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This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
CDK19 (Cyclin Dependent Kinase 19) is a Protein Coding gene. Diseases associated with CDK19 include Opitz-Kaveggia Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0016592 | mediator complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Metabolism |
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3 | Cell Cycle Control of Chromosomal Replication |
Cell Cycle Control of Chromosomal Replication
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4 | Developmental Biology |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0043065 | positive regulation of apoptotic process | IEA | -- |
GO:0050729 | positive regulation of inflammatory response | IEA | -- |
GO:0051726 | regulation of cell cycle | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
AT7519 | Pharma | Multi-CDK inhibitor | 0 | |||
Kenpaullone | Pharma | 0 | ||||
ML167 | Pharma | Clk4 inhibitor,highly selective | 0 | |||
Nu 6027 | Pharma | ATR/CDK inhibitor, potent and selective | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
AT7519 | Multi-CDK inhibitor | 844442-38-2 |
Kenpaullone | 142273-20-9 | |
ML167 | Clk4 inhibitor,highly selective | 1285702-20-6 |
Nu 6027 | ATR/CDK inhibitor, potent and selective | 220036-08-8 |
PHA-848125 | CDK inhibitor,potent and ATP-competitive | 802539-81-7 |
Purvalanol B | CDK1/CDK2/CDK4 inhibitor | 212844-54-7 |
R547 | CDK1/2/4 inhibitor,ATP-competitive | 741713-40-6 |
Ro 3306 | An ATP-competitive, potent CDK1 inhibitor | 872573-93-8 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDK19 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDK19 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK19 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk19 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cdk19 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CDK19 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK19 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk19 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | cdk-8-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cdk19 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Cdk8 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cdk-8 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSN3 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CDKE;1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0580300 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.6555 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2670731 | CNV | deletion | 23128226 |
esv2672817 | CNV | deletion | 23128226 |
esv2732571 | CNV | deletion | 23290073 |
esv3378392 | CNV | insertion | 20981092 |
esv3540312 | CNV | deletion | 23714750 |
esv3610364 | CNV | loss | 21293372 |
esv3610365 | CNV | loss | 21293372 |
nsv1032572 | CNV | gain | 25217958 |
nsv516177 | CNV | loss | 19592680 |
nsv823823 | CNV | loss | 20364138 |
nsv830770 | CNV | loss | 17160897 |
nsv830772 | CNV | gain | 17160897 |
nsv830773 | CNV | loss | 17160897 |
nsv965750 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
opitz-kaveggia syndrome |
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