CDK18 Gene (Protein Coding)

Cyclin Dependent Kinase 18

GC01P205504
GIFtS:
39

Aliases for CDK18 Gene

Aliases for CDK18 Gene

  • Cyclin Dependent Kinase 18 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-3 3 4
  • Cell Division Protein Kinase 18 3 4
  • PCTAIRE-Motif Protein Kinase 3 3 4
  • Cyclin-Dependent Kinase 18 3 4
  • PCTAIRE Protein Kinase 3 2 3
  • EC 2.7.11.22 4 54
  • PCTAIRE3 3 4
  • PCTK3 3 4
  • EC 2.7.11 54
  • PCTAIRE 3

External Ids for CDK18 Gene

Previous HGNC Symbols for CDK18 Gene

  • PCTK3

Previous GeneCards Identifiers for CDK18 Gene

  • GC01P203741
  • GC01P205474
  • GC01P176639

Summaries for CDK18 Gene

GeneCards Summary for CDK18 Gene

CDK18 (Cyclin Dependent Kinase 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.

UniProtKB/Swiss-Prot Summary for CDK18 Gene

  • May play a role in signal transduction cascades in terminally differentiated cells.

Gene Wiki entry for CDK18 Gene

Additional gene information for CDK18 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK18 Gene

Genomics for CDK18 Gene

GeneHancer (GH) Regulatory Elements for CDK18 Gene

Promoters and enhancers for CDK18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK18 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDK18 Gene

Genomic Locations for CDK18 Gene
chr1:205,504,556-205,532,793
(GRCh38/hg38)
Size:
28,238 bases
Orientation:
Plus strand
chr1:205,473,684-205,501,921
(GRCh37/hg19)
Size:
28,238 bases
Orientation:
Plus strand

Genomic View for CDK18 Gene

Genes around CDK18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK18 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK18 Gene

Proteins for CDK18 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07002-CDK18_HUMAN
    Recommended name:
    Cyclin-dependent kinase 18
    Protein Accession:
    Q07002
    Secondary Accessions:
    • Q5VXQ2
    • Q6V3A2
    • Q6V3A3
    • Q96F90

    Protein attributes for CDK18 Gene

    Size:
    474 amino acids
    Molecular mass:
    54424 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDK18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK18 Gene

Protein Expression for CDK18 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CDK18 Gene

Q07002:
  • PQPLINHAPRLD
  • ILHRDLK
  • DLKQYLD
  • IFRLLGTP
  • GELKLADFGLA
  • DFGLARA
  • LKHANIV
  • LRGLAYCH
  • SIFSLKEIQLQKDPG
  • IGFGKLETY
  • VVTLWYR
  • LADFGLA
  • KLGEGTYATV
  • GRPLFPGS
  • TYSNEVVTLWYRPPDVLLGSTEYST
  • GRPLFPG
  • LGTPTEE
  • HRDLKPQN
  • PDVLLGS

Post-translational modifications for CDK18 Gene

  • Ubiquitination at Lys146
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CDK18 Gene

Gene Families for CDK18 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDK18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK18 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ44931 fis, clone BRAMY3015799, highly similar to Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (B3KX76_HUMAN)
  • Serine/threonine-protein kinase PCTAIRE-3 (CDK18_HUMAN)
  • PCTAIRE protein kinase 3 (Q5VXQ3_HUMAN)
  • PCTAIRE protein kinase 3 (Q5VXQ4_HUMAN)
  • PCTAIRE protein kinase 3 (Q5VXQ5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07002

UniProtKB/Swiss-Prot:

CDK18_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK18: view

Function for CDK18 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CDK18 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signal transduction cascades in terminally differentiated cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.

Enzyme Numbers (IUBMB) for CDK18 Gene

Phenotypes From GWAS Catalog for CDK18 Gene

Gene Ontology (GO) - Molecular Function for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK18: view
genes like me logo Genes that share phenotypes with CDK18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK18

CRISPR Products

Clone Products

  • Addgene plasmids for CDK18

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK18 Gene

Localization for CDK18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK18 gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CDK18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK18 Gene

Pathways & Interactions for CDK18 Gene

PathCards logo

SuperPathways for CDK18 Gene

No Data Available

Pathways by source for CDK18 Gene

1 GeneTex pathway for CDK18 Gene

Gene Ontology (GO) - Biological Process for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA 21873635
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK18: view

No data available for SIGNOR curated interactions for CDK18 Gene

Drugs & Compounds for CDK18 Gene

Products:

  1. Drug

(1) Drugs for CDK18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDK18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDK18: view

Transcripts for CDK18 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDK18 Gene

(3) REFSEQ mRNAs :
(23) Additional mRNA sequences :
(195) Selected AceView cDNA sequences:
(23) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CDK18

Alternative Splicing Database (ASD) splice patterns (SP) for CDK18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14: - -
SP15:
SP16: -
SP17:
SP18: - - - - - - -
SP19: - -

ExUns: 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: -
SP10: - -
SP11:
SP12: - -
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for CDK18 Gene

GeneLoc Exon Structure for
CDK18
ECgene alternative splicing isoforms for
CDK18

Expression for CDK18 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK18 Gene

mRNA expression in normal human tissues for CDK18 Gene
mRNA expression by GTEx for CDK18 GenemRNA expression by BioGPS for CDK18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.6) and Brain - Substantia nigra (x6.2).

Protein differential expression in normal tissues from HIPED for CDK18 Gene

This gene is overexpressed in Spinal cord (31.7), Frontal cortex (13.7), and Retina (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK18 Gene



Protein tissue co-expression partners for CDK18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK18 Gene:

CDK18

SOURCE GeneReport for Unigene cluster for CDK18 Gene:

Hs.445402

mRNA Expression by UniProt/SwissProt for CDK18 Gene:

Q07002-CDK18_HUMAN
Tissue specificity: Isoform 2 expression is limited to several subcortical nuclei of the basal gangli and the spinal cord. Isoform 1 is widely expressed.

Evidence on tissue expression from TISSUES for CDK18 Gene

  • Nervous system(4.9)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CDK18: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK18 Gene

Orthologs for CDK18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK18 32
  • 94.87 (n)
cow
(Bos Taurus)
 Mammalia PCTK3 33
  • 93 (a)
 OneToOne
CDK18 32
  • 91.15 (n)
mouse
(Mus musculus)
 Mammalia Cdk18 17 33 32
  • 89.06 (n)
rat
(Rattus norvegicus)
 Mammalia Cdk18 32
  • 88.62 (n)
dog
(Canis familiaris)
 Mammalia CDK18 33 32
  • 88.31 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CDK18 33
  • 85 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CDK18 33
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CDK18 33
  • 84 (a)
 OneToOne
PCTK3 32
  • 79.42 (n)
lizard
(Anolis carolinensis)
 Reptilia CDK18 33
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cdk18 32
  • 69.65 (n)
zebrafish
(Danio rerio)
 Actinopterygii CDK18 33
  • 80 (a)
 OneToOne
LOC100150007 32
  • 72.47 (n)
worm
(Caenorhabditis elegans)
 Secernentea pct-1 33
  • 37 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PHO85 33
  • 50 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10414 33
  • 56 (a)
 OneToMany
Species where no ortholog for CDK18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK18 Gene

ENSEMBL:
Gene Tree for CDK18 (if available)
TreeFam:
Gene Tree for CDK18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK18: view image

Paralogs for CDK18 Gene

Paralogs for CDK18 Gene

(44) SIMAP similar genes for CDK18 Gene using alignment to 6 proteins:

  • CDK18_HUMAN
  • D6R9B0_HUMAN
  • D6R9X1_HUMAN
  • D6RA44_HUMAN
  • D6RGH0_HUMAN
  • E9PMF2_HUMAN
genes like me logo Genes that share paralogs with CDK18: view

Variants for CDK18 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CDK18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000039710 -- 205,524,035(+) C/T intron_variant
rs1000137140 -- 205,531,460(+) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000403035 -- 205,516,207(+) C/T intron_variant
rs1000424825 -- 205,509,288(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000472479 -- 205,504,585(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK18 Gene

Variant ID Type Subtype PubMed ID
esv2657432 CNV deletion 23128226
esv3588637 CNV loss 21293372
nsv468027 CNV loss 19166990
nsv509602 CNV insertion 20534489
nsv549043 CNV loss 21841781
nsv820091 CNV gain 19587683

Variation tolerance for CDK18 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK18

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK18 Gene

Disorders for CDK18 Gene

Additional Disease Information for CDK18

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDK18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK18 Gene

Publications for CDK18 Gene

  1. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. (PMID: 15019984) Herskovits AZ … Davies P (Gene 2004) 3 4 56
  5. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PMID: 8088790) Okuda T … Downing JR (Genomics 1994) 3 23 56

ExternalLinks

View latest publications for CDK18 gene in Mastermind

Products for CDK18 Gene

  • Addgene plasmids for CDK18

Sources for CDK18 Gene