This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediat... See more...

Aliases for CDK19 Gene

Aliases for CDK19 Gene

  • Cyclin Dependent Kinase 19 2 3 5
  • Cell Division Cycle 2-Like Protein Kinase 6 3 4
  • Cell Division Cycle 2-Like 6 (CDK8-Like) 2 3
  • Cyclin-Dependent Kinase (CDC2-Like) 11 2 3
  • Cell Division Protein Kinase 19 3 4
  • CDC2-Related Protein Kinase 6 3 4
  • Cyclin-Dependent Kinase 19 3 4
  • Cyclin-Dependent Kinase 11 3 4
  • Death-Preventing Kinase 3 4
  • BA346C16.3 2 3
  • KIAA1028 2 4
  • CDC2L6 3 4
  • CDK11 3 4
  • Cyclin Dependent Kinase 19 Variant 2 3
  • CDK8-Like Cyclin-Dependent Kinase 3
  • EC 2.7.11.22 4
  • EC 2.7.11 51
  • CDK19 5

External Ids for CDK19 Gene

Previous HGNC Symbols for CDK19 Gene

  • CDK11
  • CDC2L6

Previous GeneCards Identifiers for CDK19 Gene

  • GC06M111039
  • GC06M110932
  • GC06M108502

Summaries for CDK19 Gene

Entrez Gene Summary for CDK19 Gene

  • This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CDK19 Gene

CDK19 (Cyclin Dependent Kinase 19) is a Protein Coding gene. Diseases associated with CDK19 include Opitz-Kaveggia Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8.

Additional gene information for CDK19 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK19 Gene

Genomics for CDK19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J110813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 610.9 +1.3 1252 4.2 SP1 CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 SIX5 LEF1 CDK19 AMD1 lnc-CDK19-4 MFSD4B ENSG00000220506 RPF2 ENSG00000255389 FCF1P5 CNN2P9 BRD7P4
GH06J110817 Enhancer 0.4 ENCODE 600.7 -1.3 -1312 0.2 ZNF316 MAFK ZNF362 CDK19 lnc-CDK19-4 AMD1 RF00017-5734 GTF3C6
GH06J110873 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19 -60.1 -60070 7.2 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 LEF1 AMD1 lnc-CDK19-5 MFSD4B ENSG00000220506 BRD7P4 FCF1P5 RPF2 CDK19 CNN2P9 GTF3C6
GH06J110681 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.8 +134.1 134130 2.4 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 RFX1 ZNF143 PRDM1 PKNOX1 CDK19 AMD1 GTF3C6 RNU6-957P RPF2 CNN2P9 RF00994-942 RPS20P18 lnc-CDK19-4 SLC22A16
GH06J110780 Enhancer 0.7 Ensembl 22 +34.7 34731 1.6 ZNF629 ZNF600 ZBTB44 ZXDB RUNX3 OSR2 WT1 ZFHX2 ZNF335 EBF1 CDK19 RNU6-957P GTF3C6 RPF2 AMD1 piR-57135-054 lnc-CDK19-4 RF00004-110 SLC22A16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK19

Genomic Locations for CDK19 Gene

Genomic Locations for CDK19 Gene
chr6:110,609,978-110,816,531
(GRCh38/hg38)
Size:
206,554 bases
Orientation:
Minus strand
chr6:110,931,181-111,137,161
(GRCh37/hg19)
Size:
205,981 bases
Orientation:
Minus strand

Genomic View for CDK19 Gene

Genes around CDK19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK19 Gene

Proteins for CDK19 Gene

  • Protein details for CDK19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWU1-CDK19_HUMAN
    Recommended name:
    Cyclin-dependent kinase 19
    Protein Accession:
    Q9BWU1
    Secondary Accessions:
    • Q5JQZ7
    • Q5JR00
    • Q8TC78
    • Q9UPX2

    Protein attributes for CDK19 Gene

    Size:
    502 amino acids
    Molecular mass:
    56802 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH24247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK19 Gene

Selected DME Specific Peptides for CDK19 Gene

Q9BWU1:
  • VLHRDLK
  • YRAPELLL

Post-translational modifications for CDK19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK19 Gene

Gene Families for CDK19 Gene

Protein Domains for CDK19 Gene

Suggested Antigen Peptide Sequences for CDK19 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (B4DUB1_HUMAN)
  • Death-preventing kinase (CDK19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BWU1

UniProtKB/Swiss-Prot:

CDK19_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK19: view

Function for CDK19 Gene

Molecular function for CDK19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.

Enzyme Numbers (IUBMB) for CDK19 Gene

Phenotypes From GWAS Catalog for CDK19 Gene

Gene Ontology (GO) - Molecular Function for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK19: view
genes like me logo Genes that share phenotypes with CDK19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK19

CRISPR Products

miRNA for CDK19 Gene

miRTarBase miRNAs that target CDK19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK19

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK19 Gene

Localization for CDK19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK19 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0016592 mediator complex IBA 21873635
genes like me logo Genes that share ontologies with CDK19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK19 Gene

Pathways & Interactions for CDK19 Gene

genes like me logo Genes that share pathways with CDK19: view

Pathways by source for CDK19 Gene

1 Qiagen pathway for CDK19 Gene
  • Cell Cycle Control of Chromosomal Replication
1 GeneTex pathway for CDK19 Gene

SIGNOR curated interactions for CDK19 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0050729 positive regulation of inflammatory response IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK19: view

Drugs & Compounds for CDK19 Gene

(9) Drugs for CDK19 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
AT7519 Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0

(1) Additional Compounds for CDK19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(8) ApexBio Compounds for CDK19 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK19: view

Drug Products

Transcripts for CDK19 Gene

mRNA/cDNA for CDK19 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK19

Alternative Splicing Database (ASD) splice patterns (SP) for CDK19 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3:

Relevant External Links for CDK19 Gene

GeneLoc Exon Structure for
CDK19

Expression for CDK19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK19 Gene

This gene is overexpressed in Adrenal (38.9), Peripheral blood mononuclear cells (12.2), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK19 Gene



Protein tissue co-expression partners for CDK19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK19

SOURCE GeneReport for Unigene cluster for CDK19 Gene:

Hs.744895

Evidence on tissue expression from TISSUES for CDK19 Gene

  • Nervous system(4.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CDK19: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK19 Gene

Orthologs for CDK19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK19 30 31
  • 99.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CDK19 30 31
  • 94.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CDK19 30 31
  • 92.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK19 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDK19 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk19 30
  • 90.82 (n)
Mouse
(Mus musculus)
Mammalia Cdk19 30 17 31
  • 90.35 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CDK19 30 31
  • 85.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK19 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdk19 30
  • 81.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdk-8-prov 30
Zebrafish
(Danio rerio)
Actinopterygii cdk19 30 31
  • 74.91 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Cdk8 31
  • 72 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cdk-8 31
  • 44 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN3 31
  • 29 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CDKE;1 30
  • 51.98 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0580300 30
  • 54.77 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.6555 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 81 (a)
OneToMany
Species where no ortholog for CDK19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK19 Gene

ENSEMBL:
Gene Tree for CDK19 (if available)
TreeFam:
Gene Tree for CDK19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK19: view image

Paralogs for CDK19 Gene

(50) SIMAP similar genes for CDK19 Gene using alignment to 5 proteins:

  • CDK19_HUMAN
  • B4DUB1_HUMAN
  • H0YDW9_HUMAN
  • I6W807_HUMAN
  • Q5JQZ9_HUMAN
genes like me logo Genes that share paralogs with CDK19: view

Variants for CDK19 Gene

Additional dbSNP identifiers (rs#s) for CDK19 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK19 Gene

Variant ID Type Subtype PubMed ID
esv2670731 CNV deletion 23128226
esv2672817 CNV deletion 23128226
esv2732571 CNV deletion 23290073
esv3378392 CNV insertion 20981092
esv3540312 CNV deletion 23714750
esv3610364 CNV loss 21293372
esv3610365 CNV loss 21293372
nsv1032572 CNV gain 25217958
nsv516177 CNV loss 19592680
nsv823823 CNV loss 20364138
nsv830770 CNV loss 17160897
nsv830772 CNV gain 17160897
nsv830773 CNV loss 17160897
nsv965750 CNV duplication 23825009

Variation tolerance for CDK19 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK19 Gene

Disorders for CDK19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
opitz-kaveggia syndrome
  • oks
- elite association - COSMIC cancer census association via MalaCards
Search CDK19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDK19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CDK19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK19 Gene

Publications for CDK19 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for CDK19 Gene

Sources for CDK19 Gene