The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009] See more...

Aliases for CDK20 Gene

Aliases for CDK20 Gene

  • Cyclin Dependent Kinase 20 2 3 5
  • Cyclin-Kinase-Activating Kinase P42 3 4
  • Cyclin-Dependent Protein Kinase H 3 4
  • Cell Division Protein Kinase 20 3 4
  • Cyclin-Dependent Kinase 20 3 4
  • CDK-Activating Kinase P42 3 4
  • Cell Cycle-Related Kinase 3 4
  • CAK-Kinase P42 3 4
  • EC 2.7.11.22 4 51
  • CCRK 3 4
  • CDCH 3 4
  • P42 2 3
  • Cell Cycle Related Kinase 2
  • EC 2.7.11 51
  • PNQALRE 3
  • CDK20 5

External Ids for CDK20 Gene

Previous HGNC Symbols for CDK20 Gene

  • CCRK

Previous GeneCards Identifiers for CDK20 Gene

  • GC09M089772
  • GC09M090582
  • GC09M060404

Summaries for CDK20 Gene

Entrez Gene Summary for CDK20 Gene

  • The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK20 Gene

CDK20 (Cyclin Dependent Kinase 20) is a Protein Coding gene. Diseases associated with CDK20 include Obsessive-Compulsive Disorder and Attention Deficit-Hyperactivity Disorder. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot Summary for CDK20 Gene

  • Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.

Additional gene information for CDK20 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK20 Gene

Genomics for CDK20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J087973 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 625.8 +0.3 280 2.6 CREB1 PRDM10 ZNF629 RFX1 CTCF ZNF692 GABPA ZIC2 PKNOX1 POLR2A CDK20 LOC105376131 RF00017-7684 lnc-SPATA31E1-10 ENSG00000283205 RF00017-7683
GH09J087503 Enhancer 1.1 ENCODE dbSUPER 10.9 +469.4 469405 3.4 GATAD2A ATF7 REST TFE3 SOX13 RCOR2 ZNF7 JUND RXRB IRF2 HNRNPA1P14 SPIN1 CDK20 DAPK1 HSALNG0072475 RPS29P18 CTSL
GH09J088773 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 6.7 -801.4 -801403 4.9 PRDM10 JUND FOXA1 GABPA PRDM1 ZIC2 REST SP1 HDAC1 SOX6 CDK20 HSALNG0072566 ENSG00000286414 MIR4289 C9orf47 S1PR3 NXNL2
GH09J087984 Enhancer 0.3 ENCODE 25.2 -9.5 -9473 0.5 ZNF316 MAFK CDK20 piR-31508-054 RF00017-7683 RF00017-7684 lnc-SPATA31E1-10 LOC105376131 SPATA31C2
GH09J088004 Enhancer 0.3 ENCODE 11.6 -30.7 -30661 1.6 RFX5 GATA2 CDK20 piR-32285-093 RNU6-86P RF00026-1125 SPATA31C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK20

Genomic Locations for CDK20 Gene

Genomic Locations for CDK20 Gene
chr9:87,966,441-87,974,780
(GRCh38/hg38)
Size:
8,340 bases
Orientation:
Minus strand
chr9:90,581,356-90,589,695
(GRCh37/hg19)
Size:
8,340 bases
Orientation:
Minus strand

Genomic View for CDK20 Gene

Genes around CDK20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK20 Gene

Proteins for CDK20 Gene

  • Protein details for CDK20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZL9-CDK20_HUMAN
    Recommended name:
    Cyclin-dependent kinase 20
    Protein Accession:
    Q8IZL9
    Secondary Accessions:
    • A2A389
    • A2A390
    • B4DQX1
    • O95137
    • Q5EDC4
    • Q5VYW1
    • Q9BUF4

    Protein attributes for CDK20 Gene

    Size:
    346 amino acids
    Molecular mass:
    38695 Da
    Quaternary structure:
    • Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.
    SequenceCaution:
    • Sequence=AAC98920.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK20 Gene

Selected DME Specific Peptides for CDK20 Gene

Q8IZL9:
  • PLEEVLPD
  • VGCIMGE
  • TRWYRAPE
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for CDK20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK20 Gene

Gene Families for CDK20 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDK20 Gene

Suggested Antigen Peptide Sequences for CDK20 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ90844 fis, clone Y79AA1002381, highly similar to Homo sapiens cell cycle related kinase (CCRK), transcript variant 1, mRNA (A2A390_HUMAN)
  • cDNA FLJ78331 (A8K6P8_HUMAN)
  • Cyclin-kinase-activating kinase p42 (CDK20_HUMAN)
  • Cyclin-dependent protein kinase H (O95137_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZL9

UniProtKB/Swiss-Prot:

CDK20_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK20: view

Function for CDK20 Gene

Molecular function for CDK20 Gene

UniProtKB/Swiss-Prot Function:
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.

Enzyme Numbers (IUBMB) for CDK20 Gene

Phenotypes From GWAS Catalog for CDK20 Gene

Gene Ontology (GO) - Molecular Function for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 21986944
genes like me logo Genes that share ontologies with CDK20: view
genes like me logo Genes that share phenotypes with CDK20: view

Animal Models for CDK20 Gene

MGI Knock Outs for CDK20:
  • Cdk20 Cdk20<tm1.1Jegg>
  • Cdk20 Cdk20<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK20

CRISPR Products

miRNA for CDK20 Gene

miRTarBase miRNAs that target CDK20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK20

Clone Products

  • Addgene plasmids for CDK20

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK20 Gene

Localization for CDK20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK20 Gene

Nucleus. Cytoplasm. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK20 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CDK20: view

Pathways & Interactions for CDK20 Gene

PathCards logo

SuperPathways for CDK20 Gene

No Data Available

Pathways by source for CDK20 Gene

1 GeneTex pathway for CDK20 Gene

SIGNOR curated interactions for CDK20 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA 21873635
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016310 phosphorylation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDK20: view

Drugs & Compounds for CDK20 Gene

(17) Drugs for CDK20 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
AT7519 Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0

(5) Additional Compounds for CDK20 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(8) ApexBio Compounds for CDK20 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK20: view

Drug Products

Transcripts for CDK20 Gene

mRNA/cDNA for CDK20 Gene

5 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK20

Clone Products

  • Addgene plasmids for CDK20

Alternative Splicing Database (ASD) splice patterns (SP) for CDK20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: - - - -
SP6: -
SP7: -

Relevant External Links for CDK20 Gene

GeneLoc Exon Structure for
CDK20

Expression for CDK20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK20 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK20

SOURCE GeneReport for Unigene cluster for CDK20 Gene:

Hs.522274

Evidence on tissue expression from TISSUES for CDK20 Gene

  • Nervous system(4.5)
  • Heart(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CDK20: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK20 Gene

Orthologs for CDK20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK20 30 31
  • 96.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCRK 31
  • 92 (a)
OneToOne
CDK20 30
  • 88.63 (n)
Dog
(Canis familiaris)
Mammalia CDK20 30 31
  • 88.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cdk20 30 17 31
  • 87.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk20 30
  • 87.38 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CDK20 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK20 31
  • 84 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK20 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.7508 30
Zebrafish
(Danio rerio)
Actinopterygii cdk20 30 31
  • 68.5 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6800 30 31
  • 53.52 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004594 30
  • 52.76 (n)
Worm
(Caenorhabditis elegans)
Secernentea dyf-18 31
  • 32 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN28 31
  • 37 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 69 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5990 30
Species where no ortholog for CDK20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDK20 Gene

ENSEMBL:
Gene Tree for CDK20 (if available)
TreeFam:
Gene Tree for CDK20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK20: view image

Paralogs for CDK20 Gene

Variants for CDK20 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK20 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
720314 Benign: not provided 87,971,306(-) G/A SYNONYMOUS_VARIANT
734152 Likely Benign: not provided 87,967,465(-) C/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
751435 Likely Benign: not provided 87,967,531(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
768313 Benign: not provided 87,969,868(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
783553 Benign: not provided 87,971,267(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CDK20 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK20 Gene

Variant ID Type Subtype PubMed ID
nsv1035545 CNV gain 25217958
nsv476012 CNV novel sequence insertion 20440878
nsv614788 CNV gain 21841781

Variation tolerance for CDK20 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK20 Gene

Human Gene Mutation Database (HGMD)
CDK20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK20 Gene

Disorders for CDK20 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDK20 Gene - From: ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CDK20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDK20

genes like me logo Genes that share disorders with CDK20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK20 Gene

Publications for CDK20 Gene

  1. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. (PMID: 14597612) Liu Y … Galaktionov K (The Journal of biological chemistry 2004) 3 4 23
  2. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1. (PMID: 21986944) Wang LY … Kung HJ (Oncogene 2012) 3 4
  3. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (PMID: 19672860) Wu GQ … Kung HF (International journal of cancer 2009) 3 23
  4. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3
  5. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PMID: 16954377) Fu Z … Sturgill TW (Molecular and cellular biology 2006) 3 23

Products for CDK20 Gene

  • Signalway Proteins for CDK20

Sources for CDK20 Gene