Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediat... See more...
Aliases for CDK19 Gene
Aliases for CDK19 Gene
- Cyclin Dependent Kinase 19 2 3 5
- Cell Division Cycle 2-Like Protein Kinase 6 3 4
- Cell Division Cycle 2-Like 6 (CDK8-Like) 2 3
- Cyclin-Dependent Kinase (CDC2-Like) 11 2 3
- Cell Division Protein Kinase 19 3 4
- CDC2-Related Protein Kinase 6 3 4
- Cyclin-Dependent Kinase 19 3 4
- Cyclin-Dependent Kinase 11 3 4
- Death-Preventing Kinase 3 4
External Ids for CDK19 Gene
- HGNC: 19338
- Entrez Gene: 23097
- Ensembl: ENSG00000155111
- OMIM: 614720
- UniProtKB: Q9BWU1
Previous HGNC Symbols for CDK19 Gene
- CDK11
- CDC2L6
Previous GeneCards Identifiers for CDK19 Gene
- GC06M111039
- GC06M110932
- GC06M108502
Summaries for CDK19 Gene
-
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for CDK19 Gene
CDK19 (Cyclin Dependent Kinase 19) is a Protein Coding gene. Diseases associated with CDK19 include Opitz-Kaveggia Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8.
Additional gene information for CDK19 Gene
- HGNC(19338)
- Entrez Gene(23097)
- Ensembl(ENSG00000155111)
- OMIM(614720)
- UniProtKB(Q9BWU1)
- Open Targets Platform(ENSG00000155111)
- Search for CDK19 at DataMed
- Search for CDK19 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK19 Gene
Genomics for CDK19 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDK19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDK19 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK19
Genomic Locations for CDK19 Gene
Genomic Locations for CDK19 Gene
- chr6:110,609,978-110,816,531
- (GRCh38/hg38)
- Size:
- 206,554 bases
- Orientation:
- Minus strand
- chr6:110,931,181-111,137,161
- (GRCh37/hg19)
- Size:
- 205,981 bases
- Orientation:
- Minus strand
Genomic View for CDK19 Gene
Genes around CDK19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by HGNC
- 6q21 by Entrez Gene
- 6q21 by Ensembl
CDK19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK19 Gene
Proteins for CDK19 Gene
-
Protein details for CDK19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BWU1-CDK19_HUMAN
- Recommended name:
- Cyclin-dependent kinase 19
- Protein Accession:
- Q9BWU1
- Q5JQZ7
- Q5JR00
- Q8TC78
- Q9UPX2
Protein attributes for CDK19 Gene
- Size:
- 502 amino acids
- Molecular mass:
- 56802 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH24247.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CDK19 Gene
Selected DME Specific Peptides for CDK19 Gene
- Q9BWU1:
-
- VLHRDLK
- YRAPELLL
Post-translational modifications for CDK19 Gene
Other Protein References for CDK19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD2L6 Antibody
- Novus Biologicals Antibodies for CDK19
-
Abcam antibodies for CDK19
- Invitrogen Antibodies for CDK19 (AFLGC-Cdk19)
- antibodies-online: Show 10 available CDK19 Antibodies ranked by validation data
- Compare Top CDK19 Antibodies
-
Recommended
- 27 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 16 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Biorbyt antibodies for CDK19
-
Boster Bio Antibodies for CDK19
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK19
Protein Products
-
OriGene Purified Proteins for CDK19
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK19
- Origene Custom Protein Services for CDK19
-
Abcam proteins for CDK19
Domains & Families for CDK19 Gene
Gene Families for CDK19 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CDK19 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK19 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (B4DUB1_HUMAN)
- Death-preventing kinase (CDK19_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BWU1UniProtKB/Swiss-Prot:
CDK19_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK19 Gene
Molecular function for CDK19 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
Enzyme Numbers (IUBMB) for CDK19 Gene
Phenotypes From GWAS Catalog for CDK19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CDK19 Gene
- MGI mutant phenotypes for CDK19:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CDK19:
-
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Increased transferrin (TF) endocytosis
- Increased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased replication of vaccinia virus (VACV)
- Decreased substrate adherent cell growth
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Increased nuclear migration distance
- Decreased cell viability after pRB stimulation
- Transferrin accumulation in enlarged cytoplasmic structures
Animal Model Products
-
Taconic Biosciences Mouse Models for CDK19
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK19 - Select products 50% OFF >
- * CDK19 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK19
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK19
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
miRNA for CDK19 Gene
- miRTarBase miRNAs that target CDK19
-
- hsa-miR-373-3p (MIRT003832)
- hsa-miR-18a-5p (MIRT006818)
- mmu-miR-340-5p (MIRT010603)
- mmu-miR-30e-5p (MIRT013439)
- mmu-miR-149-5p (MIRT014714)
- hsa-miR-335-5p (MIRT017357)
- hsa-miR-130b-3p (MIRT020239)
- hsa-miR-128-3p (MIRT021943)
- hsa-miR-148a-3p (MIRT026007)
- hsa-miR-26b-5p (MIRT029199)
- hsa-miR-21-5p (MIRT030820)
- hsa-miR-19b-3p (MIRT031144)
- hsa-miR-10a-5p (MIRT047678)
- hsa-miR-20a-5p (MIRT050601)
- hsa-miR-106a-3p (MIRT448950)
- hsa-miR-526b-5p (MIRT448951)
- hsa-miR-4276 (MIRT448952)
- hsa-miR-382-3p (MIRT448953)
- hsa-miR-148b-3p (MIRT448954)
- hsa-miR-152-3p (MIRT448955)
- hsa-miR-3666 (MIRT448956)
- hsa-miR-454-3p (MIRT448957)
- hsa-miR-130a-3p (MIRT448958)
- hsa-miR-4295 (MIRT448959)
- hsa-miR-301a-3p (MIRT448960)
- hsa-miR-301b-3p (MIRT448961)
- hsa-miR-4309 (MIRT524513)
- hsa-miR-3198 (MIRT524514)
- hsa-miR-6880-5p (MIRT524515)
- hsa-miR-7847-3p (MIRT524516)
- hsa-miR-122-5p (MIRT524517)
- hsa-miR-504-3p (MIRT524518)
- hsa-miR-6851-5p (MIRT524519)
- hsa-miR-3689d (MIRT524520)
- hsa-miR-3202 (MIRT524521)
- hsa-miR-4533 (MIRT524522)
- hsa-miR-6086 (MIRT524523)
- hsa-miR-377-5p (MIRT524524)
- hsa-miR-6500-3p (MIRT524525)
- hsa-miR-3614-5p (MIRT524526)
- hsa-miR-619-3p (MIRT524527)
- hsa-miR-490-3p (MIRT524528)
- hsa-miR-4671-3p (MIRT538600)
- hsa-miR-548x-5p (MIRT538601)
- hsa-miR-548g-5p (MIRT538602)
- hsa-miR-548f-5p (MIRT538603)
- hsa-miR-548aj-5p (MIRT538604)
- hsa-miR-548p (MIRT538605)
- mmu-miR-466c-3p (MIRT584356)
- mmu-miR-466b-3p (MIRT584357)
- mmu-miR-466p-3p (MIRT584358)
- mmu-miR-466m-3p (MIRT584359)
- mmu-miR-466o-3p (MIRT584360)
- mmu-miR-669f-3p (MIRT584361)
- mmu-miR-466f-3p (MIRT584362)
- mmu-miR-467f (MIRT584363)
- mmu-miR-466a-3p (MIRT584364)
- mmu-miR-297b-3p (MIRT584365)
- mmu-miR-466e-3p (MIRT584366)
- mmu-miR-467g (MIRT584367)
- mmu-miR-466d-3p (MIRT584368)
- hsa-miR-665 (MIRT669094)
- hsa-miR-7160-5p (MIRT669095)
- hsa-miR-4722-5p (MIRT669096)
- hsa-miR-6884-5p (MIRT669097)
- hsa-miR-485-5p (MIRT669098)
- hsa-miR-1827 (MIRT669099)
- hsa-miR-4649-3p (MIRT669100)
- hsa-miR-4768-3p (MIRT669101)
- hsa-miR-4478 (MIRT669102)
- hsa-miR-4419b (MIRT669103)
- hsa-miR-3929 (MIRT669104)
- hsa-miR-940 (MIRT669105)
- hsa-miR-6893-5p (MIRT669106)
- hsa-miR-6808-5p (MIRT669107)
- hsa-miR-34b-3p (MIRT669108)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK19
Clone Products
- Applied Biological Materials (abm): Clones for CDK19 - Select products 50% OFF >
- * CDK19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG215712
- MG217289
- MR215712
- MR215712L3
- MR215712L4
- MR217289
- MR217289L3
- MR217289L4
- MR229270
- MR229612
- RC206105
- RC206105L1
- RC206105L2
- RC206105L3
- RC206105L4
- RC238257
- RC238258
- RC238346
- RG206105
- RR212690
- RR212690L3
- RR212690L4
- MR215712L3V
- MR215712L4V
- MR217289L3V
- MR217289L4V
- RC206105L1V
- RC206105L2V
- RC206105L3V
- RC206105L4V
- RR212690L3V
- RR212690L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDK19
- Addgene plasmids for CDK19
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK19
Cell Line Products
-
Horizon Cell Lines for CDK19
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK19 Gene
Localization for CDK19 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005829 | cytosol | IBA | 21873635 |
| GO:0016592 | mediator complex | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK19 Gene
Pathways & Interactions for CDK19 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.40
|
|
| 3 | Cell Cycle Control of Chromosomal Replication |
Cell Cycle Control of Chromosomal Replication
-
|
|
| 4 | Developmental Biology | ||
Pathways by source for CDK19 Gene
7 Reactome pathways for CDK19 Gene
1 Qiagen pathway for CDK19 Gene
- Cell Cycle Control of Chromosomal Replication
1 GeneTex pathway for CDK19 Gene
Interacting Proteins for CDK19 Gene
GPS-Prot Interaction Network for CDK19
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | IEA | -- |
| GO:0050729 | positive regulation of inflammatory response | IEA | -- |
| GO:0051726 | regulation of cell cycle | IEA | -- |
Drugs & Compounds for CDK19 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| AT7519 | Pharma | Multi-CDK inhibitor | 0 | |||
| Kenpaullone | Pharma | 0 | ||||
| ML167 | Pharma | Clk4 inhibitor,highly selective | 0 | |||
| Nu 6027 | Pharma | ATR/CDK inhibitor, potent and selective | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(8) ApexBio Compounds for CDK19 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT7519 | Multi-CDK inhibitor | 844442-38-2 |
| Kenpaullone | 142273-20-9 | |
| ML167 | Clk4 inhibitor,highly selective | 1285702-20-6 |
| Nu 6027 | ATR/CDK inhibitor, potent and selective | 220036-08-8 |
| PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
| Purvalanol B | CDK1/CDK2/CDK4 inhibitor | 212844-54-7 |
| R547 | CDK1/2/4 inhibitor,ATP-competitive | 741713-40-6 |
| Ro 3306 | An ATP-competitive, potent CDK1 inhibitor | 872573-93-8 |
Transcripts for CDK19 Gene
mRNA/cDNA for CDK19 Gene
- 4 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368911 6399 nts (view in UCSC)
- ENST00000323817 6067 nts (view in UCSC)
- ENST00000457688 955 nts (view in UCSC)
- ENST00000463016 604 nts (view in UCSC)
- ENST00000460913 448 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK19 - Select products 50% OFF >
- * CDK19 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK19
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK19
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK19
Clone Products
- Applied Biological Materials (abm): Clones for CDK19 - Select products 50% OFF >
- * CDK19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG215712
- MG217289
- MR215712
- MR215712L3
- MR215712L4
- MR217289
- MR217289L3
- MR217289L4
- MR229270
- MR229612
- RC206105
- RC206105L1
- RC206105L2
- RC206105L3
- RC206105L4
- RC238257
- RC238258
- RC238346
- RG206105
- RR212690
- RR212690L3
- RR212690L4
- MR215712L3V
- MR215712L4V
- MR217289L3V
- MR217289L4V
- RC206105L1V
- RC206105L2V
- RC206105L3V
- RC206105L4V
- RR212690L3V
- RR212690L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDK19
- Addgene plasmids for CDK19
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK19
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for CDK19 Gene
- GeneLoc Exon Structure for
- CDK19
Expression for CDK19 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Prostate (Endocrine System)
This gene is overexpressed in Adrenal (38.9), Peripheral blood mononuclear cells (12.2), and Testis (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK19 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK19
SOURCE GeneReport for Unigene cluster for CDK19 Gene:
Hs.744895Evidence on tissue expression from TISSUES for CDK19 Gene
- Nervous system(4.5)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for CDK19
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK19 Gene
Orthologs for CDK19 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CDK19 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK19 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdk19 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cdk19 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDK19 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CDK19 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk19 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | cdk-8-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cdk19 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cdk8 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cdk-8 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSN3 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CDKE;1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os10g0580300 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.6555 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for CDK19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for CDK19 Gene
- ENSEMBL:
- Gene Tree for CDK19 (if available)
- TreeFam:
- Gene Tree for CDK19 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDK19: view image
Paralogs for CDK19 Gene
Paralogs for CDK19 Gene
(50) SIMAP similar genes for CDK19 Gene using alignment to 5 proteins:
- CDK19_HUMAN
- B4DUB1_HUMAN
- H0YDW9_HUMAN
- I6W807_HUMAN
- Q5JQZ9_HUMAN
- DKFZp434M058
- CDK8
- MAPK8
- STK36
- STK25
- CDK11B
- CDK10
- MAPK7
- CDK16
- CDK3
- CDK6
- DKFZp564L2416
- MAK
- CDC2L2
- CDC2L1
- CDKL1
- CDK4
- NLK
- CDK1
- MAPK4
- CDK18
- CDK15
- CDK14
- CDK11A
- CCRK
- BRSK2
- PCTK3
- CDK12
- MAPK1
- CDK5
- STK11
- MOK
- MAPK13
- CDKL4
- AURKC
- CDK7
- MAPK3
- DKFZp686O0215
- DAPK3
- CDK20
- CDKL3
- CDK17
- CDK2
- DKFZp686L20222
- CDK9
- MAPK9
- MAPK14
- CDC2
- GSK3A
- CDKL2
Variants for CDK19 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670731 | CNV | deletion | 23128226 |
| esv2672817 | CNV | deletion | 23128226 |
| esv2732571 | CNV | deletion | 23290073 |
| esv3378392 | CNV | insertion | 20981092 |
| esv3540312 | CNV | deletion | 23714750 |
| esv3610364 | CNV | loss | 21293372 |
| esv3610365 | CNV | loss | 21293372 |
| nsv1032572 | CNV | gain | 25217958 |
| nsv516177 | CNV | loss | 19592680 |
| nsv823823 | CNV | loss | 20364138 |
| nsv830770 | CNV | loss | 17160897 |
| nsv830772 | CNV | gain | 17160897 |
| nsv830773 | CNV | loss | 17160897 |
| nsv965750 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.46;
10.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK19 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDK19
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK19 Gene
Disorders for CDK19 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| opitz-kaveggia syndrome |
|
|
Search CDK19 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CDK19
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CDK19 Gene
Publications for CDK19 Gene
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
ExternalLinks
Products for CDK19 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK19
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK19
- Origene Custom Protein Services for CDK19
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- OriGene qPCR primer pairs for CDK19
- OriGene CRISPR knockouts for CDK19
- MG215712
- MG217289
- MR215712
- MR215712L3
- MR215712L4
- MR217289
- MR217289L3
- MR217289L4
- MR229270
- MR229612
- RC206105
- RC206105L1
- RC206105L2
- RC206105L3
- RC206105L4
- RC238257
- RC238258
- RC238346
- RG206105
- RR212690
- RR212690L3
- RR212690L4
- MR215712L3V
- MR215712L4V
- MR217289L3V
- MR217289L4V
- RC206105L1V
- RC206105L2V
- RC206105L3V
- RC206105L4V
- RR212690L3V
- RR212690L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CDK19
- Sino Biological Human cDNA Clone for CDK19
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CDK19
- Novus Biologicals proteins and lysates for CDK19
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CDK19
- Abcam proteins for CDK19
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for CDK19
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CDK19 (AFLGC-Cdk19)
- ApexBio compounds for CDK19
- VectorBuilder Custom and pre-made DNA vectors for CDK19 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CDK19 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CDK19 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CDK19 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CDK19
- Addgene plasmids for CDK19
- antibodies-online: Show 10 available CDK19 Antibodies ranked by validation data
- Compare Top CDK19 Antibodies
- Recommended
- 27 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 16 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for available CDK19 related products ranked by validation data
- antibodies-online: Show 7 available CDK19 Proteins ranked by validation data
- Compare Top CDK19 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK19
- Search Santa Cruz Biotechnology (SCBT) for CDK19 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
- Horizon Cell Lines for CDK19
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK19
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK19
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CDK19
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK19
- Boster Bio Antibodies for CDK19
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CDK19
Sources for CDK19 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB