Aliases for CDK20 Gene
External Ids for CDK20 Gene
Previous HGNC Symbols for CDK20 Gene
Previous GeneCards Identifiers for CDK20 Gene
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
GeneCards Summary for CDK20 Gene
CDK20 (Cyclin Dependent Kinase 20) is a Protein Coding gene. Diseases associated with CDK20 include Obsessive-Compulsive Disorder and Attention Deficit-Hyperactivity Disorder. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK12.
UniProtKB/Swiss-Prot Summary for CDK20 Gene
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.