This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] See more...

Aliases for CDK3 Gene

Aliases for CDK3 Gene

  • Cyclin Dependent Kinase 3 2 3 5
  • Cell Division Protein Kinase 3 3 4
  • Cyclin-Dependent Kinase 3 3 4
  • EC 2.7.11.22 4 51
  • EC 2.7.11 51
  • CDKN3 4
  • CDK3 5

External Ids for CDK3 Gene

Previous GeneCards Identifiers for CDK3 Gene

  • GC17M073921
  • GC17P077001
  • GC17P074439
  • GC17P074572
  • GC17P074594
  • GC17P071486
  • GC17P073977
  • GC17P069422
  • GC17P073996
  • GC17P076006

Summaries for CDK3 Gene

Entrez Gene Summary for CDK3 Gene

  • This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK3 Gene

CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Diseases associated with CDK3 include Retinoblastoma and Cardiomyopathy, Dilated, 1E. Among its related pathways are GADD45 Pathway and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.

UniProtKB/Swiss-Prot Summary for CDK3 Gene

  • Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Gene Wiki entry for CDK3 Gene

Additional gene information for CDK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK3 Gene

Genomics for CDK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075975 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 620.6 -20.7 -20712 10.1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 CDK3 ACOX1 TEN1 TEN1-CDK3 lnc-EVPL-3 SRSF2 NT5C NUP85 UNK TRIM65
GH17J075995 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 627.8 -2.7 -2717 6 HNRNPL GATAD2A CTCF ATF7 PRDM10 REST TFE3 RCOR2 PRDM1 RELA CDK3 RF00017-2557 ACOX1 TEN1 UNK NUP85 GGA3 SRSF2 NT5C ENSG00000266980
GH17J076001 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.7 +0.5 456 0.1 NR2C2 CDK3 RF00017-2558 TEN1-CDK3 EVPL lnc-SRP68-1
GH17J075991 Promoter 0.3 EPDnew 609.6 -9.3 -9334 0.1 CDK3 RF00017-2557 TEN1 TEN1-CDK3 lnc-SRP68-1
GH17J076734 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 49.7 +736.4 736353 7.8 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 ZNF512 SRSF2 MFSD11 NONHSAG022835.2 MN297510 MIR636 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 ENSG00000266980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK3

Top Transcription factor binding sites by QIAGEN in the CDK3 gene promoter:
  • AML1a
  • AP-4
  • CUTL1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-kappaB1
  • Pax-5
  • RelA

Genomic Locations for CDK3 Gene

Genomic Locations for CDK3 Gene
chr17:76,000,906-76,005,999
(GRCh38/hg38)
Size:
5,094 bases
Orientation:
Plus strand
chr17:73,996,987-74,002,080
(GRCh37/hg19)
Size:
5,094 bases
Orientation:
Plus strand

Genomic View for CDK3 Gene

Genes around CDK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK3 Gene

Proteins for CDK3 Gene

  • Protein details for CDK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00526-CDK3_HUMAN
    Recommended name:
    Cyclin-dependent kinase 3
    Protein Accession:
    Q00526

    Protein attributes for CDK3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35046 Da
    Quaternary structure:
    • Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CDK3 Gene

neXtProt entry for CDK3 Gene

Selected DME Specific Peptides for CDK3 Gene

Q00526:
  • WSIGCIFAE
  • GCIFAEM
  • FCHSHRV
  • TAIREIS
  • DFGLARA
  • EVVTLWYRAP
  • VVTLWYR
  • EGVPSTA
  • LADFGLA
  • DFGLARAFG
  • SEIDQLF
  • HRDLKPQN
  • VIHRDLK
  • FQKVEKIGEGTYGVVYKA
  • VALKKIR
  • IGEGTYG
  • KLYLVFE

Post-translational modifications for CDK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK3 Gene

Domains & Families for CDK3 Gene

Gene Families for CDK3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDK3 Gene

Suggested Antigen Peptide Sequences for CDK3 Gene

GenScript: Design optimal peptide antigens:
  • Cell division protein kinase 3 (CDK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00526

UniProtKB/Swiss-Prot:

CDK3_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK3: view

Function for CDK3 Gene

Molecular function for CDK3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
GENATLAS Biochemistry:
cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

Enzyme Numbers (IUBMB) for CDK3 Gene

Phenotypes From GWAS Catalog for CDK3 Gene

Gene Ontology (GO) - Molecular Function for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 15084261
genes like me logo Genes that share ontologies with CDK3: view
genes like me logo Genes that share phenotypes with CDK3: view

Animal Model Products

CRISPR Products

miRNA for CDK3 Gene

miRTarBase miRNAs that target CDK3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK3 Gene

Localization for CDK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK3 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with CDK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK3 Gene

Pathways & Interactions for CDK3 Gene

PathCards logo

SuperPathways for CDK3 Gene

SuperPathway Contained pathways
1 Cell Cycle Control of Chromosomal Replication
-
2 GADD45 Pathway
-
genes like me logo Genes that share pathways with CDK3: view

Pathways by source for CDK3 Gene

2 Qiagen pathways for CDK3 Gene
  • Cell Cycle Control of Chromosomal Replication
  • GADD45 Pathway
1 GeneTex pathway for CDK3 Gene

SIGNOR curated interactions for CDK3 Gene

Activates:
Inactivates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8846921
GO:0006468 protein phosphorylation IBA 21873635
GO:0006974 cellular response to DNA damage stimulus IDA 24550317
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation TAS 18794154
genes like me logo Genes that share ontologies with CDK3: view

Drugs & Compounds for CDK3 Gene

(6) Drugs for CDK3 Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvocidib Experimental, Investigational Pharma inhibitor Pan-cdk inhibitor, Kinase Inhibitors 64
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
AT7519 Pharma Multi-CDK inhibitor 0
PF-562271 Pharma ATP-competitive FAK inhibitor, reversible 0
BAY 1000394 Pharma inhibitor pan-CDK inhibitor 0

(1) Additional Compounds for CDK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(2) ApexBio Compounds for CDK3 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
PF-562271 ATP-competitive FAK inhibitor, reversible 717907-75-0
genes like me logo Genes that share compounds with CDK3: view

Drug Products

Transcripts for CDK3 Gene

mRNA/cDNA for CDK3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK3

Alternative Splicing Database (ASD) splice patterns (SP) for CDK3 Gene

No ASD Table

Relevant External Links for CDK3 Gene

GeneLoc Exon Structure for
CDK3

Expression for CDK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK3 Gene

Protein differential expression in normal tissues from HIPED for CDK3 Gene

This gene is overexpressed in Lymph node (30.5), CD8 Tcells (17.3), CD4 Tcells (9.6), and Uterus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK3

SOURCE GeneReport for Unigene cluster for CDK3 Gene:

Hs.706766

mRNA Expression by UniProt/SwissProt for CDK3 Gene:

Q00526-CDK3_HUMAN
Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue.

Evidence on tissue expression from TISSUES for CDK3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CDK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK3 Gene

Orthologs for CDK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK3 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDK3 30 31
  • 90.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDK3 30 31
  • 88.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK3 31
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdk3-ps 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CDK3 30 31
  • 75.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK3 31
  • 75 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-57f11.1 31
  • 38 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta cdc2 32
  • 65 (a)
cdc2c 31 32
  • 59 (a)
OneToMany
Cdk4 32
  • 45 (a)
CG6800 32
  • 36 (a)
Worm
(Caenorhabditis elegans)
Secernentea cdk-1 32
  • 63 (a)
cdk-4 32
  • 36 (a)
H01G02.2 32
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 31
  • 62 (a)
OneToMany
Soybean
(Glycine max)
eudicotyledons Gma.13118 30
Wheat
(Triticum aestivum)
Liliopsida Ta.6675 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5702 31
  • 64 (a)
OneToMany
Species where no ortholog for CDK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)

Evolution for CDK3 Gene

ENSEMBL:
Gene Tree for CDK3 (if available)
TreeFam:
Gene Tree for CDK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK3: view image

Paralogs for CDK3 Gene

genes like me logo Genes that share paralogs with CDK3: view

Variants for CDK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
VAR_041973 A glioblastoma multiforme sample p.Ser106Asn
rs17884251 - p.Met264Thr
rs2069532 - p.Thr226Ile
rs34670267 - p.Arg214His
rs34918446 - p.Ile124Thr

Additional dbSNP identifiers (rs#s) for CDK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK3 Gene

Variant ID Type Subtype PubMed ID
nsv833546 CNV loss 17160897

Variation tolerance for CDK3 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK3 Gene

Disorders for CDK3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
cardiomyopathy, dilated, 1e
  • cmd1e
- elite association - COSMIC cancer census association via MalaCards
Search CDK3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK3 Gene

Publications for CDK3 Gene

  1. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M … Tsai LH (The EMBO journal 1992) 2 3 4 23
  2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PMID: 18794154) Zheng D … Dong Z (Cancer research 2008) 3 4 23
  3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PMID: 15084261) Ren S … Rollins BJ (Cell 2004) 3 4
  4. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PMID: 11733001) Yamochi T … Matsuoka M (European journal of biochemistry 2001) 3 23
  5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PMID: 9811456) Braun K … Hengstschläger M (Oncogene 1998) 3 23

Products for CDK3 Gene

Sources for CDK3 Gene