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The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
CDK2AP1 (Cyclin Dependent Kinase 2 Associated Protein 1) is a Protein Coding gene. Diseases associated with CDK2AP1 include Oral Cancer and Streptococcal Meningitis. Gene Ontology (GO) annotations related to this gene include DNA polymerase binding. An important paralog of this gene is CDK2AP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14985111 |
GO:0070182 | DNA polymerase binding | IPI | 9506968 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 9506968 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0048471 | perinuclear region of cytoplasm | IDA | 9506968 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | IDA | 9506968 |
GO:0006261 | DNA-dependent DNA replication | NAS | 9506968 |
GO:0007049 | cell cycle | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK2AP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gm12184 31 |
|
OneToMany | |
Cdk2ap1 30 17 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CDK2AP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDK2AP1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK2AP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk2ap1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK2AP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDK2AP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK2AP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk2ap1 30 |
|
||
Str.6181 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | cdk2ap1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100535265 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18292 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv884n106 | CNV | deletion | 24896259 |
nsv1070138 | CNV | deletion | 25765185 |
nsv826532 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
oral cancer |
|
|
streptococcal meningitis |
|
|
salmonellosis |
|
|
campylobacteriosis |
|
|