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Aliases for CDK12 Gene

Aliases for CDK12 Gene

  • Cyclin Dependent Kinase 12 2 3 5
  • Cdc2-Related Kinase, Arginine/Serine-Rich 2 3 4
  • Cell Division Cycle 2-Related Protein Kinase 7 3 4
  • Cell Division Protein Kinase 12 3 4
  • CDC2-Related Protein Kinase 7 3 4
  • EC 2.7.11.22 4 56
  • CRKRS 3 4
  • CRK7 3 4
  • CDC2 Related Protein Kinase 7 2
  • Cyclin-Dependent Kinase 12 3
  • EC 2.7.11.23 4
  • EC 2.7.11 56
  • KIAA0904 4
  • HCDK12 4
  • CRKR 3

External Ids for CDK12 Gene

Previous HGNC Symbols for CDK12 Gene

  • CRKRS

Previous GeneCards Identifiers for CDK12 Gene

  • GC17P034873
  • GC17P037618
  • GC17P033411

Summaries for CDK12 Gene

CIViC summary for CDK12 Gene

GeneCards Summary for CDK12 Gene

CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Corneal Endothelial Dystrophy. Among its related pathways are Gene Expression and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.

UniProtKB/Swiss-Prot for CDK12 Gene

  • Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene Wiki entry for CDK12 Gene

Additional gene information for CDK12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK12 Gene

Genomics for CDK12 Gene

GeneHancer (GH) Regulatory Elements for CDK12 Gene

Promoters and enhancers for CDK12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039460 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.5 +1.1 1108 4.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 CDK12 MED1 RPL23 LOC105371762 SNORA21 MED24 MSL1 SNORD124 RPL19 PGAP3
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 120.9 +856.0 856039 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
GH17I038745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 112.1 -711.7 -711713 8.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCGF2 PSMB3 LOC100287808 MED1 CDK12 LOC105371762 SNORA21 RPL23 RPL19 CISD3
GH17I038867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 65 -589.8 -589783 9.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 LASP1 MED1 CDK12 SNORA21 LOC105371762 RPL23 CWC25 PSMB3 SNORA21B C17orf98
GH17I038823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 79 -636.5 -636548 3 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CWC25 MIR4727 MED1 CDK12 SNORA21 LOC105371762 RPL23 STARD3 RPL19 PIP4K2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDK12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDK12 Gene

Genomic Locations for CDK12 Gene
chr17:39,461,486-39,567,559
(GRCh38/hg38)
Size:
106,074 bases
Orientation:
Plus strand
chr17:37,617,739-37,721,160
(GRCh37/hg19)

Genomic View for CDK12 Gene

Genes around CDK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK12 Gene

Proteins for CDK12 Gene

  • Protein details for CDK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV4-CDK12_HUMAN
    Recommended name:
    Cyclin-dependent kinase 12
    Protein Accession:
    Q9NYV4
    Secondary Accessions:
    • A7E2B2
    • B4DYX4
    • B9EIQ6
    • O94978

    Protein attributes for CDK12 Gene

    Size:
    1490 amino acids
    Molecular mass:
    164155 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.
    SequenceCaution:
    • Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK12 Gene

    Alternative splice isoforms for CDK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK12 Gene

Selected DME Specific Peptides for CDK12 Gene

Q9NYV4:
  • YCHKKNFLHRDIKCSNIL
  • CGSPCPAVWPDVIKLPYFNTMKPKKQYRR
  • NMKEIVTDK
  • ELAQLELISR
  • FLHRDIK
  • EKEGFPITAIREIKIL
  • NEKEGFPITAIREIKILRQL
  • LADFGLA
  • VITLWYRPPELLLG
  • IDVWSCGCILGELF
  • SRSRHSSISP
  • WQDCHELWSKKRRRQ
  • DLPLPPELPGGD
  • FYLVFEYMDHDLMGLLESG
  • RPYTNKVITLWYRPPELLLGEERY
  • IGEGTYG

Post-translational modifications for CDK12 Gene

Domains & Families for CDK12 Gene

Gene Families for CDK12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDK12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYV4

UniProtKB/Swiss-Prot:

CDK12_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK12: view

Function for CDK12 Gene

Molecular function for CDK12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Enzyme Numbers (IUBMB) for CDK12 Gene

Phenotypes From GWAS Catalog for CDK12 Gene

Gene Ontology (GO) - Molecular Function for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11683387
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 12841360
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK12: view
genes like me logo Genes that share phenotypes with CDK12: view

Animal Models for CDK12 Gene

MGI Knock Outs for CDK12:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK12

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK12 Gene

Localization for CDK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK12 Gene

Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK12 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IBA --
genes like me logo Genes that share ontologies with CDK12: view

Pathways & Interactions for CDK12 Gene

genes like me logo Genes that share pathways with CDK12: view

Pathways by source for CDK12 Gene

1 Cell Signaling Technology pathway for CDK12 Gene

SIGNOR curated interactions for CDK12 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006368 transcription elongation from RNA polymerase II promoter IBA --
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IEA --
GO:0008380 RNA splicing ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CDK12: view

Drugs & Compounds for CDK12 Gene

(3) Drugs for CDK12 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 23
ATP Investigational Nutra Agonist 0
Poly(ADP-ribose) Polymerase Inhibitors Pharma 389

(1) Additional Compounds for CDK12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK12: view

Transcripts for CDK12 Gene

Unigene Clusters for CDK12 Gene

Cyclin-dependent kinase 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK12

Alternative Splicing Database (ASD) splice patterns (SP) for CDK12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:

Relevant External Links for CDK12 Gene

GeneLoc Exon Structure for
CDK12
ECgene alternative splicing isoforms for
CDK12

Expression for CDK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK12 Gene

Protein differential expression in normal tissues from HIPED for CDK12 Gene

This gene is overexpressed in Liver (24.0), Peripheral blood mononuclear cells (11.7), and Lung (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK12 Gene



Protein tissue co-expression partners for CDK12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK12 Gene:

CDK12

SOURCE GeneReport for Unigene cluster for CDK12 Gene:

Hs.416108

mRNA Expression by UniProt/SwissProt for CDK12 Gene:

Q9NYV4-CDK12_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for CDK12 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CDK12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK12 Gene

Orthologs for CDK12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK12 33 34
  • 98.48 (n)
dog
(Canis familiaris)
Mammalia CDK12 33 34
  • 93.28 (n)
cow
(Bos Taurus)
Mammalia CDK12 33 34
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Cdk12 33
  • 89.31 (n)
mouse
(Mus musculus)
Mammalia Cdk12 33 16 34
  • 88.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDK12 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK12 33 34
  • 74.13 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 76 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk12 33
  • 66.92 (n)
Str.18694 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15324 33
zebrafish
(Danio rerio)
Actinopterygii cdk12 34
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 34
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 34
  • 37 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.21132 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 34
  • 57 (a)
OneToMany
Species where no ortholog for CDK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK12 Gene

ENSEMBL:
Gene Tree for CDK12 (if available)
TreeFam:
Gene Tree for CDK12 (if available)

Paralogs for CDK12 Gene

Variants for CDK12 Gene

Sequence variations from dbSNP and Humsavar for CDK12 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_041969 A colorectal adenocarcinoma sample p.Arg912His
rs141353560 not-provided, not specified 39,490,613(+) G/A coding_sequence_variant, missense_variant
rs142347393 not-provided, not specified 39,530,840(+) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs144501352 not-provided, not specified 39,471,687(+) A/C/G coding_sequence_variant, missense_variant
rs186043011 not-provided, not specified 39,531,224(+) G/T coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK12 Gene

Variant ID Type Subtype PubMed ID
dgv50n6 CNV deletion 16902084
esv1352810 CNV deletion 17803354
esv2263528 CNV deletion 18987734
esv2715901 CNV deletion 23290073
esv2715902 CNV deletion 23290073
esv2715903 CNV deletion 23290073
esv3554404 CNV deletion 23714750
nsv1063848 CNV gain 25217958
nsv1116009 CNV deletion 24896259
nsv1127568 CNV deletion 24896259
nsv1134648 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1147003 CNV deletion 26484159
nsv1152691 CNV deletion 26484159
nsv819586 CNV gain 19587683
nsv827985 CNV loss 20364138
nsv955421 CNV deletion 24416366

Variation tolerance for CDK12 Gene

Residual Variation Intolerance Score: 1.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK12 Gene

Human Gene Mutation Database (HGMD)
CDK12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK12

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK12 Gene

Disorders for CDK12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK12 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
corneal endothelial dystrophy
  • ched
- elite association - COSMIC cancer census association via MalaCards
Search CDK12 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK12_HUMAN
  • Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

Additional Disease Information for CDK12

genes like me logo Genes that share disorders with CDK12: view

No data available for Genatlas for CDK12 Gene

Publications for CDK12 Gene

  1. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. (PMID: 11683387) Ko TK … Pines J (Journal of cell science 2001) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. (PMID: 22012619) Blazek D … Peterlin BM (Genes & development 2011) 3 4 58
  4. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. (PMID: 20952539) Bartkowiak B … Greenleaf AL (Genes & development 2010) 3 4 58
  5. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3 58

Products for CDK12 Gene

  • Addgene plasmids for CDK12

Sources for CDK12 Gene