Aliases for CDK14 Gene
External Ids for CDK14 Gene
Previous HGNC Symbols for CDK14 Gene
Previous GeneCards Identifiers for CDK14 Gene
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CDK14 Gene
CDK14 (Cyclin Dependent Kinase 14) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15.
UniProtKB/Swiss-Prot Summary for CDK14 Gene
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.