Aliases for CDK4 Gene
Aliases for CDK4 Gene
External Ids for CDK4 Gene
- HGNC: 1773
- Entrez Gene: 1019
- Ensembl: ENSG00000135446
- OMIM: 123829
- UniProtKB: P11802
Previous GeneCards Identifiers for CDK4 Gene
- GC12M058284
- GC12M057858
- GC12M056428
- GC12M058142
- GC12M055178
Summaries for CDK4 Gene
-
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
-
CDK4, along with its partner CDK6, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors.
GeneCards Summary for CDK4 Gene
CDK4 (Cyclin Dependent Kinase 4) is a Protein Coding gene. Diseases associated with CDK4 include Melanoma, Cutaneous Malignant 3 and Myeloma, Multiple. Among its related pathways are Integrated Breast Cancer Pathway and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK6.
UniProtKB/Swiss-Prot for CDK4 Gene
-
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
-
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.
Additional gene information for CDK4 Gene
- Monarch Initiative
- Search for CDK4 at DataMed
- Search for CDK4 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK4 Gene
Genomics for CDK4 Gene
GeneHancer (GH) Regulatory Elements for CDK4 Gene
Promoters and enhancers for CDK4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CDK4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CDK4 gene promoter:
Regulatory Element Products
Genomic Locations for CDK4 Gene
Genomic Locations for CDK4 Gene
- chr12:57,747,727-57,756,013
- (GRCh38/hg38)
- Size:
- 8,287 bases
- Orientation:
- Minus strand
- chr12:58,141,510-58,149,796
- (GRCh37/hg19)
Genomic View for CDK4 Gene
Genes around CDK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.1 by Entrez Gene
- 12q14.1 by HGNC
- 12q14.1 by Ensembl
CDK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK4 Gene
Proteins for CDK4 Gene
-
Protein details for CDK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11802-CDK4_HUMAN
- Recommended name:
- Cyclin-dependent kinase 4
- Protein Accession:
- P11802
- B2R9A0
- B4DNF9
- O00576
- Q6FG61
Protein attributes for CDK4 Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33730 Da
- Quaternary structure:
-
- Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on Tyr-88 and Tyr-89); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155). Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Interacts with FNIP1 and FNIP2 (PubMed:27353360).
Three dimensional structures from OCA and Proteopedia for CDK4 Gene
Protein Expression for CDK4 Gene
Post-translational modifications for CDK4 Gene
- Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
- Ubiquitination at posLast=297297, Lys282, posLast=211211, Lys155, Lys106, posLast=3535, and Lys22
- Modification sites at PhosphoSitePlus
Other Protein References for CDK4 Gene
Antibody Products
- R&D Systems Antibodies for CDK4 (CDK4)
-
Custom Antibody ServicesOriGene Antibodies for CDK4
- Novus Biologicals Antibodies for CDK4
- Invitrogen Antibodies for CDK4
- antibodies-online: Search results for 322 available CDK4 Antibodies ranked by validation data
- Compare Top CDK4 Antibodies
-
Recommended
- 246 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 115 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 92 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- GeneTex CDK4 Antibody for CDK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK4
- Sino Biological Antibodies for CDK4
Protein Products
-
OriGene Purified Proteins for CDK4
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK4
- Origene Custom Protein Services for CDK4
- Sino Biological Cell Lysates for CDK4
- Sino Biological Recombinant Proteins for CDK4
- ProSpec Recombinant Proteins for CDK4
- Search GeneTex for Proteins for CDK4
-
ProSci Proteins for CDK4
Assay Products
No data available for DME Specific Peptides for CDK4 Gene
Domains & Families for CDK4 Gene
Gene Families for CDK4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CDK4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P11802UniProtKB/Swiss-Prot:
CDK4_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK4 Gene
Molecular function for CDK4 Gene
- UniProtKB/Swiss-Prot Function:
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequent activation.
- GENATLAS Biochemistry:
- cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with cyclin D (D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse large B cell lymphoma ; amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast carcinomas,predisposing to familial melanoma by inducing abnormal repair of ultraviolet radiation. Loss of CDK4 expression causes insulin deficient diabetes,and CDK4 activation results in B islet cell hyperplasia in mice
Enzyme Numbers (IUBMB) for CDK4 Gene
Phenotypes From GWAS Catalog for CDK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IDA,TAS | -- |
| GO:0005515 | protein binding | IPI | 7568034 |
Phenotypes for CDK4 Gene
- MGI mutant phenotypes for CDK4:
-
inferred from 7 alleles
- cardiovascular system phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CDK4:
-
- Decreased viability
- Decreased substrate adherent cell growth
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection
- Decreased cell migration
- Increased cell viability after pRB stimulation
- no effect
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for CDK4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK4
-
CRISPR Products
-
OriGene CRISPR knockouts for CDK4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK4
- genomics-online: gRNA clones - Search results for 149 available CDK4 gene related products
- Overview of 149 available CDK4 gene related products
- Applied Biological Materials CRISPR for CDK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK4
- GenScript: Design CRISPR guide RNA sequences for CDK4
miRNA for CDK4 Gene
- miRTarBase miRNAs that target CDK4
-
- hsa-mir-24-3p (MIRT000117)
- hsa-mir-34a-5p (MIRT000763)
- hsa-mir-34b-5p (MIRT000764)
- hsa-mir-34c-5p (MIRT000765)
- hsa-mir-124-3p (MIRT002625)
- hsa-mir-34b-3p (MIRT003450)
- hsa-mir-302a-3p (MIRT003636)
- hsa-mir-145-5p (MIRT005879)
- hsa-mir-195-5p (MIRT006252)
- hsa-mir-449b-5p (MIRT016137)
- hsa-mir-449a (MIRT016631)
- hsa-mir-155-5p (MIRT021016)
- hsa-mir-122-5p (MIRT023403)
- hsa-mir-1-3p (MIRT024107)
- hsa-mir-766-3p (MIRT039027)
- hsa-mir-193b-3p (MIRT041351)
- hsa-mir-320a (MIRT044439)
- hsa-mir-15b-5p (MIRT046412)
- hsa-mir-25-3p (MIRT050205)
- hsa-mir-206 (MIRT052933)
- hsa-mir-545-3p (MIRT054384)
- hsa-mir-506-3p (MIRT054620)
- hsa-mir-497-5p (MIRT437795)
- hsa-mir-483-3p (MIRT437861)
- hsa-mir-29a-3p (MIRT438347)
- hsa-mir-616-3p (MIRT502878)
- hsa-mir-3973 (MIRT502879)
- hsa-mir-513b-3p (MIRT502880)
- hsa-mir-216b-5p (MIRT502881)
- hsa-mir-216a-5p (MIRT502882)
- hsa-mir-3714 (MIRT502883)
- hsa-mir-3910 (MIRT502884)
- hsa-mir-559 (MIRT502885)
- hsa-mir-548y (MIRT502886)
- hsa-mir-548w (MIRT502887)
- hsa-mir-548o-5p (MIRT502888)
- hsa-mir-548j-5p (MIRT502889)
- hsa-mir-548i (MIRT502890)
- hsa-mir-548h-5p (MIRT502891)
- hsa-mir-548d-5p (MIRT502892)
- hsa-mir-548c-5p (MIRT502893)
- hsa-mir-548bb-5p (MIRT502894)
- hsa-mir-548b-5p (MIRT502895)
- hsa-mir-548ay-5p (MIRT502896)
- hsa-mir-548au-5p (MIRT502897)
- hsa-mir-548as-5p (MIRT502898)
- hsa-mir-548ar-5p (MIRT502899)
- hsa-mir-548aq-5p (MIRT502900)
- hsa-mir-548ap-5p (MIRT502901)
- hsa-mir-548ak (MIRT502902)
- hsa-mir-548am-5p (MIRT502903)
- hsa-mir-548ae-5p (MIRT502904)
- hsa-mir-548ad-5p (MIRT502905)
- hsa-mir-548ab (MIRT502906)
- hsa-mir-548a-5p (MIRT502907)
- hsa-mir-20b-3p (MIRT548928)
- hsa-mir-3137 (MIRT548929)
- hsa-mir-744-3p (MIRT636643)
- hsa-mir-6805-3p (MIRT636644)
- hsa-mir-5691 (MIRT636645)
- hsa-mir-106a-3p (MIRT636646)
- hsa-mir-7641 (MIRT636647)
- hsa-mir-4423-5p (MIRT636648)
- hsa-mir-6501-5p (MIRT636649)
- hsa-mir-431-5p (MIRT636650)
- hsa-mir-4430 (MIRT636651)
- hsa-mir-3652 (MIRT636652)
- hsa-mir-3622b-5p (MIRT636653)
- hsa-mir-504-3p (MIRT636654)
- hsa-mir-3135b (MIRT636655)
- hsa-mir-3194-3p (MIRT636656)
- hsa-mir-4695-3p (MIRT636657)
- hsa-mir-367-5p (MIRT636658)
- hsa-mir-1267 (MIRT636659)
- hsa-mir-454-3p (MIRT636660)
- hsa-mir-4295 (MIRT636661)
- hsa-mir-3666 (MIRT636662)
- hsa-mir-301b-3p (MIRT636663)
- hsa-mir-301a-3p (MIRT636664)
- hsa-mir-130b-3p (MIRT636665)
- hsa-mir-130a-3p (MIRT636666)
- hsa-mir-4284 (MIRT672187)
- hsa-mir-4638-5p (MIRT672188)
- hsa-mir-1307-3p (MIRT672189)
- hsa-mir-6741-3p (MIRT672190)
- hsa-mir-5197-5p (MIRT672191)
- hsa-mir-6878-3p (MIRT678565)
- hsa-mir-640 (MIRT678566)
- hsa-mir-378a-5p (MIRT678567)
- hsa-mir-6821-3p (MIRT678568)
- hsa-mir-6790-3p (MIRT678569)
- hsa-mir-3653-5p (MIRT678570)
- hsa-mir-1306-3p (MIRT678571)
- hsa-mir-1471 (MIRT678572)
- hsa-mir-3934-5p (MIRT678573)
- hsa-mir-764 (MIRT678574)
- hsa-mir-125a-3p (MIRT678575)
- hsa-mir-486-5p (MIRT731583)
- hsa-mir-539-5p (MIRT732106)
- hsa-mir-711 (MIRT732964)
- hsa-mir-1-5p (MIRT734384)
- hsa-mir-613 (MIRT734862)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK4
- Browse OriGene Inhibitory RNA Products For CDK4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK4
- genomics-online: shRNA clones - Search results for 149 available CDK4 gene related products
- Overview of 149 available CDK4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDK4
- VectorBuilder custom plasmid, inducible vectors for CDK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK4
- Applied Biological Materials Clones for CDK4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDK4
No data available for Transcription Factor Targets and HOMER Transcription for CDK4 Gene
Localization for CDK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK4 Gene
- Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 1 |
- Cytosol (3)
- Nuclear membrane (3)
- Nucleoli (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IDA | 17420273 |
| GO:0000785 | chromatin | IDA | 18827403 |
| GO:0005634 | nucleus | IDA,IEA | 16109376 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for CDK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 2 | Glioma |
.52
.47
|
|
| 3 | Cyclins and Cell Cycle Regulation |
.31
|
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Cell cycle Role of SCF complex in cell cycle regulation | ||
Pathways by source for CDK4 Gene
1 Sino Biological pathway for CDK4 Gene
1 GeneTex pathway for CDK4 Gene
20 BioSystems pathways for CDK4 Gene
27 Reactome pathways for CDK4 Gene
25 KEGG pathways for CDK4 Gene
7 GeneGo (Thomson Reuters) pathways for CDK4 Gene
2 R&D Systems pathways for CDK4 Gene
12 Qiagen pathways for CDK4 Gene
1 Cell Signaling Technology pathway for CDK4 Gene
Interacting Proteins for CDK4 Gene
Selected Interacting proteins:
P11802-CDK4_HUMAN
ENSP00000257904
for CDK4 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for CDK4
SIGNOR curated interactions for CDK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | 7603984 |
| GO:0002088 | lens development in camera-type eye | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0006468 | protein phosphorylation | IDA,IEA | 8114739 |
| GO:0007049 | cell cycle | IEA | -- |
Drugs & Compounds for CDK4 Gene
(160) Drugs for CDK4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Palbociclib | Approved, Investigational | Pharma | Inhibition, Target, inhibitor | 151 | ||
| Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1400 | ||
| Paclitaxel | Approved, Vet_approved | Pharma | Tubulin and Bcl2 inhibitor, Taxanes | 3027 | ||
| abemaciclib | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| (R)-CR8 |
|
294646-77-8 |
|
|
||
| Arcyriaflavin A |
|
118458-54-1 |
|
|
(5) Tocris Compounds for CDK4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (R)-CR8 | Dual cdk1/cdk5 inhibitor; also inhibits CK1 | 294646-77-8 |
| Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) | 118458-54-1 |
| AZD 5438 | Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor | 602306-29-6 |
| Olomoucine | Cyclin-dependent kinase inhibitor | 101622-51-9 |
| SU 9516 | Potent cdk2 inhibitor | 377090-84-1 |
(22) ApexBio Compounds for CDK4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ala92]-p16 (84-103) | 189064-08-2 | |
| AMG 925 | FLT3/CDK4 inhibitor,potent and selective | 1401033-86-0 |
| AT7519 | Multi-CDK inhibitor | 844442-38-2 |
| BS-181 HCl | CDK7 inhibitor,highly selective | 1397219-81-6 |
| CDK4 inhibitor | CDK4/Cyclin D1 inhibitor | 1256963-02-6 |
| Flavopiridol hydrochloride | 131740-09-5 | |
| LDC000067 | 1073485-20-7 | |
| LEE011 | CDK4/6 inhibitor | 1211441-98-3 |
| LEE011 hydrochloride | CDK inhibitor | 1211443-80-9 |
| LEE011 succinate | CDK inhibitor | 1374639-75-4 |
| LEE011 succinate hydrate | CDK inhibitor | 1374639-79-8 |
| LY2835219 | CDK4/6 inhibitor,potent and selective | 1231930-82-7 |
| LY2835219 free base | CDK inhibitor | 1231929-97-7 |
| NSC 625987 | 141992-47-4 | |
| P276-00 | CDK-1/CDK4/CDK9 inhibitor | 920113-03-7 |
| Palbociclib (PD0332991) Isethionate | CDK4/6 inhibitor,highly selective | 827022-33-3 |
| PD 0332991 (Palbociclib) HCl | CDK4/6 inhibitor,highly selective | 827022-32-2 |
| PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
| Purvalanol A | 212844-53-6 | |
| Purvalanol B | CDK1/CDK2/CDK4 inhibitor | 212844-54-7 |
| R547 | CDK1/2/4 inhibitor,ATP-competitive | 741713-40-6 |
| Ryuvidine | 265312-55-8 |
Transcripts for CDK4 Gene
mRNA/cDNA for CDK4 Gene
- (974) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000257904 2076 bps (uc001spv.4)
- ENST00000312990 1650 bps (uc001spw.4)
- ENST00000546489 776 bps (uc058qca.1)
- ENST00000547281 825 bps (uc058qcc.1)
- ENST00000547853 228 bps (uc058qcj.1)
Unigene Clusters for CDK4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK4
- genomics-online: gRNA clones - Search results for 149 available CDK4 gene related products
- Overview of 149 available CDK4 gene related products
- Applied Biological Materials CRISPR for CDK4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK4
- GenScript: Design CRISPR guide RNA sequences for CDK4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK4
- Browse OriGene Inhibitory RNA Products For CDK4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK4
- genomics-online: shRNA clones - Search results for 149 available CDK4 gene related products
- Overview of 149 available CDK4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CDK4
- VectorBuilder custom plasmid, inducible vectors for CDK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK4
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VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK4
- Applied Biological Materials Clones for CDK4
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for CDK4 Gene
This gene is overexpressed in Uterus (15.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CDK4 Gene:
CDK4SOURCE GeneReport for Unigene cluster for CDK4 Gene:
Hs.95577Evidence on tissue expression from TISSUES for CDK4 Gene
- Muscle(5)
- Nervous system(4.6)
- Skin(4.3)
- Lung(4)
- Intestine(3.8)
- Liver(3.2)
- Kidney(3.1)
- Pancreas(3)
- Blood(2.9)
- Bone marrow(2.6)
- Eye(2.6)
- Heart(2.5)
- Lymph node(2.5)
- Stomach(2.4)
- Thyroid gland(2.4)
- Adrenal gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK4 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- brain
- eye
- head
General:
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for CDK4
-
OriGene qPCR primer pairs for CDK4
- genomics-online: primer clones - Search results for 149 available CDK4 gene related products
- Overview of 149 available CDK4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK4 Gene
Orthologs for CDK4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDK4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CDK4 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | CDK4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cdk4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cdk4 33 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | CDK4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk4 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52574 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdk4 34 33 |
|
OneToOne | |
| Dr.14474 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdk4 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cdk-4 34 35 |
|
ManyToMany | |
| F52B5.2 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC28 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.3270 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3270 33 |
|
- Species where no ortholog for CDK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CDK4 Gene
- ENSEMBL:
- Gene Tree for CDK4 (if available)
- TreeFam:
- Gene Tree for CDK4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDK4: view image
Paralogs for CDK4 Gene
(219) SIMAP similar genes for CDK4 Gene using alignment to 13 proteins:
- CDK4_HUMAN
- B4DNF9_HUMAN
- F8VTV8_HUMAN
- F8VWX7_HUMAN
- F8VXD2_HUMAN
- F8VYH9_HUMAN
- F8VYY1_HUMAN
- F8VZ13_HUMAN
- F8VZ51_HUMAN
- F8VZZ0_HUMAN
- F8W1L8_HUMAN
- Q6LC83_HUMAN
- Q96BE9_HUMAN
- CDK6
- CDK3
- CAMK2G
- CDC2
- CDK1
- CDK7
- STK17A
- CAMK2A
- CDC2L1
- CDK11B
- CDC2L2
- SPEG
- CDK11A
- CDK5
- DKFZp686L20222
- CAMK2B
- SRPK2
- CDK15
- STK35
- STK17B
- CDK14
- CDK10
- PCTK3
- CDK12
- SRGAP3
- RPS6KB1
- RAF1
- PRKG2
- NEK9
- NEK1
- CCRK
- CDK16
- PCTK1
- CDK18
- CDK20
- SRPK1
- CAMK2D
- MAK
- CDK17
- SIK1
- PkB-like 1
- PRKG1
- PRKACA
- PLK3
- PKN2
- PKN1
- PDPK2
- PDPK1
- MAP3K5
- CDKL4
- DKFZp434M058
- CDKL3
- PAK2
- CDK2
- WNK3
- SIK3
- Par1b
- PRKY
- PRKACB
- PAK7
- MARK2
- MAP4K5
- MAP4K1
- KIAA0999
- FGFR4
- DCLK1
- AKT3
- CDKL5
- SRPK3
- MAPK4
- ICK
- CDK8
- PAK1
- WNK1
- STK4
- STK32A
- STK3
- RPS6KA5
- RPS6KA4
- PAK6
- MYO3A
- MAPK10
- HUNK
- DSTYK
- AURKA
- AKT2