The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript v... See more...

Aliases for CDK16 Gene

Aliases for CDK16 Gene

  • Cyclin Dependent Kinase 16 2 3 5
  • PCTAIRE1 2 3 4
  • Serine/Threonine-Protein Kinase PCTAIRE-1 3 4
  • Cell Division Protein Kinase 16 3 4
  • PCTAIRE-Motif Protein Kinase 1 3 4
  • Cyclin-Dependent Kinase 16 3 4
  • EC 2.7.11.22 4 51
  • PCTGAIRE 2 3
  • PCTAIRE 2 3
  • PCTK1 3 4
  • Testis Secretory Sperm-Binding Protein Li 224n 3
  • Serine/Threonine-Protein Kinase 2
  • PCTAIRE Protein Kinase 1 2
  • EC 2.7.11 51
  • FLJ16665 2
  • CDK16 5

External Ids for CDK16 Gene

Previous HGNC Symbols for CDK16 Gene

  • PCTK1

Previous GeneCards Identifiers for CDK16 Gene

  • GC0XP046963
  • GC0XP047078
  • GC0XP044787
  • GC0XP047079

Summaries for CDK16 Gene

Entrez Gene Summary for CDK16 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK16 Gene

CDK16 (Cyclin Dependent Kinase 16) is a Protein Coding gene. Diseases associated with CDK16 include Microcephaly. Among its related pathways are Signal transduction_PKA signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.

UniProtKB/Swiss-Prot Summary for CDK16 Gene

  • Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Gene Wiki entry for CDK16 Gene

Additional gene information for CDK16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK16 Gene

Genomics for CDK16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CDK16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ047216 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.7 744 5.2 SP1 CREB1 HNRNPL ATF7 ZNF629 PRDM10 REST SIX5 IKZF1 ZNF692 CDK16 LOC105373194 ENSG00000224072 ZNF182 LINC01560 ZNF674-AS1 ZNF81 RBM10 INE1 USP11
GH0XJ047190 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.9 -23.7 -23744 9 SP1 CTCF ATF7 TEAD4 PRDM10 ZNF629 SIX5 NFKBIZ KDM1A ZNF692 UBA1 INE1 CDK16 USP11 ZNF182 ZNF81 ENSG00000224072 RNU6-1189P RF00017-8387
GH0XJ047523 Promoter/Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.2 +305.8 305800 0.9 CTCF ZNF692 ZNF143 ZIC2 POLR2A PATZ1 REST RAD21 ZNF501 TRIM22 ZNF41 LINC01560 CDK16 USP11 ELK1 CFP SYN1 SPACA5 NUS1P1 lnc-SYN1-2
GH0XJ046836 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 2.7 -378.9 -378936 5.4 SP1 CREB1 PRDM10 ZNF629 RFX1 BACH1 FOS PRDM1 DDX20 RBFOX2 RP2 CDK16 ZNF674 CHST7 RF00017-8381 JADE3
GH0XJ047306 Enhancer 0.3 Ensembl 13.4 +88.7 88741 0.4 ATF2 USP11 CDK16 SNORA11C ENSG00000232009 piR-48759-325 ENSG00000203402 ZNF157 RF00017-8387
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK16

Genomic Locations for CDK16 Gene

Genomic Locations for CDK16 Gene
chrX:47,217,860-47,229,997
(GRCh38/hg38)
Size:
12,138 bases
Orientation:
Plus strand
chrX:47,077,259-47,089,396
(GRCh37/hg19)
Size:
12,138 bases
Orientation:
Plus strand

Genomic View for CDK16 Gene

Genes around CDK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK16 Gene

Proteins for CDK16 Gene

  • Protein details for CDK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00536-CDK16_HUMAN
    Recommended name:
    Cyclin-dependent kinase 16
    Protein Accession:
    Q00536
    Secondary Accessions:
    • A8K280
    • B7Z7C8
    • J3KN74
    • J3KQP7

    Protein attributes for CDK16 Gene

    Size:
    496 amino acids
    Molecular mass:
    55716 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
    SequenceCaution:
    • Sequence=AAH01048.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH15607.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK16 Gene

    Alternative splice isoforms for CDK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK16 Gene

Selected DME Specific Peptides for CDK16 Gene

Q00536:
  • DLKQYLD
  • GELKLADFGLA
  • DFGLARA
  • FLFQLLRGL
  • LKHANIV
  • LRGLAYCH
  • IGFGKLETY
  • VVTLWYR
  • LADFGLA
  • KLGEGTYATV
  • VLHRDLK
  • GRPLFPGS
  • GRPLFPG
  • LGTPTEE
  • HRDLKPQN
  • NVKLFLFQLLRGL

Post-translational modifications for CDK16 Gene

  • Phosphorylation at Ser-153 inhibits kinase activity.
  • Ubiquitination at Lys133, Lys143, Lys167, Lys194, Lys455, and Lys466
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK16 Gene

Gene Families for CDK16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CDK16 Gene

Suggested Antigen Peptide Sequences for CDK16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56198, highly similar to Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (B7Z8T0_HUMAN)
  • Serine/threonine-protein kinase PCTAIRE-1 (CDK16_HUMAN)
  • PCTK1 protein (Q96GA5_HUMAN)
  • PCTK1 protein (Q9BRL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00536

UniProtKB/Swiss-Prot:

CDK16_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK16: view

Function for CDK16 Gene

Molecular function for CDK16 Gene

UniProtKB/Swiss-Prot Function:
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068};.

Enzyme Numbers (IUBMB) for CDK16 Gene

Gene Ontology (GO) - Molecular Function for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 22184064
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 16091426
genes like me logo Genes that share ontologies with CDK16: view
genes like me logo Genes that share phenotypes with CDK16: view

Animal Models for CDK16 Gene

MGI Knock Outs for CDK16:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK16

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK16

Clone Products

  • Addgene plasmids for CDK16

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK16 Gene

Localization for CDK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK16 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK16 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Microtubules (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 22798068
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0008021 colocalizes_with synaptic vesicle IEA,ISS --
genes like me logo Genes that share ontologies with CDK16: view

Pathways & Interactions for CDK16 Gene

PathCards logo

SuperPathways for CDK16 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.71
2 DNA Damage
3 Signal transduction_PKA signaling
-
genes like me logo Genes that share pathways with CDK16: view

Pathways by source for CDK16 Gene

1 GeneGo (Thomson Reuters) pathway for CDK16 Gene
  • Signal transduction_PKA signaling
2 Qiagen pathways for CDK16 Gene
  • Activation of PKA through GPCR
  • cAMP Pathway
1 Cell Signaling Technology pathway for CDK16 Gene
1 GeneTex pathway for CDK16 Gene

SIGNOR curated interactions for CDK16 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IBA 21873635
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0006887 exocytosis IEA,ISS --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CDK16: view

Drugs & Compounds for CDK16 Gene

(2) Drugs for CDK16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Experimental Pharma Target 0
genes like me logo Genes that share compounds with CDK16: view

Transcripts for CDK16 Gene

mRNA/cDNA for CDK16 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK16

Clone Products

  • Addgene plasmids for CDK16

Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19:
SP20:
SP21: - - - - - -

ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK16 Gene

GeneLoc Exon Structure for
CDK16

Expression for CDK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK16 Gene

Protein differential expression in normal tissues from HIPED for CDK16 Gene

This gene is overexpressed in Plasma (20.4), Testis (15.1), Fetal Brain (12.1), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK16 Gene



Protein tissue co-expression partners for CDK16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK16

SOURCE GeneReport for Unigene cluster for CDK16 Gene:

Hs.496068

mRNA Expression by UniProt/SwissProt for CDK16 Gene:

Q00536-CDK16_HUMAN
Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas.

Evidence on tissue expression from TISSUES for CDK16 Gene

  • Nervous system(5)
  • Muscle(3.3)
  • Lung(3.1)
  • Skin(2.9)
  • Kidney(2.6)
  • Intestine(2.3)
  • Heart(2.2)
  • Adrenal gland(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with CDK16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK16 Gene

Orthologs for CDK16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CDK16 30 31
  • 99.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PCTK1 31
  • 98 (a)
OneToOne
CDK16 30
  • 94.89 (n)
Mouse
(Mus musculus)
Mammalia Cdk16 30 17 31
  • 91.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cdk16 30
  • 91.6 (n)
Dog
(Canis familiaris)
Mammalia CDK16 30 31
  • 91.11 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CDK16 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CDK16 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CDK16 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cdk16 30
  • 76.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21411 30
Zebrafish
(Danio rerio)
Actinopterygii cdk16 30 31
  • 71.99 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea pct-1 31
  • 39 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 31
  • 51 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10414 31
  • 58 (a)
OneToMany
Species where no ortholog for CDK16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CDK16 Gene

ENSEMBL:
Gene Tree for CDK16 (if available)
TreeFam:
Gene Tree for CDK16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK16: view image

Paralogs for CDK16 Gene

(61) SIMAP similar genes for CDK16 Gene using alignment to 11 proteins:

  • CDK16_HUMAN
  • E5RGN0_HUMAN
  • E5RGV7_HUMAN
  • E5RIU4_HUMAN
  • E5RIY8_HUMAN
  • E5RJM2_HUMAN
  • E5RJQ8_HUMAN
  • H0YAZ9_HUMAN
  • H0YBX5_HUMAN
  • H0YC36_HUMAN
  • H0YC60_HUMAN

Pseudogenes.org Pseudogenes for CDK16 Gene

genes like me logo Genes that share paralogs with CDK16: view

Variants for CDK16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK16 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
790236 Benign: not provided 47,224,750(+) A/T INTRON_VARIANT
rs1064795893 Uncertain Significance: not provided 47,226,693(+) A/T MISSENSE_VARIANT
rs145117961 Uncertain Significance: not provided 47,225,864(+) C/T SYNONYMOUS_VARIANT
rs1556799446 Uncertain Significance: not provided 47,227,385(+) G/A MISSENSE_VARIANT
rs17550472 Benign: not specified 47,223,273(+) C/T MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CDK16 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK16 Gene

Variant ID Type Subtype PubMed ID
nsv1077230 CNV deletion 25765185

Variation tolerance for CDK16 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK16 Gene

Human Gene Mutation Database (HGMD)
CDK16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK16 Gene

Disorders for CDK16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
microcephaly
  • microcephalus
- elite association - COSMIC cancer census association via MalaCards
Search CDK16 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CDK16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK16 Gene

Publications for CDK16 Gene

  1. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells. (PMID: 22798068) Chen XY … Yu L (The Journal of biological chemistry 2012) 3 4
  2. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. (PMID: 22184064) Mikolcevic P … Geley S (Molecular and cellular biology 2012) 3 4
  3. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. (PMID: 22796189) Shehata SN … Sakamoto K (Cellular signalling 2012) 3 4
  4. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for CDK16 Gene

Sources for CDK16 Gene