R2 Gene

miRTarBase miRNAs that target CDK5R2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK5R2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5R2 Gene

Localization for CDK5R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5R2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK5R2 gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex IEA --
genes like me logo Genes that share ontologies with CDK5R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDK5R2 Gene

Pathways & Interactions for CDK5R2 Gene

genes like me logo Genes that share pathways with CDK5R2: view

Pathways by source for CDK5R2 Gene

1 GeneTex pathway for CDK5R2 Gene
1 Qiagen pathway for CDK5R2 Gene
1 Cell Signaling Technology pathway for CDK5R2 Gene

Gene Ontology (GO) - Biological Process for CDK5R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7592934
GO:0001764 neuron migration IEA --
GO:0021549 cerebellum development IEA --
GO:0021722 superior olivary nucleus maturation IEA --
GO:0021766 hippocampus development IEA --
genes like me logo Genes that share ontologies with CDK5R2: view

No data available for SIGNOR curated interactions for CDK5R2 Gene

Drugs & Compounds for CDK5R2 Gene

(10) Drugs for CDK5R2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT7519 Investigational Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0
PHA-848125 Pharma CDK inhibitor,potent and ATP-competitive 0
genes like me logo Genes that share compounds with CDK5R2: view

Transcripts for CDK5R2 Gene

mRNA/cDNA for CDK5R2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK5R2 Gene

Cyclin-dependent kinase 5, regulatory subunit 2 (p39):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK5R2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5R2 Gene

No ASD Table

Relevant External Links for CDK5R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK5R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK5R2 Gene

mRNA differential expression in normal tissues according to GTEx for CDK5R2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.1), Brain - Putamen (basal ganglia) (x5.5), Brain - Cortex (x5.5), Brain - Hippocampus (x4.3), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CDK5R2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK5R2 Gene

Protein tissue co-expression partners for CDK5R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK5R2 Gene:


SOURCE GeneReport for Unigene cluster for CDK5R2 Gene:


mRNA Expression by UniProt/SwissProt for CDK5R2 Gene:

Tissue specificity: Brain and neuron specific.

Evidence on tissue expression from TISSUES for CDK5R2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CDK5R2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5R2 Gene

Orthologs for CDK5R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK5R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDK5R2 34 33
  • 99.36 (n)
(Bos Taurus)
Mammalia CDK5R2 34 33
  • 94.37 (n)
(Canis familiaris)
Mammalia CDK5R2 34 33
  • 93.01 (n)
(Rattus norvegicus)
Mammalia Cdk5r2 33
  • 91.28 (n)
(Mus musculus)
Mammalia Cdk5r2 16 34 33
  • 91.19 (n)
(Gallus gallus)
Aves CDK5R2 34 33
  • 76.59 (n)
(Anolis carolinensis)
Reptilia CDK5R2 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5r2 33
  • 65.39 (n)
(Danio rerio)
Actinopterygii cdk5r2a 34
  • 63 (a)
cdk5r2b 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdk5alpha 34 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea T23F11.3 35
  • 51 (a)
cdka-1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for CDK5R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5R2 Gene

Gene Tree for CDK5R2 (if available)
Gene Tree for CDK5R2 (if available)
Evolutionary constrained regions (ECRs) for CDK5R2: view image

Paralogs for CDK5R2 Gene

Paralogs for CDK5R2 Gene

(1) SIMAP similar genes for CDK5R2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDK5R2: view

Variants for CDK5R2 Gene

Sequence variations from dbSNP and Humsavar for CDK5R2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001548062 -- 218,958,461(+) G/A upstream_transcript_variant
rs1001583364 -- 218,958,345(+) C/T upstream_transcript_variant
rs1001867213 -- 218,958,000(+) G/C upstream_transcript_variant
rs1002144360 -- 218,959,696(+) CCCCC/CCCCCC 5_prime_UTR_variant
rs1002241882 -- 218,959,838(+) T/C coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK5R2 Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv3169 CNV deletion 18451855
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897

Variation tolerance for CDK5R2 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK5R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5R2 Gene

Disorders for CDK5R2 Gene

Additional Disease Information for CDK5R2

No disorders were found for CDK5R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK5R2 Gene

Publications for CDK5R2 Gene

  1. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. (PMID: 7592934) Tang D … Wang JH (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. (PMID: 15917097) Rademakers R … Cruts M (Neurobiology of aging 2005) 3 22 58
  4. Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (PMID: 10965112) Muravenko OV … Zelenin AV (Cytogenetics and cell genetics 2000) 3 22 58
  5. The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. (PMID: 25128817) Tripathi BK … Zelenka PS (Experimental cell research 2015) 3 58

Products for CDK5R2 Gene

Sources for CDK5R2 Gene

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