Aliases for CDK19 Gene
Aliases for CDK19 Gene
- Cyclin Dependent Kinase 19 2 3 5
- Cell Division Cycle 2-Like Protein Kinase 6 3 4
- Cell Division Cycle 2-Like 6 (CDK8-Like) 2 3
- Cyclin-Dependent Kinase (CDC2-Like) 11 2 3
- Cell Division Protein Kinase 19 3 4
- CDC2-Related Protein Kinase 6 3 4
- Cyclin-Dependent Kinase 11 3 4
- Death-Preventing Kinase 3 4
- CDC2L6 3 4
External Ids for CDK19 Gene
- HGNC: 19338
- Entrez Gene: 23097
- Ensembl: ENSG00000155111
- OMIM: 614720
- UniProtKB: Q9BWU1
Previous HGNC Symbols for CDK19 Gene
- CDK11
- CDC2L6
Previous GeneCards Identifiers for CDK19 Gene
- GC06M111039
- GC06M110932
- GC06M108502
Summaries for CDK19 Gene
-
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for CDK19 Gene
CDK19 (Cyclin Dependent Kinase 19) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK19 Gene
Genomics for CDK19 Gene
GeneHancer (GH) Regulatory Elements for CDK19 Gene
Promoters and enhancers for CDK19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CDK19 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CDK19 Gene
Genomic Locations for CDK19 Gene
- chr6:110,609,978-110,816,516
- (GRCh38/hg38)
- Size:
- 206,539 bases
- Orientation:
- Minus strand
- chr6:110,931,181-111,137,161
- (GRCh37/hg19)
Genomic View for CDK19 Gene
Genes around CDK19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC
CDK19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK19 Gene
Proteins for CDK19 Gene
-
Protein details for CDK19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BWU1-CDK19_HUMAN
- Recommended name:
- Cyclin-dependent kinase 19
- Protein Accession:
- Q9BWU1
- Q5JQZ7
- Q5JR00
- Q8TC78
- Q9UPX2
Protein attributes for CDK19 Gene
- Size:
- 502 amino acids
- Molecular mass:
- 56802 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH24247.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CDK19 Gene
Selected DME Specific Peptides for CDK19 Gene
- Q9BWU1:
-
- VLHRDLK
- YRAPELLL
Post-translational modifications for CDK19 Gene
Other Protein References for CDK19 Gene
Antibody Products
- Novus Biologicals Antibodies for CDK19
-
Abcam antibodies for CDK19
- Invitrogen Antibodies for CDK19
- Search GeneTex for Antibodies for CDK19
-
Santa Cruz Biotechnology (SCBT) Antibodies for CDK19
Protein Products
-
OriGene Purified Proteins for CDK19
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK19
- Origene Custom Protein Services for CDK19
- Search GeneTex for Proteins for CDK19
-
Abcam proteins for CDK19
Assay Products
Domains & Families for CDK19 Gene
Gene Families for CDK19 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CDK19 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK19 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BWU1UniProtKB/Swiss-Prot:
CDK19_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK19 Gene
Molecular function for CDK19 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
Enzyme Numbers (IUBMB) for CDK19 Gene
Phenotypes From GWAS Catalog for CDK19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for CDK19 Gene
- GenomeRNAi human phenotypes for CDK19:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased substrate adherent cell growth
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased cell viability after pRB stimulation
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Model Products
-
Taconic Biosciences Mouse Models for CDK19
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK19
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK19 gene
- Search ViGene Biosciences for CDK19
CRISPR Products
-
OriGene CRISPR knockouts for CDK19
- genomics-online: gRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- Applied Biological Materials CRISPR for CDK19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
- GenScript: Design CRISPR guide RNA sequences for CDK19
miRNA for CDK19 Gene
- miRTarBase miRNAs that target CDK19
-
- hsa-mir-373-3p (MIRT003832)
- hsa-mir-18a-5p (MIRT006818)
- hsa-mir-335-5p (MIRT017357)
- hsa-mir-130b-3p (MIRT020239)
- hsa-mir-128-3p (MIRT021943)
- hsa-mir-148a-3p (MIRT026007)
- hsa-mir-26b-5p (MIRT029199)
- hsa-mir-21-5p (MIRT030820)
- hsa-mir-19b-3p (MIRT031144)
- hsa-mir-10a-5p (MIRT047678)
- hsa-mir-20a-5p (MIRT050601)
- hsa-mir-106a-3p (MIRT448950)
- hsa-mir-526b-5p (MIRT448951)
- hsa-mir-4276 (MIRT448952)
- hsa-mir-382-3p (MIRT448953)
- hsa-mir-148b-3p (MIRT448954)
- hsa-mir-152-3p (MIRT448955)
- hsa-mir-3666 (MIRT448956)
- hsa-mir-454-3p (MIRT448957)
- hsa-mir-130a-3p (MIRT448958)
- hsa-mir-4295 (MIRT448959)
- hsa-mir-301a-3p (MIRT448960)
- hsa-mir-301b-3p (MIRT448961)
- hsa-mir-4309 (MIRT524513)
- hsa-mir-3198 (MIRT524514)
- hsa-mir-6880-5p (MIRT524515)
- hsa-mir-7847-3p (MIRT524516)
- hsa-mir-122-5p (MIRT524517)
- hsa-mir-504-3p (MIRT524518)
- hsa-mir-6851-5p (MIRT524519)
- hsa-mir-3689d (MIRT524520)
- hsa-mir-3202 (MIRT524521)
- hsa-mir-4533 (MIRT524522)
- hsa-mir-6086 (MIRT524523)
- hsa-mir-377-5p (MIRT524524)
- hsa-mir-6500-3p (MIRT524525)
- hsa-mir-3614-5p (MIRT524526)
- hsa-mir-619-3p (MIRT524527)
- hsa-mir-490-3p (MIRT524528)
- hsa-mir-4671-3p (MIRT538600)
- hsa-mir-548x-5p (MIRT538601)
- hsa-mir-548g-5p (MIRT538602)
- hsa-mir-548f-5p (MIRT538603)
- hsa-mir-548aj-5p (MIRT538604)
- hsa-mir-548p (MIRT538605)
- hsa-mir-665 (MIRT669094)
- hsa-mir-7160-5p (MIRT669095)
- hsa-mir-4722-5p (MIRT669096)
- hsa-mir-6884-5p (MIRT669097)
- hsa-mir-485-5p (MIRT669098)
- hsa-mir-1827 (MIRT669099)
- hsa-mir-4649-3p (MIRT669100)
- hsa-mir-4768-3p (MIRT669101)
- hsa-mir-4478 (MIRT669102)
- hsa-mir-4419b (MIRT669103)
- hsa-mir-3929 (MIRT669104)
- hsa-mir-940 (MIRT669105)
- hsa-mir-6893-5p (MIRT669106)
- hsa-mir-6808-5p (MIRT669107)
- hsa-mir-34b-3p (MIRT669108)
miRNA Products
- Search ViGene Biosciences for CDK19
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- genomics-online: shRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK19 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CDK19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK19
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK19
- Applied Biological Materials Clones for CDK19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CDK19
-
ViGene Biosciences adenoviral particle packaged cDNA for CDK19 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CDK19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK19 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK19 Gene
Localization for CDK19 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005829 | cytosol | IBA | -- |
| GO:0016592 | NOT mediator complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK19 Gene
Pathways & Interactions for CDK19 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.37
|
|
| 3 | Cell Cycle Control of Chromosomal Replication | ||
| 4 | Developmental Biology | ||
Pathways by source for CDK19 Gene
1 GeneTex pathway for CDK19 Gene
7 Reactome pathways for CDK19 Gene
1 Qiagen pathway for CDK19 Gene
Interacting Proteins for CDK19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA,IBA | -- |
| GO:0007346 | regulation of mitotic cell cycle | IBA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | IEA | -- |
| GO:0050729 | positive regulation of inflammatory response | IEA | -- |
Drugs & Compounds for CDK19 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(8) ApexBio Compounds for CDK19 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT7519 | Multi-CDK inhibitor | 844442-38-2 |
| Kenpaullone | 142273-20-9 | |
| ML167 | Clk4 inhibitor,highly selective | 1285702-20-6 |
| Nu 6027 | ATR/CDK inhibitor, potent and selective | 220036-08-8 |
| PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
| Purvalanol B | CDK1/CDK2/CDK4 inhibitor | 212844-54-7 |
| R547 | CDK1/2/4 inhibitor,ATP-competitive | 741713-40-6 |
| Ro 3306 | An ATP-competitive, potent CDK1 inhibitor | 872573-93-8 |
Transcripts for CDK19 Gene
mRNA/cDNA for CDK19 Gene
- (10) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CDK19 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CDK19
- genomics-online: gRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- Applied Biological Materials CRISPR for CDK19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
- GenScript: Design CRISPR guide RNA sequences for CDK19
miRNA Products
- Search ViGene Biosciences for CDK19
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- genomics-online: shRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CDK19 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CDK19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK19
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK19
- Applied Biological Materials Clones for CDK19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Expression for CDK19 Gene
This gene is overexpressed in Adrenal (38.9), Peripheral blood mononuclear cells (12.2), and Testis (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK19 Gene
NURSA nuclear receptor signaling pathways regulating expression of CDK19 Gene:
CDK19SOURCE GeneReport for Unigene cluster for CDK19 Gene:
Hs.744895Evidence on tissue expression from TISSUES for CDK19 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for CDK19
- genomics-online: primer clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK19 Gene
Orthologs for CDK19 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CDK19 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CDK19 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CDK19 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CDK19 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CDK19 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cdk19 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cdk19 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | CDK19 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CDK19 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cdk19 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | cdk-8-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cdk19 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdk8 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cdk-8 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSN3 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CDKE;1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os10g0580300 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.6555 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CDK19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for CDK19 Gene
(50) SIMAP similar genes for CDK19 Gene using alignment to 5 proteins:
- DKFZp434M058
- CDK8
- MAPK8
- STK36
- STK25
- CDK11B
- CDK10
- MAPK7
- CDK16
- CDK3
- CDK6
- DKFZp564L2416
- MAK
- CDC2L2
- CDC2L1
- CDKL1
- CDK4
- NLK
- CDK1
- MAPK4
- CDK18
- CDK15
- CDK14
- CDK11A
- CCRK
- BRSK2
- PCTK3
- CDK12
- MAPK1
- CDK5
- STK11
- MOK
- MAPK13
- CDKL4
- AURKC
- CDK7
- MAPK3
- DKFZp686O0215
- DAPK3
- CDK20
- CDKL3
- CDK17
- CDK2
- DKFZp686L20222
- CDK9
- MAPK9
- MAPK14
- CDC2
- GSK3A
- CDKL2
Variants for CDK19 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004179 | -- | 110,774,076(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000055241 | -- | 110,715,591(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000059428 | -- | 110,645,635(-) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000062440 | -- | 110,728,944(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000068426 | -- | 110,665,460(-) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670731 | CNV | deletion | 23128226 |
| esv2672817 | CNV | deletion | 23128226 |
| esv2732571 | CNV | deletion | 23290073 |
| esv3378392 | CNV | insertion | 20981092 |
| esv3540312 | CNV | deletion | 23714750 |
| esv3610364 | CNV | loss | 21293372 |
| esv3610365 | CNV | loss | 21293372 |
| nsv1032572 | CNV | gain | 25217958 |
| nsv516177 | CNV | loss | 19592680 |
| nsv823823 | CNV | loss | 20364138 |
| nsv830770 | CNV | loss | 17160897 |
| nsv830772 | CNV | gain | 17160897 |
| nsv830773 | CNV | loss | 17160897 |
| nsv965750 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.46;
10.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK19 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CDK19
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK19 Gene
Disorders for CDK19 Gene
Additional Disease Information for CDK19
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CDK19 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK19 Gene
Publications for CDK19 Gene
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
Products for CDK19 Gene
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- Browse Human Proteins and Enzymes
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- Browse Activity Assays
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- Browse Cell Culture Products
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CDK19
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK19
- Origene Custom Protein Services for CDK19
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK19
- Browse OriGene Inhibitory RNA Products For CDK19
- OriGene qPCR primer pairs for CDK19
- OriGene CRISPR knockouts for CDK19
- OriGene ORF clones in human for CDK19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for CDK19 in any vector
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- GenScript Custom overexpressing Cell Line Services for CDK19
- GenScript: Design CRISPR guide RNA sequences for CDK19
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CDK19
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CDK19
- Novus Biologicals lysates and proteins for CDK19
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CDK19
- Abcam proteins for CDK19
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for CDK19
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CDK19
- ApexBio compounds for CDK19
- Cyagen custom Knockout/knockin (KOKI) mouse models for CDK19
- VectorBuilder custom plasmid, inducible vectors for CDK19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CDK19
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CDK19
- antibodies-online: Search results for 59 available CDK19 Antibodies ranked by validation data
- Compare Top CDK19 Antibodies
- antibodies-online: Search results for available CDK19 related products ranked by validation data
- antibodies-online: Search results for 7 available CDK19 Proteins ranked by validation data
- Compare Top CDK19 Proteins
- Search GeneTex for Antibodies for CDK19
- Search GeneTex for Proteins for CDK19
- ViGene Biosciences adenoviral particle packaged cDNA for CDK19 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CDK19 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CDK19 gene
- Search ViGene Biosciences for CDK19
- Santa Cruz Biotechnology (SCBT) Antibodies for CDK19
- Search Santa Cruz Biotechnology (SCBT) for CDK19 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CDK19
- Horizon Cell Lines for CDK19
- genomics-online: cdna clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- orf clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- genomics-online: gRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- genomics-online: primer clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
- genomics-online: shRNA clones - Search results for 104 available CDK19 gene related products
- Overview of 104 available CDK19 gene related products
Sources for CDK19 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
