CDK5R1 Gene (Protein Coding)

Cyclin Dependent Kinase 5 Regulatory Subunit 1

GC17P032486
GIFtS:
46
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery... See more...

Aliases for CDK5R1 Gene

Aliases for CDK5R1 Gene

  • Cyclin Dependent Kinase 5 Regulatory Subunit 1 2 3 5
  • Cyclin-Dependent Kinase 5 Activator 1 3 4
  • TPKII Regulatory Subunit 3 4
  • CDK5 Activator 1 3 4
  • CDK5R 3 4
  • NCK5A 3 4
  • Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (P35) 2
  • Cyclin-Dependent Kinase 5 Regulatory Subunit 1 4
  • Tau Protein Kinase II 23kDa Subunit 3
  • Regulatory Partner For CDK5 Kinase 3
  • Neuronal CDK5 Activator 3
  • P35nck5a 3
  • CDK5P35 3
  • P23 3
  • P25 3
  • P35 3

External Ids for CDK5R1 Gene

Previous GeneCards Identifiers for CDK5R1 Gene

  • GC17P030580
  • GC17P032848
  • GC17P030959
  • GC17P027838
  • GC17P030813
  • GC17P027000

Summaries for CDK5R1 Gene

Entrez Gene Summary for CDK5R1 Gene

  • The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK5R1 Gene

CDK5R1 (Cyclin Dependent Kinase 5 Regulatory Subunit 1) is a Protein Coding gene. Diseases associated with CDK5R1 include Alzheimer Disease and Non-Syndromic Intellectual Disability. Among its related pathways are Allograft rejection and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein kinase binding. An important paralog of this gene is CDK5R2.

UniProtKB/Swiss-Prot Summary for CDK5R1 Gene

  • p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Gene Wiki entry for CDK5R1 Gene

Additional gene information for CDK5R1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK5R1 Gene

Genomics for CDK5R1 Gene

GeneHancer (GH) Regulatory Elements for CDK5R1 Gene

Promoters and enhancers for CDK5R1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK5R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDK5R1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • NF-1
  • NF-1/L
  • p53
  • STAT3

Genomic Locations for CDK5R1 Gene

Genomic Locations for CDK5R1 Gene
chr17:32,486,993-32,491,254
(GRCh38/hg38)
Size:
4,262 bases
Orientation:
Plus strand
chr17:30,813,637-30,818,274
(GRCh37/hg19)
Size:
4,638 bases
Orientation:
Plus strand

Genomic View for CDK5R1 Gene

Genes around CDK5R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK5R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK5R1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK5R1 Gene

Proteins for CDK5R1 Gene

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  • Protein details for CDK5R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15078-CD5R1_HUMAN
    Recommended name:
    Cyclin-dependent kinase 5 activator 1
    Protein Accession:
    Q15078
    Secondary Accessions:
    • E1P664
    • Q5U0G3

    Protein attributes for CDK5R1 Gene

    Size:
    307 amino acids
    Molecular mass:
    34060 Da
    Quaternary structure:
    • Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.
    Miscellaneous:
    • Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis.

    Three dimensional structures from OCA and Proteopedia for CDK5R1 Gene

neXtProt entry for CDK5R1 Gene

Protein Expression for CDK5R1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CDK5R1 Gene

  • The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
  • Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.
  • Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation.
  • Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK5R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CDK5R1
  • Boster Bio Antibodies for CDK5R1

No data available for DME Specific Peptides for CDK5R1 Gene

Domains & Families for CDK5R1 Gene

Gene Families for CDK5R1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDK5R1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK5R1 Gene

GenScript: Design optimal peptide antigens:
  • TPKII regulatory subunit (CD5R1_HUMAN)
  • Cyclin-dependent kinase 5, regulatory subunit 1 (P35) (Q8N619_HUMAN)
  • Cyclin-dependent kinase 5, regulatory subunit 1 (P35) (Q8TAM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15078

UniProtKB/Swiss-Prot:

CD5R1_HUMAN :
  • Belongs to the cyclin-dependent kinase 5 activator family.
Family:
  • Belongs to the cyclin-dependent kinase 5 activator family.
genes like me logo Genes that share domains with CDK5R1: view

Function for CDK5R1 Gene

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Molecular function for CDK5R1 Gene

UniProtKB/Swiss-Prot Function:
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
GENATLAS Biochemistry:
cyclin-dependent kinase 5 regulatory subunit1,short lived molecule specifically expressed in neuronal cells,constitutively expressed after cleavage,associating and activating the CDK5 p25 complex with a resulting hyperphorylation of tau,which reduces tau's ability to associate with microtubules,and may be involved in the pathogenesis of neurodegenerative diseases

Phenotypes From GWAS Catalog for CDK5R1 Gene

Gene Ontology (GO) - Molecular Function for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity TAS 7592934
GO:0005509 calcium ion binding ISS,IEA --
GO:0005515 protein binding IPI 8090221
genes like me logo Genes that share ontologies with CDK5R1: view
genes like me logo Genes that share phenotypes with CDK5R1: view

Animal Models for CDK5R1 Gene

MGI Knock Outs for CDK5R1:

Animal Model Products

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK5R1 Gene

Localization for CDK5R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5R1 Gene

Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK5R1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
extracellular 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CDK5R1: view

Pathways & Interactions for CDK5R1 Gene

genes like me logo Genes that share pathways with CDK5R1: view

Pathways by source for CDK5R1 Gene

2 KEGG pathways for CDK5R1 Gene
5 Qiagen pathways for CDK5R1 Gene
  • Alzheimers Disease Pathway
  • CDK5 Pathway
  • Rac1 Pathway
  • Reelin Pathway (Cajal-Retzius cells)
  • THC Differentiation Pathway
1 Cell Signaling Technology pathway for CDK5R1 Gene
1 GeneTex pathway for CDK5R1 Gene

SIGNOR curated interactions for CDK5R1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7592934
GO:0000226 microtubule cytoskeleton organization TAS 17491008
GO:0001764 neuron migration IEA,ISS --
GO:0007158 neuron cell-cell adhesion ISS,IEA --
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway IEA,ISS --
genes like me logo Genes that share ontologies with CDK5R1: view

Drugs & Compounds for CDK5R1 Gene

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  1. Drug

(16) Drugs for CDK5R1 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Experimental Pharma Target 0
Indirubin-3'-Monoxime Experimental Pharma Target 0
AT7519 Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0

(7) Additional Compounds for CDK5R1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(8) ApexBio Compounds for CDK5R1 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK5R1: view

Drug Products

Transcripts for CDK5R1 Gene

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mRNA/cDNA for CDK5R1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5R1 Gene

No ASD Table

Relevant External Links for CDK5R1 Gene

GeneLoc Exon Structure for
CDK5R1
ECgene alternative splicing isoforms for
CDK5R1

Expression for CDK5R1 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK5R1 Gene

mRNA expression in normal human tissues for CDK5R1 Gene
mRNA expression by GTEx for CDK5R1 GenemRNA expression by BioGPS for CDK5R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK5R1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.8), Brain - Anterior cingulate cortex (BA24) (x5.9), Brain - Cortex (x5.2), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for CDK5R1 Gene

This gene is overexpressed in Urine (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK5R1 Gene



Protein tissue co-expression partners for CDK5R1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK5R1 Gene:

CDK5R1

SOURCE GeneReport for Unigene cluster for CDK5R1 Gene:

Hs.500015

mRNA Expression by UniProt/SwissProt for CDK5R1 Gene:

Q15078-CD5R1_HUMAN
Tissue specificity: Brain and neuron specific.

Evidence on tissue expression from TISSUES for CDK5R1 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with CDK5R1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK5R1 Gene

Orthologs for CDK5R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK5R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK5R1 33 32
  • 100 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CDK5R1 33 32
  • 95.33 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CDK5R1 33 32
  • 94.68 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdk5r1 17 33 32
  • 92.51 (n)
rat
(Rattus norvegicus)
 Mammalia Cdk5r1 32
  • 92.51 (n)
oppossum
(Monodelphis domestica)
 Mammalia CDK5R1 33
  • 92 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CDK5R1 33
  • 56 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk5r1 32
  • 69.86 (n)
African clawed frog
(Xenopus laevis)
 Amphibia cdk5r1-A-prov 32
zebrafish
(Danio rerio)
 Actinopterygii cdk5r1b 33 32
  • 76.63 (n)
 OneToMany
cdk5r1a 33
  • 67 (a)
 OneToMany
CDK5R1 (1 of 3) 33
  • 58 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cdk5alpha 33 34
  • 29 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea T23F11.3 34
  • 53 (a)
cdka-1 33
  • 29 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 43 (a)
 OneToMany
Species where no ortholog for CDK5R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5R1 Gene

ENSEMBL:
Gene Tree for CDK5R1 (if available)
TreeFam:
Gene Tree for CDK5R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK5R1: view image

Paralogs for CDK5R1 Gene

Paralogs for CDK5R1 Gene

(1) SIMAP similar genes for CDK5R1 Gene using alignment to 4 proteins:

  • CD5R1_HUMAN
  • J3QRB5_HUMAN
  • Q8N619_HUMAN
  • Q8TAM4_HUMAN
genes like me logo Genes that share paralogs with CDK5R1: view

Variants for CDK5R1 Gene

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Sequence variations from dbSNP and Humsavar for CDK5R1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000018686 -- 32,487,002(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000115964 -- 32,489,966(+) A/T 3_prime_UTR_variant
rs1000577801 -- 32,483,256(+) T/A upstream_transcript_variant
rs1001557776 -- 32,485,990(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001899426 -- 32,491,718(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK5R1 Gene

Variant ID Type Subtype PubMed ID
dgv5524n54 CNV gain 21841781
dgv5525n54 CNV gain+loss 21841781
dgv5526n54 CNV loss 21841781
esv21464 CNV loss 19812545
nsv1070399 CNV deletion 25765185
nsv1121934 CNV deletion 24896259
nsv519839 CNV loss 19592680
nsv574697 CNV loss 21841781
nsv574698 CNV gain 21841781
nsv574706 CNV gain 21841781

Variation tolerance for CDK5R1 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK5R1 Gene

Human Gene Mutation Database (HGMD)
CDK5R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK5R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5R1 Gene

Disorders for CDK5R1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDK5R1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
non-syndromic intellectual disability
  • intellectual disability, non syndromic
crest syndrome
  • scleroderma, familial progressive
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDK5R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDK5R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK5R1 Gene

Publications for CDK5R1 Gene

  1. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. (PMID: 19154537) Mateo I … Combarros O (Acta neurologica Scandinavica 2009) 3 23 43 56
  2. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PMID: 16425041) Venturin M … Riva P (Neurogenetics 2006) 3 23 43 56
  3. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. (PMID: 10604467) Patrick GN … Tsai LH (Nature 1999) 3 4 23 56
  4. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. (PMID: 8090221) Tsai LH … Harlow E (Nature 1994) 2 3 4 56
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56

ExternalLinks

View latest publications for CDK5R1 gene in Mastermind

Products for CDK5R1 Gene

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Sources for CDK5R1 Gene