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The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
CDK17 (Cyclin Dependent Kinase 17) is a Protein Coding gene. Diseases associated with CDK17 include Corneal Dystrophy, Posterior Amorphous. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK16.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA,TAS | 1639063 |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 15161933 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | IBA | 21873635 |
GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0051726 | regulation of cell cycle | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CDK17 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CDK17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CDK17 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CDK17 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cdk17 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cdk17 30 |
|
||
Chicken (Gallus gallus) |
Aves | CDK17 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CDK17 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk17 30 |
|
||
Str.17214 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | cdk16 31 |
|
OneToOne | |
LOC798487 30 |
|
||||
Dr.26649 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10983 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | pct-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PHO85 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10414 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs141560239 | Benign: not provided | 96,297,725(-) |
C/T NM_002595.5(CDK17):c.716-4G>A |
INTRON | |
rs764448325 | - |
p.Thr214Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676742 | CNV | deletion | 23128226 |
esv3424108 | CNV | insertion | 20981092 |
esv3630450 | CNV | loss | 21293372 |
nsv1035411 | CNV | gain | 25217958 |
nsv1149335 | CNV | duplication | 26484159 |
nsv53730 | CNV | insertion | 16902084 |
nsv7234 | OTHER | inversion | 18451855 |
nsv836 | CNV | insertion | 18451855 |
nsv983492 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
corneal dystrophy, posterior amorphous |
|
|