Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] See more...
Aliases for CDK3 Gene
Aliases for CDK3 Gene
External Ids for CDK3 Gene
- HGNC: 1772
- Entrez Gene: 1018
- Ensembl: ENSG00000250506
- OMIM: 123828
- UniProtKB: Q00526
Previous GeneCards Identifiers for CDK3 Gene
- GC17M073921
- GC17P077001
- GC17P074439
- GC17P074572
- GC17P074594
- GC17P071486
- GC17P073977
- GC17P069422
- GC17P073996
- GC17P076006
Summaries for CDK3 Gene
-
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDK3 Gene
CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Diseases associated with CDK3 include Retinoblastoma and Cardiomyopathy, Dilated, 1E. Among its related pathways are GADD45 Pathway and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.
UniProtKB/Swiss-Prot Summary for CDK3 Gene
-
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
Additional gene information for CDK3 Gene
- HGNC(1772)
- Entrez Gene(1018)
- Ensembl(ENSG00000250506)
- OMIM(123828)
- UniProtKB(Q00526)
- Open Targets Platform(ENSG00000250506)
- Search for CDK3 at DataMed
- Search for CDK3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK3 Gene
Genomics for CDK3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDK3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK3
- Top Transcription factor binding sites by QIAGEN in the CDK3 gene promoter:
-
- AML1a
- AP-4
- CUTL1
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- NF-kappaB1
- Pax-5
- RelA
Genomic Locations for CDK3 Gene
Genomic Locations for CDK3 Gene
- chr17:76,000,906-76,005,999
- (GRCh38/hg38)
- Size:
- 5,094 bases
- Orientation:
- Plus strand
- chr17:73,996,987-74,002,080
- (GRCh37/hg19)
- Size:
- 5,094 bases
- Orientation:
- Plus strand
Genomic View for CDK3 Gene
Genes around CDK3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
CDK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK3 Gene
Proteins for CDK3 Gene
-
Protein details for CDK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00526-CDK3_HUMAN
- Recommended name:
- Cyclin-dependent kinase 3
- Protein Accession:
- Q00526
Protein attributes for CDK3 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 35046 Da
- Quaternary structure:
-
- Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.
Protein Expression for CDK3 Gene
Selected DME Specific Peptides for CDK3 Gene
- Q00526:
-
- WSIGCIFAE
- GCIFAEM
- FCHSHRV
- TAIREIS
- DFGLARA
- EVVTLWYRAP
- VVTLWYR
- EGVPSTA
- LADFGLA
- DFGLARAFG
- SEIDQLF
- HRDLKPQN
- VIHRDLK
- FQKVEKIGEGTYGVVYKA
- VALKKIR
- IGEGTYG
- KLYLVFE
Post-translational modifications for CDK3 Gene
Other Protein References for CDK3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CDK3 Polyclonal Antibody and Immunotag™ CDK3 Antibody
- Novus Biologicals Antibodies for CDK3
-
Abcam antibodies for CDK3
- Invitrogen Antibodies for CDK3 (AFLGC-Cdk3)
- antibodies-online: Show 24 available CDK3 Antibodies ranked by validation data
- Compare Top CDK3 Antibodies
-
Recommended
- 60 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
-
Boster Bio Antibodies for CDK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK3
- Sino Biological Antibodies for CDK3
Protein Products
-
OriGene Purified Proteins for CDK3
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK3
- Origene Custom Protein Services for CDK3
- ProSpec Recombinant Proteins for CDK3
-
Abcam proteins for CDK3
Assay Products
- antibodies-online: Show 3 available CDK3 Elisa Kits ranked by validation data
- Compare Top CDK3 Elisa Kits
-
Quality Products:
Domains & Families for CDK3 Gene
Gene Families for CDK3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CDK3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK3 Gene
- GenScript: Design optimal peptide antigens:
-
- Cell division protein kinase 3 (CDK3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q00526UniProtKB/Swiss-Prot:
CDK3_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK3 Gene
Molecular function for CDK3 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
- GENATLAS Biochemistry:
- cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin
Enzyme Numbers (IUBMB) for CDK3 Gene
Phenotypes From GWAS Catalog for CDK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 15084261 |
Phenotypes for CDK3 Gene
- GenomeRNAi human phenotypes for CDK3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability
- Increased circadian period length
- Decreased substrate adherent cell growth
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Actin fiber cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK3 - Select products 50% OFF >
- * CDK3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK3
miRNA for CDK3 Gene
- miRTarBase miRNAs that target CDK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK3
- Browse OriGene Inhibitory RNA Products For CDK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK3
Clone Products
- Applied Biological Materials (abm): Clones for CDK3 - Select products 50% OFF >
- * CDK3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDK3
- Addgene plasmids for CDK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK3 Gene
Localization for CDK3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK3 Gene
Pathways & Interactions for CDK3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle Control of Chromosomal Replication |
Cell Cycle Control of Chromosomal Replication
-
|
|
| 2 | GADD45 Pathway |
GADD45 Pathway
-
|
|
Pathways by source for CDK3 Gene
2 Qiagen pathways for CDK3 Gene
- Cell Cycle Control of Chromosomal Replication
- GADD45 Pathway
1 GeneTex pathway for CDK3 Gene
Interacting Proteins for CDK3 Gene
Selected Interacting proteins:
Q00526-CDK3_HUMAN
ENSP00000410561
ENSP00000400088
for CDK3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CDK3
SIGNOR curated interactions for CDK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | 8846921 |
| GO:0006468 | protein phosphorylation | IBA | 21873635 |
| GO:0006974 | cellular response to DNA damage stimulus | IDA | 24550317 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0008283 | cell proliferation | TAS | 18794154 |
Drugs & Compounds for CDK3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Alvocidib | Experimental, Investigational | Pharma | inhibitor | Pan-cdk inhibitor, Kinase Inhibitors | 64 | |
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| AT7519 | Pharma | Multi-CDK inhibitor | 0 | |||
| PF-562271 | Pharma | ATP-competitive FAK inhibitor, reversible | 0 | |||
| BAY 1000394 | Pharma | inhibitor | pan-CDK inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(2) ApexBio Compounds for CDK3 Gene
Transcripts for CDK3 Gene
mRNA/cDNA for CDK3 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000588812 570 nts (view in UCSC)
- ENST00000425876 1582 nts (view in UCSC)
- ENST00000586261 803 nts (view in UCSC)
- ENST00000448471 1570 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK3 - Select products 50% OFF >
- * CDK3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK3
- Browse OriGene Inhibitory RNA Products For CDK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK3
Clone Products
- Applied Biological Materials (abm): Clones for CDK3 - Select products 50% OFF >
- * CDK3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CDK3
- Addgene plasmids for CDK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK3
Relevant External Links for CDK3 Gene
- GeneLoc Exon Structure for
- CDK3
Expression for CDK3 Gene
This gene is overexpressed in Lymph node (30.5), CD8 Tcells (17.3), CD4 Tcells (9.6), and Uterus (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK3
SOURCE GeneReport for Unigene cluster for CDK3 Gene:
Hs.706766mRNA Expression by UniProt/SwissProt for CDK3 Gene:
Q00526-CDK3_HUMAN
Tissue specificity:
Expressed in cancer cell lines and glioblastoma tissue.
Evidence on tissue expression from TISSUES for CDK3 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for CDK3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK3 Gene
Orthologs for CDK3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDK3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDK3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDK3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CDK3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cdk3-ps 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDK3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDK3 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-57f11.1 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | cdc2 32 |
|
|
|
| cdc2c 31 32 |
|
OneToMany | |||
| Cdk4 32 |
|
|
|||
| CG6800 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | cdk-1 32 |
|
|
|
| cdk-4 32 |
|
|
|||
| H01G02.2 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC28 31 |
|
OneToMany | |
| Soybean (Glycine max) |
eudicotyledons | Gma.13118 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.6675 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5702 31 |
|
OneToMany |
- Species where no ortholog for CDK3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
Evolution for CDK3 Gene
- ENSEMBL:
- Gene Tree for CDK3 (if available)
- TreeFam:
- Gene Tree for CDK3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDK3: view image
Paralogs for CDK3 Gene
Paralogs for CDK3 Gene
(94) SIMAP similar genes for CDK3 Gene using alignment to 3 proteins:
- CDK3_HUMAN
- K7EJ83_HUMAN
- K7ELV5_HUMAN
- CDK1
- CDC2
- CDK5
- DKFZp686L20222
- CDK18
- CDK2
- PHKG2
- PCTK1
- CDK17
- CDK16
- STK3
- PCTK3
- CDK14
- CDK15
- CDC2L2
- CDK7
- CDK6
- MARK3
- CDK11B
- CDK11A
- CDC2L1
- CDKL4
- CDK10
- CDKL2
- CDK4
- TAOK3
- MARK2
- CDKL1
- CDK20
- ULK3
- MAP4K5
- MAPK7
- MAK
- CDKL5
- BRSK2
- STK11
- CCRK
- MAPK15
- ICK
- CDKL3
- PNCK
- MAP4K3
- DYRK4
- NEK9
- CDK9
- AURKC
- CDK8
- FGFR1
- DKFZp686O0215
- CDK12
- CAMK1
- NEK6
- AURKB
- MAPK3
- RPS6KA2
- CSNK2A1
- DKFZp564L2416
- CSNK2A2
- STK36
- NLK
- MAP4K1
- GSK3B
- GSK3A
- DKFZp686D0638
- DKFZp434M058
- CSNK2A3
- MOK
- CDK19
- STK38L
- RPS6KA1
- MAPK1
- MAPK14
- MAPK11
- MAPK4
- PRKAA1
- FLT4
- SIK3
- NEK3
- HIPK4
- MAPK13
- MAPK8
- STK25
- ULK1
- HUNK
- DAPK3
- WNK4
- DAPK1
- MAPK10
- TYK2
- MAPK9
- MAPK12
- MARK4
- DKFZp686M02159
- PRKACA
Variants for CDK3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041973 | A glioblastoma multiforme sample | p.Ser106Asn | |||
| rs17884251 | - | p.Met264Thr | |||
| rs2069532 | - | p.Thr226Ile | |||
| rs34670267 | - | p.Arg214His | |||
| rs34918446 | - | p.Ile124Thr |
Residual Variation Intolerance Score:
62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.18;
39.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDK3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK3 Gene
Disorders for CDK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| cardiomyopathy, dilated, 1e |
|
|
Search CDK3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDK3
No data available for UniProtKB/Swiss-Prot and Genatlas for CDK3 Gene
Publications for CDK3 Gene
- A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M … Tsai LH (The EMBO journal 1992) 2 3 4 23
- Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PMID: 18794154) Zheng D … Dong Z (Cancer research 2008) 3 4 23
- Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PMID: 15084261) Ren S … Rollins BJ (Cell 2004) 3 4
- ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PMID: 11733001) Yamochi T … Matsuoka M (European journal of biochemistry 2001) 3 23
- Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PMID: 9811456) Braun K … Hengstschläger M (Oncogene 1998) 3 23
ExternalLinks
Products for CDK3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK3
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK3
- Origene Custom Protein Services for CDK3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK3
- Browse OriGene Inhibitory RNA Products For CDK3
- OriGene qPCR primer pairs for CDK3
- OriGene CRISPR knockouts for CDK3
- OriGene ORF clones in human for CDK3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK3
- Sino Biological Human cDNA Clone for CDK3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CDK3
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CDK3
- Novus Biologicals proteins and lysates for CDK3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CDK3
- Abcam proteins for CDK3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for CDK3
- VectorBuilder Custom and pre-made DNA vectors for CDK3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDK3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDK3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDK3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDK3
- Addgene plasmids for CDK3
- antibodies-online: Show 24 available CDK3 Antibodies ranked by validation data
- Compare Top CDK3 Antibodies
- Recommended
- 60 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
- antibodies-online: Show 3 available CDK3 Elisa Kits ranked by validation data
- Compare Top CDK3 Elisa Kits
- Quality Products:
- antibodies-online: Show 9 available CDK3 Proteins ranked by validation data
- Compare Top CDK3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK3
- Search Santa Cruz Biotechnology (SCBT) for CDK3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK3
- Horizon Cell Lines for CDK3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDK3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK3
- Boster Bio Antibodies for CDK3
- Browse Boster Bio ELISA Kits
Sources for CDK3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB