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Aliases for CDK11B Gene

Aliases for CDK11B Gene

  • Cyclin Dependent Kinase 11B 2 3 5
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 1 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L1 3 4
  • Cell Division Protein Kinase 11B 3 4
  • P58 CLK-1 3 4
  • PITSLREA 3 4
  • CDC2L1 3 4
  • CDK11 3 4
  • CLK-1 3 4
  • PK58 3 4
  • Cell Division Cycle 2-Like Protein Kinase 1 4
  • CDC-Related Protein Kinase P58 3
  • Cyclin-Dependent Kinase 11B 3
  • EC 2.7.11.22 4
  • CDK11-P110 3
  • CDK11-P46 3
  • CDK11-P58 3
  • P58CDC2L1 3
  • P58CLK-1 3
  • P58 3

External Ids for CDK11B Gene

Previous HGNC Symbols for CDK11B Gene

  • CDC2L1

Previous GeneCards Identifiers for CDK11B Gene

  • GC01M001628
  • GC01M001572
  • GC01M001574
  • GC01M001636
  • GC01M001637
  • GC01M001641
  • GC01M001645
  • GC01M001650

Summaries for CDK11B Gene

Entrez Gene Summary for CDK11B Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CDK11B Gene

CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot for CDK11B Gene

  • Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11B Gene

Additional gene information for CDK11B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11B Gene

Genomics for CDK11B Gene

GeneHancer (GH) Regulatory Elements for CDK11B Gene

Promoters and enhancers for CDK11B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001658 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 713 1.9 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 CDK11B GC01P001660 ENSG00000272004 SLC35E2B LOC100129381 PIR59394
GH01J001657 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +2.4 2416 0.1 CDK11B ENSG00000272004 PIR59394
GH01J001708 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.2 -49.1 -49071 0.1 CDK11B MMP23A CDK11A ENSG00000268575
GH01J001719 Promoter 0.5 EPDnew 650.2 -59.6 -59633 0.1 CDK11B LOC100129381 CDK11A ENSG00000268575 MMP23A
GH01J001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.4 +259.7 259725 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 SLC35E2A LOC100129381 CDK11A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDK11B on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDK11B Gene

Genomic Locations for CDK11B Gene
chr1:1,635,226-1,659,839
(GRCh38/hg38)
Size:
24,614 bases
Orientation:
Minus strand
chr1:1,570,603-1,590,473
(GRCh37/hg19)
Size:
19,871 bases
Orientation:
Minus strand

Genomic View for CDK11B Gene

Genes around CDK11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11B Gene

Proteins for CDK11B Gene

  • Protein details for CDK11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21127-CD11B_HUMAN
    Recommended name:
    Cyclin-dependent kinase 11B
    Protein Accession:
    P21127
    Secondary Accessions:
    • B7ZVY7
    • J3KTL7
    • J3QR29
    • J3QR44
    • O95265
    • Q12817
    • Q12818
    • Q12819
    • Q12820
    • Q12822
    • Q8N530
    • Q9NZS5
    • Q9UBJ0
    • Q9UBQ1
    • Q9UBR0
    • Q9UNY2
    • Q9UP57
    • Q9UP58
    • Q9UP59

    Protein attributes for CDK11B Gene

    Size:
    795 amino acids
    Molecular mass:
    92620 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A (PubMed:25965346).
    Miscellaneous:
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
    SequenceCaution:
    • Sequence=AAB59449.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC83664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF36538.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11B Gene

neXtProt entry for CDK11B Gene

Post-translational modifications for CDK11B Gene

  • During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
  • Ubiquitination at posLast=660660
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDK11B Gene

Domains & Families for CDK11B Gene

Gene Families for CDK11B Gene

Protein Domains for CDK11B Gene

Suggested Antigen Peptide Sequences for CDK11B Gene

Graphical View of Domain Structure for InterPro Entry

P21127

UniProtKB/Swiss-Prot:

CD11B_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11B: view

Function for CDK11B Gene

Molecular function for CDK11B Gene

UniProtKB/Swiss-Prot Function:
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.
UniProtKB/Swiss-Prot Induction:
Isoform 7 is induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11B Gene

Phenotypes From GWAS Catalog for CDK11B Gene

Gene Ontology (GO) - Molecular Function for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0004672 protein kinase activity TAS 1639388
GO:0004674 protein serine/threonine kinase activity IDA 12501247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 12624090
genes like me logo Genes that share ontologies with CDK11B: view
genes like me logo Genes that share phenotypes with CDK11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK11B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDK11B Gene

Localization for CDK11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK11B gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8195233
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK11B: view

Pathways & Interactions for CDK11B Gene

genes like me logo Genes that share pathways with CDK11B: view

Pathways by source for CDK11B Gene

1 GeneTex pathway for CDK11B Gene
1 Cell Signaling Technology pathway for CDK11B Gene

SIGNOR curated interactions for CDK11B Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle NAS 1639388
GO:0001558 regulation of cell growth IEP 10882096
GO:0006355 regulation of transcription, DNA-templated NAS 9750192
GO:0006468 protein phosphorylation IDA,IEA 12501247
GO:0006915 apoptotic process NAS 9750192
genes like me logo Genes that share ontologies with CDK11B: view

Drugs & Compounds for CDK11B Gene

(2) Drugs for CDK11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for CDK11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDK11B: view

Transcripts for CDK11B Gene

mRNA/cDNA for CDK11B Gene

Unigene Clusters for CDK11B Gene

Cyclin-dependent kinase 11B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CDK11B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11B Gene

No ASD Table

Relevant External Links for CDK11B Gene

GeneLoc Exon Structure for
CDK11B
ECgene alternative splicing isoforms for
CDK11B

Expression for CDK11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK11B Gene

Protein differential expression in normal tissues from HIPED for CDK11B Gene

This gene is overexpressed in Pancreas (20.4), Lung (15.0), Testis (8.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK11B Gene



Protein tissue co-expression partners for CDK11B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK11B Gene:

CDK11B

SOURCE GeneReport for Unigene cluster for CDK11B Gene:

Hs.709182

mRNA Expression by UniProt/SwissProt for CDK11B Gene:

P21127-CD11B_HUMAN
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.

Evidence on tissue expression from TISSUES for CDK11B Gene

  • Blood(4)
  • Liver(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CDK11B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK11B Gene

Orthologs for CDK11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK11B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC2L1 34
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdk11b 34
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDC2L1 34
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16205 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23888 33
zebrafish
(Danio rerio)
Actinopterygii cdk11b 34
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.2 34
  • 40 (a)
ManyToMany
ZC504.3 34
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 34
  • 27 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.11311 33
barley
(Hordeum vulgare)
Liliopsida Hv.6051 33
rice
(Oryza sativa)
Liliopsida Os.11889 33
wheat
(Triticum aestivum)
Liliopsida Ta.4787 33
Species where no ortholog for CDK11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK11B Gene

ENSEMBL:
Gene Tree for CDK11B (if available)
TreeFam:
Gene Tree for CDK11B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDK11B: view image

Paralogs for CDK11B Gene

Paralogs for CDK11B Gene

Pseudogenes.org Pseudogenes for CDK11B Gene

genes like me logo Genes that share paralogs with CDK11B: view

Variants for CDK11B Gene

Sequence variations from dbSNP and Humsavar for CDK11B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008651 -- 1,642,062(-) C/T intron_variant
rs1000037479 -- 1,654,835(-) TTTTT/TTTT genic_upstream_transcript_variant, intron_variant
rs1000078484 -- 1,641,171(-) C/T intron_variant
rs1000423450 -- 1,636,319(-) T/A intron_variant
rs1000704026 -- 1,659,339(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK11B Gene

Variant ID Type Subtype PubMed ID
dgv2e199 CNV deletion 23128226
dgv3n67 CNV gain 20364138
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv1336011 CNV insertion 17803354
esv2661270 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3390461 CNV duplication 20981092
esv3550788 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3585007 CNV loss 21293372
nsv10161 CNV gain+loss 18304495
nsv1073627 CNV deletion 25765185
nsv1075361 CNV duplication 25765185
nsv1118425 CNV duplication 24896259
nsv1139466 CNV duplication 24896259
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545018 CNV loss 21841781
nsv947410 CNV duplication 23825009
nsv950452 CNV deletion 24416366

Variation tolerance for CDK11B Gene

Gene Damage Index Score: 2.65; 45.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11B Gene

Disorders for CDK11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK11B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CDK11B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDK11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK11B Gene

Publications for CDK11B Gene

  1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M … Nelson M (Biochemical and biophysical research communications 2003) 2 3 4 58
  2. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D … Kidd VJ (The Journal of biological chemistry 2003) 3 4 22 58
  3. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PMID: 1639388) Eipers PG … Kidd VJ (Genomics 1992) 3 4 22 58
  4. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. (PMID: 25965346) Yang L … Chroneos ZC (PloS one 2015) 3 4 58
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58

Products for CDK11B Gene

Sources for CDK11B Gene

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