This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] See more...

Aliases for CDK2AP2 Gene

Aliases for CDK2AP2 Gene

  • Cyclin Dependent Kinase 2 Associated Protein 2 2 3 5
  • CDK2-Associated Protein 2 2 3 4
  • DOC-1R 2 3 4
  • Tumor Suppressor Deleted In Oral Cancer Related 1 2 3
  • Cyclin-Dependent Kinase 2-Associated Protein 2 3 4
  • DOC-1-Related Protein 3 4
  • P14 2 3
  • CDK2AP2 5
  • DOC1R 4

External Ids for CDK2AP2 Gene

Previous GeneCards Identifiers for CDK2AP2 Gene

  • GC11M067031
  • GC11M067273
  • GC11M063603

Summaries for CDK2AP2 Gene

Entrez Gene Summary for CDK2AP2 Gene

  • This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for CDK2AP2 Gene

CDK2AP2 (Cyclin Dependent Kinase 2 Associated Protein 2) is a Protein Coding gene. Diseases associated with CDK2AP2 include Endocervical Adenocarcinoma. An important paralog of this gene is CDK2AP1.

UniProtKB/Swiss-Prot Summary for CDK2AP2 Gene

  • Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK2AP2 Gene

Genomics for CDK2AP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK2AP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK2AP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK2AP2

Top Transcription factor binding sites by QIAGEN in the CDK2AP2 gene promoter:
  • AP-2gamma
  • Chx10
  • Egr-3
  • Evi-1
  • Olf-1
  • Pax-5
  • Pax-6
  • PPAR-alpha

Genomic Locations for CDK2AP2 Gene

Latest Assembly
chr11:67,506,497-67,508,649
(GRCh38/hg38)
Size:
2,153 bases
Orientation:
Minus strand

Previous Assembly
chr11:67,273,968-67,275,633
(GRCh37/hg19 by Entrez Gene)
Size:
1,666 bases
Orientation:
Minus strand

chr11:67,273,968-67,276,120
(GRCh37/hg19 by Ensembl)
Size:
2,153 bases
Orientation:
Minus strand

Genomic View for CDK2AP2 Gene

Genes around CDK2AP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2AP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2AP2 Gene

Proteins for CDK2AP2 Gene

  • Protein details for CDK2AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75956-CDKA2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 2
    Protein Accession:
    O75956

    Protein attributes for CDK2AP2 Gene

    Size:
    126 amino acids
    Molecular mass:
    13101 Da
    Quaternary structure:
    • Interacts with CDK2AP1 (PubMed:14985111). Interacts with CDK2 (PubMed:23781148). Interacts with MAPK1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CDK2AP2 Gene

neXtProt entry for CDK2AP2 Gene

Post-translational modifications for CDK2AP2 Gene

Other Protein References for CDK2AP2 Gene

No data available for DME Specific Peptides for CDK2AP2 Gene

Domains & Families for CDK2AP2 Gene

Gene Families for CDK2AP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDK2AP2 Gene

InterPro:

Suggested Antigen Peptide Sequences for CDK2AP2 Gene

GenScript: Design optimal peptide antigens:
  • DOC-1-related protein (CDKA2_HUMAN)
  • cDNA FLJ10636 fis, clone NT2RP2005675, highly similar to Cyclin-dependent kinase 2-associated protein 2 (Q6IAV4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75956

UniProtKB/Swiss-Prot:

CDKA2_HUMAN :
  • Belongs to the CDK2AP family.
Family:
  • Belongs to the CDK2AP family.
genes like me logo Genes that share domains with CDK2AP2: view

Function for CDK2AP2 Gene

Molecular function for CDK2AP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).

Phenotypes From GWAS Catalog for CDK2AP2 Gene

Gene Ontology (GO) - Molecular Function for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14985111
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CDK2AP2: view
genes like me logo Genes that share phenotypes with CDK2AP2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK2AP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK2AP2 Gene

Localization for CDK2AP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Cytoplasm. Nucleus. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. {ECO:0000250 UniProtKB:Q9CPY4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK2AP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 1
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005874 microtubule IEA,ISS --
genes like me logo Genes that share ontologies with CDK2AP2: view

Pathways & Interactions for CDK2AP2 Gene

PathCards logo

SuperPathways for CDK2AP2 Gene

No Data Available

Pathways by source for CDK2AP2 Gene

1 GeneTex pathway for CDK2AP2 Gene

Gene Ontology (GO) - Biological Process for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0070507 regulation of microtubule cytoskeleton organization IEA,ISS --
GO:2000035 regulation of stem cell division IEA,ISS --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP 23781148
genes like me logo Genes that share ontologies with CDK2AP2: view

No data available for SIGNOR curated interactions for CDK2AP2 Gene

Drugs & Compounds for CDK2AP2 Gene

No Compound Related Data Available

Transcripts for CDK2AP2 Gene

mRNA/cDNA for CDK2AP2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK2AP2

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for CDK2AP2 Gene

GeneLoc Exon Structure for
CDK2AP2

Expression for CDK2AP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK2AP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK2AP2

SOURCE GeneReport for Unigene cluster for CDK2AP2 Gene:

Hs.523835

mRNA Expression by UniProt/SwissProt for CDK2AP2 Gene:

O75956-CDKA2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CDK2AP2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CDK2AP2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK2AP2 Gene

Orthologs for CDK2AP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK2AP2 29 30
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDK2AP2 29 30
  • 94.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk2ap2 29
  • 91.01 (n)
Cow
(Bos Taurus)
Mammalia CDK2AP2 29 30
  • 91.01 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK2AP2 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdk2ap2 29 16 30
  • 90.48 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK2AP2 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia MGC89864 29
  • 68.61 (n)
Str.6813 29
Zebrafish
(Danio rerio)
Actinopterygii cdk2ap2 29 30
  • 69.97 (n)
OneToOne
Dr.9481 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG18292 30
  • 18 (a)
OneToMany
Species where no ortholog for CDK2AP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CDK2AP2 Gene

ENSEMBL:
Gene Tree for CDK2AP2 (if available)
TreeFam:
Gene Tree for CDK2AP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK2AP2: view image
Alliance of Genome Resources:
Additional Orthologs for CDK2AP2

Paralogs for CDK2AP2 Gene

Paralogs for CDK2AP2 Gene

(2) SIMAP similar genes for CDK2AP2 Gene using alignment to 3 proteins:

  • CDKA2_HUMAN
  • E9PKR4_HUMAN
  • E9PQJ3_HUMAN

Pseudogenes.org Pseudogenes for CDK2AP2 Gene

genes like me logo Genes that share paralogs with CDK2AP2: view

Variants for CDK2AP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK2AP2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1196392899 Likely Benign: not provided 67,506,957(-) G/A
NM_005851.5(CDK2AP2):c.369C>T (p.Asn123=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs144468375 Benign: not provided 67,507,592(-) C/T
NM_005851.5(CDK2AP2):c.180G>A (p.Gln60=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs747499380 Likely Benign: not provided 67,507,639(-) T/G
NM_005851.5(CDK2AP2):c.133A>C (p.Arg45=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CDK2AP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CDK2AP2 Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
esv2422195 CNV duplication 17116639
nsv368 CNV insertion 18451855
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for CDK2AP2 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK2AP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK2AP2
Leiden Open Variation Database (LOVD)
CDK2AP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Disorders for CDK2AP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK2AP2 Gene - From: GCD

Disorder Aliases PubMed IDs
endocervical adenocarcinoma
  • endocervical carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDK2AP2

genes like me logo Genes that share disorders with CDK2AP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK2AP2 Gene

Publications for CDK2AP2 Gene

  1. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. (PMID: 10082655) Zhang X … Haluska FG (Biochemical and biophysical research communications 1999) 2 3 4 22
  2. Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation. (PMID: 23781148) Liu Q … Luo Y (International journal of biological sciences 2013) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). (PMID: 14985111) Buajeeb W … Wong DT (Biochemical and biophysical research communications 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CDK2AP2 Gene

Sources for CDK2AP2 Gene