Aliases for CDK12 Gene

Aliases for CDK12 Gene

  • Cyclin Dependent Kinase 12 2 3 5
  • Cdc2-Related Kinase, Arginine/Serine-Rich 2 3 4
  • Cell Division Cycle 2-Related Protein Kinase 7 3 4
  • Cell Division Protein Kinase 12 3 4
  • CDC2-Related Protein Kinase 7 3 4
  • Cyclin-Dependent Kinase 12 3 4
  • EC 2.7.11.22 4 52
  • CRKRS 3 4
  • CRK7 3 4
  • CDC2 Related Protein Kinase 7 2
  • EC 2.7.11.23 4
  • EC 2.7.11 52
  • KIAA0904 4
  • HCDK12 4
  • CrkRS 4
  • CRKR 3

External Ids for CDK12 Gene

Previous HGNC Symbols for CDK12 Gene

  • CRKRS

Previous GeneCards Identifiers for CDK12 Gene

  • GC17P034873
  • GC17P037618
  • GC17P033411

Summaries for CDK12 Gene

CIViC Summary for CDK12 Gene

GeneCards Summary for CDK12 Gene

CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Corneal Endothelial Dystrophy and Gastric Cancer. Among its related pathways are Gene Expression and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.

UniProtKB/Swiss-Prot Summary for CDK12 Gene

  • Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene Wiki entry for CDK12 Gene

Additional gene information for CDK12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK12 Gene

Genomics for CDK12 Gene

GeneHancer (GH) Regulatory Elements for CDK12 Gene

Promoters and enhancers for CDK12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK12

Genomic Locations for CDK12 Gene

Genomic Locations for CDK12 Gene
chr17:39,461,486-39,567,559
(GRCh38/hg38)
Size:
106,074 bases
Orientation:
Plus strand
chr17:37,617,739-37,721,160
(GRCh37/hg19)
Size:
103,422 bases
Orientation:
Plus strand

Genomic View for CDK12 Gene

Genes around CDK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK12 Gene

Proteins for CDK12 Gene

  • Protein details for CDK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV4-CDK12_HUMAN
    Recommended name:
    Cyclin-dependent kinase 12
    Protein Accession:
    Q9NYV4
    Secondary Accessions:
    • A7E2B2
    • B4DYX4
    • B9EIQ6
    • O94978

    Protein attributes for CDK12 Gene

    Size:
    1490 amino acids
    Molecular mass:
    164155 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.
    SequenceCaution:
    • Sequence=BAA74927.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK12 Gene

    Alternative splice isoforms for CDK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK12 Gene

Selected DME Specific Peptides for CDK12 Gene

Q9NYV4:
  • YCHKKNFLHRDIKCSNIL
  • CGSPCPAVWPDVIKLPYFNTMKPKKQYRR
  • NMKEIVTDK
  • ELAQLELISR
  • FLHRDIK
  • EKEGFPITAIREIKIL
  • NEKEGFPITAIREIKILRQL
  • LADFGLA
  • VITLWYRPPELLLG
  • IDVWSCGCILGELF
  • SRSRHSSISP
  • WQDCHELWSKKRRRQ
  • DLPLPPELPGGD
  • FYLVFEYMDHDLMGLLESG
  • RPYTNKVITLWYRPPELLLGEERY
  • IGEGTYG

Post-translational modifications for CDK12 Gene

Domains & Families for CDK12 Gene

Gene Families for CDK12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CDK12 Gene

Suggested Antigen Peptide Sequences for CDK12 Gene

GenScript: Design optimal peptide antigens:
  • Cell division protein kinase 12 (CDK12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYV4

UniProtKB/Swiss-Prot:

CDK12_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK12: view

Function for CDK12 Gene

Molecular function for CDK12 Gene

UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA-COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.

Enzyme Numbers (IUBMB) for CDK12 Gene

Phenotypes From GWAS Catalog for CDK12 Gene

Gene Ontology (GO) - Molecular Function for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 11683387
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0005515 protein binding IPI 12841360
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK12: view
genes like me logo Genes that share phenotypes with CDK12: view

Animal Models for CDK12 Gene

MGI Knock Outs for CDK12:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK12

Clone Products

  • Addgene plasmids for CDK12

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK12 Gene

Localization for CDK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK12 Gene

Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK12 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0000790 nuclear chromatin IBA 21873635
GO:0001650 fibrillar center IDA --
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with CDK12: view

Pathways & Interactions for CDK12 Gene

genes like me logo Genes that share pathways with CDK12: view

Pathways by source for CDK12 Gene

1 Cell Signaling Technology pathway for CDK12 Gene
1 GeneTex pathway for CDK12 Gene

SIGNOR curated interactions for CDK12 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0008380 RNA splicing ISS --
GO:0016310 phosphorylation IEA --
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IBA 21873635
genes like me logo Genes that share ontologies with CDK12: view

Drugs & Compounds for CDK12 Gene

(15) Drugs for CDK12 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzocaine Approved, Investigational Pharma 2900
Ipilimumab Approved Pharma Therapeutic Antibodies, Immunotherapies, Immunomodulatory agents 648
nivolumab Approved Pharma Therapeutic Antibodies, Immunotherapies 1080
Pembrolizumab Approved Pharma 1134
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 51

(1) Additional Compounds for CDK12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDK12: view

Transcripts for CDK12 Gene

mRNA/cDNA for CDK12 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK12

Clone Products

  • Addgene plasmids for CDK12

Alternative Splicing Database (ASD) splice patterns (SP) for CDK12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:

Relevant External Links for CDK12 Gene

GeneLoc Exon Structure for
CDK12

Expression for CDK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK12 Gene

Protein differential expression in normal tissues from HIPED for CDK12 Gene

This gene is overexpressed in Liver (24.0), Peripheral blood mononuclear cells (11.7), and Lung (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK12 Gene



Protein tissue co-expression partners for CDK12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK12

SOURCE GeneReport for Unigene cluster for CDK12 Gene:

Hs.416108

mRNA Expression by UniProt/SwissProt for CDK12 Gene:

Q9NYV4-CDK12_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for CDK12 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CDK12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK12 Gene

Orthologs for CDK12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK12 31 30
  • 98.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDK12 31 30
  • 93.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDK12 31 30
  • 91.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk12 30
  • 89.31 (n)
mouse
(Mus musculus)
Mammalia Cdk12 17 31 30
  • 88.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 87 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDK12 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK12 31 30
  • 74.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 76 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk12 30
  • 66.92 (n)
Str.18694 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15324 30
zebrafish
(Danio rerio)
Actinopterygii cdk12 31
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 31
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 31
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 31
  • 37 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.21132 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 31
  • 57 (a)
OneToMany
Species where no ortholog for CDK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK12 Gene

ENSEMBL:
Gene Tree for CDK12 (if available)
TreeFam:
Gene Tree for CDK12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK12: view image

Paralogs for CDK12 Gene

Variants for CDK12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK12 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1131692238 Likely Pathogenic: Lung adenocarcinoma 39,509,731(+) G/T MISSENSE_VARIANT
rs141353560 Not Provided: not specified 39,490,613(+) G/A MISSENSE_VARIANT
rs142347393 Not Provided: not specified 39,530,840(+) C/T MISSENSE_VARIANT
rs144501352 Not Provided: not specified 39,471,687(+) A/G MISSENSE_VARIANT
rs186043011 Not Provided: not specified 39,531,224(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CDK12 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDK12 Gene

Variant ID Type Subtype PubMed ID
dgv50n6 CNV deletion 16902084
esv1352810 CNV deletion 17803354
esv2263528 CNV deletion 18987734
esv2715901 CNV deletion 23290073
esv2715902 CNV deletion 23290073
esv2715903 CNV deletion 23290073
esv3554404 CNV deletion 23714750
nsv1063848 CNV gain 25217958
nsv1116009 CNV deletion 24896259
nsv1127568 CNV deletion 24896259
nsv1134648 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1147003 CNV deletion 26484159
nsv1152691 CNV deletion 26484159
nsv819586 CNV gain 19587683
nsv827985 CNV loss 20364138
nsv955421 CNV deletion 24416366