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Aliases for CDK12 Gene
Aliases for CDK12 Gene
External Ids for CDK12 Gene
- HGNC: 24224
- Entrez Gene: 51755
- Ensembl: ENSG00000167258
- OMIM: 615514
- UniProtKB: Q9NYV4
Previous HGNC Symbols for CDK12 Gene
- CRKRS
Previous GeneCards Identifiers for CDK12 Gene
- GC17P034873
- GC17P037618
- GC17P033411
Summaries for CDK12 Gene
GeneCards Summary for CDK12 Gene
CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Corneal Endothelial Dystrophy and Gastric Cancer. Among its related pathways are Gene Expression and HIV Transcription Elongation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.
UniProtKB/Swiss-Prot Summary for CDK12 Gene
-
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Additional gene information for CDK12 Gene
- HGNC(24224)
- Entrez Gene(51755)
- Ensembl(ENSG00000167258)
- OMIM(615514)
- UniProtKB(Q9NYV4)
- Open Targets Platform(ENSG00000167258)
- Search for CDK12 at DataMed
- Search for CDK12 at HumanCyc
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDK12 Gene
Genomics for CDK12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CDK12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CDK12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDK12
Genomic Locations for CDK12 Gene
Genomic Locations for CDK12 Gene
- chr17:39,461,486-39,567,560
- (GRCh38/hg38)
- Size:
- 106,075 bases
- Orientation:
- Plus strand
- chr17:37,617,739-37,721,160
- (GRCh37/hg19)
- Size:
- 103,422 bases
- Orientation:
- Plus strand
Genomic View for CDK12 Gene
Genes around CDK12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
CDK12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CDK12 Gene
Proteins for CDK12 Gene
-
Protein details for CDK12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYV4-CDK12_HUMAN
- Recommended name:
- Cyclin-dependent kinase 12
- Protein Accession:
- Q9NYV4
- A7E2B2
- B4DYX4
- B9EIQ6
- O94978
Protein attributes for CDK12 Gene
- Size:
- 1490 amino acids
- Molecular mass:
- 164155 Da
- Quaternary structure:
-
- Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.
- SequenceCaution:
-
- Sequence=BAA74927.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CDK12 Gene
Protein Expression for CDK12 Gene
Selected DME Specific Peptides for CDK12 Gene
- Q9NYV4:
-
- YCHKKNFLHRDIKCSNIL
- CGSPCPAVWPDVIKLPYFNTMKPKKQYRR
- NMKEIVTDK
- ELAQLELISR
- FLHRDIK
- EKEGFPITAIREIKIL
- NEKEGFPITAIREIKILRQL
- LADFGLA
- VITLWYRPPELLLG
- IDVWSCGCILGELF
- SRSRHSSISP
- WQDCHELWSKKRRRQ
- DLPLPPELPGGD
- FYLVFEYMDHDLMGLLESG
- RPYTNKVITLWYRPPELLLGEERY
- IGEGTYG
Post-translational modifications for CDK12 Gene
- Phosphorylation at Thr-893 increases kinase activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CDK12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005257513.1
- XP_005257515.1
- XP_011523194.1
- XP_011523195.1
- XP_011523196.1
- XP_011523197.1
- XP_011523198.1
- XP_011523199.1
- XP_011523200.1
- XP_011523201.1
- XP_011523202.1
- XP_011523203.1
- XP_011523204.1
- XP_011523205.1
- XP_011523207.1
- XP_011523208.1
- XP_011523209.1
- XP_016880236.1
- XP_016880237.1
- XP_016880238.1
- XP_016880239.1
- XP_016880240.1
- XP_016880241.1
- XP_016880242.1
- XP_024306569.1
- NP_055898.1
- NP_057591.2
Antibody Products
- LifeSpan BioSciences CDK12 / CRKRS Antibody
- G Biosciences Immunotag™ CD2L7 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CDK12
- Novus Biologicals Antibodies for CDK12
- Invitrogen Antibodies for CDK12 (AFLGC-CDK12)
-
Boster Bio Antibodies for CDK12
Protein Products
-
OriGene Purified Proteins for CDK12
- Search Origene for MassSpec and Protein Over-expression Lysates for CDK12
- Origene Custom Protein Services for CDK12
- Novus Biologicals proteins for CDK12
- antibodies-online: Show 4 available CRKRS Proteins ranked by validation data
- Compare Top CRKRS Proteins
-
Quality Products:
-
Signalway Proteins for CDK12
-
Abcam proteins for CDK12
Assay Products
- antibodies-online: Show 11 available CRKRS Elisa Kits ranked by validation data
- Compare Top CRKRS Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for CDK12
Domains & Families for CDK12 Gene
Gene Families for CDK12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for CDK12 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CDK12 Gene
- GenScript: Design optimal peptide antigens:
-
- Cell division protein kinase 12 (CDK12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NYV4UniProtKB/Swiss-Prot:
CDK12_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for CDK12 Gene
Molecular function for CDK12 Gene
- UniProtKB/Swiss-Prot Function:
- Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA-COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.23;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.
Enzyme Numbers (IUBMB) for CDK12 Gene
Phenotypes From GWAS Catalog for CDK12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA,IDA | 11683387 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 12841360 |
Phenotypes for CDK12 Gene
- MGI mutant phenotypes for CDK12:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CDK12:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- Decreased viability ratio
- Increased G1 DNA content
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased Nanog expression
- Decreased nuclei size in G2M
- Decreased viability
- Decreased Sindbis virus (SINV) infection
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased replication of vaccinia virus (VACV)
- Decreased POU5F1-GFP protein expression
- Decreased substrate adherent cell growth
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- G0/1 arrest
- Decreased cell viability after pRB stimulation
- Increased viability with 4OH tamoxifen
Animal Models for CDK12 Gene
- MGI Knock Outs for CDK12:
-
- Cdk12 Cdk12<tm1.2Mjfn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK12 - Select products 50% OFF >
- * CDK12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK12
miRNA for CDK12 Gene
- miRTarBase miRNAs that target CDK12
-
- hsa-miR-744-5p (MIRT037446)
- hsa-miR-503-5p (MIRT041108)
- hsa-miR-193b-3p (MIRT041547)
- hsa-miR-193a-3p (MIRT044886)
- hsa-miR-10b-5p (MIRT047459)
- mmu-miR-669j (MIRT584369)
- mmu-miR-669i (MIRT584370)
- mmu-miR-448-3p (MIRT584371)
- mmu-miR-466i-3p (MIRT584372)
- mmu-miR-362-3p (MIRT584373)
- mmu-miR-329-3p (MIRT584374)
- mmu-miR-669h-3p (MIRT584375)
- mmu-miR-669k-3p (MIRT584376)
- hsa-miR-4443 (MIRT624365)
- hsa-miR-6515-5p (MIRT624366)
- hsa-miR-9-5p (MIRT624367)
- hsa-miR-130b-5p (MIRT624368)
- hsa-miR-4762-5p (MIRT624369)
- hsa-miR-216b-5p (MIRT624370)
- hsa-miR-548t-3p (MIRT624371)
- hsa-miR-548ap-3p (MIRT624372)
- hsa-miR-548aa (MIRT624373)
- hsa-miR-4753-3p (MIRT638900)
- hsa-miR-6894-5p (MIRT659647)
- hsa-miR-765 (MIRT659648)
- hsa-miR-7154-3p (MIRT659649)
- hsa-miR-766-5p (MIRT659650)
- hsa-miR-3613-3p (MIRT765980)
- hsa-miR-3617-3p (MIRT766095)
- hsa-miR-4311 (MIRT768548)
- hsa-miR-4524a-3p (MIRT770001)
- hsa-miR-545-3p (MIRT774019)
- hsa-miR-548p (MIRT774471)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK12
- Browse OriGene Inhibitory RNA Products For CDK12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK12
Clone Products
- Applied Biological Materials (abm): Clones for CDK12 - Select products 50% OFF >
- * CDK12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG215624
- MG218603
- MG219170
- MR215624
- MR215624L3
- MR215624L4
- MR218603
- MR218603L3
- MR218603L4
- MR219170
- MR219170L3
- MR219170L4
- RC213898
- RC213898L1
- RC213898L2
- RC213898L3
- RC213898L4
- RC226399
- RC226399L1
- RC226399L2
- RC226399L3
- RC226399L4
- RG213898
- RG226399
- RR200174
- RR200175
- MR215624L3V
- MR215624L4V
- MR218603L3V
- MR218603L4V
- MR219170L3V
- MR219170L4V
- RC213898L1V
- RC213898L2V
- RC213898L3V
- RC213898L4V
- RC226399L1V
- RC226399L2V
- RC226399L3V
- RC226399L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDK12
- Addgene plasmids for CDK12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK12 Gene
Localization for CDK12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CDK12 Gene
- Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear speckles (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
| GO:0000790 | nuclear chromatin | IBA | 21873635 |
| GO:0002944 | cyclin K-CDK12 complex | IPI | 22012619 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CDK12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | DNA Damage | ||
| 3 | HIV Transcription Elongation | ||
| 4 | Regulation of TP53 Activity | ||
Pathways by source for CDK12 Gene
4 Reactome pathways for CDK12 Gene
1 Cell Signaling Technology pathway for CDK12 Gene
1 GeneTex pathway for CDK12 Gene
Interacting Proteins for CDK12 Gene
Selected Interacting proteins:
Q9NYV4-CDK12_HUMAN
ENSP00000398880
for CDK12 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CDK12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006368 | transcription elongation from RNA polymerase II promoter | IBA | 21873635 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,IBA | 21873635 |
| GO:0008380 | RNA splicing | ISS | -- |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for CDK12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Benzocaine | Approved, Investigational | Pharma | 3109 | |||
| Ipilimumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies, Immunomodulatory agents | 676 | ||
| nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 1165 | ||
| Pembrolizumab | Approved | Pharma | 1266 | |||
| Rucaparib | Approved, Investigational | Pharma | PARP inhibitor, PARP Inhibitors, Other | 57 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for CDK12 Gene
mRNA/cDNA for CDK12 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000447079 8287 nts (view in UCSC)
- ENST00000584632 4165 nts (view in UCSC)
- ENST00000430627 5918 nts (view in UCSC)
- ENST00000581593 559 nts (view in UCSC)
- ENST00000559663 871 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CDK12 - Select products 50% OFF >
- * CDK12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CDK12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CDK12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CDK12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CDK12
- Browse OriGene Inhibitory RNA Products For CDK12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK12
Clone Products
- Applied Biological Materials (abm): Clones for CDK12 - Select products 50% OFF >
- * CDK12 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG215624
- MG218603
- MG219170
- MR215624
- MR215624L3
- MR215624L4
- MR218603
- MR218603L3
- MR218603L4
- MR219170
- MR219170L3
- MR219170L4
- RC213898
- RC213898L1
- RC213898L2
- RC213898L3
- RC213898L4
- RC226399
- RC226399L1
- RC226399L2
- RC226399L3
- RC226399L4
- RG213898
- RG226399
- RR200174
- RR200175
- MR215624L3V
- MR215624L4V
- MR218603L3V
- MR218603L4V
- MR219170L3V
- MR219170L4V
- RC213898L1V
- RC213898L2V
- RC213898L3V
- RC213898L4V
- RC226399L1V
- RC226399L2V
- RC226399L3V
- RC226399L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CDK12
- Addgene plasmids for CDK12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CDK12
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: |
Relevant External Links for CDK12 Gene
- GeneLoc Exon Structure for
- CDK12
Expression for CDK12 Gene
This gene is overexpressed in Liver (24.0), Peripheral blood mononuclear cells (11.7), and Lung (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDK12 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDK12
SOURCE GeneReport for Unigene cluster for CDK12 Gene:
Hs.416108mRNA Expression by UniProt/SwissProt for CDK12 Gene:
Q9NYV4-CDK12_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for CDK12 Gene
- Nervous system(4.4)
- Liver(4.4)
- Skin(2.5)
- Intestine(2.4)
- Kidney(2.2)
- Lymph node(2.2)
- Blood(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for CDK12
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK12 Gene
Orthologs for CDK12 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CDK12 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CDK12 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CDK12 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cdk12 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cdk12 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CDK12 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CDK12 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cdk12 30 |
|
||
| Str.18694 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15324 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cdk12 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cdk12 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cdk-12 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTK1 31 |
|
OneToMany | |
| Wheat (Triticum aestivum) |
Liliopsida | Ta.21132 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10559 31 |
|
OneToMany |
- Species where no ortholog for CDK12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for CDK12 Gene
- ENSEMBL:
- Gene Tree for CDK12 (if available)
- TreeFam:
- Gene Tree for CDK12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CDK12: view image
Paralogs for CDK12 Gene
Paralogs for CDK12 Gene
(63) SIMAP similar genes for CDK12 Gene using alignment to 3 proteins:
- CDK12_HUMAN
- H0YLT2_HUMAN
- J3QSD7_HUMAN
- PHKG2
- CDKL2
- MAP4K2
- MAP4K5
- RPS6KA2
- CDC2
- CCRK
- TXK
- CDK10
- STK38L
- STK3
- CDK9
- CDK7
- ULK1
- STK11
- RPS6KA1
- DYRK4
- CDK1
- STK25
- NUAK1
- DKFZp686L20222
- CDK5
- CDK20
- BRSK2
- CDK4
- MAPK8
- CDK2
- MAPK7
- FGFR1
- CDK3
- MAPK3
- HUNK
- DKFZp686O0215
- CDK11B
- CDC2L1
- CDC2L2
- NEK9
- MAPK1
- DKFZp564L2416
- CDKL4
- CDK6
- CDK13
- MARK2
- MAPK14
- STK36
- MAK
- CDKL1
- CDK14
- MAPK13
- CDK19
- MAPK12
- CDK16
- PCTK1
- CDK17
- CDK15
- AURKB
- DAPK3
- CDK18
- ULK3
- MOK
- DKFZp686M02159
- PCTK3
- TYK2
Variants for CDK12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDK12 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1131692238 | Likely Pathogenic: Lung adenocarcinoma | 39,509,731(+) | G/T | MISSENSE_VARIANT | |
| rs141353560 | Not Provided: not specified | 39,490,613(+) | G/A | MISSENSE_VARIANT | |
| rs142347393 | Not Provided: not specified | 39,530,840(+) | C/T | MISSENSE_VARIANT | |
| rs144501352 | Not Provided: not specified | 39,471,687(+) | A/G | MISSENSE_VARIANT | |
| rs186043011 | Not Provided: not specified | 39,531,224(+) | G/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv50n6 | CNV | deletion | 16902084 |
| esv1352810 | CNV | deletion | 17803354 |
| esv2263528 | CNV | deletion | 18987734 |
| esv2715901 | CNV | deletion | 23290073 |
| esv2715902 | CNV | deletion | 23290073 |
| esv2715903 | CNV | deletion | 23290073 |
| esv3554404 | CNV | deletion | 23714750 |
| nsv1063848 | CNV | gain | 25217958 |
| nsv1116009 | CNV | deletion | 24896259 |
| nsv1127568 | CNV | deletion | 24896259 |
| nsv1134648 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv1147003 | CNV | deletion | 26484159 |
| nsv1152691 | CNV | deletion | 26484159 |
| nsv819586 | CNV | gain | 19587683 |
| nsv827985 | CNV | loss | 20364138 |
| nsv955421 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
1.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.35;
53.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CDK12 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK12 Gene
Disorders for CDK12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| corneal endothelial dystrophy |
|
|
| gastric cancer |
|
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| ovary adenocarcinoma |
|
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| ovarian serous cystadenocarcinoma |
|
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| suppression of tumorigenicity 12 |
|
|
Search CDK12 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CDK12_HUMAN- Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
Additional Disease Information for CDK12
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform