The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010] See more...

Aliases for CDK17 Gene

Aliases for CDK17 Gene

  • Cyclin Dependent Kinase 17 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-2 3 4
  • Cell Division Protein Kinase 17 3 4
  • PCTAIRE-Motif Protein Kinase 2 3 4
  • Cyclin-Dependent Kinase 17 3 4
  • EC 2.7.11.22 4 54
  • PCTAIRE2 3 4
  • PCTK2 3 4
  • Protein Kinase Cdc2-Related PCTAIRE-2 3
  • PCTAIRE Protein Kinase 2 2
  • EC 2.7.11 54

External Ids for CDK17 Gene

Previous HGNC Symbols for CDK17 Gene

  • PCTK2

Previous GeneCards Identifiers for CDK17 Gene

  • GC12M095196
  • GC12M096673
  • GC12M093733

Summaries for CDK17 Gene

Entrez Gene Summary for CDK17 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

GeneCards Summary for CDK17 Gene

CDK17 (Cyclin Dependent Kinase 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK16.

UniProtKB/Swiss-Prot Summary for CDK17 Gene

  • May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Gene Wiki entry for CDK17 Gene

Additional gene information for CDK17 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK17 Gene

Genomics for CDK17 Gene

GeneHancer (GH) Regulatory Elements for CDK17 Gene

Promoters and enhancers for CDK17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK17 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDK17 Gene

Genomic Locations for CDK17 Gene
chr12:96,278,261-96,400,588
(GRCh38/hg38)
Size:
122,328 bases
Orientation:
Minus strand
chr12:96,672,039-96,794,366
(GRCh37/hg19)
Size:
122,328 bases
Orientation:
Minus strand

Genomic View for CDK17 Gene

Genes around CDK17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK17 Gene

Proteins for CDK17 Gene

  • Protein details for CDK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00537-CDK17_HUMAN
    Recommended name:
    Cyclin-dependent kinase 17
    Protein Accession:
    Q00537
    Secondary Accessions:
    • A8K1U6
    • B2RCQ2
    • Q8NEB8

    Protein attributes for CDK17 Gene

    Size:
    523 amino acids
    Molecular mass:
    59582 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).

    Alternative splice isoforms for CDK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK17 Gene

Selected DME Specific Peptides for CDK17 Gene

Q00537:
  • PQPLINHAPRLD
  • LEKLGEG
  • IFRLLGTP
  • GELKLADFGLA
  • DFGLARA
  • LKHANIV
  • LRGLAYCH
  • SIFSLKEIQLQKDPG
  • VVTLWYR
  • LADFGLA
  • KLGEGTYATV
  • VLHRDLK
  • GRPLFPGS
  • GRPLFPG
  • HRDLKPQN
  • FKRRLSL
  • PDVLLGS
  • SMEDLNKRLSLP

Post-translational modifications for CDK17 Gene

  • Ubiquitination at Lys452 and Lys493
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK17 Gene

Gene Families for CDK17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDK17 Gene

Suggested Antigen Peptide Sequences for CDK17 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75213 (A8K1U6_HUMAN)
  • Serine/threonine-protein kinase PCTAIRE-2 (CDK17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00537

UniProtKB/Swiss-Prot:

CDK17_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK17: view

Function for CDK17 Gene

Molecular function for CDK17 Gene

UniProtKB/Swiss-Prot Function:
May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.

Enzyme Numbers (IUBMB) for CDK17 Gene

Phenotypes From GWAS Catalog for CDK17 Gene

Gene Ontology (GO) - Molecular Function for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA 1639063
GO:0004674 protein serine/threonine kinase activity IBA,IEA 21873635
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK17: view
genes like me logo Genes that share phenotypes with CDK17: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CDK17

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK17 Gene

Localization for CDK17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK17 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CDK17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK17 Gene

Pathways & Interactions for CDK17 Gene

PathCards logo

SuperPathways for CDK17 Gene

No Data Available

Pathways by source for CDK17 Gene

1 GeneTex pathway for CDK17 Gene

Gene Ontology (GO) - Biological Process for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK17: view

No data available for SIGNOR curated interactions for CDK17 Gene

Drugs & Compounds for CDK17 Gene

(2) Drugs for CDK17 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDK17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDK17: view

Transcripts for CDK17 Gene

mRNA/cDNA for CDK17 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CDK17

Alternative Splicing Database (ASD) splice patterns (SP) for CDK17 Gene

No ASD Table

Relevant External Links for CDK17 Gene

GeneLoc Exon Structure for
CDK17
ECgene alternative splicing isoforms for
CDK17

Expression for CDK17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK17 Gene

Protein differential expression in normal tissues from HIPED for CDK17 Gene

This gene is overexpressed in Urine (36.2), Amniocyte (9.4), and Placenta (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK17 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDK17 Gene:

CDK17

SOURCE GeneReport for Unigene cluster for CDK17 Gene:

Hs.506415

Evidence on tissue expression from TISSUES for CDK17 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CDK17: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK17 Gene

Orthologs for CDK17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK17 33 32
  • 99.62 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK17 33
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK17 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK17 33 32
  • 95.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDK17 33 32
  • 94.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk17 17 33 32
  • 90.57 (n)
rat
(Rattus norvegicus)
Mammalia Cdk17 32
  • 90.57 (n)
chicken
(Gallus gallus)
Aves CDK17 33 32
  • 84.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK17 33
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk17 32
  • 79.66 (n)
Str.17214 32
zebrafish
(Danio rerio)
Actinopterygii cdk16 33
  • 91 (a)
OneToOne
LOC798487 32
  • 75.08 (n)
Dr.26649 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10983 32
worm
(Caenorhabditis elegans)
Secernentea pct-1 33 32
  • 58.21 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 33
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 33
  • 61 (a)
OneToMany
Species where no ortholog for CDK17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK17 Gene

ENSEMBL:
Gene Tree for CDK17 (if available)
TreeFam:
Gene Tree for CDK17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK17: view image

Paralogs for CDK17 Gene

genes like me logo Genes that share paralogs with CDK17: view

Variants for CDK17 Gene

Sequence variations from dbSNP and Humsavar for CDK17 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000033130 -- 96,305,081(-) C/A/T intron_variant
rs1000049339 -- 96,347,182(-) G/C intron_variant
rs1000051447 -- 96,328,351(-) G/A intron_variant
rs1000081841 -- 96,328,673(-) C/G intron_variant
rs1000121856 -- 96,369,146(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK17 Gene

Variant ID Type Subtype PubMed ID
esv2676742 CNV deletion 23128226
esv3424108 CNV insertion 20981092
esv3630450 CNV loss 21293372
nsv1035411 CNV gain 25217958
nsv1149335 CNV duplication 26484159
nsv53730 CNV insertion 16902084
nsv7234 OTHER inversion 18451855
nsv836 CNV insertion 18451855
nsv983492 CNV duplication 23825009

Variation tolerance for CDK17 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK17 Gene

Disorders for CDK17 Gene

Additional Disease Information for CDK17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDK17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK17 Gene

Publications for CDK17 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 43 56
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. (PMID: 9370357) Hirose T … Okada M (European journal of biochemistry 1997) 2 3 56
  5. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M … Tsai LH (The EMBO journal 1992) 3 4 56

Products for CDK17 Gene

Sources for CDK17 Gene