Aliases for CDK3 Gene
External Ids for CDK3 Gene
Previous GeneCards Identifiers for CDK3 Gene
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDK3 Gene
CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Diseases associated with CDK3 include Retinoblastoma and Cardiomyopathy, Dilated, 1E. Among its related pathways are GADD45 Pathway and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.
UniProtKB/Swiss-Prot Summary for CDK3 Gene
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.